NO327996B1 - Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor - Google Patents
Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor Download PDFInfo
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- NO327996B1 NO327996B1 NO20021598A NO20021598A NO327996B1 NO 327996 B1 NO327996 B1 NO 327996B1 NO 20021598 A NO20021598 A NO 20021598A NO 20021598 A NO20021598 A NO 20021598A NO 327996 B1 NO327996 B1 NO 327996B1
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- 230000002195 synergetic effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 229960000838 tipranavir Drugs 0.000 description 1
- NZPXPXAGXYTROM-FYBSXPHGSA-N tipranavir Chemical compound C([C@@]1(CCC)OC(O)=C([C@H](CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)C(=O)C1)CC1=CC=CC=C1 NZPXPXAGXYTROM-FYBSXPHGSA-N 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15785099P | 1999-10-06 | 1999-10-06 | |
PCT/EP2000/009917 WO2001025240A1 (fr) | 1999-10-06 | 2000-10-06 | HEXAHYDROFURO'2,3-B! FURAN-3-YL-N- {3'(1,3-BENZODIOXOL-5-YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL}CARBAMATE EN TANT QU'INHIBITEUR DE PROTEASE RETROVIRALE |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20021598D0 NO20021598D0 (no) | 2002-04-04 |
NO20021598L NO20021598L (no) | 2002-05-29 |
NO327996B1 true NO327996B1 (no) | 2009-11-02 |
Family
ID=22565540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20021598A NO327996B1 (no) | 1999-10-06 | 2002-04-04 | Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor |
Country Status (26)
Country | Link |
---|---|
US (2) | US6649651B1 (fr) |
EP (1) | EP1222192B8 (fr) |
JP (1) | JP4951179B2 (fr) |
KR (1) | KR100792391B1 (fr) |
CN (1) | CN1191256C (fr) |
AP (1) | AP1459A (fr) |
AT (1) | ATE398623T1 (fr) |
AU (1) | AU781656B2 (fr) |
BR (1) | BR0014602A (fr) |
CA (1) | CA2386850C (fr) |
CZ (1) | CZ300031B6 (fr) |
DE (1) | DE60039244D1 (fr) |
DK (1) | DK1222192T3 (fr) |
ES (1) | ES2307533T3 (fr) |
HK (1) | HK1054746A1 (fr) |
HU (1) | HU228938B1 (fr) |
IL (2) | IL149005A0 (fr) |
MX (1) | MXPA02003607A (fr) |
NO (1) | NO327996B1 (fr) |
NZ (1) | NZ518580A (fr) |
OA (1) | OA12053A (fr) |
PL (1) | PL204924B1 (fr) |
RU (1) | RU2247123C2 (fr) |
SK (1) | SK287153B6 (fr) |
WO (1) | WO2001025240A1 (fr) |
ZA (1) | ZA200202655B (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1222192T3 (da) * | 1999-10-06 | 2008-10-20 | Tibotec Pharm Ltd | Hexahydrofuro-2,3-b furan-3-yl-N-3-(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino-1-benzyl-2-hydroxypropyl-carbamat som retroviral proteaseinhibitor |
AR035819A1 (es) | 2001-04-09 | 2004-07-14 | Tibotec Pharm Ltd | 2-(amino sustituido)-benzoxazol sulfonamidas, inhibidoras de la proteasa del hiv, composiciones farmaceuticas que comprenden dichos compuestos, metodo in vitro para inhibir la replicacion retroviral y uso de dichos compuestos en la fabricacion de medicamentos |
PL224030B1 (pl) | 2001-09-10 | 2016-11-30 | Tibotec Pharm Ltd | Sposób syntezy heksahydrofuro [2,3-b] furan -3-olu oraz związki pośrednie stosowane w tym sposobie |
EP1483254A4 (fr) * | 2002-01-07 | 2005-06-08 | Sequoia Pharmaceuticals | Inhibiteurs de protease retrovirale anti-resistance |
