NO960721L - Polymere matrikser og deres anvendelser i farmasöytiske preparater - Google Patents

Polymere matrikser og deres anvendelser i farmasöytiske preparater

Info

Publication number
NO960721L
NO960721L NO960721A NO960721A NO960721L NO 960721 L NO960721 L NO 960721L NO 960721 A NO960721 A NO 960721A NO 960721 A NO960721 A NO 960721A NO 960721 L NO960721 L NO 960721L
Authority
NO
Norway
Prior art keywords
polymeric matrices
applications
pharmaceutical preparations
carbomate
tnf
Prior art date
Application number
NO960721A
Other languages
English (en)
Norwegian (no)
Other versions
NO960721D0 (no
Inventor
Murat Acemoglu
Siegfried Bantle
David Bodmer
Salvatore Cammisuli
Peter Hiestand
Fritz Nimmerfall
Georg Stoll
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939317822A external-priority patent/GB9317822D0/en
Priority claimed from GB939320240A external-priority patent/GB9320240D0/en
Priority claimed from GB939325900A external-priority patent/GB9325900D0/en
Priority claimed from GB9407156A external-priority patent/GB9407156D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NO960721D0 publication Critical patent/NO960721D0/no
Publication of NO960721L publication Critical patent/NO960721L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/18Block or graft polymers
    • C08G64/183Block or graft polymers containing polyether sequences
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/204IL-6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/02Aliphatic polycarbonates
    • C08G64/0208Aliphatic polycarbonates saturated
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/20General preparatory processes
    • C08G64/32General preparatory processes using carbon dioxide
    • C08G64/34General preparatory processes using carbon dioxide and cyclic ethers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
NO960721A 1993-08-27 1996-02-23 Polymere matrikser og deres anvendelser i farmasöytiske preparater NO960721L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB939317822A GB9317822D0 (en) 1993-08-27 1993-08-27 Organic compounds
GB939320240A GB9320240D0 (en) 1993-10-01 1993-10-01 Improvements in or relating to organic compounds
GB939325900A GB9325900D0 (en) 1993-12-17 1993-12-17 Organic compounds
GB9407156A GB9407156D0 (en) 1994-04-11 1994-04-11 Organic compounds
PCT/EP1994/002833 WO1995006077A2 (en) 1993-08-27 1994-08-26 Polymeric matrices and their uses in pharmaceutical compositions

Publications (2)

Publication Number Publication Date
NO960721D0 NO960721D0 (no) 1996-02-23
NO960721L true NO960721L (no) 1996-04-26

Family

ID=27451062

Family Applications (2)

Application Number Title Priority Date Filing Date
NO960721A NO960721L (no) 1993-08-27 1996-02-23 Polymere matrikser og deres anvendelser i farmasöytiske preparater
NO20021141A NO20021141D0 (no) 1993-08-27 2002-03-07 Farmasöytiske preparater

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20021141A NO20021141D0 (no) 1993-08-27 2002-03-07 Farmasöytiske preparater

Country Status (24)

Country Link
US (2) US6083521A (zh)
EP (2) EP0719295B1 (zh)
JP (2) JP3343124B2 (zh)
KR (1) KR100341995B1 (zh)
CN (3) CN1085687C (zh)
AT (1) ATE327273T1 (zh)
AU (1) AU697995B2 (zh)
BR (1) BR9407370A (zh)
CA (1) CA2168012C (zh)
CZ (1) CZ55296A3 (zh)
DE (1) DE69434743T2 (zh)
DK (1) DK0719295T3 (zh)
ES (1) ES2262135T3 (zh)
FI (1) FI960892A (zh)
HU (1) HU220637B1 (zh)
IL (1) IL110787A0 (zh)
NO (2) NO960721L (zh)
NZ (1) NZ273319A (zh)
PL (1) PL182569B1 (zh)
PT (1) PT719295E (zh)
SG (2) SG87847A1 (zh)
SK (1) SK25496A3 (zh)
TW (1) TW492863B (zh)
WO (1) WO1995006077A2 (zh)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1009856A5 (fr) * 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
US5942253A (en) * 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
US6756060B1 (en) 1996-09-19 2004-06-29 Usbiomaterials Corp. Anti-inflammatory and antimicrobial uses for bioactive glass compositions
GB9725480D0 (en) * 1997-12-01 1998-01-28 Univ London Cytokines and their use in the treatment of established chronic infections and cancers
US8197430B1 (en) * 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US6620382B1 (en) * 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
US6100372A (en) * 1998-08-20 2000-08-08 Akzo Nobel Nv Monocarboxylic acid-terminated polymers of carbon dioxide and an alkylene oxide
EP1185247A4 (en) * 1999-04-29 2008-09-17 Usbiomaterials Corp ANTI-INFLAMMATORY BIOACTIVE GLASS PARTICLES
DE60022197T2 (de) 1999-06-14 2006-03-23 Imperial College Innovations Silberhaltige bioglas-zusammensetzungen, die von sol-gel zuständen abgeleitet werden
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6911204B2 (en) * 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
CA2416794A1 (en) * 2000-08-11 2002-02-21 Favrille, Inc. Method and composition for altering a t cell mediated pathology
CA2453050A1 (en) * 2000-09-06 2002-03-14 A.P. Pharma, Inc. Degradable polyacetal polymers
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
WO2003008578A2 (en) * 2001-07-20 2003-01-30 Board Of Trustees Of The University Of Illinois Reagents and methods for identifying gene targets for treating cancer
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
EP1572933A4 (en) 2002-02-13 2007-09-05 Univ Duke MODULATION OF IMMUNE RESPONSE BY POLYPEPTIDES OF RESPONSE TO STRESS BINDING TO NON PEPTIDES
WO2003088818A2 (en) 2002-04-18 2003-10-30 Mnemoscience Gmbh Biodegradable shape memory polymeric sutures
WO2004015070A2 (en) * 2002-08-08 2004-02-19 Baylor College Of Medicine Isolation and identification of t cells
CA2500661A1 (en) 2002-10-01 2004-04-15 Chiron Corporation Anti-cancer and anti-infectious disease compositions and methods for using same
GB0228571D0 (en) * 2002-12-06 2003-01-15 Novartis Ag Organic compounds
CA2549601A1 (en) * 2003-12-24 2005-07-14 Novartis Ag Medical devices coated with poly(ethylene carbonate) polymers
ES2393637T3 (es) * 2004-04-30 2012-12-26 Biopheresis Technologies, Inc. Método y sistema para retirar TNFR1, TNFR2, y IL2R soluble en pacientes
CA2575988C (en) 2004-08-04 2014-02-18 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
JP4870071B2 (ja) * 2005-03-18 2012-02-08 三井化学株式会社 生分解性を有する水環境応答型ポリマー、その製造方法および水崩壊性材料
US20070099867A1 (en) * 2005-05-24 2007-05-03 Glycoscience Laboratories, Inc. Pharmaceutical agent containing hyaluronan as an active ingredient
SI1787658T1 (sl) 2005-11-10 2012-07-31 Chemi Spa Formulacije z trajnim sproščanjem somatostatin analognih inhibitorjev rastnega hormona
JP2009536036A (ja) * 2006-05-05 2009-10-08 オペクサ セラピューティクス T細胞ワクチン
ATE475686T1 (de) * 2006-10-31 2010-08-15 Surmodics Pharmaceuticals Inc Kugelförmige polymer-teilchen
CA2709712C (en) 2007-12-20 2016-05-10 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
KR20120034813A (ko) 2008-09-08 2012-04-12 노보머, 인코포레이티드 폴리카보네이트 폴리올 조성물
MX2011006345A (es) * 2008-12-15 2011-07-13 Novartis Ag Composiciones de nanoparticulas.
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
KR101936374B1 (ko) 2011-07-25 2019-01-08 사우디 아람코 테크놀로지스 컴퍼니 폴리우레탄에 이용하기 위한 지방족 폴리카보네이트
TR201202779A2 (tr) 2012-03-12 2013-10-21 Petkim Petrokimya Holding Anonim Sirketi Polietilen karbonat üretim yöntemi.
EP2664641B1 (en) 2012-05-18 2018-04-25 Petkim Petrokimya Holding Anonim Sirekti Method for producing polyethylene carbonate with metal salts
CN104487485B (zh) * 2012-05-24 2018-04-20 沙特阿美技术公司 聚碳酸酯多元醇组合物和方法
WO2014074706A1 (en) 2012-11-07 2014-05-15 Novomer, Inc. High strength polyurethane foam compositions and methods
AU2016229294B2 (en) 2015-03-06 2021-11-04 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
DK3334726T3 (da) 2015-07-13 2022-05-16 Beyondspring Pharmaceuticals Inc Plinabulinsammensætninger
CA3013467A1 (en) 2016-02-08 2017-08-17 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
EP3463337A4 (en) 2016-06-06 2020-02-12 Beyondspring Pharmaceuticals, Inc. COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
US11786523B2 (en) 2018-01-24 2023-10-17 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing thrombocytopenia
WO2020028606A1 (en) 2018-08-02 2020-02-06 Saudi Aramco Technologies Company Sustainable polymer compositions and methods

