NO960952L - Kjemisk definerte ikke-polymere valensplattformmolekyler og konjugater derav - Google Patents
Kjemisk definerte ikke-polymere valensplattformmolekyler og konjugater deravInfo
- Publication number
- NO960952L NO960952L NO960952A NO960952A NO960952L NO 960952 L NO960952 L NO 960952L NO 960952 A NO960952 A NO 960952A NO 960952 A NO960952 A NO 960952A NO 960952 L NO960952 L NO 960952L
- Authority
- NO
- Norway
- Prior art keywords
- conjugates
- polymeric
- chemically defined
- defined non
- platform molecules
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/118,055 US6060056A (en) | 1991-02-08 | 1993-09-08 | Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule |
US08/152,506 US5552391A (en) | 1990-01-16 | 1993-11-15 | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
PCT/US1994/010031 WO1995007073A1 (en) | 1993-09-08 | 1994-09-08 | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
NO960952D0 NO960952D0 (no) | 1996-03-07 |
NO960952L true NO960952L (no) | 1996-05-02 |
NO319084B1 NO319084B1 (no) | 2005-06-13 |
Family
ID=26815927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19960952A NO319084B1 (no) | 1993-09-08 | 1996-03-07 | Kjemisk definerte valensplattformmolekyler, konjugater derav, farmasoytiske preparater innholdende disse, fremgangsmate for fremstilling av konjugatene, sammensetning for anvendelse ved fremstilling, samt anvendelse av en forbindelse. |
Country Status (9)
Country | Link |
---|---|
US (5) | US5552391A (no) |
EP (1) | EP0722318A4 (no) |
JP (2) | JPH09500389A (no) |
CN (2) | CN1203847C (no) |
AU (1) | AU677710B2 (no) |
CA (1) | CA2171434C (no) |
FI (1) | FI117322B (no) |
NO (1) | NO319084B1 (no) |
WO (1) | WO1995007073A1 (no) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552391A (en) * | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
US5268454A (en) | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
EP0642798B1 (en) * | 1993-09-08 | 2007-04-18 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
US8071737B2 (en) | 1995-05-04 | 2011-12-06 | Glead Sciences, Inc. | Nucleic acid ligand complexes |
US5874409A (en) * | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
US6410775B1 (en) * | 1995-06-07 | 2002-06-25 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
US6232299B1 (en) | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
WO1997046251A1 (en) * | 1996-06-06 | 1997-12-11 | Lajolla Pharmaceutical Company | aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES |
US6759509B1 (en) * | 1996-11-05 | 2004-07-06 | Bristol-Myers Squibb Company | Branched peptide linkers |
US6589940B1 (en) | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
US20040006034A1 (en) * | 1998-06-05 | 2004-01-08 | Eyal Raz | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
ES2546173T3 (es) | 1998-03-13 | 2015-09-21 | Canon Kabushiki Kaisha | Aparato y procedimiento para el procesamiento de la información |
US6251382B1 (en) * | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
DE69928995T2 (de) * | 1998-06-22 | 2006-09-07 | Affymetrix, Inc., Santa Clara | Reagenz und Verfahren zu fester Phase Synthese |
US6399578B1 (en) * | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
US20010010818A1 (en) * | 1998-12-09 | 2001-08-02 | Engle Steven B. | Methods and formulations for reducing circulating antibodies |
CA2353462A1 (en) * | 1998-12-09 | 2000-06-15 | La Jolla Pharmaceutical Company | Molecular scaffolds acting as templates comprising carbamate linkages |
US6458953B1 (en) * | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
EP1135167A2 (en) * | 1998-12-09 | 2001-09-26 | La Jolla Pharmaceutical | Methods and formulations for reducing circulating antibodies |
WO2000075105A1 (en) * | 1999-06-08 | 2000-12-14 | La Jolla Pharmaceutical Company | Valency platform molecules comprising aminooxy groups |
ATE419869T1 (de) | 1999-08-19 | 2009-01-15 | Dynavax Tech Corp | Methode zur modulierung eines immunantwortes mit immunstimulierenden sequencen und zusammensetzungen dafür |
