NO323263B1 - Heterosyklisk derivat, fremgangsmater for dets fremstilling, farmasoytiske sammensetninger som inneholder dette, anvendelse av dette for fremstilling av et preparat for medisinsk bruk samt nevnte derivat til bruk som medikament - Google Patents

Heterosyklisk derivat, fremgangsmater for dets fremstilling, farmasoytiske sammensetninger som inneholder dette, anvendelse av dette for fremstilling av et preparat for medisinsk bruk samt nevnte derivat til bruk som medikament Download PDF

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Publication number
NO323263B1
NO323263B1 NO20022682A NO20022682A NO323263B1 NO 323263 B1 NO323263 B1 NO 323263B1 NO 20022682 A NO20022682 A NO 20022682A NO 20022682 A NO20022682 A NO 20022682A NO 323263 B1 NO323263 B1 NO 323263B1
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NO
Norway
Prior art keywords
preparation
compound according
enantiomer
chloro
oxo
Prior art date
Application number
NO20022682A
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English (en)
Norwegian (no)
Other versions
NO20022682D0 (no
NO20022682L (no
Inventor
Alessandra Orlandi
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Publication of NO20022682D0 publication Critical patent/NO20022682D0/no
Publication of NO20022682L publication Critical patent/NO20022682L/no
Publication of NO323263B1 publication Critical patent/NO323263B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
NO20022682A 1999-12-08 2002-06-06 Heterosyklisk derivat, fremgangsmater for dets fremstilling, farmasoytiske sammensetninger som inneholder dette, anvendelse av dette for fremstilling av et preparat for medisinsk bruk samt nevnte derivat til bruk som medikament NO323263B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9929037.1A GB9929037D0 (en) 1999-12-08 1999-12-08 Heterocyclic derivatives
PCT/EP2000/012335 WO2001042238A1 (en) 1999-12-08 2000-12-07 Heterocyclic derivatives

Publications (3)

Publication Number Publication Date
NO20022682D0 NO20022682D0 (no) 2002-06-06
NO20022682L NO20022682L (no) 2002-07-17
NO323263B1 true NO323263B1 (no) 2007-02-19

Family

ID=10865952

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022682A NO323263B1 (no) 1999-12-08 2002-06-06 Heterosyklisk derivat, fremgangsmater for dets fremstilling, farmasoytiske sammensetninger som inneholder dette, anvendelse av dette for fremstilling av et preparat for medisinsk bruk samt nevnte derivat til bruk som medikament

Country Status (30)

Country Link
US (2) US6713491B2 (de)
EP (1) EP1237886B1 (de)
JP (1) JP4311901B2 (de)
KR (1) KR100788579B1 (de)
CN (1) CN1325488C (de)
AR (1) AR030923A1 (de)
AT (1) ATE323691T1 (de)
AU (1) AU769232B2 (de)
BR (1) BR0016235A (de)
CA (1) CA2393303C (de)
CO (1) CO5251474A1 (de)
CY (1) CY1106105T1 (de)
CZ (1) CZ301052B6 (de)
DE (1) DE60027461T2 (de)
DK (1) DK1237886T3 (de)
ES (1) ES2257343T3 (de)
GB (1) GB9929037D0 (de)
HK (1) HK1047436B (de)
HU (1) HUP0203650A3 (de)
IL (2) IL150010A0 (de)
MX (1) MXPA02005802A (de)
MY (1) MY129892A (de)
NO (1) NO323263B1 (de)
PL (1) PL356713A1 (de)
PT (1) PT1237886E (de)
TN (1) TNSN00240A1 (de)
TR (1) TR200201503T2 (de)
TW (1) TW524804B (de)
WO (1) WO2001042238A1 (de)
ZA (1) ZA200204492B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1619190B1 (de) * 2003-04-25 2010-12-29 Nippon Chemiphar Co., Ltd. Salze von (2s,3s)-3- [[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl] oxirane-2-carbonsäure
GB0327912D0 (en) * 2003-12-02 2004-01-07 Glaxo Group Ltd Medicament
US7576216B2 (en) * 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
LT3056492T (lt) * 2004-10-08 2022-01-25 Abbvie Inc. Meglumino druska ir atitinkamos vaisto (delafloksacino) kristalinės formos
EP2286800A1 (de) * 2005-04-11 2011-02-23 Abbott Laboratories Pharmazeutische Zubereitungen mit verbesserter Löslichkeit für schwerlösliche Wirkstoffe
BR112014009910B1 (pt) * 2011-10-25 2020-06-30 Janssen Pharmaceutica N.V. sal di-hidrato de meglumina de ácido 1-(5,6-dicloro-1h-benzo[d]imidazol-2-il)-1h-pirazol-4-carboxílico, composição farmacêuticae pomada tópica

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231102A (en) 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
US5529999A (en) 1994-03-04 1996-06-25 Eli Lilly And Company Antitumor compositions and methods of treatment
US6413959B1 (en) * 1995-04-14 2002-07-02 Boehringer Ingelheim Kg Method of treating depression with arylglycinamide derivatives
TR199800531T1 (xx) 1995-09-29 1998-06-22 Glaxo Wellcome Spa NMDA antagonistleri olarak tetrahidrokinolinler.
GB9617305D0 (en) 1996-08-17 1996-09-25 Glaxo Wellcome Spa Heterocyclic compounds
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives

Also Published As

Publication number Publication date
AU2006001A (en) 2001-06-18
DE60027461T2 (de) 2006-09-28
CA2393303C (en) 2009-10-20
CN1407980A (zh) 2003-04-02
US20030008899A1 (en) 2003-01-09
DK1237886T3 (da) 2006-08-14
EP1237886A1 (de) 2002-09-11
KR100788579B1 (ko) 2007-12-26
HUP0203650A2 (hu) 2003-03-28
NO20022682D0 (no) 2002-06-06
CZ20021981A3 (cs) 2003-01-15
NO20022682L (no) 2002-07-17
KR20020086854A (ko) 2002-11-20
TNSN00240A1 (en) 2002-05-30
HUP0203650A3 (en) 2004-01-28
TW524804B (en) 2003-03-21
JP4311901B2 (ja) 2009-08-12
CN1325488C (zh) 2007-07-11
ES2257343T3 (es) 2006-08-01
PL356713A1 (en) 2004-06-28
JP2003516403A (ja) 2003-05-13
IL150010A0 (en) 2002-12-01
IL150010A (en) 2009-09-01
CO5251474A1 (es) 2003-02-28
GB9929037D0 (en) 2000-02-02
US6943176B2 (en) 2005-09-13
TR200201503T2 (tr) 2002-10-21
AR030923A1 (es) 2003-09-03
HK1047436A1 (en) 2003-02-21
AU769232B2 (en) 2004-01-22
US20040162313A1 (en) 2004-08-19
WO2001042238A1 (en) 2001-06-14
HK1047436B (zh) 2006-07-21
PT1237886E (pt) 2006-07-31
CZ301052B6 (cs) 2009-10-21
EP1237886B1 (de) 2006-04-19
ZA200204492B (en) 2004-06-30
CY1106105T1 (el) 2011-06-08
US6713491B2 (en) 2004-03-30
MXPA02005802A (es) 2004-08-12
CA2393303A1 (en) 2001-06-14
BR0016235A (pt) 2002-08-27
ATE323691T1 (de) 2006-05-15
MY129892A (en) 2007-05-31
DE60027461D1 (de) 2006-05-24

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