NO328128B1 - Antigenisk formulering som omfatter et humant papillomaviruskapsomer for anvendelse som en vaksine, samt anvendelse derav for fremstilling av en farmasoytisk sammensetning for behandling og forebygging av HPV infeksjon og tilstander beslektet dermed. - Google Patents

Antigenisk formulering som omfatter et humant papillomaviruskapsomer for anvendelse som en vaksine, samt anvendelse derav for fremstilling av en farmasoytisk sammensetning for behandling og forebygging av HPV infeksjon og tilstander beslektet dermed. Download PDF

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Publication number
NO328128B1
NO328128B1 NO20001768A NO20001768A NO328128B1 NO 328128 B1 NO328128 B1 NO 328128B1 NO 20001768 A NO20001768 A NO 20001768A NO 20001768 A NO20001768 A NO 20001768A NO 328128 B1 NO328128 B1 NO 328128B1
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Prior art keywords
protein
amino acid
acid units
hpv
accordance
Prior art date
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NO20001768A
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English (en)
Norwegian (no)
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NO20001768D0 (no
NO20001768L (no
Inventor
Lutz Gissmann
Martin Mueller
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Univ Loyola Chicago
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Application filed by Univ Loyola Chicago filed Critical Univ Loyola Chicago
Publication of NO20001768D0 publication Critical patent/NO20001768D0/no
Publication of NO20001768L publication Critical patent/NO20001768L/no
Publication of NO328128B1 publication Critical patent/NO328128B1/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20023Virus like particles [VLP]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/788Of specified organic or carbon-based composition
    • Y10S977/802Virus-based particle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915Therapeutic or pharmaceutical composition
    • Y10S977/917Vaccine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20001768A 1997-10-06 2000-04-06 Antigenisk formulering som omfatter et humant papillomaviruskapsomer for anvendelse som en vaksine, samt anvendelse derav for fremstilling av en farmasoytisk sammensetning for behandling og forebygging av HPV infeksjon og tilstander beslektet dermed. NO328128B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/944,368 US6228368B1 (en) 1997-10-06 1997-10-06 Papilloma virus capsomere formulations and method of use
PCT/US1998/020965 WO1999018220A1 (en) 1997-10-06 1998-10-06 Papilloma virus capsomere vaccine formulations and methods of use

Publications (3)

Publication Number Publication Date
NO20001768D0 NO20001768D0 (no) 2000-04-06
NO20001768L NO20001768L (no) 2000-06-02
NO328128B1 true NO328128B1 (no) 2009-12-14

Family

ID=25481268

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20001768A NO328128B1 (no) 1997-10-06 2000-04-06 Antigenisk formulering som omfatter et humant papillomaviruskapsomer for anvendelse som en vaksine, samt anvendelse derav for fremstilling av en farmasoytisk sammensetning for behandling og forebygging av HPV infeksjon og tilstander beslektet dermed.
NO20091761A NO20091761L (no) 1997-10-06 2009-05-04 Viruskapsomervaksine, fremgangsmate for fremstilling samt anvendelse derav

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20091761A NO20091761L (no) 1997-10-06 2009-05-04 Viruskapsomervaksine, fremgangsmate for fremstilling samt anvendelse derav

Country Status (21)

