NO323448B1 - Hydrokloridsalter av 5-[4-[2-(N-metyl-N-(2-pyridyl)amino)etoksy]benzyl]tiazolidin-2,4-dion, fremgangsmate for fremstilling derav samt farmasoytisk preparat omfattende hydrokloridsaltet. - Google Patents
Hydrokloridsalter av 5-[4-[2-(N-metyl-N-(2-pyridyl)amino)etoksy]benzyl]tiazolidin-2,4-dion, fremgangsmate for fremstilling derav samt farmasoytisk preparat omfattende hydrokloridsaltet. Download PDFInfo
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- NO323448B1 NO323448B1 NO20024307A NO20024307A NO323448B1 NO 323448 B1 NO323448 B1 NO 323448B1 NO 20024307 A NO20024307 A NO 20024307A NO 20024307 A NO20024307 A NO 20024307A NO 323448 B1 NO323448 B1 NO 323448B1
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- Prior art keywords
- hydrochloride
- provides
- compound
- methyl
- pyridyl
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- 238000002360 preparation method Methods 0.000 title description 18
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0006133.3A GB0006133D0 (en) | 2000-03-14 | 2000-03-14 | Novel pharmaceutical |
| PCT/GB2001/001131 WO2001068646A1 (en) | 2000-03-14 | 2001-03-14 | Hydrochloride salts of 5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20024307D0 NO20024307D0 (no) | 2002-09-09 |
| NO20024307L NO20024307L (no) | 2002-09-09 |
| NO323448B1 true NO323448B1 (no) | 2007-05-07 |
Family
ID=9887600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20024307A NO323448B1 (no) | 2000-03-14 | 2002-09-09 | Hydrokloridsalter av 5-[4-[2-(N-metyl-N-(2-pyridyl)amino)etoksy]benzyl]tiazolidin-2,4-dion, fremgangsmate for fremstilling derav samt farmasoytisk preparat omfattende hydrokloridsaltet. |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7074811B2 (sk) |
| EP (1) | EP1265893B1 (sk) |
| JP (1) | JP2003527393A (sk) |
| KR (1) | KR100746813B1 (sk) |
| CN (1) | CN100516062C (sk) |
| AP (1) | AP1545A (sk) |
| AT (1) | ATE302202T1 (sk) |
| AU (1) | AU777987B2 (sk) |
| BG (1) | BG65924B1 (sk) |
| BR (1) | BR0108870A (sk) |
| CA (1) | CA2403109A1 (sk) |
| CZ (1) | CZ20023074A3 (sk) |
| DE (1) | DE60112729T2 (sk) |
| DK (1) | DK1265893T3 (sk) |
| DZ (1) | DZ3316A1 (sk) |
| EA (1) | EA005115B1 (sk) |
| ES (1) | ES2243458T3 (sk) |
| GB (1) | GB0006133D0 (sk) |
| HK (1) | HK1052502A1 (sk) |
| HU (1) | HUP0300158A3 (sk) |
| IL (2) | IL151425A0 (sk) |
| MA (1) | MA25658A1 (sk) |
| MX (1) | MXPA02008972A (sk) |
| NO (1) | NO323448B1 (sk) |
| NZ (1) | NZ520910A (sk) |
| OA (1) | OA12229A (sk) |
| PL (1) | PL357283A1 (sk) |
| SK (1) | SK286399B6 (sk) |
| UA (1) | UA73974C2 (sk) |
| WO (1) | WO2001068646A1 (sk) |
| ZA (1) | ZA200207292B (sk) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0021865D0 (en) * | 2000-09-06 | 2000-10-18 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0023971D0 (en) * | 2000-09-29 | 2000-11-15 | Smithkline Beecham Plc | Novel pharmaceutical |
| EP1448559B1 (en) * | 2001-11-21 | 2006-12-27 | Smithkline Beecham Plc | 5-(4-(2-(n-methyl-n-(2-pyridyl)amino)ethoxy)benzyl)thiazolidine-2,4-dione benzenesulfonate; process for its preparation; polymorphs i, ii and iii thereof; and its use as pharmaceutical active ingredient |
| GB0129876D0 (en) * | 2001-12-13 | 2002-02-06 | Smithkline Beecham Plc | Novel pharmaceutical |
| WO2003050112A1 (en) * | 2001-12-13 | 2003-06-19 | Smithkline Beecham Plc | Toluenesulfonate hydrates of a thiazolidinedione derivative |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| US20060235008A1 (en) | 2004-08-19 | 2006-10-19 | Hetero Drugs Limited | Novel polymorphs of efavirenz |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| NZ619413A (en) | 2006-05-04 | 2015-08-28 | Boehringer Ingelheim Int | Polymorphs of a dpp-iv enzyme inhibitor |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| US20090076093A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched rosiglitazone |
| AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| BRPI0919288A2 (pt) | 2008-09-10 | 2015-12-15 | Boehring Ingelheim Internat Gmbh | teriapia de combinação para tratamento de diabetes e condições relacionadas. |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| US20100158821A1 (en) * | 2008-12-22 | 2010-06-24 | Eastman Chemical Company | Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products |
| CN102256976A (zh) | 2008-12-23 | 2011-11-23 | 贝林格尔.英格海姆国际有限公司 | 有机化合物的盐形式 |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| US8106111B2 (en) * | 2009-05-15 | 2012-01-31 | Eastman Chemical Company | Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions |
| KR20210033559A (ko) | 2009-11-27 | 2021-03-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CN102946875A (zh) | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