WO2001041813A2 (en) | 1999-11-28 | 2001-06-14 | La Jolla Pharmaceutical Company | Methods of treating lupus based on antibody affinity and screening methods and compositions for use thereof |
AU2001268228A1 (en) | 2000-06-08 | 2001-12-17 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
EP2325337A1 (en) * | 2000-09-26 | 2011-05-25 | Duke University | RNA aptamers and methods for identifying the same |
CA2430691A1 (en) * | 2000-12-27 | 2002-07-04 | Dynavax Technologies Corporation | Immunomodulatory polynucleotides and methods of using the same |
EP1361895B1 (en) * | 2001-02-20 | 2007-11-14 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
DK1362053T3 (da) * | 2001-02-20 | 2008-03-10 | Enzon Inc | Terminalt forgrenede polymere linkere og polymere konjugater indeholdende disse |
CN1511041A (zh) * | 2001-05-17 | 2004-07-07 | ������ҩ������˾ | 利用抑制cd21的药剂治疗抗体介导的病变的方法 |
IL159053A0 (en) * | 2001-05-25 | 2004-05-12 | Univ Duke | Modulators of pharmacological agents |
US20030199466A1 (en) * | 2001-06-21 | 2003-10-23 | Fearon Karen L. | Chimeric immunomodulatory compounds and methods of using the same - ll |
US7785610B2 (en) * | 2001-06-21 | 2010-08-31 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same—III |
US20030114405A1 (en) * | 2001-08-13 | 2003-06-19 | Linnik Matthew D. | Methods of treating systemic lupus erythematosus in individuals having significantly impaired renal function |
AU2002327704A1 (en) * | 2001-09-21 | 2003-04-01 | Raven Biotechnologies, Inc. | Antibodies that bind to cancer-associated antigen cytokeratin 8 and methods of use thereof |
GB0123961D0 (en) * | 2001-10-05 | 2001-11-28 | Astrazeneca Ab | Process and intermediates |
US7105135B2 (en) * | 2001-10-16 | 2006-09-12 | Lockheed Martin Corporation | System and method for large scale detection of hazardous materials in the mail or in other objects |
US20040048312A1 (en) * | 2002-04-12 | 2004-03-11 | Ronghao Li | Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof |
CA2483912A1 (en) * | 2002-05-03 | 2003-11-13 | Raven Biotechnologies, Inc. | Alcam and alcam modulators |
DK1565489T3 (da) | 2002-06-19 | 2011-03-07 | Raven Biotechnologies Inc | Internaliserende antistoffer specifikke for RAAG10-celleoverflademålet |
JP2006505523A (ja) | 2002-08-12 | 2006-02-16 | ダイナバックス テクノロジーズ コーポレイション | 免疫調節組成物、その製造方法および使用方法 |
US7405061B2 (en) * | 2002-11-13 | 2008-07-29 | Raven Biotechnologies, Inc. | Antigen PIPA and antibodies that bind thereto |
US8158768B2 (en) * | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
WO2004058179A2 (en) | 2002-12-23 | 2004-07-15 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
US20040208864A1 (en) * | 2002-12-27 | 2004-10-21 | Vibeke Strand | Methods of improving health-related quality of life in individuals with systemic lupus erythematosus |
WO2004089422A2 (en) * | 2003-03-30 | 2004-10-21 | La Jolla Pharmaceutical Co. | Methods of treating and monitoring systemic lupus erythematosus in individuals |
CN1279056C (zh) * | 2003-06-06 | 2006-10-11 | 马菁 | 肿瘤相关抗原sm5-1的特异性抗体及其应用 |
US20050232926A1 (en) * | 2003-06-06 | 2005-10-20 | Oncomax Acquisition Corp. | Antibodies specific for cancer associated antigen SM5-1 and uses thereof |
KR20070019941A (ko) * | 2003-09-03 | 2007-02-16 | 교와 핫꼬 고교 가부시끼가이샤 | 글리세롤 유도체로 수식된 화합물 |
US7790855B2 (en) | 2003-09-18 | 2010-09-07 | Macrogenics, Inc. | KID3 and KID3 antibodies that bind thereto |
EP2460811A1 (en) * | 2004-04-22 | 2012-06-06 | Regado Biosciences, Inc. | Improved modulators of coagulation factors |
JP4824025B2 (ja) * | 2004-06-07 | 2011-11-24 | マクロジェニックス ウエスト,インコーポレイテッド | トランスフェリンレセプター抗体 |
DK1794174T3 (da) | 2004-09-01 | 2012-07-09 | Dynavax Tech Corp | Fremgangsmåder og sammensætninger til hæmning af medfødte immunresponser og autoimmunitet |
CA2591582A1 (en) * | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
EP1846767B1 (en) * | 2005-01-12 | 2012-06-06 | MacroGenics West, Inc. | Kid31 and antibodies that bind thereto |
