NO325611B1 - Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser - Google Patents
Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser Download PDFInfo
- Publication number
- NO325611B1 NO325611B1 NO19992157A NO992157A NO325611B1 NO 325611 B1 NO325611 B1 NO 325611B1 NO 19992157 A NO19992157 A NO 19992157A NO 992157 A NO992157 A NO 992157A NO 325611 B1 NO325611 B1 NO 325611B1
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- descarboethoxyloratadine
- composition according
- acceptable salt
- Prior art date
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3732597P | 1997-02-07 | 1997-02-07 | |
| US4518497P | 1997-04-30 | 1997-04-30 | |
| US5305097P | 1997-07-21 | 1997-07-21 | |
| PCT/US1998/002328 WO1998034614A1 (en) | 1997-02-07 | 1998-02-06 | Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO992157D0 NO992157D0 (no) | 1999-05-04 |
| NO992157L NO992157L (no) | 1999-05-04 |
| NO325611B1 true NO325611B1 (no) | 2008-06-23 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19992157A NO325611B1 (no) | 1997-02-07 | 1999-05-04 | Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser |
| NO20075846A NO20075846L (no) | 1997-02-07 | 2007-11-14 | Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20075846A NO20075846L (no) | 1997-02-07 | 2007-11-14 | Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser |
Country Status (29)
| Country | Link |
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| US (2) | US20020123504A1 (pl) |
| EP (2) | EP1614421A3 (pl) |
| JP (1) | JP2001511184A (pl) |
| KR (5) | KR20080003012A (pl) |
| CN (1) | CN1132579C (pl) |
| AR (3) | AR011114A1 (pl) |
| AT (1) | ATE345133T1 (pl) |
| AU (1) | AU6271998A (pl) |
| BR (1) | BR9806157A (pl) |
| CA (1) | CA2267136C (pl) |
| CO (1) | CO4940445A1 (pl) |
| CZ (1) | CZ119499A3 (pl) |
| DE (1) | DE69836424T2 (pl) |
| DK (1) | DK0969836T3 (pl) |
| ES (1) | ES2271986T3 (pl) |
| HK (1) | HK1024187A1 (pl) |
| HU (1) | HUP0001527A3 (pl) |
| MY (1) | MY136999A (pl) |
| NO (2) | NO325611B1 (pl) |
| NZ (1) | NZ335041A (pl) |
| PE (1) | PE71699A1 (pl) |
| PL (1) | PL192075B1 (pl) |
| PT (1) | PT969836E (pl) |
| RU (1) | RU2209627C2 (pl) |
| SK (1) | SK286035B6 (pl) |
| TW (1) | TW522014B (pl) |
| UA (1) | UA70290C2 (pl) |
| WO (1) | WO1998034614A1 (pl) |
| ZA (1) | ZA98977B (pl) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL139407A0 (en) * | 1998-07-10 | 2001-11-25 | Schering Corp | 8-CHLORO-6, 11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO [5,6] CYCLOHEPTA [1, 2-b] PYRIDINE ORAL COMPOSITIONS |
| US6100274A (en) * | 1999-07-07 | 2000-08-08 | Schering Corporation | 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions |
| AU7589700A (en) * | 1999-09-22 | 2001-04-24 | Schering Corporation | Treating allergic and inflammatory conditions |
| US6114346A (en) * | 1999-10-22 | 2000-09-05 | Schering Corporation | Treating sleep disorders using desloratadine |
| MY125516A (en) | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
| AU2277101A (en) | 1999-12-20 | 2001-07-03 | Schering Corporation | Stable extended release oral dosage composition |
| SK287105B6 (sk) * | 1999-12-20 | 2009-12-07 | Schering Corporation | Dvojvrstvový orálny dávkový prostriedok s predĺženým uvoľňovaním |
| KR101199654B1 (ko) * | 1999-12-20 | 2012-11-08 | 머크 샤프 앤드 돔 코포레이션 | 안정한 서방출형의 경구 투여용 조성물 |
| US7405223B2 (en) | 2000-02-03 | 2008-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
| US20060135547A1 (en) * | 2003-03-12 | 2006-06-22 | Toth Zoltan G | Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine |
| DE602004004453T2 (de) * | 2003-03-12 | 2007-11-08 | Teva Pharmaceutical Industries Ltd. | Stabile pharmazeutische zusammensetzungen mit desloratadin |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| WO2005065047A2 (en) * | 2003-12-23 | 2005-07-21 | Sun Pharmaceutical Industries Limited | Stable oral composition containing desloratadine |
| TWI415635B (zh) | 2004-05-28 | 2013-11-21 | 必治妥施貴寶公司 | 加衣錠片調製物及製備彼之方法 |
| NZ552998A (en) * | 2004-07-16 | 2010-11-26 | Cipla Ltd | Anti-histaminic composition |
| WO2006020534A2 (en) * | 2004-08-09 | 2006-02-23 | Dr. Reddy's Laboratories Ltd. | Stabilized desloratadine composition |
| US20070004671A1 (en) * | 2005-05-20 | 2007-01-04 | Agarwal Sudeep K | Stable desloratadine compositions |
| EP1728513A3 (en) * | 2005-05-20 | 2007-10-31 | Dr. Reddy's Laboratories, Inc. | Stable desloratadine compositions |
| US20070014855A1 (en) * | 2005-07-12 | 2007-01-18 | Rahul Gawande S | Stable desloratadine compositions |
| US20080118555A1 (en) * | 2005-10-20 | 2008-05-22 | Glenmark Pharmaceuticals Limited | Stable pharmaceutical composition containing desloratadine |
| CA2541045A1 (en) * | 2006-03-24 | 2007-09-24 | Pharmascience Inc. | A descarbonylethoxyloratadine containing pharmaceutical composition |
| US20070244144A1 (en) * | 2006-04-10 | 2007-10-18 | Ranbaxy Laboratories Limited | Process for the preparation of desloratadine |
