HK1054746A1 - Hexahydrofuro'2,3-B!furan-3-yl-N- Ä3'(1,3-benzodioxol -5- ylsulfonyl) (isobutyl) amino! -1-benzyl-2-hydroxypropylÜ carbamate as retroviral protease inhibitor. - Google Patents

Hexahydrofuro'2,3-B!furan-3-yl-N- Ä3'(1,3-benzodioxol -5- ylsulfonyl) (isobutyl) amino! -1-benzyl-2-hydroxypropylÜ carbamate as retroviral protease inhibitor.

Info

Publication number
HK1054746A1
HK1054746A1 HK03107022A HK03107022A HK1054746A1 HK 1054746 A1 HK1054746 A1 HK 1054746A1 HK 03107022 A HK03107022 A HK 03107022A HK 03107022 A HK03107022 A HK 03107022A HK 1054746 A1 HK1054746 A1 HK 1054746A1
Authority
HK
Hong Kong
Prior art keywords
hydroxypropylü
hexahydrofuro
ylsulfonyl
benzodioxol
furan
Prior art date
Application number
HK03107022A
Other languages
English (en)
Inventor
Piet Tom Bert Paul Wigerinck
Guangyang Wang
Michael Eissenstat
John W Erickson
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Publication of HK1054746A1 publication Critical patent/HK1054746A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK03107022A 1999-10-06 2003-09-29 Hexahydrofuro'2,3-B!furan-3-yl-N- Ä3'(1,3-benzodioxol -5- ylsulfonyl) (isobutyl) amino! -1-benzyl-2-hydroxypropylÜ carbamate as retroviral protease inhibitor. HK1054746A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15785099P 1999-10-06 1999-10-06
PCT/EP2000/009917 WO2001025240A1 (fr) 1999-10-06 2000-10-06 HEXAHYDROFURO'2,3-B! FURAN-3-YL-N- {3'(1,3-BENZODIOXOL-5-YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL}CARBAMATE EN TANT QU'INHIBITEUR DE PROTEASE RETROVIRALE

Publications (1)

Publication Number Publication Date
HK1054746A1 true HK1054746A1 (en) 2003-12-12

Family

ID=22565540

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03107022A HK1054746A1 (en) 1999-10-06 2003-09-29 Hexahydrofuro'2,3-B!furan-3-yl-N- Ä3'(1,3-benzodioxol -5- ylsulfonyl) (isobutyl) amino! -1-benzyl-2-hydroxypropylÜ carbamate as retroviral protease inhibitor.

Country Status (26)

Country Link
US (2) US6649651B1 (fr)
EP (1) EP1222192B8 (fr)
JP (1) JP4951179B2 (fr)
KR (1) KR100792391B1 (fr)
CN (1) CN1191256C (fr)
AP (1) AP1459A (fr)
AT (1) ATE398623T1 (fr)
AU (1) AU781656B2 (fr)
BR (1) BR0014602A (fr)
CA (1) CA2386850C (fr)
CZ (1) CZ300031B6 (fr)
DE (1) DE60039244D1 (fr)
DK (1) DK1222192T3 (fr)
ES (1) ES2307533T3 (fr)
HK (1) HK1054746A1 (fr)
HU (1) HU228938B1 (fr)
IL (2) IL149005A0 (fr)
MX (1) MXPA02003607A (fr)
NO (1) NO327996B1 (fr)
NZ (1) NZ518580A (fr)
OA (1) OA12053A (fr)
PL (1) PL204924B1 (fr)
RU (1) RU2247123C2 (fr)
SK (1) SK287153B6 (fr)
WO (1) WO2001025240A1 (fr)
ZA (1) ZA200202655B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1222192T3 (da) * 1999-10-06 2008-10-20 Tibotec Pharm Ltd Hexahydrofuro-2,3-b furan-3-yl-N-3-(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino-1-benzyl-2-hydroxypropyl-carbamat som retroviral proteaseinhibitor
AR035819A1 (es) 2001-04-09 2004-07-14 Tibotec Pharm Ltd 2-(amino sustituido)-benzoxazol sulfonamidas, inhibidoras de la proteasa del hiv, composiciones farmaceuticas que comprenden dichos compuestos, metodo in vitro para inhibir la replicacion retroviral y uso de dichos compuestos en la fabricacion de medicamentos
PL224030B1 (pl) 2001-09-10 2016-11-30 Tibotec Pharm Ltd Sposób syntezy heksahydrofuro [2,3-b] furan -3-olu oraz związki pośrednie stosowane w tym sposobie
EP1483254A4 (fr) * 2002-01-07 2005-06-08 Sequoia Pharmaceuticals Inhibiteurs de protease retrovirale anti-resistance
US7285566B2 (en) * 2002-01-07 2007-10-23 Erickson John W Resistance-repellent retroviral protease inhibitors
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
SI1517899T1 (sl) 2002-05-17 2008-02-29 Tibotec Pharm Ltd Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
OA12893A (en) * 2002-08-02 2006-10-13 Tibotec Pharm Ltd Broadspectrum 2-Amino-Benzothiazole Sulfonamide HIV Protease Inhibitors.
WO2004060895A1 (fr) 2002-12-27 2004-07-22 Sumitomo Chemical Company, Limited Procede de production d'un derive de d'hexahydrofuranol, intermediaire de celui-ci et procede de production correspondant
WO2005087728A1 (fr) * 2004-03-11 2005-09-22 Sequoia Pharmaceuticals, Inc. Inhibiteurs de la protease retrovirale inhibant la resistance
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
KR100698291B1 (ko) * 2004-12-29 2007-03-22 엘지전자 주식회사 조명계
KR101333627B1 (ko) 2005-02-25 2013-11-27 얀센 알 앤드 디 아일랜드 프로테아제 저해제 전구체 합성
EP2049506B2 (fr) 2006-07-07 2024-05-08 Gilead Sciences, Inc. Modulateurs de propriétés pharmacocinétiques d'agents thérapeutiques
US20090312318A1 (en) * 2006-07-24 2009-12-17 Desai Manoj C Therapeutic compounds and methods
ES2359949T3 (es) 2006-11-09 2011-05-30 Tibotec Pharmaceuticals Métodos para preparar hexhidrofuro(2,3-b)furan-3-ol.
WO2008133734A2 (fr) * 2006-11-21 2008-11-06 Purdue Research Foundation Procédé et compositions utilisés pour traiter les infections à vih
PT2487163T (pt) 2007-02-23 2016-11-21 Gilead Sciences Inc Moduladores de propriedades farmacocinéticas de agentes terapêuticos
EP2134336B1 (fr) * 2007-03-16 2013-12-11 Sequoia Pharmaceuticals Inhibiteurs de la protéase du vih dérivés de benzofuranne
AR067412A1 (es) 2007-07-06 2009-10-07 Gilead Sciences Inc Moduladores de propiedades farmaceuticas de productos terapeuticos
PT2231628E (pt) 2008-01-04 2015-12-29 Gilead Sciences Inc Inibidores de citocromo p450
US20110046199A1 (en) 2008-01-17 2011-02-24 Purdue Research Foundation Small molecule inhibitors of hiv proteases
EP2307345A4 (fr) * 2008-07-01 2012-05-02 Purdue Research Foundation Inhibiteurs de protéase de vih-1 non peptidiques
WO2010006050A1 (fr) * 2008-07-09 2010-01-14 Purdue Research Foundation Inhibiteurs de la protéase du vih et procédés d'utilisation
SG181759A1 (en) 2009-12-21 2012-07-30 Janssen R & D Ireland Degradable removable implant for the sustained release of an active compound
US8841467B2 (en) 2010-11-23 2014-09-23 Mylan Laboratories Limited Process for the preparation of (3R, 3aS, 6aR)-hexahydrofuro [2, 3-b] furan-3-ol
ES2657227T3 (es) * 2012-08-09 2018-03-02 Sumitomo Chemical Company, Limited Método para producir un derivado de hexahidrofurofuranol
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100336699B1 (ko) * 1992-08-25 2002-05-13 윌리암스 로저 에이 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드
US5723490A (en) 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
EP0715618B1 (fr) * 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino-sulfonamides aptes a etre utilises comme inhibiteurs de protease retrovirale
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
PT2336134T (pt) * 1998-06-23 2016-10-19 The Board Of Trustees Of The Univ Of Illionis Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
GB9815567D0 (en) * 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
DK1222192T3 (da) * 1999-10-06 2008-10-20 Tibotec Pharm Ltd Hexahydrofuro-2,3-b furan-3-yl-N-3-(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino-1-benzyl-2-hydroxypropyl-carbamat som retroviral proteaseinhibitor

Also Published As

Publication number Publication date
CA2386850A1 (fr) 2001-04-12
ZA200202655B (en) 2003-09-23
SK287153B6 (sk) 2010-01-07
KR20020067503A (ko) 2002-08-22
CN1407987A (zh) 2003-04-02
IL149005A0 (en) 2002-11-10
EP1222192B8 (fr) 2008-10-01
CZ20021419A3 (cs) 2002-10-16
AU781656B2 (en) 2005-06-02
ES2307533T3 (es) 2008-12-01
PL204924B1 (pl) 2010-02-26
AU7663800A (en) 2001-05-10
NZ518580A (en) 2004-01-30
CN1191256C (zh) 2005-03-02
HUP0203130A2 (hu) 2003-01-28
US20050261364A1 (en) 2005-11-24
CZ300031B6 (cs) 2009-01-14
MXPA02003607A (es) 2003-07-28
EP1222192B1 (fr) 2008-06-18
IL149005A (en) 2006-12-31
JP4951179B2 (ja) 2012-06-13
SK5702002A3 (en) 2003-01-09
KR100792391B1 (ko) 2008-01-08
OA12053A (en) 2006-05-02
ATE398623T1 (de) 2008-07-15
AP2002002472A0 (en) 2002-06-30
NO327996B1 (no) 2009-11-02
EP1222192A1 (fr) 2002-07-17
WO2001025240A1 (fr) 2001-04-12
CA2386850C (fr) 2010-03-30
DE60039244D1 (de) 2008-07-31
US7157495B2 (en) 2007-01-02
NO20021598L (no) 2002-05-29
HU228938B1 (hu) 2013-06-28
JP2003511383A (ja) 2003-03-25
BR0014602A (pt) 2002-06-11
NO20021598D0 (no) 2002-04-04
RU2247123C2 (ru) 2005-02-27
HUP0203130A3 (en) 2005-01-28
PL354351A1 (en) 2004-01-12
AP1459A (en) 2005-08-22
DK1222192T3 (da) 2008-10-20
US6649651B1 (en) 2003-11-18

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PE Patent expired

Effective date: 20201005