NO324471B1 - Kinazolinforbindelser samt anvendelse og fremgangsmate for fremstilling derav og farmasoytisk sammensetning - Google Patents
Kinazolinforbindelser samt anvendelse og fremgangsmate for fremstilling derav og farmasoytisk sammensetning Download PDFInfo
- Publication number
- NO324471B1 NO324471B1 NO20024763A NO20024763A NO324471B1 NO 324471 B1 NO324471 B1 NO 324471B1 NO 20024763 A NO20024763 A NO 20024763A NO 20024763 A NO20024763 A NO 20024763A NO 324471 B1 NO324471 B1 NO 324471B1
- Authority
- NO
- Norway
- Prior art keywords
- hydroxy
- methoxyquinazoline
- propoxy
- fluorophenylamino
- chloro
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 6
- 230000008569 process Effects 0.000 title claims abstract description 4
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 31
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 27
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 23
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 21
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 12
- 230000001772 anti-angiogenic effect Effects 0.000 claims abstract description 7
- 241001465754 Metazoa Species 0.000 claims abstract description 6
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims abstract description 3
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- 150000001875 compounds Chemical class 0.000 claims description 201
- -1 cyano, amino Chemical group 0.000 claims description 89
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- 150000003839 salts Chemical class 0.000 claims description 73
- 125000001424 substituent group Chemical group 0.000 claims description 67
- 229910052736 halogen Inorganic materials 0.000 claims description 63
- 150000002367 halogens Chemical class 0.000 claims description 63
- 125000000217 alkyl group Chemical group 0.000 claims description 53
- 125000000623 heterocyclic group Chemical group 0.000 claims description 39
- 229910052739 hydrogen Inorganic materials 0.000 claims description 37
- 239000001257 hydrogen Substances 0.000 claims description 37
- 238000006243 chemical reaction Methods 0.000 claims description 36
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 24
- 125000002947 alkylene group Chemical group 0.000 claims description 22
- 150000002431 hydrogen Chemical class 0.000 claims description 21
- 125000003545 alkoxy group Chemical group 0.000 claims description 19
- 230000000694 effects Effects 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 125000006239 protecting group Chemical group 0.000 claims description 18
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 17
- 125000004419 alkynylene group Chemical group 0.000 claims description 15
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 14
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 13
- 125000004043 oxo group Chemical group O=* 0.000 claims description 12
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims description 12
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- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims description 11
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- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 10
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
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- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 7
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 7
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- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
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- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
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Classifications
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- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
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EP00400967 | 2000-04-07 | ||
EP00400968 | 2000-04-07 | ||
EP00401033 | 2000-04-13 | ||
EP00401034 | 2000-04-13 | ||
