HRP20020651B1 - Purified lh - Google Patents

Purified lh

Info

Publication number
HRP20020651B1
HRP20020651B1 HR20020651A HRP20020651A HRP20020651B1 HR P20020651 B1 HRP20020651 B1 HR P20020651B1 HR 20020651 A HR20020651 A HR 20020651A HR P20020651 A HRP20020651 A HR P20020651A HR P20020651 B1 HRP20020651 B1 HR P20020651B1
Authority
HR
Croatia
Prior art keywords
purified
purifying
sample
reverse phase
phase hplc
Prior art date
Application number
HR20020651A
Other languages
English (en)
Croatian (hr)
Inventor
Paradisi Gianfranco
Rossi Mara
Scaglia Laura
Original Assignee
Laboratoires Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono Sa filed Critical Laboratoires Serono Sa
Publication of HRP20020651A2 publication Critical patent/HRP20020651A2/hr
Publication of HRP20020651B1 publication Critical patent/HRP20020651B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Semiconductor Lasers (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20020651A 2000-02-22 2001-01-22 Purified lh HRP20020651B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00103692 2000-02-22
PCT/EP2001/000666 WO2001062774A2 (en) 2000-02-22 2001-01-22 Purified lh

Publications (2)

Publication Number Publication Date
HRP20020651A2 HRP20020651A2 (en) 2004-12-31
HRP20020651B1 true HRP20020651B1 (en) 2011-01-31

Family

ID=8167926

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020651A HRP20020651B1 (en) 2000-02-22 2001-01-22 Purified lh

Country Status (30)

Country Link
US (2) US7053054B2 (cs)
EP (2) EP1261622B1 (cs)
JP (1) JP4959898B2 (cs)
KR (1) KR100808149B1 (cs)
CN (1) CN100480258C (cs)
AT (1) ATE356138T1 (cs)
AU (1) AU780377B2 (cs)
BG (1) BG65761B1 (cs)
BR (2) BRPI0108553B8 (cs)
CA (1) CA2399100C (cs)
CY (1) CY1108056T1 (cs)
CZ (1) CZ303274B6 (cs)
DE (1) DE60127100T2 (cs)
DK (1) DK1261622T3 (cs)
EA (1) EA004385B1 (cs)
EE (1) EE04932B1 (cs)
ES (1) ES2278722T3 (cs)
HR (1) HRP20020651B1 (cs)
HU (1) HU227007B1 (cs)
IL (2) IL151309A0 (cs)
MX (1) MXPA02007867A (cs)
NO (1) NO328693B1 (cs)
PL (1) PL207728B1 (cs)
PT (1) PT1261622E (cs)
RS (1) RS50416B (cs)
SI (1) SI1261622T1 (cs)
SK (1) SK287041B6 (cs)
UA (2) UA78676C2 (cs)
WO (1) WO2001062774A2 (cs)
ZA (1) ZA200206108B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2278722T3 (es) * 2000-02-22 2007-08-16 Applied Research Systems Ars Holding N.V. Hlh purificada recombinante que tiene una bioactividad especifica y procedimiento para su purificacion.
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
NZ542549A (en) * 2003-03-04 2008-11-28 Aspenbio Pharma Inc Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using single-chain luteinizing hormone
CN1283792C (zh) * 2003-11-14 2006-11-08 余伟明 生物大分子组分相分离法
JP4763616B2 (ja) * 2003-12-22 2011-08-31 アレス トレーディング ソシエテ アノニム Ｆｓｈを精製するための方法
EP1709065B1 (en) * 2004-10-04 2010-06-02 Novetide Ltd. A counterion exchange process for peptides
DE602005009856D1 (de) * 2004-11-09 2008-10-30 Ares Trading Sa Verfahren zur reinigung von fsh
WO2007022799A1 (en) * 2005-08-26 2007-03-01 Ares Trading S.A. Process for the preparation of glycosylated interferon beta
AU2006323925B2 (en) 2005-12-09 2012-08-02 Ares Trading S.A. Method for purifying FSH or a FSH mutant
EP2203465A1 (en) * 2007-10-22 2010-07-07 Merck Serono S.A. Method for purifying an fc-containing protein
AU2008314687A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying Fc-fusion proteins
CN101928342B (zh) * 2009-06-18 2013-05-08 上海天伟生物制药有限公司 一种高纯度绝经期促性腺素及其制备方法和用途
WO2015168622A1 (en) * 2014-05-01 2015-11-05 Virginia Tech Intellectual Properties, Inc. Keratin nanomaterials and methods of production
CN104569441B (zh) * 2015-01-19 2016-02-03 成都大熊猫繁育研究基地 大熊猫尿液促黄体素的酶联检测方法及其应用
CA3140267A1 (en) 2019-05-16 2020-11-19 Ceva Sante Animale Compositions and methods for increasing reproduction performance in non-human mammals using recombinant luteinizing hormone

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002757A1 (en) * 1988-09-02 1990-03-22 Integrated Genetics, Inc. Heteropolymeric protein
WO1998020039A1 (en) * 1996-11-07 1998-05-14 Ibsa Institut Biochimique S.A. Fsh and lh separation and purification process
WO1998058957A2 (en) * 1997-06-25 1998-12-30 Applied Research Systems Ars Holding N.V. Disulfide cross-linked glycoprotein hormone analogs, their preparation and use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0461200T3 (da) * 1989-02-21 1997-03-10 Univ Washington Modificerede former af reproduktionshormoner
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
ES2278722T3 (es) * 2000-02-22 2007-08-16 Applied Research Systems Ars Holding N.V. Hlh purificada recombinante que tiene una bioactividad especifica y procedimiento para su purificacion.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002757A1 (en) * 1988-09-02 1990-03-22 Integrated Genetics, Inc. Heteropolymeric protein
WO1998020039A1 (en) * 1996-11-07 1998-05-14 Ibsa Institut Biochimique S.A. Fsh and lh separation and purification process
WO1998058957A2 (en) * 1997-06-25 1998-12-30 Applied Research Systems Ars Holding N.V. Disulfide cross-linked glycoprotein hormone analogs, their preparation and use