EP1846032A4 (en) * | 2005-01-31 | 2009-01-28 | Raven Biotechnologies Inc | LUCA2 AND ANTIBODY BINDING |
US20060171952A1 (en) * | 2005-02-02 | 2006-08-03 | Mather Jennie P | JAM-3 and antibodies that bind thereto |
JP5328155B2 (ja) | 2005-02-02 | 2013-10-30 | マクロジェニックス ウエスト, インコーポレイテッド | Adam−9モジュレータ |
WO2006084092A2 (en) * | 2005-02-03 | 2006-08-10 | Raven Biotechnologies, Inc. | Antibodies to oncostatin m receptor |
WO2006084226A2 (en) * | 2005-02-04 | 2006-08-10 | Raven Biotechnologies, Inc. | Antibodies that bind to epha2 and methods of use thereof |
WO2008066691A2 (en) | 2006-11-08 | 2008-06-05 | Macrogenics West, Inc. | Tes7 and antibodies that bind thereto |
CA2669137A1 (en) * | 2006-11-09 | 2008-06-19 | Dynavax Technologies Corporation | Long term disease modification using immunostimulatory oligonucleotides |
AU2008317261B2 (en) | 2007-10-26 | 2015-04-09 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
EP2300102B1 (en) * | 2008-05-15 | 2014-01-08 | Dynavax Technologies Corporation | Immunostimulatory sequences containing CpG for use in the treatment of allergic rhinitis |
AU2010282340B2 (en) | 2009-08-13 | 2016-12-22 | The Johns Hopkins University | Methods of modulating immune function |
ES2560809T3 (es) * | 2010-02-12 | 2016-02-22 | Yeda Research And Development Co. Ltd. | Diagnóstico de lupus eritematoso sistémico |
PH12018501083A1 (en) | 2010-03-04 | 2019-02-18 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
EA201291357A1 (ru) | 2010-06-16 | 2013-11-29 | Дайнэвокс Текнолоджиз Корпорейшн | Способы лечения с применением ингибиторов tlr7 и/или tlr9 |
US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
EP3090064B1 (en) | 2013-12-31 | 2019-11-13 | Yeda Research and Development Co. Ltd. | Diagnosis of systemic lupus erythematosus using oligonucleotides antigens |
JP6533534B2 (ja) | 2014-02-14 | 2019-06-19 | マクロジェニクス,インコーポレーテッド | 膠芽腫の治療に使用するための組成物及びその使用 |
EP3265814B1 (en) | 2015-03-01 | 2020-11-18 | Immunarray Ltd. | Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens |
US10864279B2 (en) | 2016-12-16 | 2020-12-15 | Industrial Technology Research Institute | Linker-drug and antibody-drug conjugate (ADC) employing the same |
EP3583153A4 (en) * | 2017-02-16 | 2020-03-11 | Agency for Science, Technology and Research | BIODEGRADABLE POLYIONES |
JP7234349B2 (ja) * | 2018-05-04 | 2023-03-07 | ツインピッグバイオラブ インク. | メリチンベースのアポトシース促進ペプチドペプチドでm2様腫瘍関連マクロファージの標的化 |
GB201909103D0 (en) * | 2019-06-25 | 2019-08-07 | Univ Bath | Compounds |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4191668A (en) * | 1977-02-03 | 1980-03-04 | Scripps Clinic And Research Foundation | Induction of immunological tolerance |
US4220565A (en) * | 1979-01-18 | 1980-09-02 | Scripps Clinic & Research Foundation | Immunochemical conjugates: method and composition |
US5126131A (en) * | 1983-01-24 | 1992-06-30 | The Johns Hopkins University | Therapeutic suppression of specific immune responses by administration of antigen-competitive conjugates. |
US4650675A (en) * | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
US4751181A (en) * | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
JP2524586B2 (ja) * | 1985-06-26 | 1996-08-14 | シタス コーポレイション | ポリマ−接合を利用する医薬組成物用蛋白質の可溶化 |
US4904582A (en) * | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
US4946235A (en) * | 1989-10-11 | 1990-08-07 | Eastman Kodak Company | Nonlinear optical waveguide device |
US5552391A (en) * | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
US5162515A (en) * | 1990-01-16 | 1992-11-10 | La Jolla Pharmaceutical Company | Conjugates of biologically stable polymers and polynucleotides for treating systemic lupus erythematosus |
JPH04218000A (ja) * | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
EP0572443A1 (en) * | 1990-12-17 | 1993-12-08 | The Johns Hopkins University | Suppression of immune responses with oligomeric forms of antigen of controlled chemistry |
