NO324882B1 - Optisk rene camptotecin analoger, optisk rent mellomprodukt, fremgangsmate for fremstilling av disse, anvendelse og farmasoytisk preparat - Google Patents
Optisk rene camptotecin analoger, optisk rent mellomprodukt, fremgangsmate for fremstilling av disse, anvendelse og farmasoytisk preparat Download PDFInfo
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- NO324882B1 NO324882B1 NO20000995A NO20000995A NO324882B1 NO 324882 B1 NO324882 B1 NO 324882B1 NO 20000995 A NO20000995 A NO 20000995A NO 20000995 A NO20000995 A NO 20000995A NO 324882 B1 NO324882 B1 NO 324882B1
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- 238000000034 method Methods 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 7
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- 239000000203 mixture Substances 0.000 claims description 24
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 13
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- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 10
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- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 description 1
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- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 1
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9710785A FR2768431B1 (fr) | 1997-08-29 | 1997-08-29 | Nouveaux analogues optiquement purs de la camptothecine, nouvel intermediaire de synthese optiquement pur et son procede de preparation |
| PCT/FR1998/001768 WO1999011646A1 (fr) | 1997-08-29 | 1998-08-07 | Analogues optiquement purs de la camptothecine, intermediaire de synthese optiquement pur et son procede de preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20000995L NO20000995L (no) | 2000-02-28 |
| NO20000995D0 NO20000995D0 (no) | 2000-02-28 |
| NO324882B1 true NO324882B1 (no) | 2007-12-27 |
Family
ID=9510590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20000995A NO324882B1 (no) | 1997-08-29 | 2000-02-28 | Optisk rene camptotecin analoger, optisk rent mellomprodukt, fremgangsmate for fremstilling av disse, anvendelse og farmasoytisk preparat |
Country Status (26)
| Country | Link |
|---|---|
| EP (2) | EP1007527B1 (de) |
| JP (1) | JP2001514261A (de) |
| KR (1) | KR100570254B1 (de) |
| CN (3) | CN1104434C (de) |
| AR (1) | AR016856A1 (de) |
| AT (1) | ATE253069T1 (de) |
| AU (1) | AU760863B2 (de) |
| BR (1) | BR9811405A (de) |
| CA (1) | CA2301739C (de) |
| CZ (1) | CZ297896B6 (de) |
| DE (1) | DE69819340T2 (de) |
| DK (1) | DK1007527T3 (de) |
| ES (1) | ES2209196T3 (de) |
| FR (1) | FR2768431B1 (de) |
| HK (2) | HK1031732A1 (de) |
| HR (1) | HRP20000110A2 (de) |
| HU (1) | HUP0003429A3 (de) |
| IL (2) | IL134437A0 (de) |
| NO (1) | NO324882B1 (de) |
| NZ (1) | NZ502862A (de) |
| PL (1) | PL195289B1 (de) |
| PT (1) | PT1007527E (de) |
| RU (1) | RU2233283C2 (de) |
| TW (1) | TW419479B (de) |
| WO (1) | WO1999011646A1 (de) |
| ZA (1) | ZA987445B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2790261B1 (fr) * | 1999-02-26 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation |
| US6207832B1 (en) | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| US6372906B1 (en) | 2001-04-12 | 2002-04-16 | University Of Pittsburgh | Synthesis of silyl camptothecins and silyl homocamptothecins |
| US6723853B2 (en) | 2001-08-27 | 2004-04-20 | University Of Pittsburgh | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins |
| CN100408582C (zh) * | 2004-02-12 | 2008-08-06 | 中国人民解放军第二军医大学 | 高喜树碱类化合物及其制备方法和用途 |
| EP1794127A1 (de) * | 2004-09-21 | 2007-06-13 | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) | Neue verfahren zur herstellung von nützlichen zwischenprodukten |
| CN100465175C (zh) * | 2005-11-29 | 2009-03-04 | 中国人民解放军第二军医大学 | 7-位取代高喜树碱类化合物及作为药物的用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5459269A (en) * | 1992-06-18 | 1995-10-17 | North Carolina State University | 14-halo-camptothecins |
| PT835258E (pt) * | 1995-06-21 | 2003-02-28 | Sod Conseils Rech Applic | Novos analogos de camptotecina, processos para a sua preparacao, sua utilizacao como farmacos e composicoes farmaceuticas que os contem |
-
1997
- 1997-08-29 FR FR9710785A patent/FR2768431B1/fr not_active Expired - Fee Related
-
1998
- 1998-08-07 ES ES98941567T patent/ES2209196T3/es not_active Expired - Lifetime
- 1998-08-07 PT PT98941567T patent/PT1007527E/pt unknown
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- 1998-08-07 WO PCT/FR1998/001768 patent/WO1999011646A1/fr active IP Right Grant
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- 1998-08-07 AT AT98941567T patent/ATE253069T1/de active
- 1998-08-07 HU HU0003429A patent/HUP0003429A3/hu unknown
- 1998-08-07 DK DK98941567T patent/DK1007527T3/da active
- 1998-08-07 EP EP03077049A patent/EP1378512A1/de not_active Withdrawn
- 1998-08-07 CN CN98808720A patent/CN1104434C/zh not_active Expired - Lifetime
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- 1998-08-07 JP JP2000508685A patent/JP2001514261A/ja active Pending
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2000
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2001
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