HRP20020651B1 - Purified lh - Google Patents

Purified lh

Info

Publication number
HRP20020651B1
HRP20020651B1 HR20020651A HRP20020651A HRP20020651B1 HR P20020651 B1 HRP20020651 B1 HR P20020651B1 HR 20020651 A HR20020651 A HR 20020651A HR P20020651 A HRP20020651 A HR P20020651A HR P20020651 B1 HRP20020651 B1 HR P20020651B1
Authority
HR
Croatia
Prior art keywords
purified
purifying
sample
reverse phase
phase hplc
Prior art date
Application number
HR20020651A
Other languages
English (en)
Croatian (hr)
Inventor
Paradisi Gianfranco
Rossi Mara
Scaglia Laura
Original Assignee
Laboratoires Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono Sa filed Critical Laboratoires Serono Sa
Publication of HRP20020651A2 publication Critical patent/HRP20020651A2/hr
Publication of HRP20020651B1 publication Critical patent/HRP20020651B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Semiconductor Lasers (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
HR20020651A 2000-02-22 2002-08-01 Purified lh HRP20020651B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00103692 2000-02-22
PCT/EP2001/000666 WO2001062774A2 (en) 2000-02-22 2001-01-22 Purified lh

Publications (2)

Publication Number Publication Date
HRP20020651A2 HRP20020651A2 (en) 2004-12-31
HRP20020651B1 true HRP20020651B1 (en) 2011-01-31

Family

ID=8167926

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020651A HRP20020651B1 (en) 2000-02-22 2002-08-01 Purified lh

Country Status (31)

Country Link
US (2) US7053054B2 (xx)
EP (2) EP1261622B1 (xx)
JP (1) JP4959898B2 (xx)
KR (1) KR100808149B1 (xx)
CN (1) CN100480258C (xx)
AT (1) ATE356138T1 (xx)
AU (1) AU780377B2 (xx)
BG (1) BG65761B1 (xx)
BR (2) BRPI0108553B8 (xx)
CA (1) CA2399100C (xx)
CY (1) CY1108056T1 (xx)
CZ (1) CZ303274B6 (xx)
DE (1) DE60127100T2 (xx)
DK (1) DK1261622T3 (xx)
EA (1) EA004385B1 (xx)
EE (1) EE04932B1 (xx)
ES (1) ES2278722T3 (xx)
HK (1) HK1052014A1 (xx)
HR (1) HRP20020651B1 (xx)
HU (1) HU227007B1 (xx)
IL (2) IL151309A0 (xx)
MX (1) MXPA02007867A (xx)
NO (1) NO328693B1 (xx)
PL (1) PL207728B1 (xx)
PT (1) PT1261622E (xx)
RS (1) RS50416B (xx)
SI (1) SI1261622T1 (xx)
SK (1) SK287041B6 (xx)
UA (2) UA78676C2 (xx)
WO (1) WO2001062774A2 (xx)
ZA (1) ZA200206108B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK287041B6 (sk) * 2000-02-22 2009-10-07 Laboratoires Serono Sa Spôsob čistenia luteinizačného hormónu - LH zo vzorky, rekombinantný hLH, jeho použitie a farmaceutický prostriedok s jeho obsahom
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
EP1610803B8 (en) 2003-03-04 2011-09-14 AspenBio Pharma, Inc. LH for use in maintaining one or more pregnancies by inducing accessory corpus luteum formation.
CN1283792C (zh) * 2003-11-14 2006-11-08 余伟明 生物大分子组分相分离法
EA008924B1 (ru) * 2003-12-22 2007-08-31 Арес Трейдинг С.А. Способ очистки фсг
US20060148699A1 (en) * 2004-10-04 2006-07-06 Avi Tovi Counterion exchange process for peptides
MX2007005327A (es) * 2004-11-09 2007-08-02 Ares Trading Sa Metodo para purificacion de la hormona foliculo estimulante (hfe).
SI1917276T1 (en) * 2005-08-26 2018-05-31 Ares Trading S.A. PROCEDURE FOR PREPARATION OF GLYCOSYLATED INTERFERONE BETA
US8604175B2 (en) 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
CA2702448A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying fc-fusion proteins
EP2203465A1 (en) * 2007-10-22 2010-07-07 Merck Serono S.A. Method for purifying an fc-containing protein
CN101928342B (zh) * 2009-06-18 2013-05-08 上海天伟生物制药有限公司 一种高纯度绝经期促性腺素及其制备方法和用途
CN106999546A (zh) * 2014-05-01 2017-08-01 弗吉尼亚技术知识资产公司 角蛋白纳米材料及其制备方法
CN104569441B (zh) * 2015-01-19 2016-02-03 成都大熊猫繁育研究基地 大熊猫尿液促黄体素的酶联检测方法及其应用
US20220143131A1 (en) 2019-05-16 2022-05-12 Ceva Sante Animale Compositions and Methods for increasing Reproduction Performance in Non Human Mammals Using Recombinant Luteinizing Hormone

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002757A1 (en) * 1988-09-02 1990-03-22 Integrated Genetics, Inc. Heteropolymeric protein
WO1998020039A1 (en) * 1996-11-07 1998-05-14 Ibsa Institut Biochimique S.A. Fsh and lh separation and purification process
WO1998058957A2 (en) * 1997-06-25 1998-12-30 Applied Research Systems Ars Holding N.V. Disulfide cross-linked glycoprotein hormone analogs, their preparation and use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461200B1 (en) * 1989-02-21 1997-01-22 Washington University Modified forms of reproductive hormones
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
SK287041B6 (sk) * 2000-02-22 2009-10-07 Laboratoires Serono Sa Spôsob čistenia luteinizačného hormónu - LH zo vzorky, rekombinantný hLH, jeho použitie a farmaceutický prostriedok s jeho obsahom

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002757A1 (en) * 1988-09-02 1990-03-22 Integrated Genetics, Inc. Heteropolymeric protein
WO1998020039A1 (en) * 1996-11-07 1998-05-14 Ibsa Institut Biochimique S.A. Fsh and lh separation and purification process
WO1998058957A2 (en) * 1997-06-25 1998-12-30 Applied Research Systems Ars Holding N.V. Disulfide cross-linked glycoprotein hormone analogs, their preparation and use

Also Published As

Publication number Publication date
YU60302A (sh) 2005-09-19
RS50416B (sr) 2009-12-31
EA200200893A1 (ru) 2003-02-27
CA2399100C (en) 2011-11-08
JP4959898B2 (ja) 2012-06-27
KR100808149B1 (ko) 2008-02-29
HK1052014A1 (en) 2003-08-29
PL362891A1 (en) 2004-11-02
CN100480258C (zh) 2009-04-22
ZA200206108B (en) 2003-07-31
HRP20020651A2 (en) 2004-12-31
BG65761B1 (bg) 2009-10-30
PL207728B1 (pl) 2011-01-31
DK1261622T3 (da) 2007-05-29
DE60127100T2 (de) 2007-06-28
BRPI0108553B8 (pt) 2021-05-25
EP1261622A2 (en) 2002-12-04
CY1108056T1 (el) 2013-09-04
UA78676C2 (en) 2007-04-25
HU227007B1 (en) 2010-04-28
SK287041B6 (sk) 2009-10-07
US20030186893A1 (en) 2003-10-02
BR122012018280B1 (pt) 2018-01-09
US7053054B2 (en) 2006-05-30
WO2001062774A2 (en) 2001-08-30
WO2001062774A3 (en) 2002-03-14
KR20030001358A (ko) 2003-01-06
HUP0301814A2 (hu) 2003-08-28
CA2399100A1 (en) 2001-08-30
EP1261622B1 (en) 2007-03-07
AU3543601A (en) 2001-09-03
AU780377B2 (en) 2005-03-17
JP2003532636A (ja) 2003-11-05
BR0108553A (pt) 2003-12-23
IL151309A (en) 2010-11-30
DE60127100D1 (de) 2007-04-19
SK12052002A3 (sk) 2002-12-03
EA004385B1 (ru) 2004-04-29
ES2278722T3 (es) 2007-08-16
CZ20022856A3 (cs) 2003-01-15
ATE356138T1 (de) 2007-03-15
EP1777231A2 (en) 2007-04-25
NO328693B1 (no) 2010-04-26
HUP0301814A3 (en) 2004-10-28
BR122012018280B8 (pt) 2021-05-25
SI1261622T1 (sl) 2007-06-30
BG107001A (bg) 2003-04-30
EE200200464A (et) 2003-12-15
PT1261622E (pt) 2007-04-30
NO20023963L (no) 2002-08-20
UA92145C2 (xx) 2010-10-11
US20060079460A1 (en) 2006-04-13
CZ303274B6 (cs) 2012-07-11
EE04932B1 (et) 2007-12-17
BRPI0108553B1 (pt) 2016-06-14
NO20023963D0 (no) 2002-08-20
CN1404486A (zh) 2003-03-19
IL151309A0 (en) 2003-04-10
MXPA02007867A (es) 2003-02-10
EP1777231A3 (en) 2007-11-07

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: LABORATOIRES SERONO SA, CH

B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: MERCK SERONO SA, CH

ODRP Renewal fee for the maintenance of a patent

Payment date: 20181231

Year of fee payment: 19

ODRP Renewal fee for the maintenance of a patent

Payment date: 20191217

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20210122