DE60127100D1 - Gereinigtes recombinantes hlh mit spezifischer bioaktivität und verfahren zu dessen reinigung - Google Patents

Gereinigtes recombinantes hlh mit spezifischer bioaktivität und verfahren zu dessen reinigung

Info

Publication number
DE60127100D1
DE60127100D1 DE60127100T DE60127100T DE60127100D1 DE 60127100 D1 DE60127100 D1 DE 60127100D1 DE 60127100 T DE60127100 T DE 60127100T DE 60127100 T DE60127100 T DE 60127100T DE 60127100 D1 DE60127100 D1 DE 60127100D1
Authority
DE
Germany
Prior art keywords
cleaned
cleaning
specific bioactivity
recombinant
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60127100T
Other languages
English (en)
Other versions
DE60127100T2 (de
Inventor
Gianfranco Paradisi
Mara Rossi
Laura Scaglia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Application granted granted Critical
Publication of DE60127100D1 publication Critical patent/DE60127100D1/de
Publication of DE60127100T2 publication Critical patent/DE60127100T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Semiconductor Lasers (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
DE60127100T 2000-02-22 2001-01-22 Gereinigtes recombinantes hlh mit spezifischer bioaktivität und verfahren zu dessen reinigung Expired - Lifetime DE60127100T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00103692 2000-02-22
EP00103692 2000-02-22
PCT/EP2001/000666 WO2001062774A2 (en) 2000-02-22 2001-01-22 Purified lh

Publications (2)

Publication Number Publication Date
DE60127100D1 true DE60127100D1 (de) 2007-04-19
DE60127100T2 DE60127100T2 (de) 2007-06-28

Family

ID=8167926

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60127100T Expired - Lifetime DE60127100T2 (de) 2000-02-22 2001-01-22 Gereinigtes recombinantes hlh mit spezifischer bioaktivität und verfahren zu dessen reinigung

Country Status (31)

Country Link
US (2) US7053054B2 (de)
EP (2) EP1261622B1 (de)
JP (1) JP4959898B2 (de)
KR (1) KR100808149B1 (de)
CN (1) CN100480258C (de)
AT (1) ATE356138T1 (de)
AU (1) AU780377B2 (de)
BG (1) BG65761B1 (de)
BR (2) BRPI0108553B8 (de)
CA (1) CA2399100C (de)
CY (1) CY1108056T1 (de)
CZ (1) CZ303274B6 (de)
DE (1) DE60127100T2 (de)
DK (1) DK1261622T3 (de)
EA (1) EA004385B1 (de)
EE (1) EE04932B1 (de)
ES (1) ES2278722T3 (de)
HK (1) HK1052014A1 (de)
HR (1) HRP20020651B1 (de)
HU (1) HU227007B1 (de)
IL (2) IL151309A0 (de)
MX (1) MXPA02007867A (de)
NO (1) NO328693B1 (de)
PL (1) PL207728B1 (de)
PT (1) PT1261622E (de)
RS (1) RS50416B (de)
SI (1) SI1261622T1 (de)
SK (1) SK287041B6 (de)
UA (2) UA78676C2 (de)
WO (1) WO2001062774A2 (de)
ZA (1) ZA200206108B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK287041B6 (sk) * 2000-02-22 2009-10-07 Laboratoires Serono Sa Spôsob čistenia luteinizačného hormónu - LH zo vzorky, rekombinantný hLH, jeho použitie a farmaceutický prostriedok s jeho obsahom
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
EP1610803B8 (de) 2003-03-04 2011-09-14 AspenBio Pharma, Inc. LH zur Verwendung der Erhaltung einer oder mehreren Schwangerschaften durch Induktion der Bildung des sekundären Gelbkörpers.
CN1283792C (zh) * 2003-11-14 2006-11-08 余伟明 生物大分子组分相分离法
EA008924B1 (ru) * 2003-12-22 2007-08-31 Арес Трейдинг С.А. Способ очистки фсг
US20060148699A1 (en) * 2004-10-04 2006-07-06 Avi Tovi Counterion exchange process for peptides
MX2007005327A (es) * 2004-11-09 2007-08-02 Ares Trading Sa Metodo para purificacion de la hormona foliculo estimulante (hfe).
SI1917276T1 (en) * 2005-08-26 2018-05-31 Ares Trading S.A. PROCEDURE FOR PREPARATION OF GLYCOSYLATED INTERFERONE BETA
US8604175B2 (en) 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
CA2702448A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying fc-fusion proteins
EP2203465A1 (de) * 2007-10-22 2010-07-07 Merck Serono S.A. Verfahren zu reinigung eines fc enthaltenden proteins
CN101928342B (zh) * 2009-06-18 2013-05-08 上海天伟生物制药有限公司 一种高纯度绝经期促性腺素及其制备方法和用途
CN106999546A (zh) * 2014-05-01 2017-08-01 弗吉尼亚技术知识资产公司 角蛋白纳米材料及其制备方法
CN104569441B (zh) * 2015-01-19 2016-02-03 成都大熊猫繁育研究基地 大熊猫尿液促黄体素的酶联检测方法及其应用
US20220143131A1 (en) 2019-05-16 2022-05-12 Ceva Sante Animale Compositions and Methods for increasing Reproduction Performance in Non Human Mammals Using Recombinant Luteinizing Hormone

