NO329917B1 - Anvendelse av antistoffer for fremstilling av et farmasoytisk preparat mot cancer som uttrykker Ep-CAM - Google Patents
Anvendelse av antistoffer for fremstilling av et farmasoytisk preparat mot cancer som uttrykker Ep-CAM Download PDFInfo
- Publication number
- NO329917B1 NO329917B1 NO20013093A NO20013093A NO329917B1 NO 329917 B1 NO329917 B1 NO 329917B1 NO 20013093 A NO20013093 A NO 20013093A NO 20013093 A NO20013093 A NO 20013093A NO 329917 B1 NO329917 B1 NO 329917B1
- Authority
- NO
- Norway
- Prior art keywords
- antibody
- antibodies
- vaccination
- cam
- cells
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 60
- 201000011510 cancer Diseases 0.000 title claims abstract description 41
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 title claims description 33
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 title claims description 33
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 10
- 238000002360 preparation method Methods 0.000 title description 8
- 101710181478 Envelope glycoprotein GP350 Proteins 0.000 claims abstract description 9
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 238000002255 vaccination Methods 0.000 claims description 78
- 238000009739 binding Methods 0.000 claims description 21
- 230000001225 therapeutic effect Effects 0.000 claims description 14
- 241001529936 Murinae Species 0.000 claims description 11
- 210000000170 cell membrane Anatomy 0.000 claims description 10
- 230000000069 prophylactic effect Effects 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 4
- 238000007920 subcutaneous administration Methods 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
- 241000282414 Homo sapiens Species 0.000 abstract description 26
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 82
- 102100028654 Sperm-associated antigen 11B Human genes 0.000 description 62
- 239000000427 antigen Substances 0.000 description 45
- 102000036639 antigens Human genes 0.000 description 45
- 108091007433 antigens Proteins 0.000 description 45
- 230000028993 immune response Effects 0.000 description 36
- 241000283707 Capra Species 0.000 description 34
- 239000012634 fragment Substances 0.000 description 23
- 210000002966 serum Anatomy 0.000 description 23
- 241000282560 Macaca mulatta Species 0.000 description 22
- 238000002965 ELISA Methods 0.000 description 21
- 239000000872 buffer Substances 0.000 description 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 18
- 210000004881 tumor cell Anatomy 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 13
- 230000006698 induction Effects 0.000 description 13
- 239000000203 mixture Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 12
- 238000009472 formulation Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- 239000002671 adjuvant Substances 0.000 description 10
- 230000006870 function Effects 0.000 description 10
- 208000005718 Stomach Neoplasms Diseases 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 206010017758 gastric cancer Diseases 0.000 description 9
- 238000009169 immunotherapy Methods 0.000 description 9
- 238000000746 purification Methods 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 9
- 201000011549 stomach cancer Diseases 0.000 description 9
- 230000006735 deficit Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- 206010027476 Metastases Diseases 0.000 description 7
- 239000006285 cell suspension Substances 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000003053 immunization Effects 0.000 description 7
- 238000002649 immunization Methods 0.000 description 7
- 239000003446 ligand Substances 0.000 description 7
- 229960005486 vaccine Drugs 0.000 description 7
- 239000011534 wash buffer Substances 0.000 description 7
- -1 Lewis-Y carbohydrate Chemical class 0.000 description 6
- 239000013024 dilution buffer Substances 0.000 description 6
- 230000002163 immunogen Effects 0.000 description 6
- 230000003211 malignant effect Effects 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 201000001441 melanoma Diseases 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 5
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- 230000008878 coupling Effects 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 238000005859 coupling reaction Methods 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 238000010353 genetic engineering Methods 0.000 description 5
- 238000011835 investigation Methods 0.000 description 5
- 102000013415 peroxidase activity proteins Human genes 0.000 description 5
- 108040007629 peroxidase activity proteins Proteins 0.000 description 5
