NO322891B1 - Farmasoytisk sammensetning innbefattende et enterisk belagt mycofenolatsalt samt anvendelse av samme for fremstilling av medikament. - Google Patents
Farmasoytisk sammensetning innbefattende et enterisk belagt mycofenolatsalt samt anvendelse av samme for fremstilling av medikament. Download PDFInfo
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- NO322891B1 NO322891B1 NO19984728A NO984728A NO322891B1 NO 322891 B1 NO322891 B1 NO 322891B1 NO 19984728 A NO19984728 A NO 19984728A NO 984728 A NO984728 A NO 984728A NO 322891 B1 NO322891 B1 NO 322891B1
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- composition according
- salt
- composition
- enteric coated
- pharmaceutically acceptable
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Classifications
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- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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GBGB9607564.3A GB9607564D0 (en) | 1996-04-12 | 1996-04-12 | Organic compounds |
GBGB9622028.0A GB9622028D0 (en) | 1996-10-24 | 1996-10-24 | Organic compounds |
PCT/EP1997/001800 WO1997038689A2 (en) | 1996-04-12 | 1997-04-10 | Enteric-coated pharmaceutical compositions of mycophenolate |
Publications (3)
Publication Number | Publication Date |
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NO984728D0 NO984728D0 (no) | 1998-10-09 |
NO984728L NO984728L (no) | 1998-12-02 |
NO322891B1 true NO322891B1 (no) | 2006-12-18 |
Family
ID=26309105
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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NO19984728A NO322891B1 (no) | 1996-04-12 | 1998-10-09 | Farmasoytisk sammensetning innbefattende et enterisk belagt mycofenolatsalt samt anvendelse av samme for fremstilling av medikament. |
NO2007004C NO2007004I2 (no) | 1996-04-12 | 2007-03-26 | Farmasoytisk akseptabelt salt av mykofenolsyre |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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NO2007004C NO2007004I2 (no) | 1996-04-12 | 2007-03-26 | Farmasoytisk akseptabelt salt av mykofenolsyre |
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US (3) | US6025391A (tr) |
EP (2) | EP1221316A1 (tr) |
JP (2) | JP3779732B2 (tr) |
CN (1) | CN1104238C (tr) |
AR (2) | AR006583A1 (tr) |
AT (2) | ATE259228T1 (tr) |
AU (1) | AU725388B2 (tr) |
BE (1) | BE1010963A3 (tr) |
BR (1) | BR9708624A (tr) |
CO (1) | CO4900024A1 (tr) |
CY (1) | CY2243B1 (tr) |
CZ (1) | CZ291811B6 (tr) |
DE (4) | DE69727559T2 (tr) |
DK (1) | DK0892640T3 (tr) |
ES (2) | ES2178510B1 (tr) |
FR (1) | FR2747920B1 (tr) |
GB (1) | GB2326339B (tr) |
GR (1) | GR1002893B (tr) |
HK (2) | HK1016490A1 (tr) |
HU (1) | HU224919B1 (tr) |
ID (1) | ID18663A (tr) |
IE (1) | IE970267A1 (tr) |
IL (1) | IL126431A (tr) |
IT (1) | IT1297045B1 (tr) |
LU (1) | LU91094I2 (tr) |
MY (1) | MY119049A (tr) |
NL (1) | NL300157I2 (tr) |
NO (2) | NO322891B1 (tr) |
NZ (1) | NZ332117A (tr) |
PT (1) | PT892640E (tr) |
RU (2) | RU2615397C2 (tr) |
TR (1) | TR199802056T2 (tr) |
TW (1) | TW457098B (tr) |
WO (1) | WO1997038689A2 (tr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60044717D1 (de) * | 1999-05-10 | 2010-09-02 | Paolo Brenner | Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen |
US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
GB0124953D0 (en) * | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
BR0213661A (pt) * | 2001-10-19 | 2004-10-26 | Isotechnika Inc | Pré-concentrado de microemulsão e método para seu preparo, formulação farmacêutica e método para seu preparo, método para produzir imuno, supressão, método para aumentar os efeitos imuno supressores de isatx247, uso de formulação farmacêutica |
GB0301259D0 (en) | 2003-01-20 | 2003-02-19 | Novartis Ag | Organic compounds |
GB0314553D0 (en) * | 2003-06-21 | 2003-07-30 | Weatherford Lamb | Electric submersible pumps |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
AR045957A1 (es) * | 2003-10-03 | 2005-11-16 | Novartis Ag | Composicion farmaceutica y combinacion |
PT1729797E (pt) * | 2004-03-22 | 2008-12-17 | Solvay Pharm Gmbh | Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos |
TW200613294A (en) | 2004-04-26 | 2006-05-01 | Teva Gyogyszergyar Reszvenytarsasag | Process for preparation of mycophenolic acid and ester derivatives thereof |
US20050250773A1 (en) | 2004-04-27 | 2005-11-10 | Sandor Molnar | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
WO2006012385A2 (en) | 2004-07-20 | 2006-02-02 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Crystalline mycophenolate sodium |
GB0419355D0 (en) * | 2004-08-31 | 2004-09-29 | Novartis Ag | Organic compounds |
US20060235070A1 (en) * | 2005-02-08 | 2006-10-19 | Hayden Michael R | Compositions and methods for treating vascular, autoimmune, and inflammatory diseases |
US20060235009A1 (en) | 2005-02-08 | 2006-10-19 | Richard Glickman | Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors |
BRPI0614914A2 (pt) * | 2005-07-29 | 2011-04-19 | Solvay Pharm Gmbh | processos para a fabricação de pó de pancreatina esterilizada |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US9198871B2 (en) * | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
CN1985994B (zh) * | 2005-12-19 | 2011-01-12 | 康泰乐(北京)医药科技发展有限公司 | 改进的包含霉酚酸盐的包有肠溶衣的药物组合物 |
CN101378749A (zh) * | 2006-02-13 | 2009-03-04 | 诺瓦提斯公司 | 高剂量的麦考酚酸(mpa) |
JP2007230948A (ja) * | 2006-03-02 | 2007-09-13 | Univ Meijo | 腸溶性化硬カプセル |
US10072256B2 (en) * | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
SI2032712T1 (sl) * | 2006-06-29 | 2010-06-30 | Ivax Pharmaceuticals Sro | Regulacija proizvodnje kislinskega metabolita |
US20080176937A1 (en) * | 2007-01-23 | 2008-07-24 | Apotex Fermentation Inc. | Novel crystalline mycophenolate sodium polymorph and processes to manufacture same |
US20080182998A1 (en) * | 2007-01-25 | 2008-07-31 | Apotex Fermentation Inc. | Novel crystalline mycophenolate sodium polymorph and processes to manufacture same |
EP2024506A1 (en) * | 2007-04-11 | 2009-02-18 | Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság | Method for reducing impurity level in mycophenolic acid fermentation |
WO2009022355A1 (en) * | 2007-08-13 | 2009-02-19 | Panacea Biotec Limited | Extended release compositions comprising mycophenolate sodium and processes thereof |
US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
JP2011527339A (ja) * | 2008-07-09 | 2011-10-27 | アスプレバ インターナショナル リミテッド | 眼障害を処置するためのミコフェノール酸ナトリウムのpH特異的な溶液 |
WO2011046546A1 (en) * | 2009-10-13 | 2011-04-21 | Teva Pharmaceutical Industries Ltd. | Delayed release compositions |
US20110086102A1 (en) * | 2009-10-13 | 2011-04-14 | Teva Pharmaceutical Industries Ltd. | Delayed release compositions |
WO2011051967A2 (en) * | 2009-10-23 | 2011-05-05 | Alkem Laboratories Ltd | Pharmaceutical compositions comprising mycophenolate and processes for preparing thereof |
CN103880799A (zh) * | 2010-11-16 | 2014-06-25 | 北京京卫信康医药科技发展有限公司 | 麦考酚酸钠的新晶型及其制备方法 |
CN103880800A (zh) * | 2010-11-16 | 2014-06-25 | 北京京卫信康医药科技发展有限公司 | 麦考酚酸钠的新晶型及其制备方法 |
GB201100786D0 (en) | 2011-01-18 | 2011-03-02 | Ems Sa | Pharmaceutical compositions of immunosuppressants |
WO2013041205A1 (de) | 2011-09-19 | 2013-03-28 | Pyxirion Pharma Gmbh | Neue therapeutische konzepte zur behandlung von gefässerkrankungen |
NZ631337A (en) | 2013-03-14 | 2017-01-27 | Alkermes Pharma Ireland Ltd | Prodrugs of fumarates and their use in treating various diseases |
US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
WO2014167442A1 (en) | 2013-03-26 | 2014-10-16 | Wockhardt Limited | Pharmaceutical compositions comprising mycophenolic acid or salts thereof |
EP3091974B1 (en) * | 2014-01-06 | 2020-04-01 | Shield TX (UK) Limited | Dosage regimen of ferric trimaltol |
CA2940845C (en) | 2014-02-24 | 2019-09-24 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
GB201418710D0 (en) | 2014-10-21 | 2014-12-03 | Iron Therapeutics Holdings Ag | Dosage regimen |
US10213411B2 (en) | 2015-08-27 | 2019-02-26 | Vijaykumar Rajasekhar | Use of prodrugs of fumarates in treating heart failure diseases |
US10463642B2 (en) | 2016-02-01 | 2019-11-05 | Vijaykumar Rajasekhar | Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate |
KR20190131036A (ko) | 2017-03-13 | 2019-11-25 | 오카바 파마슈티컬즈 인코포레이티드 | 비-사람 포유동물에게 마이코페놀산 활성제를 전달하기 위한 방법 및 조성물 |
CN117177749A (zh) | 2021-03-03 | 2023-12-05 | 萨那生物科技公司 | 与心肌细胞疗法一起使用的免疫抑制疗法以及相关的方法和组合物 |
CN114028334B (zh) * | 2021-12-10 | 2023-08-29 | 卓和药业集团股份有限公司 | 一种肺部给药的免疫抑制剂的制备方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1157099A (en) * | 1966-09-27 | 1969-07-02 | Ici Ltd | Fermentation Process |
GB1157100A (en) * | 1966-09-27 | 1969-07-02 | Ici Ltd | Pharmaceutical Compositions |
GB1173942A (en) * | 1967-06-06 | 1969-12-10 | Bellon Labor Sa Roger | New 2,3-Dihydro-1,4-Benzoxazines |
GB1158387A (en) * | 1967-06-13 | 1969-07-16 | Ici Ltd | Procedure for Isolation of Mycophenolic Acid |
GB1203328A (en) * | 1968-06-04 | 1970-08-26 | Ici Ltd | Pharmaceutical compositions |
GB1261060A (en) * | 1969-09-09 | 1972-01-19 | Ici Ltd | Phthalen-1-one derivatives |
US3705946A (en) * | 1971-05-25 | 1972-12-12 | Lilly Co Eli | Method of treating hyperuricemia |
JPS5542995B2 (tr) * | 1972-02-24 | 1980-11-04 | ||
US3825571A (en) * | 1971-07-31 | 1974-07-23 | Chugai Pharmaceutical Co Ltd | Mycophenolic acid derivatives |
US3777020A (en) * | 1972-08-14 | 1973-12-04 | Lilly Co Eli | Psoriasis treatment with mycophenolic acid |
US3868454A (en) * | 1972-08-14 | 1975-02-25 | Lilly Co Eli | Psoriasis treatment with mycophenolic acid derivatives |
US4005108A (en) * | 1973-04-03 | 1977-01-25 | Research Corporation | Novel anti-leukemic diterpenoid triepoxides |
US3880995A (en) * | 1973-05-14 | 1975-04-29 | Lilly Co Eli | Treatment of arthritis with mycophenolic acid and derivatives |
US3903071A (en) * | 1973-05-22 | 1975-09-02 | Lilly Co Eli | Mycophenolic acid derivatives |
JPS517116A (en) * | 1974-06-11 | 1976-01-21 | Shinetsu Chemical Co | Choyoseihifukuyakuzaino seizohoho |
US4234684A (en) * | 1979-12-11 | 1980-11-18 | Eli Lilly And Company | Method of preparing mycophenolic acid glucoside |
IT1150194B (it) * | 1982-02-23 | 1986-12-10 | Chiesi Farma Spa | Formulazioni farmaceutiche ad attivita'antiinfiammatoria, analgesica,antipiretica e gastroprotettiva |
US4680299A (en) * | 1984-04-30 | 1987-07-14 | E.I. Du Pont De Nemours And Company | 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof |
US4686234A (en) * | 1985-11-27 | 1987-08-11 | Syntex (U.S.A) Inc. | Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis |
US4725622A (en) * | 1986-01-23 | 1988-02-16 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
US4959387A (en) * | 1986-01-23 | 1990-09-25 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
US4727069A (en) * | 1987-01-30 | 1988-02-23 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions |
US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
US4847381A (en) * | 1987-08-31 | 1989-07-11 | American Cyanamid Company | 2-Phenyl-4-quinoline carboxylic acids |
US5135934A (en) * | 1990-07-06 | 1992-08-04 | Du Pont Merck Pharmaceutical Company | 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents |
US5372298A (en) * | 1992-01-07 | 1994-12-13 | The Regents Of The University Of California | Transient liquid phase ceramic bonding |
CA2086642C (en) * | 1992-01-09 | 2004-06-15 | Randall E. Morris | Method of treating hyperproliferative vascular disease |
US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
US5283257A (en) * | 1992-07-10 | 1994-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Method of treating hyperproliferative vascular disease |
AU6826194A (en) * | 1993-05-06 | 1994-12-12 | Pharmagenesis, Inc. | 16-hydroxytriptolide composition and method for immunotherapy |
US5455045A (en) * | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
SG55007A1 (en) * | 1993-10-01 | 1998-12-21 | Syntrex U S A Inc | Mycophenolate mofetil high dose oral suspensions |
WO1995013082A1 (en) * | 1993-11-08 | 1995-05-18 | Pharmagenesis, Inc. | Immunotherapy composition and method |
CA2175215C (en) * | 1993-11-19 | 2008-06-03 | Yat Sun Or | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
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1997
- 1997-04-01 ID IDP971201A patent/ID18663A/id unknown
