NO20021598L - Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5- ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamatsom retrovital proteaseinhibitor - Google Patents

Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5- ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamatsom retrovital proteaseinhibitor

Info

Publication number
NO20021598L
NO20021598L NO20021598A NO20021598A NO20021598L NO 20021598 L NO20021598 L NO 20021598L NO 20021598 A NO20021598 A NO 20021598A NO 20021598 A NO20021598 A NO 20021598A NO 20021598 L NO20021598 L NO 20021598L
Authority
NO
Norway
Prior art keywords
retrovital
bifuran
hexahydrofuro
ylsulfonyl
benzodioxol
Prior art date
Application number
NO20021598A
Other languages
English (en)
Other versions
NO327996B1 (no
NO20021598D0 (no
Inventor
Piet Tom Bert Paul Wigerinck
Guangyang Wang
Michael Eissenstat
John W Erickson
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Publication of NO20021598D0 publication Critical patent/NO20021598D0/no
Publication of NO20021598L publication Critical patent/NO20021598L/no
Publication of NO327996B1 publication Critical patent/NO327996B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO20021598A 1999-10-06 2002-04-04 Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor NO327996B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15785099P 1999-10-06 1999-10-06
PCT/EP2000/009917 WO2001025240A1 (en) 1999-10-06 2000-10-06 HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR

Publications (3)

Publication Number Publication Date
NO20021598D0 NO20021598D0 (no) 2002-04-04
NO20021598L true NO20021598L (no) 2002-05-29
NO327996B1 NO327996B1 (no) 2009-11-02

Family

ID=22565540

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021598A NO327996B1 (no) 1999-10-06 2002-04-04 Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor

Country Status (26)

Country Link
US (2) US6649651B1 (no)
EP (1) EP1222192B8 (no)
JP (1) JP4951179B2 (no)
KR (1) KR100792391B1 (no)
CN (1) CN1191256C (no)
AP (1) AP1459A (no)
AT (1) ATE398623T1 (no)
AU (1) AU781656B2 (no)
BR (1) BR0014602A (no)
CA (1) CA2386850C (no)
CZ (1) CZ300031B6 (no)
DE (1) DE60039244D1 (no)
DK (1) DK1222192T3 (no)
ES (1) ES2307533T3 (no)
HK (1) HK1054746A1 (no)
HU (1) HU228938B1 (no)
IL (2) IL149005A0 (no)
MX (1) MXPA02003607A (no)
NO (1) NO327996B1 (no)
NZ (1) NZ518580A (no)
OA (1) OA12053A (no)
PL (1) PL204924B1 (no)
RU (1) RU2247123C2 (no)
SK (1) SK287153B6 (no)
WO (1) WO2001025240A1 (no)
ZA (1) ZA200202655B (no)

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RU2247123C2 (ru) * 1999-10-06 2005-02-27 Тиботек Фармасьютикалз Лтд. Гексагидрофуро [2,3-b] фуран-3-ил-n-{3-[(1,3-бензодиоксол-5- илсульфонил)(изобутил)амино]-1-бензил -2-гидроксипропил}карбамат, фармацевтическая композиция на их основе, способы ингибирования и способ лечения
PL367084A1 (en) 2001-04-09 2005-02-21 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
NZ531641A (en) * 2001-09-10 2005-08-26 Tibotec Pharm Ltd Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol
US7285566B2 (en) * 2002-01-07 2007-10-23 Erickson John W Resistance-repellent retroviral protease inhibitors
EP1472536A4 (en) * 2002-01-07 2007-02-14 Sequoia Pharmaceuticals VERSATILE INHIBITORS
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
DE60315984T2 (de) 2002-05-17 2008-05-29 Tibotec Pharmaceuticals Ltd. Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung
OA12893A (en) * 2002-08-02 2006-10-13 Tibotec Pharm Ltd Broadspectrum 2-Amino-Benzothiazole Sulfonamide HIV Protease Inhibitors.
AU2003275675A1 (en) 2002-12-27 2004-07-29 Sumitomo Chemical Company, Limited Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same
CN1953964A (zh) * 2004-03-11 2007-04-25 塞阔伊亚药品公司 抗耐药性反转录病毒蛋白酶抑制剂
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
KR100698291B1 (ko) * 2004-12-29 2007-03-22 엘지전자 주식회사 조명계
DK1856125T3 (da) 2005-02-25 2009-12-07 Tibotec Pharm Ltd Syntese af proteasehæmmerforstadie
NZ573060A (en) 2006-07-07 2012-02-24 Gilead Sciences Inc Modulators of pharmacokinetic properties of therapeutics
US20090312318A1 (en) * 2006-07-24 2009-12-17 Desai Manoj C Therapeutic compounds and methods
DE602007012365D1 (de) 2006-11-09 2011-03-17 Little Island Co Cork Verfahren zur herstellung von hexahydrofuroä2,3-büfuran-3-ol
EP2120562A4 (en) * 2006-11-21 2010-01-13 Purdue Research Foundation METHOD AND COMPOSITIONS FOR TREATING HIV INFECTIONS
HUE029842T2 (en) 2007-02-23 2017-04-28 Gilead Sciences Inc Modulation of pharmacokinetic parameters of therapeutic agents
WO2008115894A1 (en) 2007-03-16 2008-09-25 Sequoia Pharmaceuticals Benzofuran-derived hiv protease inhibitors
WO2009008989A1 (en) 2007-07-06 2009-01-15 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
WO2009088719A1 (en) 2008-01-04 2009-07-16 Gilead Sciences, Inc. Inhibitors of cytochrome p450
WO2009091941A1 (en) 2008-01-17 2009-07-23 Purdue Research Foundation Small molecule inhibitors of hiv proteases
EP2307345A4 (en) 2008-07-01 2012-05-02 Purdue Research Foundation NON-PEPTIDINHIBITORS OF HIV-1 PROTEASE
US8501961B2 (en) 2008-07-09 2013-08-06 Purdue Research Foundation HIV protease inhibitors and methods for using
EP2515877B1 (en) 2009-12-21 2016-08-10 Janssen Sciences Ireland UC Degradable removable implant for the sustained release of an active compound
DK2643326T3 (en) 2010-11-23 2017-01-09 Mylan Laboratories Ltd A process for the preparation of (3R, 3aS, 6aR) -hexahydrofuro [2,3-b] furan-3-ol
WO2014024898A1 (ja) 2012-08-09 2014-02-13 住友化学株式会社 ヘキサヒドロフロフラノール誘導体の製造方法
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法