US7285566B2 (en) * | 2002-01-07 | 2007-10-23 | Erickson John W | Resistance-repellent retroviral protease inhibitors |
US7157489B2 (en) * | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
SI1517899T1 (sl) | 2002-05-17 | 2008-02-29 | Tibotec Pharm Ltd | Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji |
OA12893A (en) * | 2002-08-02 | 2006-10-13 | Tibotec Pharm Ltd | Broadspectrum 2-Amino-Benzothiazole Sulfonamide HIV Protease Inhibitors. |
WO2004060895A1 (fr) | 2002-12-27 | 2004-07-22 | Sumitomo Chemical Company, Limited | Procede de production d'un derive de d'hexahydrofuranol, intermediaire de celui-ci et procede de production correspondant |
WO2005087728A1 (fr) * | 2004-03-11 | 2005-09-22 | Sequoia Pharmaceuticals, Inc. | Inhibiteurs de la protease retrovirale inhibant la resistance |
TWI383975B (zh) | 2004-03-31 | 2013-02-01 | Tibotec Pharm Ltd | 製備(3R,3aS,6aR)六氫-呋喃并〔2,3-b〕呋喃-3-醇之方法 |
KR100698291B1 (ko) * | 2004-12-29 | 2007-03-22 | 엘지전자 주식회사 | 조명계 |
KR101333627B1 (ko) | 2005-02-25 | 2013-11-27 | 얀센 알 앤드 디 아일랜드 | 프로테아제 저해제 전구체 합성 |
EP2049506B2 (fr) | 2006-07-07 | 2024-05-08 | Gilead Sciences, Inc. | Modulateurs de propriétés pharmacocinétiques d'agents thérapeutiques |
US20090312318A1 (en) * | 2006-07-24 | 2009-12-17 | Desai Manoj C | Therapeutic compounds and methods |
ES2359949T3 (es) | 2006-11-09 | 2011-05-30 | Tibotec Pharmaceuticals | Métodos para preparar hexhidrofuro(2,3-b)furan-3-ol. |
WO2008133734A2 (fr) * | 2006-11-21 | 2008-11-06 | Purdue Research Foundation | Procédé et compositions utilisés pour traiter les infections à vih |
PT2487163T (pt) | 2007-02-23 | 2016-11-21 | Gilead Sciences Inc | Moduladores de propriedades farmacocinéticas de agentes terapêuticos |
EP2134336B1 (fr) * | 2007-03-16 | 2013-12-11 | Sequoia Pharmaceuticals | Inhibiteurs de la protéase du vih dérivés de benzofuranne |
AR067412A1 (es) | 2007-07-06 | 2009-10-07 | Gilead Sciences Inc | Moduladores de propiedades farmaceuticas de productos terapeuticos |
PT2231628E (pt) | 2008-01-04 | 2015-12-29 | Gilead Sciences Inc | Inibidores de citocromo p450 |
US20110046199A1 (en) | 2008-01-17 | 2011-02-24 | Purdue Research Foundation | Small molecule inhibitors of hiv proteases |
EP2307345A4 (fr) * | 2008-07-01 | 2012-05-02 | Purdue Research Foundation | Inhibiteurs de protéase de vih-1 non peptidiques |
WO2010006050A1 (fr) * | 2008-07-09 | 2010-01-14 | Purdue Research Foundation | Inhibiteurs de la protéase du vih et procédés d'utilisation |
SG181759A1 (en) | 2009-12-21 | 2012-07-30 | Janssen R & D Ireland | Degradable removable implant for the sustained release of an active compound |
US8841467B2 (en) | 2010-11-23 | 2014-09-23 | Mylan Laboratories Limited | Process for the preparation of (3R, 3aS, 6aR)-hexahydrofuro [2, 3-b] furan-3-ol |
ES2657227T3 (es) * | 2012-08-09 | 2018-03-02 | Sumitomo Chemical Company, Limited | Método para producir un derivado de hexahidrofurofuranol |
CN103664976B (zh) * | 2013-12-12 | 2015-11-04 | 惠州市莱佛士制药技术有限公司 | 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100336699B1 (ko) * | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
US5723490A (en) | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