| US20100022576A1 (en) * | 2006-06-07 | 2010-01-28 | Ramaswami Bharatrajan | Stable and bioavailable formulations and a novel form of desloratadine |
| ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
| TR200806298A2 (tr) | 2008-08-22 | 2010-03-22 | Bi̇lgi̇ç Mahmut | Farmasötik formülasyon |
| EP2398468B1 (en) | 2009-02-17 | 2016-11-30 | KRKA, D.D., Novo Mesto | Pharmaceutical compositions comprising prasugrel base or its pharmaceutically acceptable acid addition salts and processes for their preparation |
| EP2269586B1 (en) | 2009-07-01 | 2011-09-21 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical composition comprising desloratadine |
| ES2709487T3 (es) | 2010-05-10 | 2019-04-16 | Lesvi Laboratorios Sl | Formulaciones farmacéuticas estables que contienen un antihistamínico |
| TR201009396A2 (tr) | 2010-11-11 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Desloratadin granüller |
| CN102813640B (zh) * | 2012-09-06 | 2016-12-21 | 无锡万全医药技术有限公司 | 一种含地氯雷他定的软胶囊及其制备方法 |
| US20170135969A1 (en) | 2015-11-12 | 2017-05-18 | Jds Therapeutics, Llc | Topical arginine-silicate-inositol for wound healing |
| JP2019526638A (ja) | 2016-09-01 | 2019-09-19 | ジェイディーエス・セラピューティクス、エルエルシー | ビオチン酸マグネシウム組成物および使用方法 |
| CN113230235B (zh) * | 2021-04-15 | 2022-11-11 | 海南普利制药股份有限公司 | 含地氯雷他定的复方缓释胶囊及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| AU570306B2 (en) * | 1984-02-15 | 1988-03-10 | Schering Corporation | 8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridine and its salts. |
| US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
| CA2098198A1 (en) * | 1990-12-18 | 1992-06-18 | Ann Christie King | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
| RU2068689C1 (ru) * | 1992-09-24 | 1996-11-10 | Товарищество с ограниченной ответственностью "Лекрон" | Способ получения таблеток парацетамола |
| US5314697A (en) * | 1992-10-23 | 1994-05-24 | Schering Corporation | Stable extended release oral dosage composition comprising loratadine and pseudoephedrine |
| DE4442999A1 (de) * | 1994-12-02 | 1996-06-05 | Hexal Pharma Gmbh | Pharmazeutische Zusammensetzung mit einem aktiven Loratidin-Metaboliten |
| US5595997A (en) * | 1994-12-30 | 1997-01-21 | Sepracor Inc. | Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine |
| US5939426A (en) * | 1997-02-28 | 1999-08-17 | Sepracor Inc. | Methods for treating urinary incontinence using descarboethoxyloratadine |
| US6162829A (en) * | 1997-10-17 | 2000-12-19 | Atlantic Pharmaceuticals, Inc. | (3R,4R)-Δ8 -tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics |
| US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
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1998
- 1998-02-03 PE PE1998000074A patent/PE71699A1/es not_active Application Discontinuation
- 1998-02-03 TW TW087101236A patent/TW522014B/zh not_active IP Right Cessation
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- 1998-02-05 MY MYPI98000458A patent/MY136999A/en unknown
- 1998-02-06 NZ NZ335041A patent/NZ335041A/xx not_active IP Right Cessation
- 1998-02-06 BR BR9806157-7A patent/BR9806157A/pt not_active Application Discontinuation
- 1998-02-06 WO PCT/US1998/002328 patent/WO1998034614A1/en active Application Filing
- 1998-02-06 ES ES98904980T patent/ES2271986T3/es not_active Expired - Lifetime
- 1998-02-06 KR KR1020077028293A patent/KR20080003012A/ko not_active Application Discontinuation
- 1998-02-06 KR KR1019997003990A patent/KR100624259B1/ko not_active IP Right Cessation
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- 1998-02-06 RU RU99107283/14A patent/RU2209627C2/ru not_active IP Right Cessation
- 1998-02-06 SK SK472-99A patent/SK286035B6/sk not_active IP Right Cessation
- 1998-02-06 KR KR1020077015138A patent/KR20070086880A/ko not_active Application Discontinuation
- 1998-02-06 DE DE69836424T patent/DE69836424T2/de not_active Revoked
- 1998-02-06 CA CA002267136A patent/CA2267136C/en not_active Expired - Fee Related
- 1998-02-06 JP JP53491998A patent/JP2001511184A/ja active Pending
- 1998-02-06 EP EP05108474A patent/EP1614421A3/en not_active Withdrawn
- 1998-02-06 ZA ZA98977A patent/ZA98977B/xx unknown
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- 1998-02-06 AT AT98904980T patent/ATE345133T1/de not_active IP Right Cessation
- 1998-02-06 CZ CZ991194A patent/CZ119499A3/cs unknown
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- 1998-02-06 CN CN98802313XA patent/CN1132579C/zh not_active Expired - Fee Related
- 1998-02-06 KR KR1020067011519A patent/KR20060076330A/ko active Search and Examination
- 1998-02-06 EP EP98904980A patent/EP0969836B1/en not_active Revoked
- 1998-02-06 PT PT98904980T patent/PT969836E/pt unknown
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- 1998-02-06 HU HU0001527A patent/HUP0001527A3/hu unknown
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