NO327996B1 - Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor - Google Patents
Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor Download PDFInfo
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- NO327996B1 NO327996B1 NO20021598A NO20021598A NO327996B1 NO 327996 B1 NO327996 B1 NO 327996B1 NO 20021598 A NO20021598 A NO 20021598A NO 20021598 A NO20021598 A NO 20021598A NO 327996 B1 NO327996 B1 NO 327996B1
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- 230000002195 synergetic effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 229960000838 tipranavir Drugs 0.000 description 1
- NZPXPXAGXYTROM-FYBSXPHGSA-N tipranavir Chemical compound C([C@@]1(CCC)OC(O)=C([C@H](CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)C(=O)C1)CC1=CC=CC=C1 NZPXPXAGXYTROM-FYBSXPHGSA-N 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15785099P | 1999-10-06 | 1999-10-06 | |
| PCT/EP2000/009917 WO2001025240A1 (en) | 1999-10-06 | 2000-10-06 | HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20021598D0 NO20021598D0 (no) | 2002-04-04 |
| NO20021598L NO20021598L (no) | 2002-05-29 |
| NO327996B1 true NO327996B1 (no) | 2009-11-02 |
Family
ID=22565540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021598A NO327996B1 (no) | 1999-10-06 | 2002-04-04 | Heksahydrofuro'2,3-B!furan-3-yl-N-{3'(1,3-benzodioksol-5-ylsulfonyl)(isobutyl)amino!-1-benzyl-2-hydroksypropyl}-karbamat som retrovital proteaseinhibitor |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6649651B1 (cs) |
| EP (1) | EP1222192B8 (cs) |
| JP (1) | JP4951179B2 (cs) |
| KR (1) | KR100792391B1 (cs) |
| CN (1) | CN1191256C (cs) |
| AP (1) | AP1459A (cs) |
| AT (1) | ATE398623T1 (cs) |
| AU (1) | AU781656B2 (cs) |
| BR (1) | BR0014602A (cs) |
| CA (1) | CA2386850C (cs) |
| CZ (1) | CZ300031B6 (cs) |
| DE (1) | DE60039244D1 (cs) |
| DK (1) | DK1222192T3 (cs) |
| ES (1) | ES2307533T3 (cs) |
| HU (1) | HU228938B1 (cs) |
| IL (2) | IL149005A0 (cs) |
| MX (1) | MXPA02003607A (cs) |
| NO (1) | NO327996B1 (cs) |
| NZ (1) | NZ518580A (cs) |
| OA (1) | OA12053A (cs) |
| PL (1) | PL204924B1 (cs) |
| RU (1) | RU2247123C2 (cs) |
| SK (1) | SK287153B6 (cs) |
| WO (1) | WO2001025240A1 (cs) |
| ZA (1) | ZA200202655B (cs) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6649651B1 (en) * | 1999-10-06 | 2003-11-18 | Tibotec Pharmaceuticals Ltd | Hexahydrofuro[2,3-B]furan-3-yl-n{3[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor |
| PL367084A1 (en) * | 2001-04-09 | 2005-02-21 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors |
| JP4521185B2 (ja) | 2001-09-10 | 2010-08-11 | テイボテク・フアーマシユーチカルズ・リミテツド | ヘキサヒドロ−フロ［２，３−ｂ］フラン−３−オールの製造法 |
| US7285566B2 (en) * | 2002-01-07 | 2007-10-23 | Erickson John W | Resistance-repellent retroviral protease inhibitors |
| CA2472580A1 (en) * | 2002-01-07 | 2003-07-17 | Sequoia Pharmaceuticals | Broad spectrum inhibitors |
| US7157489B2 (en) * | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
| HRP20050607B1 (hr) | 2002-05-17 | 2014-07-04 | Tibotec Pharmaceuticals Ltd. | Supstituirani benzizoksazol sulfonamid hiv proteazni inhibitori širokog spektra |