EP0715618B1 (fr) * | 1993-08-24 | 1998-12-16 | G.D. Searle & Co. | Hydroxyethylamino-sulfonamides aptes a etre utilises comme inhibiteurs de protease retrovirale |
UA49803C2 (uk) * | 1994-06-03 | 2002-10-15 | Дж.Д. Сьорль Енд Ко | Спосіб лікування ретровірусних інфекцій |
US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
AU4828199A (en) * | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
PT2336134T (pt) * | 1998-06-23 | 2016-10-19 | The Board Of Trustees Of The Univ Of Illionis | Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia |
GB9815567D0 (en) * | 1998-07-18 | 1998-09-16 | Glaxo Group Ltd | Antiviral compound |
DK1222192T3 (da) * | 1999-10-06 | 2008-10-20 | Tibotec Pharm Ltd | Hexahydrofuro-2,3-b furan-3-yl-N-3-(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino-1-benzyl-2-hydroxypropyl-carbamat som retroviral proteaseinhibitor |
-
2000
- 2000-10-06 DK DK00966144T patent/DK1222192T3/da active
- 2000-10-06 RU RU2002111657/04A patent/RU2247123C2/ru active
- 2000-10-06 BR BR0014602-1A patent/BR0014602A/pt not_active Application Discontinuation
- 2000-10-06 US US10/089,991 patent/US6649651B1/en not_active Expired - Lifetime
- 2000-10-06 WO PCT/EP2000/009917 patent/WO2001025240A1/fr active IP Right Grant
- 2000-10-06 KR KR1020027004284A patent/KR100792391B1/ko active IP Right Grant
- 2000-10-06 AP APAP/P/2002/002472A patent/AP1459A/en active
- 2000-10-06 PL PL354351A patent/PL204924B1/pl unknown
- 2000-10-06 HU HU0203130A patent/HU228938B1/hu unknown
- 2000-10-06 IL IL14900500A patent/IL149005A0/xx active IP Right Grant
- 2000-10-06 ES ES00966144T patent/ES2307533T3/es not_active Expired - Lifetime
- 2000-10-06 SK SK570-2002A patent/SK287153B6/sk not_active IP Right Cessation
- 2000-10-06 CN CNB008165874A patent/CN1191256C/zh not_active Expired - Lifetime
- 2000-10-06 OA OA1200200096A patent/OA12053A/en unknown
- 2000-10-06 JP JP2001528184A patent/JP4951179B2/ja not_active Expired - Lifetime
- 2000-10-06 CA CA2386850A patent/CA2386850C/fr not_active Expired - Lifetime
- 2000-10-06 CZ CZ20021419A patent/CZ300031B6/cs not_active IP Right Cessation
- 2000-10-06 AU AU76638/00A patent/AU781656B2/en not_active Expired
- 2000-10-06 AT AT00966144T patent/ATE398623T1/de not_active IP Right Cessation
- 2000-10-06 DE DE60039244T patent/DE60039244D1/de not_active Expired - Lifetime
- 2000-10-06 EP EP00966144A patent/EP1222192B8/fr not_active Expired - Lifetime
- 2000-10-06 NZ NZ518580A patent/NZ518580A/en not_active IP Right Cessation
- 2000-10-06 MX MXPA02003607A patent/MXPA02003607A/es active IP Right Grant
-
2002
- 2002-04-04 NO NO20021598A patent/NO327996B1/no not_active IP Right Cessation
- 2002-04-04 IL IL149005A patent/IL149005A/en unknown
- 2002-04-04 ZA ZA200202655A patent/ZA200202655B/xx unknown
-
2003
- 2003-06-25 US US10/606,342 patent/US7157495B2/en not_active Expired - Lifetime
- 2003-09-29 HK HK03107022A patent/HK1054746A1/xx not_active IP Right Cessation
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Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERI, IE |
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MK1K | Patent expired |