- 239000000902 placebo Substances 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- 102000005962 receptors Human genes 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 102000000588 Interleukin-2 Human genes 0.000 description 4
- 108010002350 Interleukin-2 Proteins 0.000 description 4
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000009089 cytolysis Effects 0.000 description 4
- 210000005260 human cell Anatomy 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 208000000587 small cell lung carcinoma Diseases 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 206010009944 Colon cancer Diseases 0.000 description 3
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 102000007066 Prostate-Specific Antigen Human genes 0.000 description 3
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 3
- 238000002306 biochemical method Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012894 fetal calf serum Substances 0.000 description 3
- 230000028996 humoral immune response Effects 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 229940072221 immunoglobulins Drugs 0.000 description 3
- 201000002313 intestinal cancer Diseases 0.000 description 3
- 238000007918 intramuscular administration Methods 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000003278 mimic effect Effects 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000012089 stop solution Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 231100000041 toxicology testing Toxicity 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
- 241001467552 Mycobacterium bovis BCG Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- 206010041067 Small cell lung cancer Diseases 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000000735 allogeneic effect Effects 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 description 2
- 239000012148 binding buffer Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 150000002270 gangliosides Chemical class 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000008611 intercellular interaction Effects 0.000 description 2
- 150000002632 lipids Chemical group 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 2
- 229940033663 thimerosal Drugs 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 1
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
- 206010002199 Anaphylactic shock Diseases 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 102000000905 Cadherin Human genes 0.000 description 1
- 108050007957 Cadherin Proteins 0.000 description 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 102100032768 Complement receptor type 2 Human genes 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000001301 EGF receptor Human genes 0.000 description 1
- 108060006698 EGF receptor Proteins 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 101150029707 ERBB2 gene Proteins 0.000 description 1
- 101710190709 Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 description 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102100021852 Neuronal cell adhesion molecule Human genes 0.000 description 1
- 101710130688 Neuronal cell adhesion molecule Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 108010055044 Tetanus Toxin Proteins 0.000 description 1
- 108010033576 Transferrin Receptors Proteins 0.000 description 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 description 1
- 102100026145 Transitional endoplasmic reticulum ATPase Human genes 0.000 description 1
- 101710132062 Transitional endoplasmic reticulum ATPase Proteins 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- SRHNADOZAAWYLV-XLMUYGLTSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](NC(C)=O)[C@H](O)O[C@@H]2CO)O[C@H]2[C@H]([C@H](O)[C@H](O)[C@H](C)O2)O)O[C@H](CO)[C@H](O)[C@@H]1O SRHNADOZAAWYLV-XLMUYGLTSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- RIIWUGSYXOBDMC-UHFFFAOYSA-N benzene-1,2-diamine;hydron;dichloride Chemical compound Cl.Cl.NC1=CC=CC=C1N RIIWUGSYXOBDMC-UHFFFAOYSA-N 0.000 description 1
- 238000001815 biotherapy Methods 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 238000002619 cancer immunotherapy Methods 0.000 description 1
- 238000009566 cancer vaccine Methods 0.000 description 1
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000003889 chemical engineering Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000024203 complement activation Effects 0.000 description 1
- 231100000050 cytotoxic potential Toxicity 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000008175 fetal development Effects 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 102000035122 glycosylated proteins Human genes 0.000 description 1
- 108091005608 glycosylated proteins Proteins 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 210000004201 immune sera Anatomy 0.000 description 1
- 229940042743 immune sera Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229960002385 streptomycin sulfate Drugs 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 101150047061 tag-72 gene Proteins 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940118376 tetanus toxin Drugs 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH5199 | 1999-01-13 | ||
PCT/EP2000/000174 WO2000041722A1 (de) | 1999-01-13 | 2000-01-12 | Verwendung von antikörpern zur vakzinierung gegen krebs |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20013093D0 NO20013093D0 (no) | 2001-06-21 |
NO20013093L NO20013093L (no) | 2001-09-10 |
NO329917B1 true NO329917B1 (no) | 2011-01-24 |
Family
ID=4178206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20013093A NO329917B1 (no) | 1999-01-13 | 2001-06-21 | Anvendelse av antistoffer for fremstilling av et farmasoytisk preparat mot cancer som uttrykker Ep-CAM |
Country Status (28)
Country | Link |
---|---|
US (3) | US7691372B2 (xx) |
EP (2) | EP1230932B1 (xx) |
JP (1) | JP4774551B2 (xx) |
KR (1) | KR100771752B1 (xx) |
CN (1) | CN1188169C (xx) |
AT (2) | ATE219687T1 (xx) |
AU (1) | AU768515B2 (xx) |
CA (1) | CA2360382C (xx) |
CZ (1) | CZ302801B6 (xx) |
DE (2) | DE50000243D1 (xx) |
DK (2) | DK1230932T3 (xx) |
EE (1) | EE05474B1 (xx) |
ES (2) | ES2236375T3 (xx) |
HK (1) | HK1044487B (xx) |
HR (1) | HRP20010526A2 (xx) |
HU (1) | HU226150B1 (xx) |
ID (1) | ID30223A (xx) |
IL (2) | IL144265A0 (xx) |
IS (1) | IS5998A (xx) |
MX (1) | MXPA01007148A (xx) |
NO (1) | NO329917B1 (xx) |
NZ (1) | NZ512722A (xx) |
PL (1) | PL201533B1 (xx) |
PT (2) | PT1230932E (xx) |
SI (2) | SI1140168T1 (xx) |
SK (1) | SK286627B6 (xx) |
TR (1) | TR200102034T2 (xx) |
WO (1) | WO2000041722A1 (xx) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01007148A (es) * | 1999-01-13 | 2002-03-27 | Igeneon Krebs Immuntherapie | Uso de anticuerpos para vacunacion anti-cancer. |
AT410172B (de) * | 2000-03-21 | 2003-02-25 | Igeneon Gmbh | Verfahren zur herstellung einer vakzineformulierung |
AT502293B1 (de) * | 2002-05-15 | 2008-03-15 | Igeneon Krebs Immuntherapie | Immunogener, monoklonaler antikörper |
AT500647A1 (de) * | 2002-05-21 | 2006-02-15 | Igeneon Krebs Immuntherapie | Verwendung eines impfstoffes |
AT500650B1 (de) * | 2003-04-17 | 2009-11-15 | Altropus Gmbh | Immunogener rekombinanter antikörper |
AT500651B9 (de) * | 2003-05-27 | 2010-04-15 | Altropus Gmbh | Aktiv immunisierender antikörper |
CA2573505C (en) | 2004-07-14 | 2013-06-25 | Igeneon Krebs-Immuntherapie Forschungs-Und Entwicklungs-Ag | N-glycosylated antibody |
EP1618890B1 (en) * | 2004-07-20 | 2010-10-06 | Altropus Gmbh | Use of antibodies in a very low dose for the vaccination against cancer |
WO2006116423A2 (en) * | 2005-04-26 | 2006-11-02 | Eisai Co., Ltd | Compositions and methods for cancer immunotherapy |
EP1762575A1 (en) * | 2005-09-12 | 2007-03-14 | Ganymed Pharmaceuticals AG | Identification of tumor-associated antigens for diagnosis and therapy |
AT504231A1 (de) | 2006-10-03 | 2008-04-15 | Hans Dr Loibner | Prädiktive parameter |
CN103263443B (zh) | 2007-12-07 | 2016-09-14 | 努特里希亚公司 | 用于尘螨变态反应的双歧杆菌 |
MX2011007049A (es) | 2009-02-24 | 2011-08-03 | Esbatech Alcon Biomed Res Unit | Metodos para identificar inmunoligadores de los antegenos de la superficie celular. |
US8887373B2 (en) | 2012-02-24 | 2014-11-18 | Covidien Lp | Vessel sealing instrument with reduced thermal spread and method of manufacture therefor |
US20140276968A1 (en) * | 2013-03-14 | 2014-09-18 | Ethicon, Inc. | Applicator systems for surgical fasteners |
US10196458B2 (en) * | 2013-07-26 | 2019-02-05 | The Regents Of The University Of California | Anti-immunoglobulin E antibodies and methods of using thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1341281C (en) * | 1986-07-09 | 2001-08-07 | Hubert J.P. Schoemaker | Immunotherapy of tumor with monoclonal antibody against the 17-1a antigen |
US5270202A (en) | 1989-11-03 | 1993-12-14 | Syamal Raychaudhuri | Anti-idiotypic antibodies to human melanoma-associated proteoglycan antigen |
US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US5798100A (en) * | 1994-07-06 | 1998-08-25 | Immunomedics, Inc. | Multi-stage cascade boosting vaccine |
WO1997005597A1 (en) * | 1995-07-31 | 1997-02-13 | Litton Systems Canada Limited | Flat panel pixel array incorporating photoconductive switches |
EP0857176A1 (en) * | 1995-10-25 | 1998-08-12 | Centocor B.V. | HUMAN EPITHELIAL ANTIGEN Ep-CAM DERIVED PEPTIDES AND THEIR USE |
US6235280B1 (en) | 1996-04-12 | 2001-05-22 | Malaya Chatterjee | Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1 |