AU3423293A (en) * | 1991-12-19 | 1993-07-19 | Baylor College Of Medicine | Pva or peg conjugates of peptides for epitope-specific immunosuppression |
EP0642798B1 (en) * | 1993-09-08 | 2007-04-18 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
-
1993
- 1993-11-15 US US08/152,506 patent/US5552391A/en not_active Expired - Lifetime
-
1994
- 1994-09-08 WO PCT/US1994/010031 patent/WO1995007073A1/en active IP Right Grant
- 1994-09-08 CN CNB941939936A patent/CN1203847C/zh not_active Expired - Fee Related
- 1994-09-08 JP JP7508766A patent/JPH09500389A/ja active Pending
- 1994-09-08 CN CNB2004100621268A patent/CN1318023C/zh not_active Expired - Fee Related
- 1994-09-08 AU AU77209/94A patent/AU677710B2/en not_active Ceased
- 1994-09-08 CA CA002171434A patent/CA2171434C/en not_active Expired - Fee Related
- 1994-09-08 EP EP94928016A patent/EP0722318A4/en not_active Withdrawn
-
1995
- 1995-05-30 US US08/453,452 patent/US5633395A/en not_active Expired - Lifetime
- 1995-05-30 US US08/453,254 patent/US5606047A/en not_active Expired - Lifetime
-
1996
- 1996-03-07 NO NO19960952A patent/NO319084B1/no not_active IP Right Cessation
- 1996-03-08 FI FI961100A patent/FI117322B/fi active IP Right Grant
-
2001
- 2001-07-13 JP JP2001214569A patent/JP2002085062A/ja active Pending
-
2006
- 2006-10-02 US US11/542,313 patent/US20070254851A1/en not_active Abandoned
-
2008
- 2008-04-09 US US12/100,356 patent/US20080293660A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FI961100A (fi) | 1996-05-08 |
NO319084B1 (no) | 2005-06-13 |
FI117322B (fi) | 2006-09-15 |
JPH09500389A (ja) | 1997-01-14 |
NO960952D0 (no) | 1996-03-07 |
AU7720994A (en) | 1995-03-27 |
CN1134109A (zh) | 1996-10-23 |
US20070254851A1 (en) | 2007-11-01 |
US20080293660A1 (en) | 2008-11-27 |
FI961100A0 (fi) | 1996-03-08 |
US5606047A (en) | 1997-02-25 |
CA2171434C (en) | 2009-03-17 |
US5633395A (en) | 1997-05-27 |
CN1572797A (zh) | 2005-02-02 |
EP0722318A4 (en) | 1998-08-05 |
AU677710B2 (en) | 1997-05-01 |
CN1203847C (zh) | 2005-06-01 |
CN1318023C (zh) | 2007-05-30 |
CA2171434A1 (en) | 1995-03-16 |
WO1995007073A1 (en) | 1995-03-16 |
EP0722318A1 (en) | 1996-07-24 |
US5552391A (en) | 1996-09-03 |
JP2002085062A (ja) | 2002-03-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO960952D0 (no) | Kjemisk definerte ikke-polymere valensplattformmolekyler og konjugater derav | |
DK0776339T3 (da) | MHC-komplekser og anvendelser deraf | |
NO961425D0 (no) | 1N-alkyl-N-arylpyrimidinaminer og derivater derav | |
NO20001307D0 (no) | Cyklopentafenantreneyl-metallkomplekser og polymerisasjonsprosess | |
NO943763D0 (no) | 4-arylamino-benzopyraner og beslektede forbindelser | |
KR950702113A (ko) | 분자 인식 물질로써 아미니미드 함유 분자와 물질(aminimide-containing molecules and materials as molecular recognition agents) | |
DE69431499T2 (de) | Meta-data-Struktur und Handhabung | |
DE69416773T2 (de) | Variabler Längen-Kodieren und variabler Längen-Dekodierer | |
DE69401016D1 (de) | Biegverfahren und -gerät | |
DE69419687D1 (de) | Lackierverfahren und Lackiereinrichtung | |
DE69405421T2 (de) | Verstellbares Kettenrad und Komponenten davon | |
NO954207D0 (no) | Preparat inneholdende kolestyramin og fremgangsmåte for dets fremstilling | |
DE69318691D1 (de) | Bindemittel und damit hergestelltes produkt | |
NO953749D0 (no) | Hepatitt B-escapemutantspesifikke bindingsmolekyler | |
DE69427811T2 (de) | Transportieren und biegen von glasscheiben | |
NO930137D0 (no) | X-pakke multikomponent koder og tilsvarende dekoder | |
BR9406976A (pt) | Extremidade de recipiente e recipiente | |
DE9313148U1 (de) | Lineareinheit in Zahnstangenausführung | |
DE9315888U1 (de) | Kunststoff- und Metallgebinde | |
DE9316347U1 (de) | Abkant- und Biegebank | |
NO950076D0 (no) | Lyozyndimer og materialer inneholdende samme | |
DE69334115D1 (de) | CELP Kodierer und Dekodierer | |
DE9316460U1 (de) | Abkant- und Biegebank | |
ITMI931648A1 (it) | Azaciclo e azabiciclo ammidi | |
NO177046C (no) | Anordning ved tverrtransportör |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |