IL149005A0 - Hexahydrofuro-2', 3-bifuran-3-yl-n-{3'(1, 3-benzodioxol-5-ylsulfonyl) (isobutyl) amino-1-benzyl-2-hydroxypropyl} carbamate as restroviral protease inhibitor - Google Patents

Hexahydrofuro-2', 3-bifuran-3-yl-n-{3'(1, 3-benzodioxol-5-ylsulfonyl) (isobutyl) amino-1-benzyl-2-hydroxypropyl} carbamate as restroviral protease inhibitor

Info

Publication number
IL149005A0
IL149005A0 IL14900500A IL14900500A IL149005A0 IL 149005 A0 IL149005 A0 IL 149005A0 IL 14900500 A IL14900500 A IL 14900500A IL 14900500 A IL14900500 A IL 14900500A IL 149005 A0 IL149005 A0 IL 149005A0
Authority
IL
Israel
Prior art keywords
restroviral
bifuran
hexahydrofuro
ylsulfonyl
benzodioxol
Prior art date
Application number
IL14900500A
Other languages
English (en)
Original Assignee
Us Gov Health & Human Serv
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Tibotec Pharm Ltd filed Critical Us Gov Health & Human Serv
Publication of IL149005A0 publication Critical patent/IL149005A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL14900500A 1999-10-06 2000-10-06 Hexahydrofuro-2', 3-bifuran-3-yl-n-{3'(1, 3-benzodioxol-5-ylsulfonyl) (isobutyl) amino-1-benzyl-2-hydroxypropyl} carbamate as restroviral protease inhibitor IL149005A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15785099P 1999-10-06 1999-10-06
PCT/EP2000/009917 WO2001025240A1 (en) 1999-10-06 2000-10-06 HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR

Publications (1)

Publication Number Publication Date
IL149005A0 true IL149005A0 (en) 2002-11-10

Family

ID=22565540

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14900500A IL149005A0 (en) 1999-10-06 2000-10-06 Hexahydrofuro-2', 3-bifuran-3-yl-n-{3'(1, 3-benzodioxol-5-ylsulfonyl) (isobutyl) amino-1-benzyl-2-hydroxypropyl} carbamate as restroviral protease inhibitor
IL149005A IL149005A (en) 1999-10-06 2002-04-04 Hexhydropuro - [2,3-b] Furan-3-Il N - {[(1,3-Benzodioxole-5-Isulfonyl) (isobutyl) amino] - 1-Benzyl-2-Hydroxypropyl} Carbamate used as a retroviral protease inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL149005A IL149005A (en) 1999-10-06 2002-04-04 Hexhydropuro - [2,3-b] Furan-3-Il N - {[(1,3-Benzodioxole-5-Isulfonyl) (isobutyl) amino] - 1-Benzyl-2-Hydroxypropyl} Carbamate used as a retroviral protease inhibitor

Country Status (26)

