ES8403321A1 - Procedimiento para la produccion de un preparado solido de fibrinogeno. - Google Patents
Procedimiento para la produccion de un preparado solido de fibrinogeno.Info
- Publication number
- ES8403321A1 ES8403321A1 ES519469A ES519469A ES8403321A1 ES 8403321 A1 ES8403321 A1 ES 8403321A1 ES 519469 A ES519469 A ES 519469A ES 519469 A ES519469 A ES 519469A ES 8403321 A1 ES8403321 A1 ES 8403321A1
- Authority
- ES
- Spain
- Prior art keywords
- fibrinogen
- manufacture
- preparation
- formulation
- fibrinogen preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UN PREPARADO SOLIDO DE FIBRINOGENO.CONSISTE EN PREPARAR UNA DISOLUCION QUE CONTIENE FIBRINOGENO A PARTIR DE UN CRIOPRECIPITADO; AJUSTAR EL PH DE LA DISOLUCION A 5-8, MANTENIENDO LA TEMPERATURA ENTRE 0JC Y 15JC, HASTA PRECIPITACION DE LOS POLIMEROS DE FIBRINOGENO. SEPARAR ESTOS POLIMEROS Y AÑADIR A LA DISOLUCION UNA SUSTANCIA QUE CONTIENE UREA O GUANIDINO; Y, FINALMENTE, SECAR LA DISOLUCION.ESTE PREPARADO TIENE APLICACIONES PARA LA OBTENCION DE DISOLUCIONES ADECUADAS COMO ADHESIVO O PEGAMENTO PARA TEJIDOS HUMANOS Y ANIMALES Y COMO CONCENTRADODE FIBRINOGENO PARA APLICACION POR VIA INTRAVENOSA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823203775 DE3203775A1 (de) | 1982-02-04 | 1982-02-04 | Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8403321A1 true ES8403321A1 (es) | 1984-03-16 |
ES519469A0 ES519469A0 (es) | 1984-03-16 |
Family
ID=6154769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519469A Granted ES519469A0 (es) | 1982-02-04 | 1983-02-02 | Procedimiento para la produccion de un preparado solido de fibrinogeno. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4650678A (es) |
EP (1) | EP0085923B2 (es) |
JP (1) | JPS58135817A (es) |
AR (1) | AR231233A1 (es) |
AT (1) | ATE22806T1 (es) |
AU (1) | AU556068B2 (es) |
CA (1) | CA1186995A (es) |
DE (2) | DE3203775A1 (es) |
DK (1) | DK158282C (es) |
ES (1) | ES519469A0 (es) |
FI (1) | FI77985C (es) |
GR (1) | GR77184B (es) |
IE (1) | IE54547B1 (es) |
IL (1) | IL67823A (es) |
NO (1) | NO155177B (es) |
NZ (1) | NZ203164A (es) |
PT (1) | PT76193B (es) |
ZA (1) | ZA83726B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2156731A1 (es) * | 1999-05-31 | 2001-07-01 | Grifols Grupo Sa | Utilizacion del acido tranexamico para la preparacion de una composicion de fibrinogeno humano. |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
DE3622642A1 (de) * | 1986-07-05 | 1988-01-14 | Behringwerke Ag | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
DK475386D0 (da) * | 1986-10-03 | 1986-10-03 | Weis Fogh Ulla Sivertsen | Fremgangsmaade og apparat til fremstilling af biologiske stoffer |
US4743632A (en) * | 1987-02-25 | 1988-05-10 | Pfizer Hospital Products Group, Inc. | Polyetherurethane urea polymers as space filling tissue adhesives |
US5449759A (en) * | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
FR2618784B1 (fr) * | 1987-07-30 | 1990-04-06 | Lille Transfusion Sanguine | Concentre de proteines coagulables par la thrombine, son procede d'obtention et son utilisation a titre de colle biologique |
AT407834B (de) * | 1987-10-08 | 2001-06-25 | Aventis Behring Gmbh | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
DE3734923C1 (de) * | 1987-10-15 | 1989-01-26 | Biotest Pharma Gmbh | Verfahren zur Herstellung einer sterilen Plasmaproteinloesung,die Fibrinogen und den Gerinnungsfaktor XIII enthaelt |