IL121041A0 (en) * | 1997-06-09 | 1997-11-20 | Yeda Res & Dev | Immunogenic compositions for induction of anti-tumor immunity |
US6274143B1 (en) * | 1997-06-13 | 2001-08-14 | Malaya Chatterjee | Methods of delaying development of HMFG-associated tumors using anti-idiotype antibody 11D10 |
US6881405B2 (en) * | 1998-06-15 | 2005-04-19 | Altarex Medical Corp. | Reagents and methods for inducing an immune response to prostate specific antigen |
MXPA01007148A (es) * | 1999-01-13 | 2002-03-27 | Igeneon Krebs Immuntherapie | Uso de anticuerpos para vacunacion anti-cancer. |
US6632431B2 (en) | 2000-05-16 | 2003-10-14 | New York University | Anti-idiotypic antibody against FimH adhesion of uropathogenic type I-fimbriated Escherichia coli, compositions containing same and method for using same |
-
2000
- 2000-01-12 MX MXPA01007148A patent/MXPA01007148A/es not_active IP Right Cessation
- 2000-01-12 DK DK02005394T patent/DK1230932T3/da active
- 2000-01-12 PT PT02005394T patent/PT1230932E/pt unknown
- 2000-01-12 ID IDW00200101396A patent/ID30223A/id unknown
- 2000-01-12 DE DE50000243T patent/DE50000243D1/de not_active Expired - Lifetime
- 2000-01-12 EP EP02005394A patent/EP1230932B1/de not_active Expired - Lifetime
- 2000-01-12 JP JP2000593332A patent/JP4774551B2/ja not_active Expired - Fee Related
- 2000-01-12 WO PCT/EP2000/000174 patent/WO2000041722A1/de active IP Right Grant
- 2000-01-12 EE EEP200100366A patent/EE05474B1/xx not_active IP Right Cessation
- 2000-01-12 CZ CZ20012581A patent/CZ302801B6/cs not_active IP Right Cessation
- 2000-01-12 HU HU0200527A patent/HU226150B1/hu not_active IP Right Cessation
- 2000-01-12 EP EP00906191A patent/EP1140168B1/de not_active Expired - Lifetime
- 2000-01-12 PT PT00906191T patent/PT1140168E/pt unknown
- 2000-01-12 DE DE50009240T patent/DE50009240D1/de not_active Expired - Lifetime
- 2000-01-12 AT AT00906191T patent/ATE219687T1/de active
- 2000-01-12 KR KR1020017008697A patent/KR100771752B1/ko not_active IP Right Cessation
- 2000-01-12 AT AT02005394T patent/ATE286745T1/de active
- 2000-01-12 IL IL14426500A patent/IL144265A0/xx active IP Right Grant
- 2000-01-12 CN CNB008027641A patent/CN1188169C/zh not_active Expired - Fee Related
- 2000-01-12 AU AU27964/00A patent/AU768515B2/en not_active Ceased
- 2000-01-12 DK DK00906191T patent/DK1140168T3/da active
- 2000-01-12 ES ES02005394T patent/ES2236375T3/es not_active Expired - Lifetime
- 2000-01-12 PL PL364747A patent/PL201533B1/pl not_active IP Right Cessation
- 2000-01-12 SI SI200030015T patent/SI1140168T1/xx unknown
- 2000-01-12 TR TR2001/02034T patent/TR200102034T2/xx unknown
- 2000-01-12 SI SI200030594T patent/SI1230932T1/xx unknown
- 2000-01-12 ES ES00906191T patent/ES2177509T3/es not_active Expired - Lifetime
- 2000-01-12 SK SK964-2001A patent/SK286627B6/sk not_active IP Right Cessation
- 2000-01-12 CA CA2360382A patent/CA2360382C/en not_active Expired - Fee Related
- 2000-01-12 NZ NZ512722A patent/NZ512722A/en not_active IP Right Cessation
-
2001
- 2001-06-21 NO NO20013093A patent/NO329917B1/no not_active IP Right Cessation
- 2001-07-10 IS IS5998A patent/IS5998A/is unknown
- 2001-07-11 IL IL144265A patent/IL144265A/en not_active IP Right Cessation
- 2001-07-12 HR HR20010526A patent/HRP20010526A2/hr not_active Application Discontinuation
-
2002
- 2002-08-23 HK HK02106215.4A patent/HK1044487B/zh not_active IP Right Cessation
-
2006
- 2006-10-10 US US11/548,269 patent/US7691372B2/en not_active Expired - Fee Related
-
2009
- 2009-09-18 US US12/562,886 patent/US20100233178A1/en not_active Abandoned
-
2011
- 2011-08-12 US US13/209,285 patent/US8444974B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8444974B2 (en) | Use of antibodies for the vaccination against cancer | |
JP2004534741A (ja) | 癌に対する抗体 | |
NO321511B1 (no) | Sammensetning for rekonformering av multi-epitopiske antigener for a initiere en immunrespons og anvendelse av sammensetningen til fremstilling av et legemiddel | |
AU780853B2 (en) | Use of anti-idiotypical antibodies as vaccines against cancer | |
AU2005306186B2 (en) | Immunotherapeutic formulations with Interleukin-2-neutralising capacity | |
US20080241177A1 (en) | Idiotypic vaccine | |
US20060018901A1 (en) | Use of antibodies in a very low dose for the vaccination against cancer | |
US10092635B2 (en) | Tumor vaccines and methods of use thereof | |
US20040265318A1 (en) | Use of antibodies for the vaccination against cancer | |
JP2004532261A (ja) | ポリクローナル免疫グロブリンの使用 | |
Dakappagari | Evaluation of chimeric B-cell epitope vaccines of HER-2: application to cancer patients | |
JP2001055341A (ja) | 免疫応答を惹起するための、多数エピトープ含有抗原の再構成法および組成物 | |
AU2004213066A1 (en) | Idiotypic vaccine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |