NO322633B1 - Fremgangsmate og system til inaktivering av mikroorganismer ved a bruke foto-sensitiviserende stoffer, samt anordning for separering av fullblod i blodkomponenter. - Google Patents
Fremgangsmate og system til inaktivering av mikroorganismer ved a bruke foto-sensitiviserende stoffer, samt anordning for separering av fullblod i blodkomponenter. Download PDFInfo
- Publication number
- NO322633B1 NO322633B1 NO20001440A NO20001440A NO322633B1 NO 322633 B1 NO322633 B1 NO 322633B1 NO 20001440 A NO20001440 A NO 20001440A NO 20001440 A NO20001440 A NO 20001440A NO 322633 B1 NO322633 B1 NO 322633B1
- Authority
- NO
- Norway
- Prior art keywords
- liquid
- light
- blood
- substance
- photosensitizing
- Prior art date
Links
- 239000003504 photosensitizing agent Substances 0.000 title claims description 102
- 210000004369 blood Anatomy 0.000 title claims description 78
- 239000008280 blood Substances 0.000 title claims description 78
- 238000000034 method Methods 0.000 title claims description 47
- 244000005700 microbiome Species 0.000 title claims description 46
- 239000012503 blood component Substances 0.000 title claims description 42
- 230000000415 inactivating effect Effects 0.000 title claims description 4
- 239000007788 liquid Substances 0.000 claims description 119
- 239000000126 substance Substances 0.000 claims description 90
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 84
- 239000002151 riboflavin Substances 0.000 claims description 69
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 68
- 235000019192 riboflavin Nutrition 0.000 claims description 68
- 230000002779 inactivation Effects 0.000 claims description 57
- HAUGRYOERYOXHX-UHFFFAOYSA-N Alloxazine Chemical compound C1=CC=C2N=C(C(=O)NC(=O)N3)C3=NC2=C1 HAUGRYOERYOXHX-UHFFFAOYSA-N 0.000 claims description 49
- 230000002165 photosensitisation Effects 0.000 claims description 42
- 239000000463 material Substances 0.000 claims description 25
- 102000004169 proteins and genes Human genes 0.000 claims description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 24
- 241000700605 Viruses Species 0.000 claims description 23
- 239000000306 component Substances 0.000 claims description 23
- 239000003146 anticoagulant agent Substances 0.000 claims description 19
- 229940127219 anticoagulant drug Drugs 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 19
- 239000012530 fluid Substances 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 230000001235 sensitizing effect Effects 0.000 claims description 14
- KPDQZGKJTJRBGU-UHFFFAOYSA-N lumiflavin Chemical compound CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O KPDQZGKJTJRBGU-UHFFFAOYSA-N 0.000 claims description 10
- ZJTJUVIJVLLGSP-UHFFFAOYSA-N lumichrome Chemical compound N1C(=O)NC(=O)C2=C1N=C1C=C(C)C(C)=CC1=N2 ZJTJUVIJVLLGSP-UHFFFAOYSA-N 0.000 claims description 9
- 241000191963 Staphylococcus epidermidis Species 0.000 claims description 8
- 230000035515 penetration Effects 0.000 claims description 8
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 claims description 6
- 231100000252 nontoxic Toxicity 0.000 claims description 6
- 230000003000 nontoxic effect Effects 0.000 claims description 6
- 241001515965 unidentified phage Species 0.000 claims description 6
- 241000282414 Homo sapiens Species 0.000 claims description 5
- 241000700618 Vaccinia virus Species 0.000 claims description 5
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 5
- 230000004913 activation Effects 0.000 claims description 4
- 241000186779 Listeria monocytogenes Species 0.000 claims description 3
- 241000700584 Simplexvirus Species 0.000 claims description 3
- 238000002211 ultraviolet spectrum Methods 0.000 claims description 3
- 238000001429 visible spectrum Methods 0.000 claims description 3
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 2
- 241000701022 Cytomegalovirus Species 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims description 2
- 208000008771 Lymphadenopathy Diseases 0.000 claims description 2
- 241000125945 Protoparvovirus Species 0.000 claims description 2
- 241000607715 Serratia marcescens Species 0.000 claims description 2
- 241000711975 Vesicular stomatitis virus Species 0.000 claims description 2
- 229960005305 adenosine Drugs 0.000 claims description 2
- 208000006454 hepatitis Diseases 0.000 claims description 2
- 231100000283 hepatitis Toxicity 0.000 claims description 2
- 208000018555 lymphatic system disease Diseases 0.000 claims description 2
- 241001430294 unidentified retrovirus Species 0.000 claims description 2
- 230000003187 abdominal effect Effects 0.000 claims 4
- 241000710960 Sindbis virus Species 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000001772 blood platelet Anatomy 0.000 description 58
- 239000000523 sample Substances 0.000 description 44
- 210000003743 erythrocyte Anatomy 0.000 description 35
- 238000000746 purification Methods 0.000 description 34
- 210000002381 plasma Anatomy 0.000 description 33
- 239000000243 solution Substances 0.000 description 33
- 239000002609 medium Substances 0.000 description 29
- 239000003634 thrombocyte concentrate Substances 0.000 description 26
- 239000010836 blood and blood product Substances 0.000 description 24
- 210000004027 cell Anatomy 0.000 description 24
- 229940125691 blood product Drugs 0.000 description 23
- 230000005855 radiation Effects 0.000 description 21
- 235000018102 proteins Nutrition 0.000 description 20
- 238000002835 absorbance Methods 0.000 description 18
- 229940090993 isolyte s Drugs 0.000 description 18
- GRPSNTXTTSBKGW-BVGHQBMWSA-J magnesium;potassium;sodium;(3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol;triacetate;chloride Chemical compound [Na+].[Mg+2].[Cl-].[K+].CC([O-])=O.CC([O-])=O.CC([O-])=O.OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O GRPSNTXTTSBKGW-BVGHQBMWSA-J 0.000 description 18
- 230000006870 function Effects 0.000 description 17
- 230000000694 effects Effects 0.000 description 16