AT397203B (de) * | 1988-05-31 | 1994-02-25 | Immuno Ag | Gewebeklebstoff |
FR2639958B1 (fr) * | 1988-12-06 | 1992-08-21 | Lille Transfusion Sanguine | Support biologique pour cultures cellulaires constitue de proteines plasmatiques coagulees par la thrombine, son utilisation pour la culture des keratinocytes, leur recuperation et leur transport a des fins d'utilisation therapeutique |
US4980165A (en) * | 1989-01-27 | 1990-12-25 | Genetics Institute, Inc. | Pharmaceutical formulations of plasminogen activator proteins |
FR2663226B1 (fr) * | 1990-06-15 | 1994-11-18 | Fondation Nale Transfusion San | Colle biologique fluide. |
IE912528A1 (en) * | 1990-07-19 | 1992-01-29 | Scripps Clinic Res | Inhabition of mac-1 receptor binding fibrinogen using d30¹homologs |
US5420250A (en) * | 1990-08-06 | 1995-05-30 | Fibrin Corporation | Phase transfer process for producing native plasma protein concentrates |
US5644032A (en) * | 1990-08-06 | 1997-07-01 | Fibrin Corporation | Process for producing fibrinogen concentrates |
US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
DE4202667C1 (es) | 1992-01-29 | 1993-05-13 | Behringwerke Ag, 3550 Marburg, De | |
WO1993022336A1 (en) * | 1992-04-30 | 1993-11-11 | Alpha Therapeutic Corporation | Improved solubilization and stabilization of factor viii complex |
PT644768E (pt) * | 1992-06-11 | 2002-03-28 | Scripps Research Inst | Metodos e composicoes para inibir a inflamacao mediada por celulas endoteliais e fibrinogenio |
US5599790A (en) | 1992-06-11 | 1997-02-04 | The Scripps Research Institute | Fibrinogen γ chain polypeptide and compositions thereof |
US5385606A (en) * | 1992-07-06 | 1995-01-31 | Kowanko; Nicholas | Adhesive composition and method |
CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
CA2146976A1 (en) * | 1992-10-14 | 1994-04-28 | Oswald Raymond Graham Kitchenman | Ozone generation apparatus and method |
US5330974A (en) * | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
CA2175203A1 (en) * | 1993-11-03 | 1995-05-11 | Thaddeus P. Pruss | Hemostatic patch |
WO1995026749A1 (en) * | 1994-03-31 | 1995-10-12 | Fibrin Corporation | Cryoprecipitated native fibrinogen concentrates |
US5585007A (en) | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
EP0835667B1 (en) * | 1996-03-15 | 2005-11-09 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Spray device for applying tissue adhesive |
CA2252374C (en) | 1996-04-19 | 2007-08-07 | Alpha Therapeutic Corporation | A process for viral inactivation of lyophilized blood proteins |
DE19617369A1 (de) * | 1996-04-30 | 1997-11-06 | Immuno Ag | Lagerstabile Fibrinogen-Präparate |
US6503527B1 (en) | 1997-11-17 | 2003-01-07 | Haemacure Corporation | Fibrin sealants or adhesives comprising a hyaluronic acid derivative material |
AUPP276098A0 (en) * | 1998-04-01 | 1998-04-30 | Nokuta Pty Ltd | A method for treating gelatine |
CA2350628A1 (en) * | 1998-11-12 | 2000-05-18 | Polymer Biosciences, Inc. | Hemostatic polymer useful for rapid blood coagulation and hemostasis |
AU774118B2 (en) | 1999-02-12 | 2004-06-17 | Baxter Healthcare Sa | A method for producing a preparation based on fibrinogen and fibronectin as well as protein compositions obtainable according to this method |
US6916911B1 (en) | 1999-08-13 | 2005-07-12 | Omrix Biopharmaceuticals Sa | Use of fibrinogen multimers |
JP2003507091A (ja) * | 1999-08-13 | 2003-02-25 | オムリックス・バイオファーマシューティカルズ・エス.アー. | フィブリノゲン多量体の使用 |
