DK1222192T3 - Hexahydrofuro-2,3-b furan-3-yl-N-3-(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino-1-benzyl-2-hydroxypropyl-carbamat som retroviral proteaseinhibitor - Google Patents

Hexahydrofuro-2,3-b furan-3-yl-N-3-(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino-1-benzyl-2-hydroxypropyl-carbamat som retroviral proteaseinhibitor

Info

Publication number
DK1222192T3
DK1222192T3 DK00966144T DK00966144T DK1222192T3 DK 1222192 T3 DK1222192 T3 DK 1222192T3 DK 00966144 T DK00966144 T DK 00966144T DK 00966144 T DK00966144 T DK 00966144T DK 1222192 T3 DK1222192 T3 DK 1222192T3
Authority
DK
Denmark
Prior art keywords
hexahydrofuro
ylsulfonyl
benzodioxol
furan
isobutyl
Prior art date
Application number
DK00966144T
Other languages
English (en)
Inventor
Michael Eissenstat
John W Erickson
Piet Tom Bert Paul Wigerinck
Guangyang Wang
Original Assignee
Tibotec Pharm Ltd
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd, Us Gov Health & Human Serv filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of DK1222192T3 publication Critical patent/DK1222192T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK00966144T 1999-10-06 2000-10-06 Hexahydrofuro-2,3-b furan-3-yl-N-3-(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino-1-benzyl-2-hydroxypropyl-carbamat som retroviral proteaseinhibitor DK1222192T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15785099P 1999-10-06 1999-10-06
PCT/EP2000/009917 WO2001025240A1 (en) 1999-10-06 2000-10-06 HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR

Publications (1)

Publication Number Publication Date
DK1222192T3 true DK1222192T3 (da) 2008-10-20

Family

ID=22565540

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00966144T DK1222192T3 (da) 1999-10-06 2000-10-06 Hexahydrofuro-2,3-b furan-3-yl-N-3-(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino-1-benzyl-2-hydroxypropyl-carbamat som retroviral proteaseinhibitor

Country Status (26)

Country Link
US (2) US6649651B1 (da)
EP (1) EP1222192B8 (da)
JP (1) JP4951179B2 (da)
KR (1) KR100792391B1 (da)
CN (1) CN1191256C (da)
AP (1) AP1459A (da)
AT (1) ATE398623T1 (da)
AU (1) AU781656B2 (da)
BR (1) BR0014602A (da)
CA (1) CA2386850C (da)
CZ (1) CZ300031B6 (da)
DE (1) DE60039244D1 (da)
DK (1) DK1222192T3 (da)
ES (1) ES2307533T3 (da)
HK (1) HK1054746A1 (da)
HU (1) HU228938B1 (da)
IL (2) IL149005A0 (da)
MX (1) MXPA02003607A (da)
NO (1) NO327996B1 (da)
NZ (1) NZ518580A (da)
OA (1) OA12053A (da)
PL (1) PL204924B1 (da)
RU (1) RU2247123C2 (da)
SK (1) SK287153B6 (da)
WO (1) WO2001025240A1 (da)
ZA (1) ZA200202655B (da)

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SK287153B6 (sk) * 1999-10-06 2010-01-07 Tibotec Pharmaceuticals Ltd. Hexahydrofuro[2,3-b]furan-3-yl-N-{3-[(1,3-benzodioxol-5- ylsulfonyl)(izobutyl)amino]1-benzyl-2-hydroxypropyl}karbamát, jeho použitie a farmaceutický prípravok s jeho obsahom
SK288232B6 (sk) 2001-04-09 2014-11-04 Tibotec Pharmaceuticals Ltd. 2-(substituovaný amino)benzoxazolsulfónamidový derivát, jeho aplikácie ako liečiva, farmaceutická kompozícia s jeho obsahom a spôsob in vitro inhibície retrovírusovej replikácie
AU2002333809C1 (en) * 2001-09-10 2009-02-05 Janssen Sciences Ireland Unlimited Company Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol
US7285566B2 (en) * 2002-01-07 2007-10-23 Erickson John W Resistance-repellent retroviral protease inhibitors
EP1472536A4 (en) * 2002-01-07 2007-02-14 Sequoia Pharmaceuticals VERSATILE INHIBITORS
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
AU2003238074B2 (en) 2002-05-17 2009-04-30 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted benzisoxazole sulfonamide HIV protease inhibitors
CN101445493A (zh) * 2002-08-02 2009-06-03 泰博特克药品有限公司 广谱2-氨基-苯并噻唑磺酰胺类hiv蛋白酶抑制剂
AU2003275675A1 (en) 2002-12-27 2004-07-29 Sumitomo Chemical Company, Limited Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same
AU2005222435B2 (en) 2004-03-11 2012-03-15 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
KR100698291B1 (ko) * 2004-12-29 2007-03-22 엘지전자 주식회사 조명계
ES2331257T3 (es) 2005-02-25 2009-12-28 Tibotec Pharmaceuticals Sintesis de precursores de inhibidores de proteasas.
AU2007275860C1 (en) 2006-07-07 2014-06-12 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
JP2009544708A (ja) * 2006-07-24 2009-12-17 ギリアード サイエンシーズ， インコーポレイテッド ビスフラニルプロテアーゼ阻害剤
BRPI0718706B8 (pt) 2006-11-09 2021-05-25 Janssen R & D Ireland métodos para a preparação de hexa-hidrofuro[2,3- b]furan-3-ol
EP2491785A1 (en) * 2006-11-21 2012-08-29 Purdue Research Foundation Method and compositions for treating HIV infections
EP3150586B1 (en) 2007-02-23 2020-01-08 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US7981929B2 (en) 2007-03-16 2011-07-19 Sequoia Pharmaceuticals, Inc. Benzofuran derived HIV protease inhibitors
JP5393665B2 (ja) 2007-07-06 2014-01-22 ギリアード サイエンシーズ， インコーポレイテッド 治療剤の薬物動態特性の調整剤
WO2009088719A1 (en) 2008-01-04 2009-07-16 Gilead Sciences, Inc. Inhibitors of cytochrome p450
EP2244571A4 (en) * 2008-01-17 2014-02-19 Purdue Research Foundation SMALL INHIBITORY MOLECULES OF HIV PROTEASES
US8791135B2 (en) * 2008-07-01 2014-07-29 Purdue Research Foundation Nonpeptide HIV-1 protease inhibitors
EP2304043A4 (en) 2008-07-09 2012-05-30 Purdue Research Foundation HIV PROTEASE INHIBITORS AND METHOD FOR THEIR USE
JP5950825B2 (ja) 2009-12-21 2016-07-13 ヤンセン・サイエンシズ・アイルランド・ユーシー 活性化合物の持続放出のための分解性の取り外し可能なインプラント
DK2643326T3 (da) 2010-11-23 2017-01-09 Mylan Laboratories Ltd Fremgangsmåde til fremstilling af (3R, 3aS, 6aR)-hexahydrofuro[2,3-b]furan-3-ol
JPWO2014024898A1 (ja) 2012-08-09 2016-07-25 住友化学株式会社 ヘキサヒドロフロフラノール誘導体の製造方法
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100336699B1 (ko) * 1992-08-25 2002-05-13 윌리암스 로저 에이 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DE69415326T2 (de) * 1993-08-24 1999-06-02 Searle & Co Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
ATE500823T1 (de) * 1998-06-23 2011-03-15 Us Of America Represented By The Secretary Dept Of Health And Human Services Arzneimittel zur behandlung von hiv-infizierten säugetieren
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
GB9815567D0 (en) * 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
SK287153B6 (sk) * 1999-10-06 2010-01-07 Tibotec Pharmaceuticals Ltd. Hexahydrofuro[2,3-b]furan-3-yl-N-{3-[(1,3-benzodioxol-5- ylsulfonyl)(izobutyl)amino]1-benzyl-2-hydroxypropyl}karbamát, jeho použitie a farmaceutický prípravok s jeho obsahom

Also Published As

Publication number Publication date
CA2386850C (en) 2010-03-30
HUP0203130A3 (en) 2005-01-28
OA12053A (en) 2006-05-02
US7157495B2 (en) 2007-01-02
HU228938B1 (hu) 2013-06-28
CA2386850A1 (en) 2001-04-12
PL204924B1 (pl) 2010-02-26
US6649651B1 (en) 2003-11-18
SK5702002A3 (en) 2003-01-09
NO327996B1 (no) 2009-11-02
AU7663800A (en) 2001-05-10
CZ300031B6 (cs) 2009-01-14
EP1222192B1 (en) 2008-06-18
KR20020067503A (ko) 2002-08-22
AP2002002472A0 (en) 2002-06-30
CN1407987A (zh) 2003-04-02
ES2307533T3 (es) 2008-12-01
ZA200202655B (en) 2003-09-23
NO20021598D0 (no) 2002-04-04
EP1222192B8 (en) 2008-10-01
MXPA02003607A (es) 2003-07-28
CZ20021419A3 (cs) 2002-10-16
HUP0203130A2 (hu) 2003-01-28
BR0014602A (pt) 2002-06-11
ATE398623T1 (de) 2008-07-15
NZ518580A (en) 2004-01-30
CN1191256C (zh) 2005-03-02
IL149005A0 (en) 2002-11-10
JP4951179B2 (ja) 2012-06-13
RU2247123C2 (ru) 2005-02-27
KR100792391B1 (ko) 2008-01-08
NO20021598L (no) 2002-05-29
EP1222192A1 (en) 2002-07-17
HK1054746A1 (en) 2003-12-12
DE60039244D1 (de) 2008-07-31
AU781656B2 (en) 2005-06-02
JP2003511383A (ja) 2003-03-25
WO2001025240A1 (en) 2001-04-12
US20050261364A1 (en) 2005-11-24
AP1459A (en) 2005-08-22
PL354351A1 (en) 2004-01-12
IL149005A (en) 2006-12-31
SK287153B6 (sk) 2010-01-07

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