| EP3124041A1 (en) | 2010-06-24 | 2017-02-01 | Boehringer Ingelheim International GmbH | Diabetes therapy |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| AU2012285904C1 (en) | 2011-07-15 | 2017-08-31 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| EP2849755A1 (en) | 2012-05-14 | 2015-03-25 | Boehringer Ingelheim International GmbH | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
| WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US120078A (en) * | 1871-10-17 | Improvement in revolving flower-stands | ||
| US137940A (en) * | 1873-04-15 | Improvement in elevators | ||
| US6288095B1 (en) * | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
| EP0842925A1 (en) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB9413975D0 (en) * | 1994-07-11 | 1994-08-31 | Fujisawa Pharmaceutical Co | New heterobicyclic derivatives |
| GB9124513D0 (en) * | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
| US5741803A (en) * | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| US5708012A (en) * | 1995-04-28 | 1998-01-13 | Sankyo Company, Limited | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus |
| IL133142A0 (en) | 1997-06-18 | 2001-03-19 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione and metformin |
| US20020137940A1 (en) * | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
| US6664278B2 (en) * | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
| GB9909075D0 (en) | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB9909041D0 (en) | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
| RS50114B (sr) | 1999-04-23 | 2009-03-25 | Smithkline Beecham P.L.C., | Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline |
| TR200103062T2 (tr) | 1999-04-23 | 2002-05-21 | Smithkline Beecham P.L.C. | Yeni farmasötik maddeler |
| YU75401A (sh) | 1999-04-23 | 2004-09-03 | Smithkline Beecham P.L.C. | Polimorfni oblik soli maleinske kiseline 5-/4-/2-(n-metil- -(2-piridil)amino)etoksi/-benzil/tiazolidin-2,4-dion |
| HU225919B1 (en) | 1999-12-18 | 2007-12-28 | Richter Gedeon Nyrt | Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates |
| CN1277965A (zh) | 2000-06-14 | 2000-12-27 | 中国医药研究开发中心 | 盐酸罗格列酮及其应用 |
| GB0021865D0 (en) | 2000-09-06 | 2000-10-18 | Smithkline Beecham Plc | Novel pharmaceutical |
-
2000
- 2000-03-14 GB GBGB0006133.3A patent/GB0006133D0/en not_active Ceased
-
2001
- 2001-03-14 DE DE60112729T patent/DE60112729T2/de not_active Expired - Lifetime
- 2001-03-14 EA EA200200975A patent/EA005115B1/ru not_active IP Right Cessation
- 2001-03-14 UA UA2002097390A patent/UA73974C2/uk unknown
- 2001-03-14 OA OA1200200285A patent/OA12229A/en unknown
- 2001-03-14 BR BR0108870-0A patent/BR0108870A/pt not_active IP Right Cessation
- 2001-03-14 WO PCT/GB2001/001131 patent/WO2001068646A1/en active IP Right Grant
- 2001-03-14 HU HU0300158A patent/HUP0300158A3/hu unknown
- 2001-03-14 JP JP2001567737A patent/JP2003527393A/ja active Pending
- 2001-03-14 MX MXPA02008972A patent/MXPA02008972A/es active IP Right Grant
- 2001-03-14 NZ NZ520910A patent/NZ520910A/en not_active IP Right Cessation
- 2001-03-14 CZ CZ20023074A patent/CZ20023074A3/cs unknown
- 2001-03-14 EP EP01911921A patent/EP1265893B1/en not_active Expired - Lifetime
- 2001-03-14 DZ DZ013316A patent/DZ3316A1/fr active
- 2001-03-14 AP APAP/P/2002/002600A patent/AP1545A/en active
- 2001-03-14 PL PL01357283A patent/PL357283A1/xx not_active Application Discontinuation
- 2001-03-14 ES ES01911921T patent/ES2243458T3/es not_active Expired - Lifetime
- 2001-03-14 US US10/221,686 patent/US7074811B2/en not_active Expired - Fee Related
- 2001-03-14 AT AT01911921T patent/ATE302202T1/de active
- 2001-03-14 CA CA002403109A patent/CA2403109A1/en not_active Abandoned
- 2001-03-14 CN CNB018000010A patent/CN100516062C/zh not_active Expired - Fee Related
- 2001-03-14 SK SK1330-2002A patent/SK286399B6/sk not_active IP Right Cessation
- 2001-03-14 IL IL15142501A patent/IL151425A0/xx unknown
- 2001-03-14 KR KR1020027011997A patent/KR100746813B1/ko not_active IP Right Cessation
- 2001-03-14 DK DK01911921T patent/DK1265893T3/da active
- 2001-03-14 AU AU40843/01A patent/AU777987B2/en not_active Ceased
-
2002
- 2002-08-20 BG BG107012A patent/BG65924B1/bg unknown
- 2002-08-22 IL IL151425A patent/IL151425A/en not_active IP Right Cessation
- 2002-09-09 NO NO20024307A patent/NO323448B1/no not_active IP Right Cessation
- 2002-09-11 ZA ZA200207292A patent/ZA200207292B/en unknown
- 2002-09-12 MA MA26814A patent/MA25658A1/fr unknown
-
2003
- 2003-05-13 HK HK03103374A patent/HK1052502A1/xx not_active IP Right Cessation
-
2005
- 2005-07-18 US US11/183,353 patent/US20050267162A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |