NO328738B1 - Anvendelse av RAR-agonist for fremstilling av medikamenter. - Google Patents
Anvendelse av RAR-agonist for fremstilling av medikamenter. Download PDFInfo
- Publication number
- NO328738B1 NO328738B1 NO20021823A NO20021823A NO328738B1 NO 328738 B1 NO328738 B1 NO 328738B1 NO 20021823 A NO20021823 A NO 20021823A NO 20021823 A NO20021823 A NO 20021823A NO 328738 B1 NO328738 B1 NO 328738B1
- Authority
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- Norway
- Prior art keywords
- rarγ
- selective
- agonist
- rar
- lung
- Prior art date
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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- Y02P20/50—Improvements relating to the production of bulk chemicals
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Landscapes
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Applications Claiming Priority (2)
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US16041599P | 1999-10-19 | 1999-10-19 | |
PCT/EP2000/010076 WO2001030326A1 (en) | 1999-10-19 | 2000-10-13 | Treatment of emphysema using rar selective retinoid agonists |
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NO20021823D0 NO20021823D0 (no) | 2002-04-18 |
NO20021823L NO20021823L (no) | 2002-04-18 |
NO328738B1 true NO328738B1 (no) | 2010-05-03 |
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NO20021823A NO328738B1 (no) | 1999-10-19 | 2002-04-18 | Anvendelse av RAR-agonist for fremstilling av medikamenter. |
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AT (1) | ATE344661T1 (xx) |
AU (1) | AU777325B2 (xx) |
BR (1) | BR0015225A (xx) |
CA (1) | CA2387844C (xx) |
CY (1) | CY1105941T1 (xx) |
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HR (1) | HRP20020329A2 (xx) |
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MA (1) | MA26835A1 (xx) |
MX (1) | MXPA02003843A (xx) |
MY (1) | MY129001A (xx) |
NO (1) | NO328738B1 (xx) |
NZ (1) | NZ518118A (xx) |
PE (1) | PE20010678A1 (xx) |
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PT (1) | PT1225878E (xx) |
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RU (1) | RU2257383C2 (xx) |
TR (1) | TR200201071T2 (xx) |
TW (1) | TWI288639B (xx) |
WO (1) | WO2001030326A1 (xx) |
ZA (1) | ZA200202576B (xx) |
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AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
WO2003024921A1 (en) * | 2001-09-18 | 2003-03-27 | F. Hoffmann-La Roche Ag | Alkyl urea retinoid agonists i |
CA2458266C (en) | 2001-09-18 | 2011-03-15 | F. Hoffmann-La Roche Ag | Substituted urea retinoid agonists ii |
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
US20070104809A1 (en) | 2003-08-22 | 2007-05-10 | Danisco A/S | Composition comprising a bacteriocin and an extract from a plant of the labiatae family |
GB2388581A (en) | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
WO2008063842A2 (en) * | 2006-11-02 | 2008-05-29 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain with agonists of ppar-gamma |
DK2613776T3 (da) | 2010-09-01 | 2020-10-19 | Univ Jefferson | Sammensætning og fremgangsmåde til muskelreparation og -regenerering |
CA2840272C (en) | 2011-06-24 | 2020-09-15 | Glycoregimmune, Inc. | Prevention and treatment of inflammatory conditions |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
WO2013019653A1 (en) * | 2011-07-29 | 2013-02-07 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
BR112015014178A2 (pt) | 2012-12-17 | 2017-07-11 | Parion Sciences Inc | compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida |
ES2619954T3 (es) | 2012-12-17 | 2017-06-27 | Parion Sciences, Inc. | Derivados de cloropiracinocarboxamida útiles para el tratamiento de enfermedades favorecidas por una hidratación mucosa insuficiente |
WO2015026990A2 (en) | 2013-08-20 | 2015-02-26 | University Of Washington Through Its Center For Commercialization | Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydrolase |
EP3039126B1 (en) | 2013-08-26 | 2019-10-09 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Small molecule cellular reprogramming to generate neuronal cells |
US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
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AU618590B2 (en) * | 1988-04-11 | 1992-01-02 | Allergan, Inc. | Tetralin esters of phenols or benzoic acids having retinoid like activity |
CA2129773C (en) * | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
US5498795A (en) * | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
US5807900A (en) * | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
FR2739557B1 (fr) * | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
US5726191A (en) * | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
FR2747041B1 (fr) | 1996-04-05 | 1998-05-22 | Cird Galderma | Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies |
ZA9810122B (en) * | 1997-11-12 | 1999-05-12 | Hoffmann La Roche | Treatment of T-helper cell type 2 mediated immune diseases |
US6083973A (en) * | 1998-03-09 | 2000-07-04 | Syntex (U.S.A.) Inc. | Methods for inhibiting mucin secretion using RAR α selective antagonists |
WO2000061232A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-beta antagonist |
WO2000061182A2 (en) | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a selective rar-alpha agonist |
AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
CA2386793C (en) * | 1999-08-02 | 2006-03-28 | F. Hoffmann-La Roche Ag | New selective retinoid agonists |
US6479670B1 (en) * | 1999-08-25 | 2002-11-12 | Hoffmann-La Roche Inc. | Selective retinoid acid receptor agonists |
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