- 1997-04-08 BE BE9700319A patent/BE1010963A3/fr not_active IP Right Cessation
- 1997-04-10 DE DE69727559T patent/DE69727559T2/de not_active Expired - Lifetime
- 1997-04-10 EP EP02001803A patent/EP1221316A1/en not_active Withdrawn
- 1997-04-10 GB GB9821304A patent/GB2326339B/en not_active Expired - Lifetime
- 1997-04-10 PT PT97919330T patent/PT892640E/pt unknown
- 1997-04-10 AT AT97919330T patent/ATE259228T1/de active
- 1997-04-10 RU RU0098120360A patent/RU2615397C2/ru active
- 1997-04-10 IL IL12643197A patent/IL126431A/xx active Protection Beyond IP Right Term
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- 1997-04-10 JP JP53672597A patent/JP3779732B2/ja not_active Expired - Lifetime
- 1997-04-10 DE DE19781690T patent/DE19781690D2/de not_active Expired - Lifetime
- 1997-04-10 AT AT0905997A patent/AT408415B/de not_active IP Right Cessation
- 1997-04-10 DE DE1997627559 patent/DE122004000038I2/de active Active
- 1997-04-10 MY MYPI97001573A patent/MY119049A/en unknown
- 1997-04-10 RU RU98120360/14A patent/RU2203659C2/ru active
- 1997-04-10 AR ARP970101419A patent/AR006583A1/es active IP Right Grant
- 1997-04-10 GR GR970100135A patent/GR1002893B/el not_active IP Right Cessation
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- 1997-04-10 CN CN97193760A patent/CN1104238C/zh not_active Expired - Lifetime
- 1997-04-10 DE DE200412000038 patent/DE122004000038I1/de active Pending
- 1997-04-10 ES ES009850018A patent/ES2178510B1/es not_active Expired - Fee Related
- 1997-04-10 IE IE970267A patent/IE970267A1/en not_active IP Right Cessation
- 1997-04-10 AU AU23843/97A patent/AU725388B2/en not_active Expired
- 1997-04-10 CO CO97018556A patent/CO4900024A1/es unknown
- 1997-04-10 CZ CZ19983267A patent/CZ291811B6/cs not_active IP Right Cessation
- 1997-04-10 ES ES97919330T patent/ES2216141T3/es not_active Expired - Lifetime
- 1997-04-10 TR TR1998/02056T patent/TR199802056T2/tr unknown
- 1997-04-10 US US09/077,398 patent/US6025391A/en not_active Expired - Lifetime
- 1997-04-10 NZ NZ332117A patent/NZ332117A/xx not_active IP Right Cessation
- 1997-04-10 EP EP97919330A patent/EP0892640B1/en not_active Expired - Lifetime
- 1997-04-10 HU HU9903373A patent/HU224919B1/hu active Protection Beyond IP Right Term
- 1997-04-10 WO PCT/EP1997/001800 patent/WO1997038689A2/en active IP Right Grant
- 1997-04-11 FR FR9704496A patent/FR2747920B1/fr not_active Expired - Lifetime
- 1997-04-11 IT IT97RM000207A patent/IT1297045B1/it active IP Right Grant
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1998
- 1998-10-09 NO NO19984728A patent/NO322891B1/no not_active IP Right Cessation
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1999
- 1999-04-13 HK HK99101579A patent/HK1016490A1/xx not_active IP Right Cessation
- 1999-04-13 HK HK03100274.4A patent/HK1051484A1/zh unknown
- 1999-12-22 US US09/469,536 patent/US6172107B1/en not_active Expired - Lifetime
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2000
- 2000-10-23 US US09/694,209 patent/US6306900B1/en not_active Expired - Lifetime
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2001
- 2001-10-12 CY CY0100032A patent/CY2243B1/xx unknown
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2004
- 2004-08-05 NL NL300157C patent/NL300157I2/nl unknown
- 2004-08-11 LU LU91094C patent/LU91094I2/fr unknown
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2005
- 2005-11-09 JP JP2005325141A patent/JP2006063086A/ja active Pending
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2007
- 2007-03-01 AR ARP070100839A patent/AR059693A2/es not_active Application Discontinuation
- 2007-03-26 NO NO2007004C patent/NO2007004I2/no unknown
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Free format text: PRODUCT NAME: MYFORTIC; NAT. REG. NO/DATE: 03-2258 OG 03-2259 20040319; FIRST REG. NO/DATE: LI , 5611501/02 20021024 Spc suppl protection certif: 2007004 Filing date: 20070326 Extension date: 20171024 |
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MK1K | Patent expired | ||
SPCX | Expiry of an spc |
Spc suppl protection certif: 2007004 Effective date: 20171024 |