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0394363A1 (de) * 1988-09-02 1990-10-31 Integrated Genetics, Inc. Heteropolymeres protein
EP0461200B1 (de) * 1989-02-21 1997-01-22 Washington University Modifizierte formen von fortpflanzungshormonen
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
IT1287138B1 (it) 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
SI0996629T1 (sl) * 1997-06-25 2006-12-31 Applied Research Systems Analogi glikoproteinskega hormona povezanega z disulfidi, priprava in uporaba
SK287041B6 (sk) * 2000-02-22 2009-10-07 Laboratoires Serono Sa Spôsob čistenia luteinizačného hormónu - LH zo vzorky, rekombinantný hLH, jeho použitie a farmaceutický prostriedok s jeho obsahom

Also Published As

Publication number Publication date
YU60302A (sh) 2005-09-19
RS50416B (sr) 2009-12-31
EA200200893A1 (ru) 2003-02-27
CA2399100C (en) 2011-11-08
JP4959898B2 (ja) 2012-06-27
KR100808149B1 (ko) 2008-02-29
HK1052014A1 (en) 2003-08-29
PL362891A1 (en) 2004-11-02
CN100480258C (zh) 2009-04-22
ZA200206108B (en) 2003-07-31
HRP20020651A2 (en) 2004-12-31
BG65761B1 (bg) 2009-10-30
PL207728B1 (pl) 2011-01-31
DK1261622T3 (da) 2007-05-29
DE60127100T2 (de) 2007-06-28
BRPI0108553B8 (pt) 2021-05-25
EP1261622A2 (de) 2002-12-04
CY1108056T1 (el) 2013-09-04
UA78676C2 (en) 2007-04-25
HU227007B1 (en) 2010-04-28
SK287041B6 (sk) 2009-10-07
US20030186893A1 (en) 2003-10-02
BR122012018280B1 (pt) 2018-01-09
US7053054B2 (en) 2006-05-30
WO2001062774A2 (en) 2001-08-30
WO2001062774A3 (en) 2002-03-14
KR20030001358A (ko) 2003-01-06
HUP0301814A2 (hu) 2003-08-28
CA2399100A1 (en) 2001-08-30
EP1261622B1 (de) 2007-03-07
AU3543601A (en) 2001-09-03
AU780377B2 (en) 2005-03-17
JP2003532636A (ja) 2003-11-05
BR0108553A (pt) 2003-12-23
IL151309A (en) 2010-11-30
SK12052002A3 (sk) 2002-12-03
EA004385B1 (ru) 2004-04-29
ES2278722T3 (es) 2007-08-16
CZ20022856A3 (cs) 2003-01-15
ATE356138T1 (de) 2007-03-15
EP1777231A2 (de) 2007-04-25
NO328693B1 (no) 2010-04-26
HUP0301814A3 (en) 2004-10-28
BR122012018280B8 (pt) 2021-05-25
SI1261622T1 (sl) 2007-06-30
BG107001A (bg) 2003-04-30
EE200200464A (et) 2003-12-15
PT1261622E (pt) 2007-04-30
NO20023963L (no) 2002-08-20
UA92145C2 (en) 2010-10-11
HRP20020651B1 (en) 2011-01-31
US20060079460A1 (en) 2006-04-13
CZ303274B6 (cs) 2012-07-11
EE04932B1 (et) 2007-12-17
BRPI0108553B1 (pt) 2016-06-14
NO20023963D0 (no) 2002-08-20
CN1404486A (zh) 2003-03-19
IL151309A0 (en) 2003-04-10
MXPA02007867A (es) 2003-02-10
EP1777231A3 (de) 2007-11-07

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH