NO20021598L - Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5- ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamatsom retrovital proteaseinhibitor - Google Patents

Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5- ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamatsom retrovital proteaseinhibitor

Info

Publication number
NO20021598L
NO20021598L NO20021598A NO20021598A NO20021598L NO 20021598 L NO20021598 L NO 20021598L NO 20021598 A NO20021598 A NO 20021598A NO 20021598 A NO20021598 A NO 20021598A NO 20021598 L NO20021598 L NO 20021598L
Authority
NO
Norway
Prior art keywords
retrovital
bifuran
hexahydrofuro
ylsulfonyl
benzodioxol
Prior art date
Application number
NO20021598A
Other languages
English (en)
Other versions
NO327996B1 (no
NO20021598D0 (no
Inventor
Piet Tom Bert Paul Wigerinck
Guangyang Wang
Michael Eissenstat
John W Erickson
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Publication of NO20021598D0 publication Critical patent/NO20021598D0/no
Publication of NO20021598L publication Critical patent/NO20021598L/no
Publication of NO327996B1 publication Critical patent/NO327996B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO20021598A 1999-10-06 2002-04-04 Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor NO327996B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15785099P 1999-10-06 1999-10-06
PCT/EP2000/009917 WO2001025240A1 (en) 1999-10-06 2000-10-06 HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR

Publications (3)

Publication Number Publication Date
NO20021598D0 NO20021598D0 (no) 2002-04-04
NO20021598L true NO20021598L (no) 2002-05-29
NO327996B1 NO327996B1 (no) 2009-11-02

Family

ID=22565540

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021598A NO327996B1 (no) 1999-10-06 2002-04-04 Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor

Country Status (25)

Country Link
US (2) US6649651B1 (no)
EP (1) EP1222192B8 (no)
JP (1) JP4951179B2 (no)
KR (1) KR100792391B1 (no)
CN (1) CN1191256C (no)
AP (1) AP1459A (no)
AT (1) ATE398623T1 (no)
AU (1) AU781656B2 (no)
BR (1) BR0014602A (no)
CA (1) CA2386850C (no)
CZ (1) CZ300031B6 (no)
DE (1) DE60039244D1 (no)
DK (1) DK1222192T3 (no)
ES (1) ES2307533T3 (no)
HU (1) HU228938B1 (no)
IL (2) IL149005A0 (no)
MX (1) MXPA02003607A (no)
NO (1) NO327996B1 (no)
NZ (1) NZ518580A (no)
OA (1) OA12053A (no)
PL (1) PL204924B1 (no)
RU (1) RU2247123C2 (no)
SK (1) SK287153B6 (no)
WO (1) WO2001025240A1 (no)
ZA (1) ZA200202655B (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA12053A (en) * 1999-10-06 2006-05-02 Tibotec Pharm Ltd HexahydrofuroÄ2,3-bÜfuran-3-yl-N-ä3-Ä(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)aminoÜ-1-benzyl-2-hydroxypropylücarbamate as retroviral protease inhibitor.
SK288232B6 (sk) 2001-04-09 2014-11-04 Tibotec Pharmaceuticals Ltd. 2-(substituovaný amino)benzoxazolsulfónamidový derivát, jeho aplikácie ako liečiva, farmaceutická kompozícia s jeho obsahom a spôsob in vitro inhibície retrovírusovej replikácie
JP4521185B2 (ja) * 2001-09-10 2010-08-11 テイボテク・フアーマシユーチカルズ・リミテツド ヘキサヒドロ−フロ［２，３−ｂ］フラン−３−オールの製造法
CA2472580A1 (en) * 2002-01-07 2003-07-17 Sequoia Pharmaceuticals Broad spectrum inhibitors
US7285566B2 (en) * 2002-01-07 2007-10-23 Erickson John W Resistance-repellent retroviral protease inhibitors
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
EP1517899B1 (en) 2002-05-17 2007-08-29 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
OA12893A (en) * 2002-08-02 2006-10-13 Tibotec Pharm Ltd Broadspectrum 2-Amino-Benzothiazole Sulfonamide HIV Protease Inhibitors.
AU2003275675A1 (en) 2002-12-27 2004-07-29 Sumitomo Chemical Company, Limited Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same
CN1953964A (zh) * 2004-03-11 2007-04-25 塞阔伊亚药品公司 抗耐药性反转录病毒蛋白酶抑制剂
TWI383975B (zh) 2004-03-31 2013-02-01 悌柏泰克醫藥有限公司 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
KR100698291B1 (ko) * 2004-12-29 2007-03-22 엘지전자 주식회사 조명계
ATE440848T1 (de) 2005-02-25 2009-09-15 Tibotec Pharm Ltd Synthese von proteaseinhibitorvorstufen
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
PT2049506E (pt) 2006-07-07 2015-10-09 Gilead Sciences Inc Moduladores de propriedades farmacocinéticas de agentes terapêuticos
AU2007277253A1 (en) * 2006-07-24 2008-01-31 Gilead Sciences, Inc. Bisfuranyl protease inhibitors
WO2008055970A2 (en) 2006-11-09 2008-05-15 Tibotec Pharmaceuticals Ltd. Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol
EP2491785A1 (en) * 2006-11-21 2012-08-29 Purdue Research Foundation Method and compositions for treating HIV infections
BRPI0807581A2 (pt) 2007-02-23 2014-07-01 Gilead Science, Inc. Moduladores de propriedades farmacocinéticas de produtos terapêuticos
EP2134336B1 (en) 2007-03-16 2013-12-11 Sequoia Pharmaceuticals Benzofuran-derived hiv protease inhibitors
TWI448457B (zh) 2007-07-06 2014-08-11 Gilead Sciences Inc 治療劑的藥物動力學性質之調節劑
ES2555209T3 (es) 2008-01-04 2015-12-29 Gilead Sciences, Inc. Inhibidores del citocromo P450
EP2244571A4 (en) * 2008-01-17 2014-02-19 Purdue Research Foundation SMALL MOLECULAR INHIBITORS OF HIV PROTEASES
EP2307345A4 (en) 2008-07-01 2012-05-02 Purdue Research Foundation NON-PEPTIDINHIBITORS OF HIV-1 PROTEASE
EP2304043A4 (en) * 2008-07-09 2012-05-30 Purdue Research Foundation HIV PROTEASE INHIBITORS AND METHOD FOR THEIR USE
RU2593790C2 (ru) 2009-12-21 2016-08-10 Янссен Сайенсиз Айрлэнд Юси Разлагаемый удаляемый имплантат для непрерывного высвобождения активного соединения
WO2012070057A1 (en) 2010-11-23 2012-05-31 Matrix Laboratories Ltd Process for the preparation of (3r, 3as, 6ar)-hexahydrofuro [2, 3- b] furan-3-ol
ES2657227T3 (es) 2012-08-09 2018-03-02 Sumitomo Chemical Company, Limited Método para producir un derivado de hexahidrofurofuranol
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656886B1 (en) * 1992-08-25 1997-06-25 G.D. Searle & Co. N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors
DK0810209T3 (da) * 1992-08-25 2002-08-12 Monsanto Co Alpha - and beta-aminosyre-hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
AU7669794A (en) * 1993-08-24 1995-03-21 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
ES2604662T3 (es) 1998-06-23 2017-03-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Ensayo de acondicionamiento físico y métodos para reducir la resistencia del VIH a la terapia
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
GB9815567D0 (en) * 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
OA12053A (en) * 1999-10-06 2006-05-02 Tibotec Pharm Ltd HexahydrofuroÄ2,3-bÜfuran-3-yl-N-ä3-Ä(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)aminoÜ-1-benzyl-2-hydroxypropylücarbamate as retroviral protease inhibitor.

