NO324959B1 - 5-beta-sapogenin- og pseudosapogeninderivater samt deres anvendelse ved behandling av demens - Google Patents
5-beta-sapogenin- og pseudosapogeninderivater samt deres anvendelse ved behandling av demens Download PDFInfo
- Publication number
- NO324959B1 NO324959B1 NO20021541A NO20021541A NO324959B1 NO 324959 B1 NO324959 B1 NO 324959B1 NO 20021541 A NO20021541 A NO 20021541A NO 20021541 A NO20021541 A NO 20021541A NO 324959 B1 NO324959 B1 NO 324959B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkoxycarbonyl
- amino
- optionally substituted
- carbamoyl
- Prior art date
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- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 229960003565 tacrine hydrochloride Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- KOZCINYDCJVLDW-YOGGMVBGSA-N tomatanine Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CCCCC4CC[C@H]3[C@@H]2C1)C)[C@@H]1C)C11CCC(C)CN1 KOZCINYDCJVLDW-YOGGMVBGSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9923076.5A GB9923076D0 (en) | 1999-09-29 | 1999-09-29 | Sapogenin derivatives and their use |
PCT/GB2000/003737 WO2001023406A1 (fr) | 1999-09-29 | 2000-09-29 | Derives de 5-beta-sapogenine et de pseudosapogenine et leurs utilisations dans le traitement de la demence |
Publications (3)
Publication Number | Publication Date |
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NO20021541D0 NO20021541D0 (no) | 2002-03-27 |
NO20021541L NO20021541L (no) | 2002-05-28 |
NO324959B1 true NO324959B1 (no) | 2008-01-14 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20021541A NO324959B1 (no) | 1999-09-29 | 2002-03-27 | 5-beta-sapogenin- og pseudosapogeninderivater samt deres anvendelse ved behandling av demens |
Country Status (27)
Country | Link |
---|---|
US (2) | US7138427B2 (fr) |
EP (2) | EP1224205B1 (fr) |
JP (1) | JP2003510332A (fr) |
KR (1) | KR100771491B1 (fr) |
CN (2) | CN101411712A (fr) |
AT (1) | ATE325808T1 (fr) |
AU (1) | AU778294C (fr) |
BR (1) | BR0014381A (fr) |
CA (2) | CA2640998A1 (fr) |
CY (1) | CY1105225T1 (fr) |
CZ (1) | CZ300150B6 (fr) |
DE (1) | DE60027913T2 (fr) |
DK (1) | DK1224205T3 (fr) |
ES (1) | ES2260055T3 (fr) |
GB (1) | GB9923076D0 (fr) |
HK (1) | HK1045525B (fr) |
HR (2) | HRP20020255A2 (fr) |
IL (2) | IL148920A0 (fr) |
MX (1) | MXPA02003305A (fr) |
NO (1) | NO324959B1 (fr) |
NZ (1) | NZ518596A (fr) |
PT (1) | PT1224205E (fr) |
RU (1) | RU2325396C2 (fr) |
TR (1) | TR200200821T2 (fr) |
UA (1) | UA82978C2 (fr) |
WO (1) | WO2001023406A1 (fr) |
ZA (1) | ZA200202382B (fr) |
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GB9923076D0 (en) | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
KR20080031062A (ko) * | 2002-03-27 | 2008-04-07 | 파이토팜 피엘씨 | 사포게닌 및 그 유도체의 치료 방법 및 용도 |
KR20100093621A (ko) * | 2002-03-27 | 2010-08-25 | 파이토팜 피엘씨 | 사포게닌 및 그 유도체의 치료 방법 및 용도 |
CA2477787C (fr) * | 2002-03-27 | 2011-12-20 | Phytopharm Plc | Methodes therapeutiques et utilisations des sapogenines et de leurs derives |
US7718792B2 (en) | 2002-10-28 | 2010-05-18 | Phytopharm Plc | Stereospecific reduction of sapogen-3-ones |
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GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
GB0409567D0 (en) | 2004-04-28 | 2004-06-02 | Phytopharm Plc | Chemical compounds |
GB0424528D0 (en) | 2004-11-05 | 2004-12-08 | Phytopharm Plc | Chemical compounds |
GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
GB0513883D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
MX2011007842A (es) | 2009-01-24 | 2012-01-12 | Phytopharm Plc | Tratamiento de trastornos mediados por factores neurotroficos. |
