NO332229B1 - Proteiner som omfatter konserverte regioner av Neissinia menigitidis overflateantigen NhhA, farmasoytisk sammensetning inneholdende disse, antistoff, isolert nukleinsyre, ekspresjonsvektor, vertscelle, fremgangsmater og anvendelse knyttet til proteinene - Google Patents
Proteiner som omfatter konserverte regioner av Neissinia menigitidis overflateantigen NhhA, farmasoytisk sammensetning inneholdende disse, antistoff, isolert nukleinsyre, ekspresjonsvektor, vertscelle, fremgangsmater og anvendelse knyttet til proteinene Download PDFInfo
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- NO332229B1 NO332229B1 NO20023487A NO20023487A NO332229B1 NO 332229 B1 NO332229 B1 NO 332229B1 NO 20023487 A NO20023487 A NO 20023487A NO 20023487 A NO20023487 A NO 20023487A NO 332229 B1 NO332229 B1 NO 332229B1
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- nhha
- meningitidis
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- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 150000003461 sulfonyl halides Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940126577 synthetic vaccine Drugs 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- IESDGNYHXIOKRW-LEOABGAYSA-N tuftsin Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-LEOABGAYSA-N 0.000 description 1
- 229940035670 tuftsin Drugs 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17791700P | 2000-01-25 | 2000-01-25 | |
| PCT/AU2001/000069 WO2001055182A1 (en) | 2000-01-25 | 2001-01-25 | PROTEINS COMPRISING CONSERVED REGIONS OF NEISSERIA MENINGITIDIS SURFACE ANTIGEN NhhA |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20023487D0 NO20023487D0 (no) | 2002-07-22 |
| NO20023487L NO20023487L (no) | 2002-09-24 |
| NO332229B1 true NO332229B1 (no) | 2012-08-06 |
Family
ID=22650445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023487A NO332229B1 (no) | 2000-01-25 | 2002-07-22 | Proteiner som omfatter konserverte regioner av Neissinia menigitidis overflateantigen NhhA, farmasoytisk sammensetning inneholdende disse, antistoff, isolert nukleinsyre, ekspresjonsvektor, vertscelle, fremgangsmater og anvendelse knyttet til proteinene |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US7947291B2 (de) |
| EP (2) | EP1252182B1 (de) |
| JP (3) | JP2003523208A (de) |
| KR (1) | KR100698561B1 (de) |
| CN (2) | CN1419564A (de) |
| AU (1) | AU2818101A (de) |
| BR (1) | BR0107857A (de) |
| CA (1) | CA2398139A1 (de) |
| CZ (1) | CZ304379B6 (de) |
| ES (1) | ES2389719T3 (de) |
| HU (1) | HUP0300696A3 (de) |
| IL (2) | IL150822A0 (de) |
| MX (1) | MXPA02007184A (de) |
| NO (1) | NO332229B1 (de) |
| NZ (1) | NZ520445A (de) |
| PL (1) | PL216780B1 (de) |
| WO (1) | WO2001055182A1 (de) |
| ZA (1) | ZA200206153B (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PT1047784E (pt) * | 1998-01-14 | 2009-12-21 | Novartis Vaccines & Diagnostic | Antigénios de neisseria meningitidis |
| BR9910089A (pt) | 1998-05-01 | 2004-06-08 | Chiron Corp | Composições e antìgenos de neisseria meningitidis |
| ES2397918T3 (es) * | 1999-04-30 | 2013-03-12 | Novartis Vaccines And Diagnostics S.R.L. | Antígenos Neisseriales conservados |
| CN100338218C (zh) * | 1999-05-19 | 2007-09-19 | 启龙股份公司 | 组合式奈瑟球菌组合物 |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| CN1419564A (zh) * | 2000-01-25 | 2003-05-21 | 昆士兰大学 | 包含脑膜炎奈瑟氏球菌表面抗原NhhA的保守区域的蛋白质 |
| EP2270030B1 (de) * | 2000-02-28 | 2012-05-23 | Novartis Vaccines and Diagnostics S.r.l. | Heterologe Expression Neisserscher Proteine |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| GB0220199D0 (en) * | 2002-08-30 | 2002-10-09 | Univ Utrecht | Mutant protein and refolding method |
| TWI360424B (en) * | 2002-08-02 | 2012-03-21 | Glaxosmithkline Biolog Sa | Vaccine |
| PT1549338E (pt) | 2002-10-11 | 2011-02-23 | Novartis Vaccines & Diagnostic | Vacinas polipeptídicas para protecção alargada contra linhagens meningocócicas hipervirulentas |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| WO2007042326A2 (en) * | 2005-10-14 | 2007-04-19 | Intercell Ag | Neisseria meningitidis antigens |