Country Link
US (4) US6228368B1 (ko)
EP (2) EP1690941B1 (ko)
JP (3) JP4520034B2 (ko)
KR (1) KR20010030969A (ko)
AT (2) ATE449852T1 (ko)
AU (1) AU9684698A (ko)
BR (1) BR9814606A (ko)
CA (1) CA2305382A1 (ko)
CY (1) CY1105963T1 (ko)
CZ (1) CZ302351B6 (ko)
DE (2) DE69836753T2 (ko)
DK (1) DK1021547T3 (ko)
ES (2) ES2280104T3 (ko)
HU (1) HU225893B1 (ko)
IL (3) IL135528A0 (ko)
NO (2) NO328128B1 (ko)
NZ (1) NZ503830A (ko)
PL (1) PL195332B1 (ko)
PT (1) PT1021547E (ko)
TR (1) TR200001842T2 (ko)
WO (1) WO1999018220A1 (ko)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011272A2 (de) * 1994-10-07 1996-04-18 Medigene Gesellschaft Für Molekularbiologische Diagnostik, Theraphie Und Technologie Mbh Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung
AU7704498A (en) * 1997-05-29 1998-12-30 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Human frp and fragments thereof including methods for using them
US6228368B1 (en) * 1997-10-06 2001-05-08 Loyola University Of Chicago Papilloma virus capsomere formulations and method of use
CA2229955C (en) * 1998-02-20 2003-12-09 Medigene Gmbh Papilloma virus capsomere vaccine formulations and methods of use
US7182947B2 (en) * 1998-02-20 2007-02-27 Medigene Ag Papillomavirus truncated L1 protein and fusion protein constructs
US7494658B2 (en) * 1998-02-20 2009-02-24 Medigene Ag Papilloma virus truncated L1 protein and fusion protein constructs
US20020039584A1 (en) * 1998-02-20 2002-04-04 Medigene Ag Papilloma virus capsomere vaccine formulations and methods of use
GB9806666D0 (en) * 1998-03-27 1998-05-27 Stanley Margaret Antigen preparation and use
AUPP765398A0 (en) * 1998-12-11 1999-01-14 University Of Queensland, The Treatment of papillomavirus infections
DE19905883C2 (de) 1999-02-11 2001-05-23 Deutsches Krebsforsch Chimäre Virus-ähnliche Partikel bzw. chimäre Capsomere von BPV
FI107932B (fi) * 1999-02-16 2001-10-31 Mikael Paronen Polymeerikalvo ja menetelmä sen valmistamiseksi
WO2000054730A2 (en) * 1999-03-18 2000-09-21 The President & Fellows Of Harvard College Compositions preparations and uses of human papillomavirus l1 protein
DE19925199A1 (de) 1999-06-01 2000-12-07 Medigene Ag Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie
DE19925235A1 (de) 1999-06-01 2000-12-07 Medigene Ag Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie
DE19925234A1 (de) * 1999-06-01 2000-12-14 Medigene Ag Capsomere, stabile Capsomere, Capside, VLPs, oder CVLPs bzw. damit beladenen Zellen und ihre Verwendung in Diagnostik und Therapie
CA2381991A1 (en) * 1999-08-25 2001-03-01 Merck & Co., Inc. Synthetic human papillomavirus genes
CA2875298A1 (en) * 1999-12-09 2001-06-14 Medimmune, Inc. In vitro method for disassembly/reassembly of papillomavirus virus-like particles (vlps)
US6600018B1 (en) * 2000-04-10 2003-07-29 The United States Of America As Represented By The Department Of Health And Human Services Secreted frizzled related protein, sFRP, fragments and methods of use thereof
US6908613B2 (en) * 2000-06-21 2005-06-21 Medimmune, Inc. Chimeric human papillomavirus (HPV) L1 molecules and uses therefor
DE10055545A1 (de) * 2000-11-09 2002-07-25 Deutsches Krebsforsch Für Expression in Eukaryonten optimierte HPV 16-L1 und HPV 16-L2 kodierende DNA Sequenzen
DE10059630A1 (de) * 2000-12-01 2002-06-06 Medigene Ag Arzneimittel zur Vermeidung oder Behandlung von durch humanen Papillomavirus-Typ 18-hervorgerufenem Tumor
DE60236806D1 (de) 2001-08-13 2010-08-05 Univ Rochester Transkutane immunisierung gegen papillomavirus mit virusähnlichen papillomaviruspartikeln
US20050090435A1 (en) * 2001-08-31 2005-04-28 Rybicki Edward P. Pharmaceutical compositions, and a method of preparing and isolating said pharmaceutical compositions, and use of said pharmaceutical compositions for prophylactic treatment of lesions and carcinomas
AU2003213065A1 (en) * 2002-02-14 2003-09-04 Novavax, Inc. Novel insect cell line
ES2323634T5 (es) 2002-05-17 2012-09-04 University Of Cape Town Proteínas quiméricas l1 del virus del papiloma humano 16 que contienen un péptido l2, partículas tipo virus preparadas a partir de estas proteínas y un método para preparar las partículas
MXPA05000287A (es) 2002-07-05 2005-09-08 Leclerc Denis Particula viral adyuvante.
US8101189B2 (en) 2002-07-05 2012-01-24 Folia Biotech Inc. Vaccines and immunopotentiating compositions and methods for making and using them
SE0202897D0 (sv) * 2002-10-01 2002-10-01 Quantovir Ab Method and kit for quantitative and qualitative determination of human papillomavirus
SE0202896D0 (sv) * 2002-10-01 2002-10-01 Quantovir Ab Method for estimating the risk of carcinoma development
US7763259B2 (en) * 2003-01-10 2010-07-27 The Regents Of The University Of Colorado Therapeutic and prophylactic vaccine for the treatment and prevention of papillomavirus infection
US7172773B2 (en) * 2004-04-26 2007-02-06 Renew Life Inc. Food supplement formulation
KR101187625B1 (ko) * 2004-09-10 2012-10-05 도쿠리츠다이가쿠호징 가나자와다이가쿠 경구 투여 백신
ATE476528T1 (de) 2004-12-08 2010-08-15 Gen Probe Inc Nukleinsäuredetektion aus verschiedenen typen des humanen papillomavirus
US7314630B2 (en) * 2005-01-07 2008-01-01 Yao-Xiong Hu Compounds and methods of early diagnosis of cervical cancer and genital condyloma with HPV, CHSP60 tumor suppressor H-Ras, K-Ras and PTEN derived peptides modified
US9364529B2 (en) 2007-04-29 2016-06-14 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated L1 protein of human papillomavirus type 18
US9428555B2 (en) * 2007-04-29 2016-08-30 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated L1 protein of Human Papillomavirus type 16
EP2154149B1 (en) * 2007-05-29 2019-07-10 Xiamen University A truncated l1 protein of human papillomavirus 6
US8507811B2 (en) * 2009-02-02 2013-08-13 Apple Inc. Touch sensor panels with reduced static capacitance
EP2377879A1 (en) * 2010-04-14 2011-10-19 Deutsches Krebsforschungszentrum N-terminal HPV E7 fusion proteins
WO2015196112A1 (en) 2014-06-19 2015-12-23 The Regents Of The University Of Colorado, A Body Corporate Human papilloma virus constructs
WO2016026919A1 (en) * 2014-08-20 2016-02-25 Ruprecht-Karls-Universität Heidelberg Vaccines and manufacturing methods for treatment and prevention of disease
CN114127099B (zh) * 2019-07-19 2024-04-19 神州细胞工程有限公司 嵌合的人乳头瘤病毒6型l1蛋白
US11382700B2 (en) 2020-05-08 2022-07-12 Globus Medical Inc. Extended reality headset tool tracking and control
US11510750B2 (en) 2020-05-08 2022-11-29 Globus Medical, Inc. Leveraging two-dimensional digital imaging and communication in medicine imagery in three-dimensional extended reality applications

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG48769A1 (en) 1991-07-19 1998-05-18 Univ Queensland Papilloma virus vaccine
GB9207701D0 (en) 1992-04-08 1992-05-27 Cancer Res Campaign Tech Papillomavirus e7 protein
DE122007000099I1 (de) 1992-06-25 2008-03-27 Papillomavirus vakzine
US5618536A (en) 1992-09-03 1997-04-08 The United States Of America As Represented By The Department Of Health And Human Services Chimeric papillomavirus-like particles
US5437951A (en) * 1992-09-03 1995-08-01 The United States Of America As Represented By The Department Of Health And Human Services Self-assembling recombinant papillomavirus capsid proteins
ES2263406T3 (es) * 1993-03-09 2011-06-06 The University Of Rochester Producción de la proteína de capside l1 del papilomavirus humano hpv-11 y partículas de tipo virus.
AUPM566794A0 (en) * 1994-05-17 1994-06-09 University Of Queensland, The Process and product
DE4447664C2 (de) 1994-10-07 1999-04-15 Lutz Prof Dr Gissmann Fusionsproteine, Verfahren zu deren Herstellung sowie deren Anwendung
WO1996011272A2 (de) * 1994-10-07 1996-04-18 Medigene Gesellschaft Für Molekularbiologische Diagnostik, Theraphie Und Technologie Mbh Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung
JP3413020B2 (ja) * 1996-07-17 2003-06-03 株式会社東芝 半導体装置の製造方法
DE19712541C1 (de) 1997-03-25 1998-11-05 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
WO1999001557A1 (en) * 1997-07-03 1999-01-14 University Of Colorado, University Technology Corporation Homogeneous human papilloma virus capsomere containing compositions, methods for manufacture, and the use thereof as diagnostic, prophylactic or therapy
JP3559048B2 (ja) 1997-08-26 2004-08-25 日本精工株式会社 転がり軸受の製造方法
US6228368B1 (en) * 1997-10-06 2001-05-08 Loyola University Of Chicago Papilloma virus capsomere formulations and method of use

Also Published As

Publication number Publication date
JP2001519161A (ja) 2001-10-23
EP1690941A1 (en) 2006-08-16
KR20010030969A (ko) 2001-04-16
TR200001842T2 (tr) 2000-12-21
US7371391B2 (en) 2008-05-13
PL195332B1 (pl) 2007-09-28
WO1999018220A1 (en) 1999-04-15
AU9684698A (en) 1999-04-27
EP1690941B1 (en) 2009-11-25
JP2010095530A (ja) 2010-04-30
EP1021547B1 (en) 2006-12-27
IL190554A0 (en) 2008-11-03
ES2337492T3 (es) 2010-04-26
JP4520034B2 (ja) 2010-08-04
US20060198853A1 (en) 2006-09-07
US7754430B2 (en) 2010-07-13
NO20091761L (no) 2000-06-02
JP5296665B2 (ja) 2013-09-25
EP1021547A1 (en) 2000-07-26
US20050031636A1 (en) 2005-02-10
DE69836753T2 (de) 2007-10-25
IL135528A (en) 2008-06-05
CZ20001244A3 (en) 2001-05-16
CY1105963T1 (el) 2011-04-06
NO20001768D0 (no) 2000-04-06
JP2013147507A (ja) 2013-08-01
US6228368B1 (en) 2001-05-08
IL135528A0 (en) 2001-05-20
CZ302351B6 (cs) 2011-03-30
US20090028894A1 (en) 2009-01-29
DK1021547T3 (da) 2007-04-23
DE69836753D1 (de) 2007-02-08
PT1021547E (pt) 2007-02-28
NO20001768L (no) 2000-06-02
HU225893B1 (en) 2007-12-28
HUP0004360A2 (en) 2001-03-28
ES2280104T3 (es) 2007-09-01
PL339735A1 (en) 2001-01-02
CA2305382A1 (en) 1999-04-15
ATE349536T1 (de) 2007-01-15
HUP0004360A3 (en) 2003-03-28
ATE449852T1 (de) 2009-12-15
NZ503830A (en) 2002-09-27
DE69841342D1 (de) 2010-01-07
BR9814606A (pt) 2002-01-02

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