NO322808B1 - Pyrimidin derivater, samt anvendelse derav og farmasoytisk preparat. - Google Patents
Pyrimidin derivater, samt anvendelse derav og farmasoytisk preparat. Download PDFInfo
- Publication number
- NO322808B1 NO322808B1 NO20021728A NO20021728A NO322808B1 NO 322808 B1 NO322808 B1 NO 322808B1 NO 20021728 A NO20021728 A NO 20021728A NO 20021728 A NO20021728 A NO 20021728A NO 322808 B1 NO322808 B1 NO 322808B1
- Authority
- NO
- Norway
- Prior art keywords
- pyrrolidin
- group
- methyl
- formula
- substituent
- Prior art date
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- 150000003230 pyrimidines Chemical class 0.000 title claims abstract description 30
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract description 41
- 150000002148 esters Chemical class 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 37
- 238000001727 in vivo Methods 0.000 claims abstract description 31
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 28
- 102000004127 Cytokines Human genes 0.000 claims abstract description 20
- 108090000695 Cytokines Proteins 0.000 claims abstract description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 16
- 201000010099 disease Diseases 0.000 claims abstract description 14
- 125000005843 halogen group Chemical group 0.000 claims abstract description 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 9
- 239000001257 hydrogen Substances 0.000 claims abstract description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 7
- 238000011282 treatment Methods 0.000 claims abstract description 6
- 230000001404 mediated effect Effects 0.000 claims abstract description 3
- -1 chloro, bromo, amino, carbamoyl Chemical group 0.000 claims description 269
- 150000001875 compounds Chemical class 0.000 claims description 98
- 125000001424 substituent group Chemical group 0.000 claims description 59
- 238000006243 chemical reaction Methods 0.000 claims description 33
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 29
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 28
- 125000003282 alkyl amino group Chemical group 0.000 claims description 24
- 125000003545 alkoxy group Chemical group 0.000 claims description 22
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 20
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 16
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 14
- 239000000460 chlorine Substances 0.000 claims description 14
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 13
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 10
- 229910052731 fluorine Inorganic materials 0.000 claims description 10
- 239000011737 fluorine Substances 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 8
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 8
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- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 6
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- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims description 6
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 5
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
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- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
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- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
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Classifications
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9924092.1A GB9924092D0 (en) | 1999-10-13 | 1999-10-13 | Pyrimidine derivatives |
PCT/GB2000/003929 WO2001027089A1 (fr) | 1999-10-13 | 2000-10-10 | Derives de pyrimidine |
Publications (3)
Publication Number | Publication Date |
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NO20021728D0 NO20021728D0 (no) | 2002-04-12 |
NO20021728L NO20021728L (no) | 2002-06-12 |
