HUP0203130A2 - Hexahidrofuro[2,3-b]furán-3-il-N-{3-(1,3-benzodioxol-5-il-szulfonil)-(izobutil)-amino-1-benzil-2-(hidroxi-propil)}-karbamát mint retrovírus-proteáz-gátló - Google Patents

Hexahidrofuro[2,3-b]furán-3-il-N-{3-(1,3-benzodioxol-5-il-szulfonil)-(izobutil)-amino-1-benzil-2-(hidroxi-propil)}-karbamát mint retrovírus-proteáz-gátló

Info

Publication number
HUP0203130A2
HUP0203130A2 HU0203130A HUP0203130A HUP0203130A2 HU P0203130 A2 HUP0203130 A2 HU P0203130A2 HU 0203130 A HU0203130 A HU 0203130A HU P0203130 A HUP0203130 A HU P0203130A HU P0203130 A2 HUP0203130 A2 HU P0203130A2
Authority
HU
Hungary
Prior art keywords
hexahydrofuro
ylsulfonyl
benzodioxol
furan
carbamate
Prior art date
Application number
HU0203130A
Other languages
English (en)
Inventor
Michael Eissenstat
John W. Erickson
Guangyang Wang
Piet Tom Bert Paul Wigerinck
Original Assignee
The Government Of The United States Of America
Tibotec Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Government Of The United States Of America, Tibotec Pharmaceuticals Ltd. filed Critical The Government Of The United States Of America
Publication of HUP0203130A2 publication Critical patent/HUP0203130A2/hu
Publication of HUP0203130A3 publication Critical patent/HUP0203130A3/hu
Publication of HU228938B1 publication Critical patent/HU228938B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A találmány új hisz-tetrahidrofurán- benzodioxolil-szulfonamidvegyületekre vonatkozik, amelyek meglepően hatékony proteáz-gátlók. Atalálmány gyógyászati készítményekre, valamint retrovírus-proteázok,különösen több hatóanyaggal szemben rezisztens retrovírus-proteázokgátlására alkalmas gyógyászati készítmények előállítására isvonatkozik. Ó
HU0203130A 1999-10-06 2000-10-06 Hexahidrofuro[2,3-b]furán-3-il-N-{3-(1,3-benzodioxol-5-il-szulfonil)-(izobutil)-amino-1-benzil-2- -(hidroxi-propil)}-karbamát mint retrovírus proteáz gátló HU228938B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15785099P 1999-10-06 1999-10-06
PCT/EP2000/009917 WO2001025240A1 (en) 1999-10-06 2000-10-06 HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR

Publications (3)

Publication Number Publication Date
HUP0203130A2 true HUP0203130A2 (hu) 2003-01-28
HUP0203130A3 HUP0203130A3 (en) 2005-01-28
HU228938B1 HU228938B1 (hu) 2013-06-28

Family

ID=22565540

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203130A HU228938B1 (hu) 1999-10-06 2000-10-06 Hexahidrofuro[2,3-b]furán-3-il-N-{3-(1,3-benzodioxol-5-il-szulfonil)-(izobutil)-amino-1-benzil-2- -(hidroxi-propil)}-karbamát mint retrovírus proteáz gátló

Country Status (26)

Country Link
US (2) US6649651B1 (hu)
EP (1) EP1222192B8 (hu)
JP (1) JP4951179B2 (hu)
KR (1) KR100792391B1 (hu)
CN (1) CN1191256C (hu)
AP (1) AP1459A (hu)
AT (1) ATE398623T1 (hu)
AU (1) AU781656B2 (hu)
BR (1) BR0014602A (hu)
CA (1) CA2386850C (hu)
CZ (1) CZ300031B6 (hu)
DE (1) DE60039244D1 (hu)
DK (1) DK1222192T3 (hu)
ES (1) ES2307533T3 (hu)
HK (1) HK1054746A1 (hu)
HU (1) HU228938B1 (hu)
IL (2) IL149005A0 (hu)
MX (1) MXPA02003607A (hu)
NO (1) NO327996B1 (hu)
NZ (1) NZ518580A (hu)
OA (1) OA12053A (hu)
PL (1) PL204924B1 (hu)
RU (1) RU2247123C2 (hu)
SK (1) SK287153B6 (hu)
WO (1) WO2001025240A1 (hu)
ZA (1) ZA200202655B (hu)

Families Citing this family (28)

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MXPA02003607A (es) * 1999-10-06 2003-07-28 Tibotec Pharm Ltd Hexahidrofuro '[2,3-bifuran-3 -h- 3-il-n- (3 '[(1,3-benzodioxil -5-ilsulfonil) (isobutil)amino]-1 -bencil-2-hidroxipropil] carbamato como inhibidor de la proteasa retroviral.
BR0208796A (pt) 2001-04-09 2004-03-09 Tibotec Pharm Ltd Inibidores 2-(amino substituìdo)-benzoxazol sulfonamida hiv protease de amplo espectro
US7126015B2 (en) * 2001-09-10 2006-10-24 Tibotec Pharmaceuticals Ltd. Method for the preparation of hexahydro-furo-[2,3-b]furan-3-ol
US7285566B2 (en) * 2002-01-07 2007-10-23 Erickson John W Resistance-repellent retroviral protease inhibitors
AU2003202914A1 (en) * 2002-01-07 2003-07-24 Sequoia Pharmaceuticals Broad spectrum inhibitors
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
CA2485903C (en) 2002-05-17 2011-08-16 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
KR101327772B1 (ko) * 2002-08-02 2013-11-11 얀센 알 앤드 디 아일랜드 광범위 2-아미노-벤조티아졸 설폰아미드 ｈｉｖ 프로테아제 저해제
WO2004060895A1 (ja) 2002-12-27 2004-07-22 Sumitomo Chemical Company, Limited ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法
EP1732891A4 (en) * 2004-03-11 2009-05-06 Sequoia Pharmaceuticals Inc RESISTANT PREVENTIVE INHIBITORS FOR RETROVIRAL PROTEASES
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
KR100698291B1 (ko) * 2004-12-29 2007-03-22 엘지전자 주식회사 조명계
JP5260965B2 (ja) 2005-02-25 2013-08-14 テイボテク・フアーマシユーチカルズ プロテアーゼ阻害剤前駆体合成
RS54237B9 (sr) 2006-07-07 2019-07-31 Gilead Sciences Inc Modulatori farmakokinetičkih svojstava terapeutika
JP2009544708A (ja) * 2006-07-24 2009-12-17 ギリアード サイエンシーズ， インコーポレイテッド ビスフラニルプロテアーゼ阻害剤
AU2007316562B2 (en) 2006-11-09 2013-02-21 Janssen Sciences Ireland Unlimited Company Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol
WO2008133734A2 (en) * 2006-11-21 2008-11-06 Purdue Research Foundation Method and compositions for treating hiv infections
AR065439A1 (es) 2007-02-23 2009-06-10 Gilead Sciences Inc Derivados de tiazoles 1,3 no condensados,composiciones farmaceuticas que los contienen y usos como agentes antivirales, en particular anti hiv.
EP2134336B1 (en) 2007-03-16 2013-12-11 Sequoia Pharmaceuticals Benzofuran-derived hiv protease inhibitors
TWI448457B (zh) 2007-07-06 2014-08-11 Gilead Sciences Inc 治療劑的藥物動力學性質之調節劑
ES2555209T3 (es) 2008-01-04 2015-12-29 Gilead Sciences, Inc. Inhibidores del citocromo P450
US20110046199A1 (en) 2008-01-17 2011-02-24 Purdue Research Foundation Small molecule inhibitors of hiv proteases
US8791135B2 (en) * 2008-07-01 2014-07-29 Purdue Research Foundation Nonpeptide HIV-1 protease inhibitors
EP2304043A4 (en) 2008-07-09 2012-05-30 Purdue Research Foundation HIV PROTEASE INHIBITORS AND METHOD FOR THEIR USE
BR112012015114B1 (pt) 2009-12-21 2023-01-10 Janssen Sciences Ireland Uc Implante farmacêutico subcutâneo removível degradável para liberação sustentada de um composto ativo
PT2643326T (pt) 2010-11-23 2016-12-23 Mylan Laboratories Ltd Processo para a preparação de (3r,3as,6ar)-hexa-hidrofuro[2,3-b]furan-3-ol
EP2883858B1 (en) 2012-08-09 2017-12-27 Sumitomo Chemical Company Limited Method for producing hexahydrofurofuranol derivative
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法

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Publication number Priority date Publication date Assignee Title
KR100336699B1 (ko) * 1992-08-25 2002-05-13 윌리암스 로저 에이 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
DE69415326T2 (de) * 1993-08-24 1999-06-02 Searle & Co Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
AU4828199A (en) 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
EP2336134B1 (en) * 1998-06-23 2016-08-31 The United States of America, represented by the Secretary, Department of Health and Human Services Fitness assay and methods for reducing resistance of HIV to therapy
GB9815567D0 (en) * 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
MXPA02003607A (es) * 1999-10-06 2003-07-28 Tibotec Pharm Ltd Hexahidrofuro '[2,3-bifuran-3 -h- 3-il-n- (3 '[(1,3-benzodioxil -5-ilsulfonil) (isobutil)amino]-1 -bencil-2-hidroxipropil] carbamato como inhibidor de la proteasa retroviral.

Also Published As

Publication number Publication date
JP4951179B2 (ja) 2012-06-13
MXPA02003607A (es) 2003-07-28
CN1191256C (zh) 2005-03-02
IL149005A0 (en) 2002-11-10
BR0014602A (pt) 2002-06-11
NO20021598D0 (no) 2002-04-04
CA2386850C (en) 2010-03-30
KR20020067503A (ko) 2002-08-22
PL354351A1 (en) 2004-01-12
AP2002002472A0 (en) 2002-06-30
EP1222192B8 (en) 2008-10-01
US6649651B1 (en) 2003-11-18
DE60039244D1 (de) 2008-07-31
WO2001025240A1 (en) 2001-04-12
IL149005A (en) 2006-12-31
DK1222192T3 (da) 2008-10-20
OA12053A (en) 2006-05-02
AU781656B2 (en) 2005-06-02
NO327996B1 (no) 2009-11-02
US7157495B2 (en) 2007-01-02
NO20021598L (no) 2002-05-29
AP1459A (en) 2005-08-22
PL204924B1 (pl) 2010-02-26
CZ20021419A3 (cs) 2002-10-16
EP1222192B1 (en) 2008-06-18
ATE398623T1 (de) 2008-07-15
HK1054746A1 (en) 2003-12-12
SK287153B6 (sk) 2010-01-07
EP1222192A1 (en) 2002-07-17
HUP0203130A3 (en) 2005-01-28
KR100792391B1 (ko) 2008-01-08
JP2003511383A (ja) 2003-03-25
SK5702002A3 (en) 2003-01-09
CN1407987A (zh) 2003-04-02
NZ518580A (en) 2004-01-30
AU7663800A (en) 2001-05-10
HU228938B1 (hu) 2013-06-28
ZA200202655B (en) 2003-09-23
US20050261364A1 (en) 2005-11-24
CA2386850A1 (en) 2001-04-12
ES2307533T3 (es) 2008-12-01
CZ300031B6 (cs) 2009-01-14
RU2247123C2 (ru) 2005-02-27

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: TIBOTEC PHARMACEUTICALS LTD., IE

Free format text: FORMER OWNER(S): TIBOTEC PHARMACEUTICALS LTD., IE

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, US

Free format text: FORMER OWNER(S): TIBOTEC PHARMACEUTICALS LTD., IE

GB9A Succession in title

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, US

Free format text: FORMER OWNER(S): TIBOTEC PHARMACEUTICALS LTD., IE; TIBOTEC PHARMACEUTICALS LTD., IE

Owner name: JANSSEN SCIENCES IRELAND UC, IE

Free format text: FORMER OWNER(S): TIBOTEC PHARMACEUTICALS LTD., IE; TIBOTEC PHARMACEUTICALS LTD., IE