ATE236993T1 - Antithrombose mittel und gegen den von willebrand-faktor gerichtete monoklonale antikörper - Google Patents

Antithrombose mittel und gegen den von willebrand-faktor gerichtete monoklonale antikörper

Info

Publication number
ATE236993T1
ATE236993T1 AT95938608T AT95938608T ATE236993T1 AT E236993 T1 ATE236993 T1 AT E236993T1 AT 95938608 T AT95938608 T AT 95938608T AT 95938608 T AT95938608 T AT 95938608T AT E236993 T1 ATE236993 T1 AT E236993T1
Authority
AT
Austria
Prior art keywords
von willebrand
willebrand factor
monoclonal antibodies
directed against
antibodies directed
Prior art date
Application number
AT95938608T
Other languages
English (en)
Inventor
Mitsuyo Nagano
Hiroshi Yamamoto
Morikazu Kito
Ryota Yoshimoto
Tsuyoshi Kobayashi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE236993T1 publication Critical patent/ATE236993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT95938608T 1994-11-30 1995-11-29 Antithrombose mittel und gegen den von willebrand-faktor gerichtete monoklonale antikörper ATE236993T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29707094 1994-11-30
PCT/JP1995/002435 WO1996017078A1 (en) 1994-11-30 1995-11-29 Antithrombotic agent and anti-von willebrand factor monoclonal antibodies

Publications (1)

Publication Number Publication Date
ATE236993T1 true ATE236993T1 (de) 2003-04-15

Family

ID=17841828

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95938608T ATE236993T1 (de) 1994-11-30 1995-11-29 Antithrombose mittel und gegen den von willebrand-faktor gerichtete monoklonale antikörper

Country Status (13)