NO322808B1 true NO322808B1 (no) | 2006-12-11 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20021728A NO322808B1 (no) | 1999-10-13 | 2002-04-12 | Pyrimidin derivater, samt anvendelse derav og farmasoytisk preparat. |
Country Status (18)
Country | Link |
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US (1) | US6846827B1 (fr) |
EP (1) | EP1226126B1 (fr) |
JP (1) | JP2003511442A (fr) |
KR (1) | KR100738862B1 (fr) |
CN (1) | CN100415724C (fr) |
AT (1) | ATE286501T1 (fr) |
AU (1) | AU772293B2 (fr) |
BR (1) | BR0014596A (fr) |
CA (1) | CA2382605A1 (fr) |
DE (1) | DE60017279T2 (fr) |
GB (1) | GB9924092D0 (fr) |
HK (1) | HK1045511B (fr) |
IL (2) | IL148428A0 (fr) |
MX (1) | MXPA02003533A (fr) |
NO (1) | NO322808B1 (fr) |
NZ (1) | NZ517572A (fr) |
WO (1) | WO2001027089A1 (fr) |
ZA (1) | ZA200201557B (fr) |
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WO2000012486A1 (fr) | 1998-08-29 | 2000-03-09 | Astrazeneca Ab | Composes pyrimidiniques |
SK285520B6 (sk) | 1998-09-25 | 2007-03-01 | Astrazeneca Ab | Amidové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie na prípravu liečiva na liečbu stavov sprostredkovaných cytokínmi |
EP1117653B1 (fr) * | 1998-10-01 | 2003-02-05 | AstraZeneca AB | Derives quinoline et quinazoline et leur utilisation comme inhibiteurs de maladies dans lesquelles la cytokine intervient |
DE60022328T2 (de) | 1999-03-17 | 2006-06-01 | Astrazeneca Ab | Amid-derivate |
PL200804B1 (pl) | 1999-03-17 | 2009-02-27 | Astrazeneca Ab | Pochodne amidowe, sposoby ich wytwarzania, ich kompozycje farmaceutyczne oraz ich zastosowanie |
GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
-
1999
- 1999-10-13 GB GBGB9924092.1A patent/GB9924092D0/en not_active Ceased
-
2000
- 2000-10-10 CA CA002382605A patent/CA2382605A1/fr not_active Abandoned
- 2000-10-10 AU AU78042/00A patent/AU772293B2/en not_active Ceased
- 2000-10-10 BR BR0014596-3A patent/BR0014596A/pt not_active Application Discontinuation
- 2000-10-10 AT AT00968084T patent/ATE286501T1/de not_active IP Right Cessation
- 2000-10-10 KR KR1020027004779A patent/KR100738862B1/ko not_active IP Right Cessation
- 2000-10-10 DE DE60017279T patent/DE60017279T2/de not_active Expired - Fee Related
- 2000-10-10 EP EP00968084A patent/EP1226126B1/fr not_active Expired - Lifetime
- 2000-10-10 WO PCT/GB2000/003929 patent/WO2001027089A1/fr active IP Right Grant
- 2000-10-10 JP JP2001530109A patent/JP2003511442A/ja active Pending
- 2000-10-10 IL IL14842800A patent/IL148428A0/xx active IP Right Grant
- 2000-10-10 MX MXPA02003533A patent/MXPA02003533A/es active IP Right Grant
- 2000-10-10 NZ NZ517572A patent/NZ517572A/en unknown
- 2000-10-10 CN CNB008141452A patent/CN100415724C/zh not_active Expired - Fee Related
- 2000-10-10 US US10/070,360 patent/US6846827B1/en not_active Expired - Fee Related
-
2002
- 2002-02-25 ZA ZA200201557A patent/ZA200201557B/en unknown
- 2002-02-27 IL IL148428A patent/IL148428A/en not_active IP Right Cessation
- 2002-04-12 NO NO20021728A patent/NO322808B1/no not_active IP Right Cessation
- 2002-09-25 HK HK02107003.8A patent/HK1045511B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2382605A1 (fr) | 2001-04-19 |
DE60017279D1 (en) | 2005-02-10 |
MXPA02003533A (es) | 2002-08-20 |
HK1045511B (zh) | 2005-06-03 |
IL148428A0 (en) | 2002-09-12 |
EP1226126B1 (fr) | 2005-01-05 |
HK1045511A1 (en) | 2002-11-29 |
DE60017279T2 (de) | 2005-12-08 |
NO20021728D0 (no) | 2002-04-12 |
ZA200201557B (en) | 2003-07-30 |
WO2001027089A1 (fr) | 2001-04-19 |
CN1378537A (zh) | 2002-11-06 |
CN100415724C (zh) | 2008-09-03 |
KR100738862B1 (ko) | 2007-07-13 |
EP1226126A1 (fr) | 2002-07-31 |
ATE286501T1 (de) | 2005-01-15 |
NZ517572A (en) | 2003-11-28 |
JP2003511442A (ja) | 2003-03-25 |
US6846827B1 (en) | 2005-01-25 |
BR0014596A (pt) | 2002-06-11 |
AU772293B2 (en) | 2004-04-22 |
NO20021728L (no) | 2002-06-12 |
KR20020091830A (ko) | 2002-12-06 |
AU7804200A (en) | 2001-04-23 |
IL148428A (en) | 2006-12-10 |
GB9924092D0 (en) | 1999-12-15 |
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