NO814239L - Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidinon-derivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidinon-derivater

Info

Publication number
NO814239L
NO814239L NO814239A NO814239A NO814239L NO 814239 L NO814239 L NO 814239L NO 814239 A NO814239 A NO 814239A NO 814239 A NO814239 A NO 814239A NO 814239 L NO814239 L NO 814239L
Authority
NO
Norway
Prior art keywords
phenyl
methyl
hydroxy
group
dihydro
Prior art date
Application number
NO814239A
Other languages
English (en)
Norwegian (no)
Inventor
Joachim Heider
Volkhard Austel
Wolfgang Eberlein
Rudolf Kadatz
Christian Lillie
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803046871 external-priority patent/DE3046871A1/de
Priority claimed from DE19813115447 external-priority patent/DE3115447A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO814239L publication Critical patent/NO814239L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
NO814239A 1980-12-12 1981-12-11 Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidinon-derivater NO814239L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803046871 DE3046871A1 (de) 1980-12-12 1980-12-12 Neue chinazolinone, ihre herstellung und ihre verwendung als arzneimittel
DE19813115447 DE3115447A1 (de) 1981-04-16 1981-04-16 Neue pyrimidinone, ihre herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
NO814239L true NO814239L (no) 1982-06-14

Family

ID=25789685

Family Applications (1)

Application Number Title Priority Date Filing Date
NO814239A NO814239L (no) 1980-12-12 1981-12-11 Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidinon-derivater

Country Status (22)

Country Link
US (1) US4379788A (OSRAM)
EP (1) EP0054132B1 (OSRAM)
AR (1) AR227567A1 (OSRAM)
AU (1) AU543568B2 (OSRAM)
CA (1) CA1217767A (OSRAM)
CS (1) CS227024B2 (OSRAM)
DD (1) DD208151A5 (OSRAM)
DE (1) DE3166627D1 (OSRAM)
DK (1) DK525481A (OSRAM)
ES (2) ES8207156A1 (OSRAM)
FI (1) FI813971A7 (OSRAM)
GB (1) GB2090249B (OSRAM)
GR (1) GR76952B (OSRAM)
HU (1) HU187384B (OSRAM)
IL (1) IL64504A (OSRAM)
MY (1) MY8700562A (OSRAM)
NO (1) NO814239L (OSRAM)
NZ (1) NZ199254A (OSRAM)
PH (1) PH18930A (OSRAM)
PL (1) PL135330B1 (OSRAM)
PT (1) PT74116B (OSRAM)
SU (1) SU1056900A3 (OSRAM)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460589A (en) * 1980-10-03 1984-07-17 The Upjohn Company Process for treating hypertension
US4379778A (en) * 1980-10-10 1983-04-12 Air Products And Chemicals, Inc. Hydrogen peroxide synthesis
DE3428476A1 (de) * 1984-08-02 1986-02-13 Basf Ag, 6700 Ludwigshafen 4h-pyrido(2,3-d)(1,3)oxazin-4-on-derivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
DE3631294A1 (de) * 1986-09-13 1988-03-24 Thomae Gmbh Dr K Neue synergistische kombination bestehend aus einem phosphodiesterase-hemmer und einem thromboxan-a(pfeil abwaerts)2(pfeil abwaerts)-antagonisten und deren verwendung bzw. herstellung
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
GB8928346D0 (en) * 1989-12-15 1990-02-21 Smith Kline French Lab Chemical compounds
GB9126260D0 (en) * 1991-12-11 1992-02-12 Pfizer Ltd Therapeutic agents
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
ID25871A (id) * 1997-11-12 2000-11-09 Bayer Ag Imidazotriazinon tersubstitusi-2-fenil
RU2207337C2 (ru) * 1998-11-18 2003-06-27 Изаксон Елена Александровна 6-(3-ацетилфенил)аминоурацил
US20040102324A1 (en) 2002-02-28 2004-05-27 Annis Gary David Heterocyclic diamide invertebrate pest control agents
US6642244B2 (en) 2001-03-16 2003-11-04 Bristol-Myers Squibb Co. Pyrazolopyridopyrimidine inhibitors of cGMP phosphodiesterase
CN1518447A (zh) * 2001-04-23 2004-08-04 �������Ǵ�ѧר������� 作为抗血管生成剂的新的苯邻二甲酰亚胺模拟物的合成和评估
ES2278927T3 (es) * 2001-05-09 2007-08-16 Bayer Healthcare Ag Nuevo uso de imidazotriazinonas de 2-(2-etoxi-5-(4-metil-piperazin-1-sulfonil)-fenil)-5-metil-7-propil-3h-imidazo(5,1-f)(1,2,4)triazin-4-ona.
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
WO2005065183A2 (en) * 2003-12-19 2005-07-21 Merck & Co., Inc. Mitotic kinesin inhibitors
SE0401345D0 (sv) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds: Pyridine as scaffold
SE0401342D0 (sv) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds
WO2005115993A1 (ja) * 2004-05-31 2005-12-08 Banyu Pharmaceutical Co., Ltd. キナゾリン誘導体
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009240A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
EP1931797A2 (en) * 2005-09-29 2008-06-18 Bayer HealthCare AG Pde inhibitors and combinations thereof for the treatment of urological disorders
CN101547922B (zh) * 2006-10-04 2012-06-20 辉瑞产品公司 作为钙受体拮抗剂的吡啶并[4,3-d]嘧啶-4(3H)-酮衍生物
CA2689638A1 (en) * 2007-06-13 2008-12-18 Bayer Schering Pharma Aktiengesellschaft Pde inhibitors for the treatment of hearing impairment
CN101531638B (zh) * 2008-03-13 2011-12-28 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
EP2273882A4 (en) * 2008-05-13 2011-07-13 Poniard Pharmaceuticals Inc BIOACTIVE COMPOUNDS FOR THE TREATMENT OF CANCER AND NEURODEEGENERATIVE DISEASES
CN101628913B (zh) 2008-07-18 2013-01-23 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
AU2013324681B2 (en) * 2012-09-26 2017-08-10 Merck Patent Gmbh Quinazolinone derivatives as PARP inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3265697A (en) * 1964-09-04 1966-08-09 Shulton Inc 2-p-dialkylaminoalkoxyphenyl-2, 3-dihydro-4 (1h)-quinazolinones and their derivatives
DE1939109A1 (de) * 1968-08-31 1970-03-05 Troponwerke Dinklage & Co 2-Methyl-3-[2-(2-diaethylaminoaethoxy)-phenyl]-chinazolinon-(4) und Verfahren zu seiner Herstellung
US3862191A (en) * 1972-09-27 1975-01-21 Pfizer Pyrido{8 2,3-d{9 pyrimidin-4(3H)-one

Also Published As

Publication number Publication date
ES507761A0 (es) 1982-09-01
IL64504A (en) 1985-02-28
MY8700562A (en) 1987-12-31
PT74116A (de) 1982-01-01
PL234175A1 (OSRAM) 1982-08-16
ES511835A0 (es) 1983-02-16
GB2090249A (en) 1982-07-07
FI813971L (fi) 1982-06-13
NZ199254A (en) 1985-02-28
PL135330B1 (en) 1985-10-31
ES8304096A1 (es) 1983-02-16
CS227024B2 (en) 1984-04-16
DE3166627D1 (en) 1984-11-15
PT74116B (de) 1983-12-19
AR227567A1 (es) 1982-11-15
AU7847381A (en) 1982-06-17
AU543568B2 (en) 1985-04-26
GR76952B (OSRAM) 1984-09-04
IL64504A0 (en) 1982-03-31
ES8207156A1 (es) 1982-09-01
HU187384B (en) 1985-12-28
US4379788A (en) 1983-04-12
GB2090249B (en) 1984-08-22
EP0054132A1 (de) 1982-06-23
EP0054132B1 (de) 1984-10-10
PH18930A (en) 1985-11-11
FI813971A7 (fi) 1982-06-13
DD208151A5 (de) 1984-03-28
SU1056900A3 (ru) 1983-11-23
CA1217767A (en) 1987-02-10
DK525481A (da) 1982-06-13

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