| JP4879484B2 (ja) * | 2002-08-02 | 2012-02-22 | テイボテク・フアーマシユーチカルズ・リミテツド | 広スペクトルの２−アミノ−ベンゾチアゾールスルホンアミドｈｉｖプロテアーゼ阻害剤 |
| WO2004060895A1 (ja) | 2002-12-27 | 2004-07-22 | Sumitomo Chemical Company, Limited | ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法 |
| EP1732891A4 (en) * | 2004-03-11 | 2009-05-06 | Sequoia Pharmaceuticals Inc | RESISTANT PREVENTIVE INHIBITORS FOR RETROVIRAL PROTEASES |
| TWI383975B (zh) | 2004-03-31 | 2013-02-01 | Tibotec Pharm Ltd | 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法 |
| KR100698291B1 (ko) * | 2004-12-29 | 2007-03-22 | 엘지전자 주식회사 | 조명계 |
| KR101333627B1 (ko) | 2005-02-25 | 2013-11-27 | 얀센 알 앤드 디 아일랜드 | 프로테아제 저해제 전구체 합성 |
| FR2888849B1 (fr) * | 2005-07-19 | 2007-10-05 | Pierre Fabre Medicament Sa | Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine |
| PT2049506E (pt) | 2006-07-07 | 2015-10-09 | Gilead Sciences Inc | Moduladores de propriedades farmacocinéticas de agentes terapêuticos |
| US20090312318A1 (en) * | 2006-07-24 | 2009-12-17 | Desai Manoj C | Therapeutic compounds and methods |
| ES2359949T3 (es) | 2006-11-09 | 2011-05-30 | Tibotec Pharmaceuticals | Métodos para preparar hexhidrofuro(2,3-b)furan-3-ol. |
| EP2491785A1 (en) * | 2006-11-21 | 2012-08-29 | Purdue Research Foundation | Method and compositions for treating HIV infections |
| AP2986A (en) | 2007-02-23 | 2014-09-30 | Gilead Sciences Inc | Modulators of pharmacokinetic properties of therapeutics |
| WO2008115894A1 (en) * | 2007-03-16 | 2008-09-25 | Sequoia Pharmaceuticals | Benzofuran-derived hiv protease inhibitors |
| AR067412A1 (es) | 2007-07-06 | 2009-10-07 | Gilead Sciences Inc | Moduladores de propiedades farmaceuticas de productos terapeuticos |
| EP2231628B1 (en) | 2008-01-04 | 2015-10-28 | Gilead Sciences, Inc. | Inhibitors of cytochrome p450 |
| EP2244571A4 (en) * | 2008-01-17 | 2014-02-19 | Purdue Research Foundation | SMALL MOLECULAR INHIBITORS OF HIV PROTEASES |
| EP2307345A4 (en) | 2008-07-01 | 2012-05-02 | Purdue Research Foundation | NON-PEPTIDINHIBITORS OF HIV-1 PROTEASE |
| EP2304043A4 (en) | 2008-07-09 | 2012-05-30 | Purdue Research Foundation | HIV PROTEASE INHIBITORS AND METHOD FOR THEIR USE |
| SG181759A1 (en) | 2009-12-21 | 2012-07-30 | Janssen R & D Ireland | Degradable removable implant for the sustained release of an active compound |
| CA2818895C (en) | 2010-11-23 | 2020-02-25 | Matrix Laboratories Ltd | Process for the preparation of (3r, 3as, 6ar)-hexahydrofuro [2,3-b] furan-3-ol |
| JPWO2014024898A1 (ja) | 2012-08-09 | 2016-07-25 | 住友化学株式会社 | ヘキサヒドロフロフラノール誘導体の製造方法 |
| CN103664976B (zh) * | 2013-12-12 | 2015-11-04 | 惠州市莱佛士制药技术有限公司 | 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3657002B2 (ja) * | 1992-08-25 | 2005-06-08 | ジー．ディー．サール アンド カンパニー | レトロウイルスプロテアーゼ阻害剤として有用なα−およびβ−アミノ酸ヒドロキシエチルアミノスルホンアミド |
| ES2103488T3 (es) * | 1992-08-25 | 1997-09-16 | Searle & Co | N-(alcanoilamino-2-hidroxipropil)sulfonamidas utiles como inhibidores de proteasas retrovirales. |