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WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
PT810209E (pt) * 1992-08-25 2002-09-30 Searle & Co Hidroxietilamino-sulfonamidas de alfa- e beta-aminoacidos uteis como inibidores de protease retroviral
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
JP4776775B2 (ja) 1998-06-23 2011-09-21 アメリカ合衆国 Ｈｉｖ感染哺乳動物を治療するための医薬組成物
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
GB9815567D0 (en) * 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
RU2247123C2 (ru) * 1999-10-06 2005-02-27 Тиботек Фармасьютикалз Лтд. Гексагидрофуро [2,3-b] фуран-3-ил-n-{3-[(1,3-бензодиоксол-5- илсульфонил)(изобутил)амино]-1-бензил -2-гидроксипропил}карбамат, фармацевтическая композиция на их основе, способы ингибирования и способ лечения

Also Published As

Publication number Publication date
HUP0203130A3 (en) 2005-01-28
JP2003511383A (ja) 2003-03-25
ATE398623T1 (de) 2008-07-15
EP1222192B1 (en) 2008-06-18
US6649651B1 (en) 2003-11-18
AU7663800A (en) 2001-05-10
ES2307533T3 (es) 2008-12-01
AP1459A (en) 2005-08-22
NZ518580A (en) 2004-01-30
EP1222192A1 (en) 2002-07-17
NO327996B1 (no) 2009-11-02
HUP0203130A2 (hu) 2003-01-28
CN1407987A (zh) 2003-04-02
PL204924B1 (pl) 2010-02-26
EP1222192B8 (en) 2008-10-01
SK5702002A3 (en) 2003-01-09
HU228938B1 (hu) 2013-06-28
ZA200202655B (en) 2003-09-23
NO20021598D0 (no) 2002-04-04
US7157495B2 (en) 2007-01-02
CZ20021419A3 (cs) 2002-10-16
MXPA02003607A (es) 2003-07-28
IL149005A0 (en) 2002-11-10
CA2386850A1 (en) 2001-04-12
HK1054746A1 (en) 2003-12-12
KR100792391B1 (ko) 2008-01-08
IL149005A (en) 2006-12-31
OA12053A (en) 2006-05-02
PL354351A1 (en) 2004-01-12
DK1222192T3 (da) 2008-10-20
CA2386850C (en) 2010-03-30
AU781656B2 (en) 2005-06-02
CZ300031B6 (cs) 2009-01-14
CN1191256C (zh) 2005-03-02
DE60039244D1 (de) 2008-07-31
SK287153B6 (sk) 2010-01-07
WO2001025240A1 (en) 2001-04-12
RU2247123C2 (ru) 2005-02-27
US20050261364A1 (en) 2005-11-24
JP4951179B2 (ja) 2012-06-13
AP2002002472A0 (en) 2002-06-30
KR20020067503A (ko) 2002-08-22
BR0014602A (pt) 2002-06-11

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Legal Events

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CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERI, IE

MK1K Patent expired