DE60042343D1 (de) * | 1999-12-23 | 2009-07-16 | Csl Ltd | Abtrennung von fibrinogen von plasmaproteasen |
US6468660B2 (en) | 2000-12-29 | 2002-10-22 | St. Jude Medical, Inc. | Biocompatible adhesives |
US20020146409A1 (en) * | 2001-01-30 | 2002-10-10 | Herring Steven W. | Methods for stabilizing lyophilized blood proteins |
US20020173770A1 (en) * | 2001-05-16 | 2002-11-21 | Flory Alan R. | Adhesive delivery system |
US20030224994A1 (en) * | 2002-04-05 | 2003-12-04 | Newton Colin John | Storage stable liquid sealer protein complex |
US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US7374678B2 (en) * | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
US7832566B2 (en) * | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
AU2003249642A1 (en) | 2002-05-24 | 2003-12-12 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
FR2857267B1 (fr) * | 2003-07-09 | 2006-03-10 | Lab Francais Du Fractionnement | Formulation stabilisante et solubilisante pour les proteines cryoprecipitables. |
US8137450B2 (en) * | 2004-07-08 | 2012-03-20 | Symatese | Collagen-based lyophilised glue and the use thereof for producing an adhesive prosthesis |
FR2872821B1 (fr) * | 2004-07-08 | 2006-09-29 | Symatese Soc Par Actions Simpl | Colle lyophilisee a base de collagene et son utilisation pour la fabrication de protheses collantes |
JP4961354B2 (ja) * | 2005-02-07 | 2012-06-27 | ハヌマン リミテッド ライアビリティ カンパニー | 多血小板血漿濃縮装置および方法 |
EP1848474B1 (en) * | 2005-02-07 | 2013-06-12 | Hanuman LLC | Platelet rich plasma concentrate apparatus and method |
US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
US20070248653A1 (en) * | 2006-04-20 | 2007-10-25 | Cochrum Kent C | Hemostatic compositions and methods for controlling bleeding |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8430813B2 (en) * | 2006-05-26 | 2013-04-30 | Depuy Spine, Inc. | Illuminated surgical access system including a surgical access device and integrated light emitter |
AU2008230476B2 (en) | 2007-03-22 | 2012-11-01 | Km Biologics Co., Ltd. | Solid fibrinogen preparation |
US7806276B2 (en) * | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
PL2259774T3 (pl) | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1 |
WO2009111338A1 (en) * | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | A system and process for separating a material |
US8012077B2 (en) * | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
US8313954B2 (en) * | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
US9011800B2 (en) * | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
MX351980B (es) | 2011-12-29 | 2017-11-03 | Omrix Biopharmaceuticals Ltd | Método y dispositivo para la disolucion rápida de composición sólida de proteinas solidas. |
ES2642383T3 (es) | 2012-03-13 | 2017-11-16 | Octapharma Ag | Procedimiento mejorado de producción de fibrinógeno y fibrinógeno producido por el mismo |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
EP3151662B1 (en) | 2014-06-09 | 2020-10-21 | Terumo BCT, Inc. | Lyophilization |
US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
US20170136070A1 (en) * | 2015-11-18 | 2017-05-18 | Dregalla Patent Holdco, LLC | Acellular Regenerative Products and Methods of Their Manufacture |
JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ,エルエルシー | 凍結乾燥方法 |
US11604026B2 (en) | 2019-03-14 | 2023-03-14 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
