NO971672L - Benzofuran og benzokondenserte forbindelser, deres fremstilling og deres anvendelse som leukotrien B4(LTB4)antagonister - Google Patents

Benzofuran og benzokondenserte forbindelser, deres fremstilling og deres anvendelse som leukotrien B4(LTB4)antagonister

Info

Publication number
NO971672L
NO971672L NO971672A NO971672A NO971672L NO 971672 L NO971672 L NO 971672L NO 971672 A NO971672 A NO 971672A NO 971672 A NO971672 A NO 971672A NO 971672 L NO971672 L NO 971672L
Authority
NO
Norway
Prior art keywords
ltb4
antagonists
compounds
benzo
heteroatoms
Prior art date
Application number
NO971672A
Other languages
English (en)
Norwegian (no)
Other versions
NO971672D0 (no
Inventor
Mark A Dombroski
Kevin Koch
Anthony D Piscopio
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO971672D0 publication Critical patent/NO971672D0/no
Publication of NO971672L publication Critical patent/NO971672L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
NO971672A 1994-10-13 1997-04-11 Benzofuran og benzokondenserte forbindelser, deres fremstilling og deres anvendelse som leukotrien B4(LTB4)antagonister NO971672L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32287694A 1994-10-13 1994-10-13
PCT/IB1995/000401 WO1996011920A1 (en) 1994-10-13 1995-05-26 Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4 (ltb4) antagonists

Publications (2)

Publication Number Publication Date
NO971672D0 NO971672D0 (no) 1997-04-11
NO971672L true NO971672L (no) 1997-06-11

Family

ID=23256829

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971672A NO971672L (no) 1994-10-13 1997-04-11 Benzofuran og benzokondenserte forbindelser, deres fremstilling og deres anvendelse som leukotrien B4(LTB4)antagonister

Country Status (23)

Country Link
US (2) US6051601A (sh)
EP (1) EP0785930A1 (sh)
JP (1) JP2983295B2 (sh)
KR (1) KR100232341B1 (sh)
CN (1) CN1160399A (sh)
AU (1) AU696890B2 (sh)
BR (1) BR9504385A (sh)
CA (1) CA2201742A1 (sh)
CO (1) CO4480024A1 (sh)
CZ (1) CZ111797A3 (sh)
FI (1) FI971524A0 (sh)
HU (1) HUT77515A (sh)
IL (1) IL115529A0 (sh)
MX (1) MX9702731A (sh)
NO (1) NO971672L (sh)
NZ (1) NZ285156A (sh)
PE (1) PE10897A1 (sh)
PL (1) PL319688A1 (sh)
RU (1) RU2128655C1 (sh)
TR (1) TR199501270A2 (sh)
TW (1) TW304941B (sh)
WO (1) WO1996011920A1 (sh)
ZA (1) ZA958597B (sh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK31399A3 (en) * 1996-09-16 2000-05-16 Pfizer Processes and intermediates for preparing substituted chromanol derivatives
CA2274908A1 (en) * 1996-12-13 1998-06-18 Eli Lilly And Company Leukotriene antagonists for cerebral focal stroke
IL128731A0 (en) * 1998-03-12 2000-01-31 Pfizer Prod Inc Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
CA2433516A1 (en) * 2001-01-30 2002-08-08 Keith Michael Devries Processes for preparing chromanylbenzoic acids
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
WO2004000830A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel compounds, their use and preparation
CA2574627A1 (en) * 2004-07-22 2006-02-02 Pharmacia Corporation Compositions for treatment of inflammation and pain using a combination of a cox-2 selective inhibitor and a ltb4 receptor antagonist
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
BRPI0519013A2 (pt) 2004-12-13 2009-11-03 Lilly Co Eli composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto
CA2600004A1 (en) 2005-02-25 2006-09-08 Eli Lilly And Company Spiro-heterocyclic chromans, thiochromans and dihydroquinolines
US7842713B2 (en) * 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
US7928238B2 (en) 2006-05-11 2011-04-19 Janssen Pharmaceutica Nv 1,2,3,4-tetrahydro-quinoline derivatives as CETP inhibitors
JP2009536954A (ja) 2006-05-11 2009-10-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃｅｔｐ阻害剤としての３，４−ジヒドロ−２ｈ−ベンゾ［１，４］オキサジンおよびチアジン誘導体
PE20110303A1 (es) 2008-09-11 2011-05-21 Pfizer Derivados de heteroaril acetamidas como activadores de glucoquinasa
EP2406253B1 (en) 2009-03-11 2013-07-03 Pfizer Inc. Benzofuranyl derivatives used as glucokinase inhibitors
US9453022B2 (en) 2012-02-14 2016-09-27 Children's Hospital Medical Center Use of small molecule inhibitors targeting the interaction between Rac GTPase and p67 (phox)
CN102920692A (zh) * 2012-10-25 2013-02-13 中国人民解放军第二军医大学 (e)-2-(1-羟基-4-环己酮)乙基咖啡酸酯在制备防治类风湿关节炎的药物中的应用
SG11201707418WA (en) 2015-03-13 2017-10-30 Forma Therapeutics Inc Alpha-cinnamide compounds and compositions as hdac8 inhibitors
WO2017040963A1 (en) 2015-09-03 2017-03-09 Forma Therapeutics, Inc. [6,6] fused bicyclic hdac8 inhibitors
US10450309B2 (en) 2015-11-30 2019-10-22 Merch Sharp & Dohme Corp. Aryl sulfonamides as BLT1 antagonists
US10336733B2 (en) 2015-11-30 2019-07-02 Merk Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
US20190382363A1 (en) * 2015-11-30 2019-12-19 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
EP3383389B1 (en) 2015-11-30 2021-04-28 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
WO2018071687A1 (en) * 2016-10-13 2018-04-19 The Regents Of The University Of California Methods of treating pruritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
US4996230A (en) * 1990-02-16 1991-02-26 Eli Lilly And Company Leukotriene antagonists
US5073562A (en) * 1990-05-10 1991-12-17 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5051438A (en) * 1990-05-16 1991-09-24 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use
US5124350A (en) * 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists
MX9300312A (es) * 1992-01-23 1993-07-31 Pfizer Antagonistas benzopiranicos y relacionado de ltb.
WO1993015066A1 (en) * 1992-01-23 1993-08-05 Pfizer Inc. Benzopyran and related ltb4 antagonists