Country Link
US (2) US6649651B1 (da)
EP (1) EP1222192B8 (da)
JP (1) JP4951179B2 (da)
KR (1) KR100792391B1 (da)
CN (1) CN1191256C (da)
AP (1) AP1459A (da)
AT (1) ATE398623T1 (da)
AU (1) AU781656B2 (da)
BR (1) BR0014602A (da)
CA (1) CA2386850C (da)
CZ (1) CZ300031B6 (da)
DE (1) DE60039244D1 (da)
DK (1) DK1222192T3 (da)
ES (1) ES2307533T3 (da)
HK (1) HK1054746A1 (da)
HU (1) HU228938B1 (da)
IL (2) IL149005A0 (da)
MX (1) MXPA02003607A (da)
NO (1) NO327996B1 (da)
NZ (1) NZ518580A (da)
OA (1) OA12053A (da)
PL (1) PL204924B1 (da)
RU (1) RU2247123C2 (da)
SK (1) SK287153B6 (da)
WO (1) WO2001025240A1 (da)
ZA (1) ZA200202655B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1459A (en) * 1999-10-06 2005-08-22 Tibotec Pharm Ltd Hexahydrofuro [2,3-b] furan-3- YL-N-{3-[(1,3- benzodioxol-5- ylsufonyl) (isobutyl) amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor.
NZ528954A (en) * 2001-04-09 2005-04-29 Tibotec Pharm Ltd Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
DE60234952D1 (de) * 2001-09-10 2010-02-11 Tibotec Pharm Ltd VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL
EP1472536A4 (en) * 2002-01-07 2007-02-14 Sequoia Pharmaceuticals VERSATILE INHIBITORS
US7285566B2 (en) * 2002-01-07 2007-10-23 Erickson John W Resistance-repellent retroviral protease inhibitors
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
IL165043A0 (en) 2002-05-17 2005-12-18 Tibotec Pharm Ltd broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
OA12893A (en) * 2002-08-02 2006-10-13 Tibotec Pharm Ltd Broadspectrum 2-Amino-Benzothiazole Sulfonamide HIV Protease Inhibitors.
EP1589018A4 (en) 2002-12-27 2007-03-14 Sumitomo Chemical Co PROCESS FOR PRODUCING A DERIVATIVE OF HEXAHYDROFURANOL, INTERMEDIATE THEREOF AND PROCESS FOR PRODUCING THE SAME
AU2005222435B2 (en) * 2004-03-11 2012-03-15 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
KR100698291B1 (ko) * 2004-12-29 2007-03-22 엘지전자 주식회사 조명계
RU2421459C2 (ru) 2005-02-25 2011-06-20 Тиботек Фармасьютикалз Лтд. Синтез предшественника ингибитора протеазы
EP2049506B2 (en) 2006-07-07 2024-05-08 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US20090312318A1 (en) * 2006-07-24 2009-12-17 Desai Manoj C Therapeutic compounds and methods
DE602007012365D1 (de) 2006-11-09 2011-03-17 Little Island Co Cork Verfahren zur herstellung von hexahydrofuroä2,3-büfuran-3-ol
US9808527B2 (en) 2006-11-21 2017-11-07 Purdue Research Foundation Methods and compositions for treating HIV infections
PT2487166T (pt) 2007-02-23 2016-10-17 Gilead Sciences Inc Moduladores de propriedades farmacocinéticas de agentes terapêuticos
EP2134336B1 (en) * 2007-03-16 2013-12-11 Sequoia Pharmaceuticals Benzofuran-derived hiv protease inhibitors
CN101796040A (zh) 2007-07-06 2010-08-04 吉里德科学公司 治疗剂的药代动力学特性调节剂
US8759379B2 (en) 2008-01-04 2014-06-24 Gilead Sciences, Inc. Inhibitors of cytochrome P450
WO2009091941A1 (en) 2008-01-17 2009-07-23 Purdue Research Foundation Small molecule inhibitors of hiv proteases
EP2307345A4 (en) 2008-07-01 2012-05-02 Purdue Research Foundation NON-PEPTIDINHIBITORS OF HIV-1 PROTEASE
EP2304043A4 (en) * 2008-07-09 2012-05-30 Purdue Research Foundation HIV PROTEASE INHIBITORS AND METHOD FOR THEIR USE
UA112155C2 (uk) 2009-12-21 2016-08-10 ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі Розкладаний видалюваний імплантат для безперервного вивільнення активної сполуки
LT2643326T (lt) 2010-11-23 2017-02-27 Mylan Laboratories, Limited (3r,3as,6ar)-heksahidrofuro[2,3-b]furan-3-olio gavimo būdas
CN104520262A (zh) * 2012-08-09 2015-04-15 住友化学株式会社 六氢呋喃并呋喃醇衍生物的制造方法
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0810209B1 (en) * 1992-08-25 2002-06-05 G.D. Searle & Co. Alpha - and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
EP0715618B1 (en) * 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
WO1999067417A2 (en) 1998-06-23 1999-12-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Fitness assay and associated methods
GB9815567D0 (en) * 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
AP1459A (en) * 1999-10-06 2005-08-22 Tibotec Pharm Ltd Hexahydrofuro [2,3-b] furan-3- YL-N-{3-[(1,3- benzodioxol-5- ylsufonyl) (isobutyl) amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor.

Also Published As

Publication number Publication date
OA12053A (en) 2006-05-02
CN1407987A (zh) 2003-04-02
NO20021598D0 (no) 2002-04-04
AU781656B2 (en) 2005-06-02
NO327996B1 (no) 2009-11-02
CA2386850C (en) 2010-03-30
ES2307533T3 (es) 2008-12-01
HUP0203130A2 (hu) 2003-01-28
CZ300031B6 (cs) 2009-01-14
CN1191256C (zh) 2005-03-02
IL149005A (en) 2006-12-31
CZ20021419A3 (cs) 2002-10-16
JP2003511383A (ja) 2003-03-25
MXPA02003607A (es) 2003-07-28
WO2001025240A1 (en) 2001-04-12
DE60039244D1 (de) 2008-07-31
HK1054746A1 (en) 2003-12-12
RU2247123C2 (ru) 2005-02-27
ATE398623T1 (de) 2008-07-15
EP1222192B8 (en) 2008-10-01
PL204924B1 (pl) 2010-02-26
DK1222192T3 (da) 2008-10-20
AP2002002472A0 (en) 2002-06-30
AP1459A (en) 2005-08-22
AU7663800A (en) 2001-05-10
NZ518580A (en) 2004-01-30
NO20021598L (no) 2002-05-29
US6649651B1 (en) 2003-11-18
US20050261364A1 (en) 2005-11-24
HU228938B1 (hu) 2013-06-28
US7157495B2 (en) 2007-01-02
EP1222192B1 (en) 2008-06-18
CA2386850A1 (en) 2001-04-12
ZA200202655B (en) 2003-09-23
HUP0203130A3 (en) 2005-01-28
SK5702002A3 (en) 2003-01-09
PL354351A1 (en) 2004-01-12
KR100792391B1 (ko) 2008-01-08
EP1222192A1 (en) 2002-07-17
KR20020067503A (ko) 2002-08-22
JP4951179B2 (ja) 2012-06-13
BR0014602A (pt) 2002-06-11
SK287153B6 (sk) 2010-01-07

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