Also Published As

Publication number Publication date
CA2386850C (en) 2010-03-30
HUP0203130A3 (en) 2005-01-28
IL149005A0 (en) 2002-11-10
WO2001025240A1 (en) 2001-04-12
JP2003511383A (ja) 2003-03-25
CZ300031B6 (cs) 2009-01-14
JP4951179B2 (ja) 2012-06-13
SK287153B6 (sk) 2010-01-07
PL204924B1 (pl) 2010-02-26
KR20020067503A (ko) 2002-08-22
CN1191256C (zh) 2005-03-02
NZ518580A (en) 2004-01-30
AU781656B2 (en) 2005-06-02
PL354351A1 (en) 2004-01-12
ZA200202655B (en) 2003-09-23
AP1459A (en) 2005-08-22
SK5702002A3 (en) 2003-01-09
HU228938B1 (hu) 2013-06-28
AP2002002472A0 (en) 2002-06-30
IL149005A (en) 2006-12-31
NO327996B1 (no) 2009-11-02
EP1222192B8 (en) 2008-10-01
KR100792391B1 (ko) 2008-01-08
NO20021598D0 (no) 2002-04-04
HUP0203130A2 (hu) 2003-01-28
ATE398623T1 (de) 2008-07-15
US20050261364A1 (en) 2005-11-24
CN1407987A (zh) 2003-04-02
CA2386850A1 (en) 2001-04-12
RU2247123C2 (ru) 2005-02-27
US6649651B1 (en) 2003-11-18
DK1222192T3 (da) 2008-10-20
US7157495B2 (en) 2007-01-02
AU7663800A (en) 2001-05-10
BR0014602A (pt) 2002-06-11
DE60039244D1 (de) 2008-07-31
OA12053A (en) 2006-05-02
EP1222192A1 (en) 2002-07-17
ES2307533T3 (es) 2008-12-01
HK1054746A1 (en) 2003-12-12
CZ20021419A3 (cs) 2002-10-16
EP1222192B1 (en) 2008-06-18
MXPA02003607A (es) 2003-07-28

Similar Documents

Publication Publication Date Title
NO20021598L (no) Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5- ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamatsom retrovital proteaseinhibitor
EP1120205A4 (en) ROBOT
ZA200107496B (en) Amine derivatives as protease inhitors.
NO20012980L (no) Proteaseinhibitorer
EE200200273A (et) Uudsed diabeedivastased agensid
NO995433D0 (no) Protease-inhibitorer
NO20011966L (no) Serin-protease-inhibitor
DK0979240T3 (da) Serinproteaseinhibitor
DE60219955D1 (de) Gleichlaufgelenke
DE69918062D1 (de) 6,9-disubstituierte 2-(trans-(4-aminocyclohexyl)amino)purine
NO995435D0 (no) Protease-inhibitorer
ITMI20011306A0 (it) Poliuretani vulcanizzabili
FR2792045B1 (fr) Joint homocinetique a billes
DK1218383T3 (da) Biocykliske imidazo-5-yl-aminoderivater
DE69907381D1 (de) Gelenkroboter
NO995268D0 (no) Proteaseinhibitorer
NO995434L (no) Proteaseinhibitorer
NO981846D0 (no) Beskyttelsesbrille, spesielt arbeidsbeskyttelsesbrille
DE50010618D1 (de) Schnellkupplung
PL349774A1 (en) Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors
DK1220717T3 (da) Malehoved
AU2001277790A1 (en) Flashlight for wrist
NL1012028A1 (nl) Aminozuursequentie.
EP1195163A4 (en) Serine protease inhibitors
ITAT990002U1 (it) Progetto "millenium due"

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERI, IE

MK1K Patent expired