NO342865B1 - Trisykliske aminderivater som proteintyrosinkinase inhibitorer - Google Patents

Trisykliske aminderivater som proteintyrosinkinase inhibitorer Download PDF

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Publication number
NO342865B1
NO342865B1 NO20092658A NO20092658A NO342865B1 NO 342865 B1 NO342865 B1 NO 342865B1 NO 20092658 A NO20092658 A NO 20092658A NO 20092658 A NO20092658 A NO 20092658A NO 342865 B1 NO342865 B1 NO 342865B1
Authority
NO
Norway
Prior art keywords
phenyl
pyridin
imidazo
groups
thiadiazol
Prior art date
Application number
NO20092658A
Other languages
English (en)
Norwegian (no)
Other versions
NO20092658L (no
Inventor
Valerio Berdini
Gordon Saxty
Michael Alistair O'brien
Maria Grazia Carr
Adrian Liam Gill
Miles Stuart Congreve
Gilbert Ebai Besong
Owen Callaghan
Charlotte Mary Griffiths-Jones
Andrew Madin
Christopher William Murray
Rajdeep Kaur Nijjar
Andrew Pike
Richard David Taylor
Emma Vickerstaffe
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0625827A external-priority patent/GB0625827D0/en
Priority claimed from GB0719998A external-priority patent/GB0719998D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of NO20092658L publication Critical patent/NO20092658L/no
Publication of NO342865B1 publication Critical patent/NO342865B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO20092658A 2006-12-22 2009-07-13 Trisykliske aminderivater som proteintyrosinkinase inhibitorer NO342865B1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87153806P 2006-12-22 2006-12-22
GB0625827A GB0625827D0 (en) 2006-12-22 2006-12-22 New compounds
US97958207P 2007-10-12 2007-10-12
GB0719998A GB0719998D0 (en) 2007-10-12 2007-10-12 New compounds
PCT/GB2007/004960 WO2008078100A2 (en) 2006-12-22 2007-12-21 Tricyclic amine derivatives as protein tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
NO20092658L NO20092658L (no) 2009-09-17
NO342865B1 true NO342865B1 (no) 2018-08-20

Family

ID=39322759

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092658A NO342865B1 (no) 2006-12-22 2009-07-13 Trisykliske aminderivater som proteintyrosinkinase inhibitorer

Country Status (12)

Country Link
US (1) US8513276B2 (Direct)
EP (1) EP2121687B1 (Direct)
JP (1) JP5442449B2 (Direct)
CN (1) CN101679409B (Direct)
AU (1) AU2007337895C1 (Direct)
CA (1) CA2672213C (Direct)
CY (1) CY1117319T1 (Direct)
HR (1) HRP20151398T1 (Direct)
MX (1) MX2009006704A (Direct)
NO (1) NO342865B1 (Direct)
PL (1) PL2121687T3 (Direct)
WO (1) WO2008078100A2 (Direct)

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