Also Published As

Publication number Publication date
IL115529A0 (en) 1996-01-19
PL319688A1 (en) 1997-08-18
CO4480024A1 (es) 1997-07-09
FI971524A (fi) 1997-04-11
CN1160399A (zh) 1997-09-24
RU2128655C1 (ru) 1999-04-10
EP0785930A1 (en) 1997-07-30
HUT77515A (hu) 1998-05-28
MX9702731A (es) 1997-06-28
FI971524A0 (fi) 1997-04-11
AU696890B2 (en) 1998-09-24
US6051601A (en) 2000-04-18
CA2201742A1 (en) 1996-04-25
PE10897A1 (es) 1997-04-21
JP2983295B2 (ja) 1999-11-29
TR199501270A2 (tr) 1996-06-21
BR9504385A (pt) 1997-05-27
NO971672D0 (no) 1997-04-11
WO1996011920A1 (en) 1996-04-25
AU2416795A (en) 1996-05-06
CZ111797A3 (cs) 1998-07-15
ZA958597B (en) 1997-04-14
JPH09512035A (ja) 1997-12-02
US6133286A (en) 2000-10-17
KR100232341B1 (ko) 2000-07-01
NZ285156A (en) 1999-01-28
TW304941B (sh) 1997-05-11
KR970706270A (ko) 1997-11-03

Similar Documents

Publication Publication Date Title
NO971672L (no) Benzofuran og benzokondenserte forbindelser, deres fremstilling og deres anvendelse som leukotrien B4(LTB4)antagonister
DE60214996T2 (de) Antagonisten der mcp-1-funktion und verfahren zu deren verwendung
DE60208159T2 (de) Antagonisten von mcp-1 tätigkeit und deren verwendungsmethoden
NO971673L (no) Benzopyran og benzokondenserte forbindelser, deres fremstiling og anvendelse som leukotrien B4 (LTB4) antagonister
DE69915508T2 (de) Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen
CN102227417B (zh) 作为沉默调节蛋白调节剂的色烯酮类似物
CN101248041A (zh) 鞘氨醇激酶抑制剂
JP2004532227A (ja) ベータ−３アデノレセプタ作動薬として有用な２，６−置換クロマン誘導体
AU2020354138B2 (en) Heteroarylamidopyridinol derivative and pharmaceutical composition comprising same as active ingredient for prevention or treatment of autoimmune disease
HU211171A9 (en) N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro- 2h-benzopyran or dihydrobenzodioxin) carboxamide derivatives
DE69318238T2 (de) Benzopyran-Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Zellenschutzmittel
US20040167171A1 (en) Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof
JP2007520539A (ja) カンナビノイド受容体モジュレーターとしてのピリジン誘導体
CN115397412A (zh) Mas相关g蛋白受体x4的调节剂及相关产物和方法
NZ323543A (en) Substituted 4-(1h-benzimidazol-2-yl-amino)piperidine derivatives useful for the treatment of allergic diseases
RU2154064C2 (ru) N-замещенные пиперидинилбензоаты, их n-оксидные формы, фармацевтически приемлемые соли присоединения кислот и стереохимически изомерные формы, способы их получения, фармацевтическая композиция на их основе и промежуточный продукт
DE69330283T2 (de) Neue 4-(3-benzofuranyl) piperidinyl und 4-(3-benzothienyl) piperidinyl-derivate und diese enthaltende pharmazeutische zusammenstellungen
JPS60184074A (ja) 上昇した眼内圧の治療用の２‐スルフアモイルベンゾ〔ｂ〕フラン誘導体
JPH072850A (ja) 新規（アリール（アルキル）カルボニル）ヘテロ環状 化合物
KR20070012407A (ko) 2-아미노피리미딘 유도체
EP0699197B1 (en) 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis and schizophrenia
RU2004126953A (ru) Производное пиперидина и фармацевтическая композиция, включающая его в качестве активного ингредиента
BR9707643A (pt) Novas N-metil-n-(4-(piperidin-1-il)-2-(aril)butil)benzamidas substituídas úteis para o tratamento de doenças alérgicas
WO2012081570A1 (ja) ラクタム化合物又はその塩及びｐｐａｒ活性化剤
JP2022505401A (ja) ムスカリンｍ１受容体陽性アロステリックモジュレーターとしてのピロロ－ピリダジン誘導体

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application