CN117794516A (zh) | 2021-08-13 | 2024-03-29 | 生物测试股份公司 | 纤维蛋白原组合物和制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2461969A1 (de) * | 1974-12-31 | 1976-07-08 | Behringwerke Ag | Stabiles blutplasma, verfahren zu dessen herstellung und seine verwendung als vergleichsplasma bei gerinnungs- untersuchungen |
JPS5598196A (en) * | 1979-01-16 | 1980-07-25 | Meito Sangyo Kk | Fractionation of fibrinogen or its constituents and their use |
AT359653B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
AT359652B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
US4362661A (en) * | 1979-08-09 | 1982-12-07 | Teijin Limited | Immunoglobulin composition having a high monomer content, and process for production thereof |
US4440679A (en) * | 1980-03-05 | 1984-04-03 | Cutter Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
-
1982
- 1982-02-04 DE DE19823203775 patent/DE3203775A1/de not_active Withdrawn
-
1983
- 1983-01-31 DE DE8383100869T patent/DE3366841D1/de not_active Expired
- 1983-01-31 AT AT83100869T patent/ATE22806T1/de not_active IP Right Cessation
- 1983-01-31 EP EP83100869A patent/EP0085923B2/de not_active Expired - Lifetime
- 1983-02-02 FI FI830361A patent/FI77985C/fi not_active IP Right Cessation
- 1983-02-02 GR GR70394A patent/GR77184B/el unknown
- 1983-02-02 ES ES519469A patent/ES519469A0/es active Granted
- 1983-02-02 NZ NZ203164A patent/NZ203164A/en unknown
- 1983-02-02 AR AR292015A patent/AR231233A1/es active
- 1983-02-02 IL IL67823A patent/IL67823A/xx not_active IP Right Cessation
- 1983-02-03 PT PT76193A patent/PT76193B/pt not_active IP Right Cessation
- 1983-02-03 NO NO830371A patent/NO155177B/no not_active IP Right Cessation
- 1983-02-03 IE IE207/83A patent/IE54547B1/en not_active IP Right Cessation
- 1983-02-03 CA CA000420880A patent/CA1186995A/en not_active Expired
- 1983-02-03 AU AU11105/83A patent/AU556068B2/en not_active Ceased
- 1983-02-03 JP JP58015556A patent/JPS58135817A/ja active Granted
- 1983-02-03 DK DK044483A patent/DK158282C/da active
- 1983-02-03 ZA ZA83726A patent/ZA83726B/xx unknown
-
1984
- 1984-08-10 US US06/639,617 patent/US4650678A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2156731A1 (es) * | 1999-05-31 | 2001-07-01 | Grifols Grupo Sa | Utilizacion del acido tranexamico para la preparacion de una composicion de fibrinogeno humano. |
Also Published As
Publication number | Publication date |
---|---|
NO830371L (no) | 1983-08-05 |
CA1186995A (en) | 1985-05-14 |
DK158282B (da) | 1990-04-30 |
NO155177B (no) | 1986-11-17 |
IE830207L (en) | 1983-08-04 |
DE3366841D1 (en) | 1986-11-20 |
FI830361A0 (fi) | 1983-02-02 |
IE54547B1 (en) | 1989-11-08 |
JPH047328B2 (es) | 1992-02-10 |
AR231233A1 (es) | 1984-10-31 |
EP0085923B2 (de) | 1991-01-23 |
FI77985C (fi) | 1989-06-12 |
NZ203164A (en) | 1985-08-30 |
AU556068B2 (en) | 1986-10-23 |
PT76193A (de) | 1983-03-01 |
IL67823A (en) | 1986-01-31 |
FI77985B (fi) | 1989-02-28 |
DE3203775A1 (de) | 1983-08-11 |
IL67823A0 (en) | 1983-06-15 |
JPS58135817A (ja) | 1983-08-12 |
AU1110583A (en) | 1983-08-11 |
ES519469A0 (es) | 1984-03-16 |
DK158282C (da) | 1990-10-01 |
US4650678A (en) | 1987-03-17 |
EP0085923B1 (de) | 1986-10-15 |
DK44483D0 (da) | 1983-02-03 |
FI830361L (fi) | 1983-08-05 |
GR77184B (es) | 1984-09-11 |
ATE22806T1 (de) | 1986-11-15 |
EP0085923A1 (de) | 1983-08-17 |
DK44483A (da) | 1983-08-05 |
PT76193B (de) | 1986-01-10 |
ZA83726B (en) | 1983-10-26 |
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Effective date: 20040601 |