PCT/GB2001/001514 WO2001077085A1 (en) | 2000-04-07 | 2001-04-03 | Quinazoline compounds |
Publications (3)
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NO20024763D0 NO20024763D0 (no) | 2002-10-03 |
NO20024763L NO20024763L (no) | 2002-11-19 |
NO324471B1 true NO324471B1 (no) | 2007-10-29 |
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NO20024763A NO324471B1 (no) | 2000-04-07 | 2002-10-03 | Kinazolinforbindelser samt anvendelse og fremgangsmate for fremstilling derav og farmasoytisk sammensetning |
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US (2) | US7160889B2 (da) |
EP (1) | EP1274692B1 (da) |
JP (2) | JP4970689B2 (da) |
KR (1) | KR100858069B1 (da) |
CN (1) | CN1240688C (da) |
AT (1) | ATE334973T1 (da) |
AU (1) | AU779695B2 (da) |
BR (1) | BR0109828A (da) |
CA (1) | CA2403365A1 (da) |
CY (1) | CY1107539T1 (da) |
DE (1) | DE60121931T2 (da) |
DK (1) | DK1274692T3 (da) |
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IL (2) | IL151626A0 (da) |
MX (1) | MXPA02009891A (da) |
NO (1) | NO324471B1 (da) |
NZ (1) | NZ521421A (da) |
PT (1) | PT1274692E (da) |
SI (1) | SI1274692T1 (da) |
WO (1) | WO2001077085A1 (da) |
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NZ516633A (en) * | 1999-06-21 | 2004-09-24 | Boehringer Ingelheim Pharma | Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof |
UA72946C2 (uk) | 1999-11-05 | 2005-05-16 | Астразенека Аб | Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf) |
JP2003525897A (ja) | 2000-03-06 | 2003-09-02 | アストラゼネカ アクチボラグ | 治 療 |
UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
MXPA03001332A (es) | 2000-08-21 | 2004-07-08 | Astrazeneca Ab | Derivados de quinazolina. |
US6849625B2 (en) | 2000-10-13 | 2005-02-01 | Astrazeneca Ab | Quinazoline derivatives with anti-tumour activity |
US6939866B2 (en) | 2000-10-13 | 2005-09-06 | Astrazeneca Ab | Quinazoline derivatives |
EP1330444B1 (en) | 2000-11-01 | 2011-03-23 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocyclic compounds and process for making them |
US7019012B2 (en) * | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
DE60229046D1 (de) | 2001-04-19 | 2008-11-06 | Astrazeneca Ab | Chinazolin derivate |
PL371486A1 (en) * | 2002-02-01 | 2005-06-13 | Astrazeneca Ab | Quinazoline compounds |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
EP2280003B1 (en) * | 2002-07-15 | 2014-04-02 | Symphony Evolution, Inc. | Process for preparing receptor-type kinase modulators |
RU2350618C2 (ru) | 2002-11-04 | 2009-03-27 | Астразенека Аб | ПРОИЗВОДНЫЕ ХИНАЗОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Src ТИРОЗИНКИНАЗЫ |
WO2004056812A1 (en) * | 2002-12-23 | 2004-07-08 | Astrazeneca Ab | 4- (pyridin-4-ylamino) -quinazoline derivatives as anti-tumor agents |
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- 2001-04-03 WO PCT/GB2001/001514 patent/WO2001077085A1/en active IP Right Grant
- 2001-04-03 DK DK01921530T patent/DK1274692T3/da active
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KR20020084295A (ko) | 2002-11-04 |
US20030191308A1 (en) | 2003-10-09 |
EP1274692A1 (en) | 2003-01-15 |
CA2403365A1 (en) | 2001-10-18 |
DK1274692T3 (da) | 2006-10-30 |
CY1107539T1 (el) | 2013-03-13 |
US7160889B2 (en) | 2007-01-09 |
EP1274692B1 (en) | 2006-08-02 |
IL151626A (en) | 2008-06-05 |
AU779695B2 (en) | 2005-02-10 |
CN1240688C (zh) | 2006-02-08 |
MXPA02009891A (es) | 2003-03-27 |
WO2001077085A1 (en) | 2001-10-18 |
ATE334973T1 (de) | 2006-08-15 |
BR0109828A (pt) | 2002-12-17 |
US20070066633A1 (en) | 2007-03-22 |
KR100858069B1 (ko) | 2008-09-22 |
NO20024763D0 (no) | 2002-10-03 |
SI1274692T1 (sl) | 2006-12-31 |
JP2003530387A (ja) | 2003-10-14 |
PT1274692E (pt) | 2006-11-30 |
JP4970689B2 (ja) | 2012-07-11 |
AU4850701A (en) | 2001-10-23 |
NZ521421A (en) | 2004-09-24 |
NO20024763L (no) | 2002-11-19 |
DE60121931T2 (de) | 2007-03-01 |
CN1433405A (zh) | 2003-07-30 |
IL151626A0 (en) | 2003-04-10 |
DE60121931D1 (de) | 2006-09-14 |
ES2267748T3 (es) | 2007-03-16 |
JP2012136537A (ja) | 2012-07-19 |
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