Country Link
US (3) US5916805A (de)
EP (1) EP0795608B1 (de)
JP (1) JP3331377B2 (de)
KR (1) KR100406072B1 (de)
CN (1) CN1254275C (de)
AT (1) ATE236993T1 (de)
DE (1) DE69530316T2 (de)
DK (1) DK0795608T3 (de)
ES (1) ES2197210T3 (de)
FI (1) FI119734B (de)
NO (1) NO319738B1 (de)
PT (1) PT795608E (de)
WO (1) WO1996017078A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2197210T3 (es) * 1994-11-30 2004-01-01 Ajinomoto Co., Inc. Agente antitrombotico y anticuerpos monoclonales contra el factor von willebrand.
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
US6228360B1 (en) 1998-08-19 2001-05-08 Ajinomoto Co., Inc. Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody
US6251393B1 (en) * 1998-10-23 2001-06-26 The Brigham And Women's Hospital, Inc. Conformation-specific anti-von Willebrand Factor antibodies
CN1198198C (zh) * 2001-02-27 2005-04-20 索尼公司 字符输入方法及字符输入装置
JP2005298336A (ja) * 2002-01-29 2005-10-27 Ajinomoto Co Inc 炎症性疾患治療用薬剤
JPWO2004011030A1 (ja) * 2002-07-29 2005-11-24 味の素株式会社 血小板減少症治療用医薬組成物
US20050136056A1 (en) * 2002-07-29 2005-06-23 Shunsuke Kageyama Pharmaceutical composition for the treatment of thrombocytopenia
ATE512364T1 (de) * 2002-08-07 2011-06-15 Ablynx Nv Modulation der blutplättchen-adhäsion basierend auf dem oberflächen-exponierten beta-switch loop des blutplättchen-glycoproteins ib-alpha
NZ540194A (en) 2002-11-08 2008-07-31 Ablynx Nv Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
US20060034845A1 (en) * 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
US20100003253A1 (en) * 2002-11-08 2010-01-07 Ablynx N.V. Single domain antibodies directed against epidermal growth factor receptor and uses therefor
EP1558645B1 (de) * 2002-11-08 2011-07-27 Ablynx N.V. Stabilisierte einzel-domänen-antikörper in einer pharmazeutischen zusammensetzung ausgestaltet für inhalation
US9320792B2 (en) 2002-11-08 2016-04-26 Ablynx N.V. Pulmonary administration of immunoglobulin single variable domains and constructs thereof
RU2524129C2 (ru) * 2003-01-10 2014-07-27 Аблинкс Н.В. Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
CN1323713C (zh) * 2003-07-07 2007-07-04 张新侯 可溶性p－选择素及炭疽致死毒素的新用途
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
JP2008512098A (ja) 2004-09-07 2008-04-24 アーケミックス コーポレイション フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用
AU2005282380A1 (en) * 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
SI1836500T1 (sl) 2005-01-14 2010-11-30 Ablynx Nv Postopki in testi za razlikovanje med različnimioblikami bolezni in motenj ki so označene s trombocitopenijo in ali s spontano interakcijo med von Willebrandovim faktorjem vWF in krvnimi ploščicami
LT2444424T (lt) * 2005-05-20 2018-10-25 Ablynx N.V. Pagerintos tm nanodalelės, skirtos agregacijos sąlygotų sutrikimų gydymui
EP1918302A3 (de) * 2006-05-18 2009-11-18 AvantGen, Inc. Verfahren zur Identifikation und Isolation von epitopspezifischen Antikörpern
US8669045B2 (en) 2007-02-13 2014-03-11 Ajinomoto Co., Inc. Method for inactivating viruses with slightly acidic arginine
WO2008150495A2 (en) * 2007-06-01 2008-12-11 Archemix Corp. Vwf aptamer formulations and methods for use
AR070141A1 (es) * 2008-01-23 2010-03-17 Glenmark Pharmaceuticals Sa Anticuerpos humanizados especificos para el factor von willebrand
US20110158996A1 (en) * 2008-03-21 2011-06-30 Ablynx N.V. Von willebrand factor specific binders and methods of use therefor
CN102089319B (zh) 2008-05-08 2013-11-13 味之素株式会社 蛋白质的重折叠方法
CN102532316B (zh) * 2010-12-24 2014-06-18 神州细胞工程有限公司 一种抗vWF单克隆抗体及其应用
CN103608463A (zh) 2011-06-23 2014-02-26 味之素株式会社 由使具有免疫球蛋白折叠结构的蛋白和能够形成亚单元结构的蛋白融合而得到的单体蛋白组成的多聚体蛋白的制备方法
EP3361254B1 (de) * 2013-12-18 2019-10-23 Siemens Healthcare Diagnostics Inc. Detektion von endothelialer erkrankung
EP3131929B1 (de) * 2014-04-16 2022-06-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antikörper zur prophylaxe oder behandlung von blutungsepisoden
DK3993876T3 (en) 2019-07-01 2024-12-02 Tonix Pharma Ltd Anti-cd154 antibodies and uses thereof
WO2021118845A1 (en) * 2019-12-12 2021-06-17 Corning Incorporated Light-diffusing element configured to affect thrombi formation on intravenous catheter
AU2022205313A1 (en) 2021-01-06 2023-07-20 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202264A (en) * 1989-10-27 1993-04-13 Health Research, Incorporated ELISA using multi-species antibodies for detection of von Willebrand factor in multiple species
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
ES2197210T3 (es) * 1994-11-30 2004-01-01 Ajinomoto Co., Inc. Agente antitrombotico y anticuerpos monoclonales contra el factor von willebrand.
AU724579B2 (en) 1996-04-01 2000-09-28 Sankyo Company Limited Anti-Fas recombinant antibodies and DNA therefor

Also Published As

Publication number Publication date
US20020028204A1 (en) 2002-03-07
NO319738B1 (no) 2005-09-12
NO972253D0 (no) 1997-05-16
PT795608E (pt) 2003-08-29
WO1996017078A1 (en) 1996-06-06
DE69530316T2 (de) 2004-02-12
JP3331377B2 (ja) 2002-10-07
CN1174575A (zh) 1998-02-25
FI972279L (fi) 1997-07-29
FI119734B (fi) 2009-02-27
EP0795608A4 (de) 2001-11-28
NO972253L (no) 1997-07-29
US6793920B2 (en) 2004-09-21
EP0795608A1 (de) 1997-09-17
FI972279A0 (fi) 1997-05-29
DK0795608T3 (da) 2003-07-21
ES2197210T3 (es) 2004-01-01
CN1254275C (zh) 2006-05-03
EP0795608B1 (de) 2003-04-09
KR100406072B1 (ko) 2004-03-30
US6280731B1 (en) 2001-08-28
DE69530316D1 (de) 2003-05-15
US5916805A (en) 1999-06-29

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