| JP5275983B2 (ja) | 2006-06-12 | 2013-08-28 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| JP2012512240A (ja) | 2008-12-17 | 2012-05-31 | ノバルティス アーゲー | ヘモグロビン受容体を含む髄膜炎菌ワクチン |
| US20120070458A1 (en) | 2009-03-24 | 2012-03-22 | Novartis Ag | Adjuvanting meningococcal factor h binding protein |
| WO2010109324A1 (en) | 2009-03-24 | 2010-09-30 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| WO2011024071A1 (en) | 2009-08-27 | 2011-03-03 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
| NZ622048A (en) | 2009-08-27 | 2015-10-30 | Novartis Ag | Hybrid polypeptides including meningococcal fhbp sequences |
| CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
| BR112012010531A2 (pt) | 2009-10-27 | 2019-09-24 | Novartis Ag | "polipeptídeos de modificação meningocócica fhbp" |
| EP2544713A1 (de) | 2010-03-10 | 2013-01-16 | GlaxoSmithKline Biologicals S.A. | Immunogene zusammensetzung |
| JP2013522177A (ja) | 2010-03-11 | 2013-06-13 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | グラム陰性細菌性、例えば髄膜炎菌性の感染または疾患に対する免疫原性組成物またはワクチン |
| CN102802662A (zh) | 2010-03-18 | 2012-11-28 | 诺华有限公司 | 用于脑膜炎球菌血清组b的含佐剂疫苗 |
| AU2011268507B2 (en) | 2010-06-25 | 2014-08-14 | Novartis Ag | Combinations of meningococcal factor H binding proteins |
| EP2598521A4 (de) * | 2010-07-30 | 2014-03-19 | Univ Griffith | Rekombinante neisseria-meningitidis-por-a-porin-proteine |
| GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
| WO2012032498A2 (en) | 2010-09-10 | 2012-03-15 | Novartis Ag | Developments in meningococcal outer membrane vesicles |
| WO2012054879A1 (en) * | 2010-10-22 | 2012-04-26 | Duke University | Compositions and methods for the treatment of septic arthritis, osteomyelitis, and bacteremia |
| US20150147356A1 (en) | 2011-05-12 | 2015-05-28 | Alan Kimura | Antipyretics to enhance tolerability of vesicle-based vaccines |
| CA2862247A1 (en) | 2011-12-29 | 2013-07-04 | Novartis Ag | Adjuvanted combinations of meningococcal factor h binding proteins |
| AU2013214105A1 (en) | 2012-02-02 | 2014-07-24 | Novartis Ag | Promoters for increased protein expression in meningococcus |
| ES2750366T3 (es) | 2012-03-08 | 2020-03-25 | Glaxosmithkline Biologicals Sa | Ensayo de potencia in vitro para vacunas meningocócicas basadas en proteína |
| CN104602704B (zh) | 2012-06-14 | 2019-08-06 | 诺华股份有限公司 | 针对血清组x脑膜炎球菌的疫苗 |
| CA2882619A1 (en) | 2012-09-06 | 2014-03-13 | Novartis Ag | Combination vaccines with serogroup b meningococcus and d/t/p |
| SG11201606478YA (en) | 2014-02-28 | 2016-09-29 | Glaxosmithkline Biolog Sa | Modified meningococcal fhbp polypeptides |
| CN110214022A (zh) | 2016-11-25 | 2019-09-06 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性缀合物及其用途 |
| BR112019010625A2 (pt) | 2016-11-25 | 2019-10-22 | Glaxosmithkline Biologicals Sa | conjugado imunogênico, processo para preparar o conjugado imunogênico, nomv-ligante intermediário, usos do mesmo e de nomv, composição imunogênica, e, vacina. |
| WO2024178355A1 (en) * | 2023-02-24 | 2024-08-29 | BioNTech SE | Systems and methods for engineering synthetic antigens to promote tailored immune responses |
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| US4843000A (en) | 1979-12-26 | 1989-06-27 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4849338A (en) | 1982-07-16 | 1989-07-18 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4550081A (en) | 1980-05-19 | 1985-10-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Non-reverting salmonella |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| EP0273116A3 (de) * | 1986-10-09 | 1990-05-02 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Gonokokken- und Meningokokken-Polypeptide, Impfstoffe und Diagnostiken |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5785973A (en) | 1988-02-01 | 1998-07-28 | Praxis Biologics, Inc. | Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines |
| WO1989009385A1 (fr) | 1988-03-24 | 1989-10-05 | Zach, Johann | Dispositif manometrique ou dynamometrique |
| EP0449958B9 (de) * | 1988-12-19 | 2003-05-28 | American Cyanamid Company | Meningococcales klasse i-aussenmembranprotein-vakzin |