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CU20110244A7 (es) * | 2011-12-27 | 2013-08-29 | Ct De Investigación Y Desarrollo De Medicamentos Cidem | Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios |
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CN102924559B (zh) * | 2012-11-16 | 2015-10-28 | 沈阳药科大学 | 菝葜皂苷元衍生物及其制备和应用 |
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CN103232520A (zh) * | 2013-05-13 | 2013-08-07 | 中国药科大学 | 一种螺甾类化合物、其制备方法及医药用途 |
CN106905407B (zh) * | 2015-01-27 | 2019-08-13 | 华东理工大学 | 知母皂苷元结构修饰的衍生物、其药物组合物及其应用 |
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CN106977581B (zh) * | 2017-04-17 | 2021-01-01 | 华东理工大学 | 知母皂苷元结构修饰的衍生物的应用以及药物组合物 |
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US20050130948A1 (en) | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
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1999
- 1999-09-29 GB GBGB9923076.5A patent/GB9923076D0/en not_active Ceased
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2000
- 2000-09-29 DE DE60027913T patent/DE60027913T2/de not_active Expired - Lifetime
- 2000-09-29 CA CA002640998A patent/CA2640998A1/fr not_active Abandoned
- 2000-09-29 AT AT00964439T patent/ATE325808T1/de active
- 2000-09-29 PT PT00964439T patent/PT1224205E/pt unknown
- 2000-09-29 TR TR2002/00821T patent/TR200200821T2/xx unknown
- 2000-09-29 WO PCT/GB2000/003737 patent/WO2001023406A1/fr active Application Filing
- 2000-09-29 JP JP2001526556A patent/JP2003510332A/ja active Pending
- 2000-09-29 AU AU75375/00A patent/AU778294C/en not_active Ceased
- 2000-09-29 CA CA002385402A patent/CA2385402C/fr not_active Expired - Fee Related
- 2000-09-29 CZ CZ20021114A patent/CZ300150B6/cs not_active IP Right Cessation
- 2000-09-29 UA UA2002043435A patent/UA82978C2/ru unknown
- 2000-09-29 EP EP00964439A patent/EP1224205B1/fr not_active Expired - Lifetime
- 2000-09-29 DK DK00964439T patent/DK1224205T3/da active
- 2000-09-29 CN CNA2008101760374A patent/CN101411712A/zh active Pending
- 2000-09-29 CN CNB008136068A patent/CN100445295C/zh not_active Expired - Fee Related
- 2000-09-29 IL IL14892000A patent/IL148920A0/xx not_active IP Right Cessation
- 2000-09-29 KR KR1020027003973A patent/KR100771491B1/ko not_active IP Right Cessation
- 2000-09-29 ES ES00964439T patent/ES2260055T3/es not_active Expired - Lifetime
- 2000-09-29 MX MXPA02003305A patent/MXPA02003305A/es active IP Right Grant
- 2000-09-29 EP EP06005887A patent/EP1724279A2/fr not_active Withdrawn
- 2000-09-29 BR BR0014381-2A patent/BR0014381A/pt not_active Application Discontinuation
- 2000-09-29 NZ NZ518596A patent/NZ518596A/en unknown
- 2000-09-29 RU RU2002111355/04A patent/RU2325396C2/ru not_active IP Right Cessation
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2002
- 2002-03-25 ZA ZA200202382A patent/ZA200202382B/en unknown
- 2002-03-27 NO NO20021541A patent/NO324959B1/no not_active IP Right Cessation
- 2002-03-27 HR HR20020255A patent/HRP20020255A2/hr not_active Application Discontinuation
- 2002-03-28 US US10/109,095 patent/US7138427B2/en not_active Expired - Fee Related
- 2002-09-11 HK HK02106662.2A patent/HK1045525B/zh not_active IP Right Cessation
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2006
- 2006-07-17 CY CY20061100986T patent/CY1105225T1/el unknown
- 2006-08-11 US US11/502,784 patent/US7507720B2/en not_active Expired - Fee Related
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2007
- 2007-01-25 IL IL180972A patent/IL180972A0/en unknown
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2008
- 2008-09-22 HR HR20080467A patent/HRP20080467A2/xx not_active Application Discontinuation
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