| US5723490A (en) | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| DK0715618T3 (da) * | 1993-08-24 | 1999-08-23 | Searle & Co | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
| UA49803C2 (uk) * | 1994-06-03 | 2002-10-15 | Дж.Д. Сьорль Енд Ко | Спосіб лікування ретровірусних інфекцій |
| US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
| EP1088098B2 (en) | 1998-06-23 | 2015-07-01 | THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Fitness assay and methods for reducing resistance of hiv to therapy |
| AU4828199A (en) * | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
| GB9815567D0 (en) * | 1998-07-18 | 1998-09-16 | Glaxo Group Ltd | Antiviral compound |
| US6649651B1 (en) * | 1999-10-06 | 2003-11-18 | Tibotec Pharmaceuticals Ltd | Hexahydrofuro[2,3-B]furan-3-yl-n{3[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor |
-
2000
- 2000-10-06 US US10/089,991 patent/US6649651B1/en not_active Expired - Lifetime
- 2000-10-06 JP JP2001528184A patent/JP4951179B2/ja not_active Expired - Lifetime
- 2000-10-06 NZ NZ518580A patent/NZ518580A/en not_active IP Right Cessation
- 2000-10-06 PL PL354351A patent/PL204924B1/pl unknown
- 2000-10-06 CA CA2386850A patent/CA2386850C/en not_active Expired - Lifetime
- 2000-10-06 CN CNB008165874A patent/CN1191256C/zh not_active Expired - Lifetime
- 2000-10-06 BR BR0014602-1A patent/BR0014602A/pt not_active Application Discontinuation
- 2000-10-06 IL IL14900500A patent/IL149005A0/xx active IP Right Grant
- 2000-10-06 OA OA1200200096A patent/OA12053A/en unknown
- 2000-10-06 AP APAP/P/2002/002472A patent/AP1459A/en active
- 2000-10-06 WO PCT/EP2000/009917 patent/WO2001025240A1/en not_active Ceased
- 2000-10-06 SK SK570-2002A patent/SK287153B6/sk not_active IP Right Cessation
- 2000-10-06 HU HU0203130A patent/HU228938B1/hu unknown
- 2000-10-06 DK DK00966144T patent/DK1222192T3/da active
- 2000-10-06 DE DE60039244T patent/DE60039244D1/de not_active Expired - Lifetime
- 2000-10-06 EP EP00966144A patent/EP1222192B8/en not_active Expired - Lifetime
- 2000-10-06 MX MXPA02003607A patent/MXPA02003607A/es active IP Right Grant
- 2000-10-06 AU AU76638/00A patent/AU781656B2/en not_active Expired
- 2000-10-06 ES ES00966144T patent/ES2307533T3/es not_active Expired - Lifetime
- 2000-10-06 CZ CZ20021419A patent/CZ300031B6/cs not_active IP Right Cessation
- 2000-10-06 RU RU2002111657/04A patent/RU2247123C2/ru active
- 2000-10-06 AT AT00966144T patent/ATE398623T1/de not_active IP Right Cessation
- 2000-10-06 KR KR1020027004284A patent/KR100792391B1/ko not_active Expired - Lifetime
-
2002
- 2002-04-04 IL IL149005A patent/IL149005A/en unknown
- 2002-04-04 ZA ZA200202655A patent/ZA200202655B/xx unknown
- 2002-04-04 NO NO20021598A patent/NO327996B1/no not_active IP Right Cessation
-
2003
- 2003-06-25 US US10/606,342 patent/US7157495B2/en not_active Expired - Lifetime
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| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERI, IE |
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| MK1K | Patent expired |