Also Published As

Publication number Publication date
ATE356138T1 (de) 2007-03-15
NO328693B1 (no) 2010-04-26
BG107001A (bg) 2003-04-30
EA200200893A1 (ru) 2003-02-27
DE60127100T2 (de) 2007-06-28
RS50416B (sr) 2009-12-31
NO20023963D0 (no) 2002-08-20
BR122012018280B1 (pt) 2018-01-09
CN100480258C (zh) 2009-04-22
SK12052002A3 (sk) 2002-12-03
CA2399100A1 (en) 2001-08-30
ES2278722T3 (es) 2007-08-16
BR122012018280B8 (pt) 2021-05-25
WO2001062774A2 (en) 2001-08-30
EP1261622A2 (en) 2002-12-04
EP1777231A2 (en) 2007-04-25
JP2003532636A (ja) 2003-11-05
HU227007B1 (en) 2010-04-28
DK1261622T3 (da) 2007-05-29
US20030186893A1 (en) 2003-10-02
BG65761B1 (bg) 2009-10-30
BRPI0108553B1 (pt) 2016-06-14
AU780377B2 (en) 2005-03-17
CZ303274B6 (cs) 2012-07-11
DE60127100D1 (de) 2007-04-19
EA004385B1 (ru) 2004-04-29
UA78676C2 (en) 2007-04-25
PL207728B1 (pl) 2011-01-31
CA2399100C (en) 2011-11-08
HUP0301814A2 (hu) 2003-08-28
KR20030001358A (ko) 2003-01-06
SI1261622T1 (sl) 2007-06-30
IL151309A (en) 2010-11-30
CY1108056T1 (el) 2013-09-04
YU60302A (sh) 2005-09-19
PL362891A1 (en) 2004-11-02
US20060079460A1 (en) 2006-04-13
SK287041B6 (sk) 2009-10-07
WO2001062774A3 (en) 2002-03-14
EE200200464A (et) 2003-12-15
BRPI0108553B8 (pt) 2021-05-25
ZA200206108B (en) 2003-07-31
PT1261622E (pt) 2007-04-30
CN1404486A (zh) 2003-03-19
NO20023963L (no) 2002-08-20
HRP20020651A2 (en) 2004-12-31
EP1777231A3 (en) 2007-11-07
HUP0301814A3 (en) 2004-10-28
EE04932B1 (et) 2007-12-17
JP4959898B2 (ja) 2012-06-27
AU3543601A (en) 2001-09-03
BR0108553A (pt) 2003-12-23
IL151309A0 (en) 2003-04-10
KR100808149B1 (ko) 2008-02-29
EP1261622B1 (en) 2007-03-07
MXPA02007867A (es) 2003-02-10
CZ20022856A3 (cs) 2003-01-15
HK1052014A1 (zh) 2003-08-29
US7053054B2 (en) 2006-05-30
UA92145C2 (en) 2010-10-11

Similar Documents

Publication Publication Date Title
HRP20020651B1 (en) Purified lh
DE60140899D1 (de) Presspassungs-targetanordnung für hochleistungszerstäubungsvorgang
ZA200300447B (en) Granulation process.
ITTO20010332A0 (it) Gruppo cingolato per macchina operatrice.
ITMI20000945A0 (it) Struttura di sella, particolarmente studiata per cicli
AU2001233703A1 (en) Diethyloctandioldicarbamates and diethyloctandioldiallophanates, method for the production and use thereof
GB2287953B (en) High stability, organic tanning processes
BR0106265B1 (pt) processo para cultura aeràbica.
IT1320029B1 (it) Gruppo di frenatura per bicicletta, e bicicletta utilizzante talegruppo.
ES1045920Y (es) Cuadro de bicicleta perfeccionado.
ES1048019Y (es) Cajon.
ES1046662Y (es) Sujetador perfeccionado.
ES1047296Y (es) Sujetador perfeccionado.
ES1046999Y (es) Abrazadera perfeccionada.
ES1045289Y (es) Pinza perfeccionada.
IT1315666B1 (it) Gruppo sterzante ad azionamento fluidomeccanico perfezionato
ES1047379Y (es) Portalamparas perfeccionado.
ZA200100722B (en) Effluent treatment process.
ES1047516Y (es) Tornillo perfeccionado, autorroscante.
ES1045376Y (es) Embudo encauzador de persiana perfeccionado.
ES1029156Y (es) Estuche/maletin perfeccionado, porta-herramientas manuales.
ES1045027Y (es) Bicicleta perfeccionada.
ES1047789Y (es) Guitarra perfeccionada.
ES1046870Y (es) Grifo perfeccionado.
IT250057Y1 (it) Macchina smussatrice perfezionata.

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: LABORATOIRES SERONO SA, CH

B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: MERCK SERONO SA, CH

ODRP Renewal fee for the maintenance of a patent

Payment date: 20181231

Year of fee payment: 19

ODRP Renewal fee for the maintenance of a patent

Payment date: 20191217

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20210122