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3585168A (en) * 1968-09-21 1971-06-15 Shohei Inoue Process for producing copolymer of epoxide and carbon dioxide
US3706713A (en) * 1970-08-11 1972-12-19 Shell Oil Co Aliphatic polycarbonates
JPS5341117B2 (zh) * 1971-12-21 1978-10-31
US3953383A (en) * 1972-07-21 1976-04-27 Nippon Oil Seal Industry Co., Ltd. Catalytic process for copolymerizing epoxy compounds with carbon dioxide
JPS553288B2 (zh) * 1973-08-06 1980-01-24
JPS5761769B2 (zh) * 1974-03-20 1982-12-25 Nippon Oil Seal Ind Co Ltd
JPS5922731B2 (ja) * 1975-09-12 1984-05-29 エヌオーケー株式会社 共重合用触媒の製造法
JPS5438397A (en) * 1977-08-31 1979-03-22 Hidetoshi Tsuchida Copolymerization catalyst consisting of carbon dioxide and oxirane compoud
US4379138A (en) * 1981-12-28 1983-04-05 Research Triangle Institute Biodegradable polymers of lactones
NZ217844A (en) * 1985-10-11 1989-10-27 Sumitomo Pharma A sustained release pharmaceutical composition containing silicone elastomer and an albumin
JPH0725688B2 (ja) * 1986-03-31 1995-03-22 住友製薬株式会社 Csf徐放性製剤
US4665136A (en) * 1986-04-07 1987-05-12 Air Products And Chemicals, Inc. Process for producing novel block alkylene polycarbonate copolymers
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
US5114719A (en) * 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US4783445A (en) * 1987-12-14 1988-11-08 Arco Chemical Company Soluble epoxide/carbon dioxide copolymerization catalysts
US5274074A (en) * 1987-12-17 1993-12-28 United States Surgical Corporation Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
WO1989005664A1 (en) * 1987-12-17 1989-06-29 Allied-Signal Inc. Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
US4789727A (en) * 1987-12-18 1988-12-06 Arco Chemical Company Reduction of catalyst usage in epoxide/CO2 polymerization
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
EP0358326B1 (en) * 1988-08-09 1996-12-27 Mitsui Petrochemical Industries, Ltd. Process for preparing a zinc-containing solid catalyst and process for preparing polyalkylene carbonate
ES2096553T3 (es) * 1988-12-19 1997-03-16 American Cyanamid Co Metodo para el tratamiento de choque endotoxico en un animal mamifero.
WO1990009798A1 (en) * 1989-02-24 1990-09-07 Immunotherapeutics, Inc. Immobilized cytokines
US4999417A (en) * 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
US4960862A (en) * 1989-03-31 1990-10-02 Air Products And Chemicals, Inc. Regeneration of metallo-organic catalyst for carbon dioxide-epoxide copolymerization
US5026676A (en) * 1989-06-07 1991-06-25 Air Products And Chemicals, Inc. Catalyst for the copolymerization of epoxides with CO2
US4943677A (en) * 1989-06-08 1990-07-24 Air Products And Chemicals, Inc. Making poly(alkylene carbonates) of controlled molecular weight
JP2693584B2 (ja) * 1989-06-26 1997-12-24 三井石油化学工業株式会社 ポリアルキレンカーボネート製造用触媒成分の製造方法
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
JP2930362B2 (ja) * 1990-04-09 1999-08-03 東ソー株式会社 感作t細胞関与疾患の治療剤
ATE104826T1 (de) * 1990-07-02 1994-05-15 Bend Res Inc Asymmetrische mikroporoese kuegelchen fuer regulierbare freigabe.
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
DE69126764T2 (de) * 1990-11-13 1998-02-12 Isi Ist Sierovaccinogeno Ital Funktionelle Polyester aus Glycidylderivaten und cyclischen Anhydriden oder Kohlendioxid
JPH07503700A (ja) * 1991-01-03 1995-04-20 アルカーメス コントロールド セラピューティックス, インコーポレイテッド カチオン生体ポリマーによるタンパク質の安定化
CA2060635A1 (en) * 1991-02-12 1992-08-13 Keith D'alessio Bioabsorbable medical implants
IT1248061B (it) * 1991-06-14 1995-01-05 Mediolanum Farmaceutici Spa Policarbonati e loro uso per la preparazione di matrici bioerodibili
US5344644A (en) * 1991-08-01 1994-09-06 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release
DE69220317T2 (de) * 1991-10-01 1997-10-16 Takeda Chemical Industries Ltd Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe
WO1993011793A1 (en) * 1991-12-17 1993-06-24 Schering Corporation Use of the combination of anti-tumor necrosis factor plus interleukin-6 to treat septic shock
JPH05194253A (ja) * 1992-01-16 1993-08-03 Kirin Brewery Co Ltd 水溶性ポリペプチドホルモンを含む徐放性微小粒子状製剤及びその製造法
GB9206736D0 (en) * 1992-03-27 1992-05-13 Sandoz Ltd Improvements of organic compounds and their use in pharmaceutical compositions
ZA933926B (en) * 1992-06-17 1994-01-03 Amgen Inc Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
GB9406094D0 (en) * 1994-03-28 1994-05-18 Univ Nottingham And University Polymer microspheres and a method of production thereof
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
JP3028227B1 (ja) 1998-12-15 2000-04-04 穎助 藤本 デスポーザル無針注射器