| WO1992001813A1 (en) | 1990-07-25 | 1992-02-06 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5646259A (en) | 1995-03-24 | 1997-07-08 | St. Louis University | DNA encoding haemophilus adhesion proteins |
| US6143495A (en) | 1995-11-21 | 2000-11-07 | Yale University | Unimolecular segment amplification and sequencing |
| GB9611673D0 (en) * | 1996-06-05 | 1996-08-07 | Peptide Therapeutics Ltd | Meningococcal vaccine |
| EP1900818A3 (de) | 1997-11-06 | 2008-06-11 | Novartis Vaccines and Diagnostics S.r.l. | Neissersche Antigene |
| GB9726398D0 (en) * | 1997-12-12 | 1998-02-11 | Isis Innovation | Polypeptide and coding sequences |
| PT1047784E (pt) | 1998-01-14 | 2009-12-21 | Novartis Vaccines & Diagnostic | Antigénios de neisseria meningitidis |
| BR9910089A (pt) | 1998-05-01 | 2004-06-08 | Chiron Corp | Composições e antìgenos de neisseria meningitidis |
| GB9810276D0 (en) | 1998-05-13 | 1998-07-15 | Smithkline Beecham Biolog | Novel compounds |
| WO2000061165A1 (en) * | 1999-04-13 | 2000-10-19 | Smithkline Beecham Corporation | Conserved adhesin motif and methods of use thereof |
| ES2397918T3 (es) | 1999-04-30 | 2013-03-12 | Novartis Vaccines And Diagnostics S.R.L. | Antígenos Neisseriales conservados |
| WO2000066791A1 (en) * | 1999-04-30 | 2000-11-09 | Chiron Corporation | Neisseria genomic sequences and methods of their use |
| GB9916529D0 (en) * | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| CN1419564A (zh) * | 2000-01-25 | 2003-05-21 | 昆士兰大学 | 包含脑膜炎奈瑟氏球菌表面抗原NhhA的保守区域的蛋白质 |
| TWI360424B (en) * | 2002-08-02 | 2012-03-21 | Glaxosmithkline Biolog Sa | Vaccine |
| US7628995B2 (en) * | 2003-12-23 | 2009-12-08 | Glaxosmithkline Biologicals S.A. | Outer membrane vesicles and uses thereof |
-
2001
- 2001-01-25 CN CN01807183A patent/CN1419564A/zh active Pending
- 2001-01-25 JP JP2001561034A patent/JP2003523208A/ja active Pending
- 2001-01-25 AU AU28181/01A patent/AU2818101A/en not_active Abandoned
- 2001-01-25 NZ NZ520445A patent/NZ520445A/en not_active IP Right Cessation
- 2001-01-25 HU HU0300696A patent/HUP0300696A3/hu unknown
- 2001-01-25 EP EP01946868A patent/EP1252182B1/de not_active Expired - Lifetime
- 2001-01-25 IL IL15082201A patent/IL150822A0/xx unknown
- 2001-01-25 PL PL356819A patent/PL216780B1/pl not_active IP Right Cessation
- 2001-01-25 MX MXPA02007184A patent/MXPA02007184A/es active IP Right Grant
- 2001-01-25 ES ES01946868T patent/ES2389719T3/es not_active Expired - Lifetime
- 2001-01-25 WO PCT/AU2001/000069 patent/WO2001055182A1/en active IP Right Grant
- 2001-01-25 CZ CZ2002-2482A patent/CZ304379B6/cs not_active IP Right Cessation
- 2001-01-25 CA CA002398139A patent/CA2398139A1/en not_active Abandoned
- 2001-01-25 CN CN2011102811093A patent/CN102417537A/zh active Pending
- 2001-01-25 EP EP10184045A patent/EP2395013A3/de not_active Withdrawn
- 2001-01-25 BR BR0107857-7A patent/BR0107857A/pt active Search and Examination
- 2001-01-25 KR KR1020027009512A patent/KR100698561B1/ko not_active IP Right Cessation
- 2001-01-25 US US09/771,382 patent/US7947291B2/en not_active Expired - Fee Related
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2002
- 2002-07-18 IL IL150822A patent/IL150822A/en not_active IP Right Cessation
- 2002-07-22 NO NO20023487A patent/NO332229B1/no not_active IP Right Cessation
- 2002-08-01 ZA ZA200206153A patent/ZA200206153B/xx unknown
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2007
- 2007-10-31 US US11/933,411 patent/US8383790B2/en not_active Expired - Fee Related
- 2007-10-31 US US11/933,245 patent/US8367070B2/en not_active Expired - Fee Related
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2011
- 2011-09-30 JP JP2011218296A patent/JP2012051902A/ja active Pending
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2013
- 2013-02-01 US US13/757,124 patent/US20130136762A1/en not_active Abandoned
- 2013-09-11 JP JP2013188798A patent/JP2014024849A/ja active Pending
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Legal Events
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| MM1K | Lapsed by not paying the annual fees |