NO328693B1 - Fremgangsmate for rensing av LH fra en prove, rekombinant LH med spesifikk aktivitet, anvendelse av rekombinant LH i fremstilling av medikamenter og farmasoytiske preparater omfattende rekombinante LH. - Google Patents
Fremgangsmate for rensing av LH fra en prove, rekombinant LH med spesifikk aktivitet, anvendelse av rekombinant LH i fremstilling av medikamenter og farmasoytiske preparater omfattende rekombinante LH. Download PDFInfo
- Publication number
- NO328693B1 NO328693B1 NO20023963A NO20023963A NO328693B1 NO 328693 B1 NO328693 B1 NO 328693B1 NO 20023963 A NO20023963 A NO 20023963A NO 20023963 A NO20023963 A NO 20023963A NO 328693 B1 NO328693 B1 NO 328693B1
- Authority
- NO
- Norway
- Prior art keywords
- recombinant
- phase hplc
- column
- exchange chromatography
- sample
- Prior art date
Links
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- 238000002360 preparation method Methods 0.000 title claims description 20
- 239000003814 drug Substances 0.000 title claims description 5
- 229940079593 drug Drugs 0.000 title claims description 4
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- 239000008194 pharmaceutical composition Substances 0.000 title description 3
- 238000004007 reversed phase HPLC Methods 0.000 claims abstract description 28
- 238000004255 ion exchange chromatography Methods 0.000 claims abstract description 24
- 238000000746 purification Methods 0.000 claims abstract description 22
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims abstract description 3
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- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims description 17
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- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 claims 1
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- 108010073521 Luteinizing Hormone Proteins 0.000 abstract description 57
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicinal Preparation (AREA)
- Semiconductor Lasers (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00103692 | 2000-02-22 | ||
| PCT/EP2001/000666 WO2001062774A2 (en) | 2000-02-22 | 2001-01-22 | Purified lh |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20023963L NO20023963L (no) | 2002-08-20 |
| NO20023963D0 NO20023963D0 (no) | 2002-08-20 |
| NO328693B1 true NO328693B1 (no) | 2010-04-26 |
Family
ID=8167926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023963A NO328693B1 (no) | 2000-02-22 | 2002-08-20 | Fremgangsmate for rensing av LH fra en prove, rekombinant LH med spesifikk aktivitet, anvendelse av rekombinant LH i fremstilling av medikamenter og farmasoytiske preparater omfattende rekombinante LH. |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7053054B2 (cs) |
| EP (2) | EP1777231A3 (cs) |
| JP (1) | JP4959898B2 (cs) |
| KR (1) | KR100808149B1 (cs) |
| CN (1) | CN100480258C (cs) |
| AT (1) | ATE356138T1 (cs) |
| AU (1) | AU780377B2 (cs) |
| BG (1) | BG65761B1 (cs) |
| BR (2) | BRPI0108553B8 (cs) |
| CA (1) | CA2399100C (cs) |
| CY (1) | CY1108056T1 (cs) |
| CZ (1) | CZ303274B6 (cs) |
| DE (1) | DE60127100T2 (cs) |
| DK (1) | DK1261622T3 (cs) |
| EA (1) | EA004385B1 (cs) |
| EE (1) | EE04932B1 (cs) |
| ES (1) | ES2278722T3 (cs) |
| HR (1) | HRP20020651B1 (cs) |
| HU (1) | HU227007B1 (cs) |
| IL (2) | IL151309A0 (cs) |
| MX (1) | MXPA02007867A (cs) |
| NO (1) | NO328693B1 (cs) |
| PL (1) | PL207728B1 (cs) |
| PT (1) | PT1261622E (cs) |
| RS (1) | RS50416B (cs) |
| SI (1) | SI1261622T1 (cs) |
| SK (1) | SK287041B6 (cs) |
| UA (2) | UA92145C2 (cs) |
| WO (1) | WO2001062774A2 (cs) |
| ZA (1) | ZA200206108B (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK287041B6 (sk) * | 2000-02-22 | 2009-10-07 | Laboratoires Serono Sa | Spôsob čistenia luteinizačného hormónu - LH zo vzorky, rekombinantný hLH, jeho použitie a farmaceutický prostriedok s jeho obsahom |
| DE10235168A1 (de) * | 2002-08-01 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Verfahren zur Reinigung von Preproinsulin |
| BRPI0409571B1 (pt) | 2003-03-04 | 2016-05-31 | Aspenbio Pharma Inc | método para manter uma ou mais gravidezes em um ou mais mamíferos |
| CN1283792C (zh) * | 2003-11-14 | 2006-11-08 | 余伟明 | 生物大分子组分相分离法 |
| CA2544333A1 (en) * | 2003-12-22 | 2005-07-14 | Ares Trading S.A. | Method for purifying fsh |
| DE602005021614D1 (de) * | 2004-10-04 | 2010-07-15 | Novetide Ltd | Gegenionenaustauschverfahren für peptide |
| ATE408624T1 (de) * | 2004-11-09 | 2008-10-15 | Ares Trading Sa | Verfahren zur reinigung von fsh |
| US20080219952A1 (en) * | 2005-08-26 | 2008-09-11 | Ares Trading S.A. | Process For the Preparation of Glycosylated Interferon Beta |
| WO2007065918A2 (en) | 2005-12-09 | 2007-06-14 | Ares Trading S.A. | Method for purifying fsh or a fsh mutant |
| CA2702448A1 (en) * | 2007-10-22 | 2009-04-30 | Merck Serono S.A. | Method for purifying fc-fusion proteins |
| EP2203465A1 (en) * | 2007-10-22 | 2010-07-07 | Merck Serono S.A. | Method for purifying an fc-containing protein |
| CN101928342B (zh) * | 2009-06-18 | 2013-05-08 | 上海天伟生物制药有限公司 | 一种高纯度绝经期促性腺素及其制备方法和用途 |
| CN106999546A (zh) * | 2014-05-01 | 2017-08-01 | 弗吉尼亚技术知识资产公司 | 角蛋白纳米材料及其制备方法 |
| CN104569441B (zh) * | 2015-01-19 | 2016-02-03 | 成都大熊猫繁育研究基地 | 大熊猫尿液促黄体素的酶联检测方法及其应用 |
| WO2020229699A1 (en) | 2019-05-16 | 2020-11-19 | Ceva Sante Animale | Compositions and methods for increasing reproduction performance in non human mammals using recombinant luteinizing hormone |
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| WO1990002757A1 (en) * | 1988-09-02 | 1990-03-22 | Integrated Genetics, Inc. | Heteropolymeric protein |
| WO1990009800A1 (en) * | 1989-02-21 | 1990-09-07 | Washington University | Modified forms of reproductive hormones |
| US5087615A (en) * | 1989-03-17 | 1992-02-11 | Applied Research Systems Ars Holding N.V. | Novel method of ovulation induction in humans |
| IT1250075B (it) * | 1991-12-18 | 1995-03-30 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti gonadotropine. |
| IT1287138B1 (it) * | 1996-11-07 | 1998-08-04 | Ibsa Inst Biochimique Sa | Procedimento per la separazione e purificazione di fsh e lh |
| TW518235B (en) * | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
| SI0996629T1 (sl) * | 1997-06-25 | 2006-12-31 | Applied Research Systems | Analogi glikoproteinskega hormona povezanega z disulfidi, priprava in uporaba |
| SK287041B6 (sk) * | 2000-02-22 | 2009-10-07 | Laboratoires Serono Sa | Spôsob čistenia luteinizačného hormónu - LH zo vzorky, rekombinantný hLH, jeho použitie a farmaceutický prostriedok s jeho obsahom |
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