Also Published As

Publication number Publication date
CN1344755A (zh) 2002-04-17
JPH09501967A (ja) 1997-02-25
CA2168012C (en) 2005-08-09
SG87847A1 (en) 2002-04-16
NO20021141L (no) 1996-04-26
DE69434743D1 (de) 2006-06-29
CN1506116A (zh) 2004-06-23
FI960892A0 (fi) 1996-02-26
HU9600456D0 (en) 1996-04-29
CN1085687C (zh) 2002-05-29
KR100341995B1 (ko) 2002-11-23
TW492863B (en) 2002-07-01
HU220637B1 (hu) 2002-03-28
WO1995006077A3 (en) 1995-05-04
NO960721D0 (no) 1996-02-23
CN1258551C (zh) 2006-06-07
CN1129947A (zh) 1996-08-28
EP0719295B1 (en) 2006-05-24
AU697995B2 (en) 1998-10-22
NO20021141D0 (no) 2002-03-07
WO1995006077A2 (en) 1995-03-02
DE69434743T2 (de) 2006-11-16
ES2262135T3 (es) 2006-11-16
JP3343124B2 (ja) 2002-11-11
PL182569B1 (pl) 2002-01-31
CZ55296A3 (en) 1996-09-11
SK25496A3 (en) 1997-03-05
FI960892A (fi) 1996-04-18
CN1326568C (zh) 2007-07-18
ATE327273T1 (de) 2006-06-15
CA2168012A1 (en) 1995-03-02
EP1028137A3 (en) 2000-11-02
SG50724A1 (en) 1999-10-19
JP2003002844A (ja) 2003-01-08
AU7655794A (en) 1995-03-21
EP0719295A1 (en) 1996-07-03
EP1028137A2 (en) 2000-08-16
BR9407370A (pt) 1996-07-16
PL312717A1 (en) 1996-05-13
DK0719295T3 (da) 2006-09-25
JP4477813B2 (ja) 2010-06-09
NZ273319A (en) 1998-02-26
IL110787A0 (en) 1994-11-11
PT719295E (pt) 2006-10-31
US6262127B1 (en) 2001-07-17
US6083521A (en) 2000-07-04
HUT74568A (en) 1997-01-28

Similar Documents

Publication Publication Date Title
DK0719295T3 (da) Polymere matrixer og deres anvendelser i farmaceutiske præparater
ES2145013T3 (es) Formulaciones de coagulo de sangre-matriz polimera de proteinas osteogenicas.
ES2094359T3 (es) Formulaciones farmaceuticas de proteinas osteogenicas.
ES2167784T3 (es) Copolimeros reticulados a base de polimeros policarboxilicos.
NO20055349D0 (no) Selvtilpassede sementsystemer
DK0388220T3 (da) Præparater til vedvarende frigivelse af klorhexidin
NO20002113L (no) Nye tricykliske forbindelser og deres anvendelse i medisin, fremgangsmÕte for deres fremstillling og farmasøytiske sammensetninger inneholdende dem
DK0526905T3 (da) Multimerer af TNF-receptorers oplöselige former, deres fremstilling og farmaceutiske præparater indeholdende dem
DE60237241D1 (de) Medizinische geräte, die rapamycinanaloga enthalten
GT199700089A (es) Derivados 6.6 o 6.7 -biciclicos sustituidos que contienen pirido o pirimido.
DK0679092T3 (da) Cytokindæmpende midler
NO20043290L (no) Deazapuriner og anvendelse av slike
ATE438389T1 (de) Mischsystem zur löslichkeitsvermittlung von pharmazeutischen wirkstoffen in polymermatrizes
NZ330944A (en) Peptide derivatives
DK1177226T3 (da) Styrenholdige popcorn-polymerisater, fremgangsmåde til disses fremstilling og deres anvendelse
DK1017667T3 (da) 2-amino-6-methyl-7-acetyltetralin og farmaceutiske præparater til forebyggelse og terapeutisk behandling af inflammatoriske og/eller autoimmune patalogier
FR2799196B1 (fr) Copolymeres reticules a base de copolymeres polycarboxyliques non reticules
CA2474988A1 (en) Polymeric matrices and their uses in pharmaceutical compositions
ATE111920T1 (de) Lymphokine, dns-sequenzen, die diese lymphokine kodieren, und sie enthaltende pharmazeutische zusammensetzungen.
WO2005023181A3 (en) Polymeric systems for controlled drug therapy
ATE288924T1 (de) Tnf inhibierendes protein tip-b1 und dessen verwendung

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application