- 239000000654 additive Substances 0.000 description 15
- 238000004140 cleaning Methods 0.000 description 15
- 238000005534 hematocrit Methods 0.000 description 15
- 108020004414 DNA Proteins 0.000 description 14
- 102000053602 DNA Human genes 0.000 description 14
- 230000000996 additive effect Effects 0.000 description 13
- 238000012545 processing Methods 0.000 description 13
- 229960002477 riboflavin Drugs 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 12
- 230000006378 damage Effects 0.000 description 12
- 102000039446 nucleic acids Human genes 0.000 description 11
- 108020004707 nucleic acids Proteins 0.000 description 11
- 150000007523 nucleic acids Chemical class 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 10
- 238000002617 apheresis Methods 0.000 description 10
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 10
- 238000001228 spectrum Methods 0.000 description 10
- 238000003860 storage Methods 0.000 description 10
- 230000004071 biological effect Effects 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 230000004907 flux Effects 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- -1 oxygen radicals Chemical class 0.000 description 8
- 238000000926 separation method Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 229940072107 ascorbate Drugs 0.000 description 6
- 235000010323 ascorbic acid Nutrition 0.000 description 6
- 239000011668 ascorbic acid Substances 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 5
- 230000008033 biological extinction Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000000356 contaminant Substances 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 239000008188 pellet Substances 0.000 description 5
- 239000004417 polycarbonate Substances 0.000 description 5
- 229920000515 polycarbonate Polymers 0.000 description 5
- 239000011550 stock solution Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- WDVSHHCDHLJJJR-UHFFFAOYSA-N Proflavine Chemical compound C1=CC(N)=CC2=NC3=CC(N)=CC=C3C=C21 WDVSHHCDHLJJJR-UHFFFAOYSA-N 0.000 description 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 239000003623 enhancer Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000002452 interceptive effect Effects 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 150000004032 porphyrins Chemical class 0.000 description 4
- 229960000286 proflavine Drugs 0.000 description 4
- 150000003718 vitamin K5 derivatives Chemical class 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 108010035766 P-Selectin Proteins 0.000 description 3
- 102100023472 P-selectin Human genes 0.000 description 3
- 102000013566 Plasminogen Human genes 0.000 description 3
- 108010051456 Plasminogen Proteins 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 230000000886 photobiology Effects 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 235000004252 protein component Nutrition 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 2
- IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 description 2
- 229930024421 Adenine Natural products 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
- 108090000935 Antithrombin III Proteins 0.000 description 2
- 102000004411 Antithrombin III Human genes 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 102100037904 CD9 antigen Human genes 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 108010054218 Factor VIII Proteins 0.000 description 2
- 102000001690 Factor VIII Human genes 0.000 description 2
- 102100037362 Fibronectin Human genes 0.000 description 2
- 108010067306 Fibronectins Proteins 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 102100027378 Prothrombin Human genes 0.000 description 2
- 108010094028 Prothrombin Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229960000643 adenine Drugs 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 229960005348 antithrombin iii Drugs 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000005281 excited state Effects 0.000 description 2
- 229960000301 factor viii Drugs 0.000 description 2
- VEPSWGHMGZQCIN-UHFFFAOYSA-H ferric oxalate Chemical compound [Fe+3].[Fe+3].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O VEPSWGHMGZQCIN-UHFFFAOYSA-H 0.000 description 2
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 description 2
- 235000019162 flavin adenine dinucleotide Nutrition 0.000 description 2
- 239000011714 flavin adenine dinucleotide Substances 0.000 description 2
- 229940013640 flavin mononucleotide Drugs 0.000 description 2
- 239000011768 flavin mononucleotide Substances 0.000 description 2
- FVTCRASFADXXNN-UHFFFAOYSA-N flavin mononucleotide Natural products OP(=O)(O)OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-UHFFFAOYSA-N 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 239000000122 growth hormone Substances 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 231100000956 nontoxicity Toxicity 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 229940081857 plasma protein fraction Drugs 0.000 description 2
- 108010058237 plasma protein fraction Proteins 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 150000004033 porphyrin derivatives Chemical class 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 229940039716 prothrombin Drugs 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000000171 quenching effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 235000019231 riboflavin-5'-phosphate Nutrition 0.000 description 2
- 229920002477 rna polymer Polymers 0.000 description 2
- 239000000176 sodium gluconate Substances 0.000 description 2
- 235000012207 sodium gluconate Nutrition 0.000 description 2
- 229940005574 sodium gluconate Drugs 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- RYAUSSKQMZRMAI-YESZJQIVSA-N (S)-fenpropimorph Chemical compound C([C@@H](C)CC=1C=CC(=CC=1)C(C)(C)C)N1C[C@H](C)O[C@H](C)C1 RYAUSSKQMZRMAI-YESZJQIVSA-N 0.000 description 1
- FSCGLKWYHHSLST-UHFFFAOYSA-N 2-(3-sulfanylpropanoylamino)acetic acid Chemical compound OC(=O)CNC(=O)CCS FSCGLKWYHHSLST-UHFFFAOYSA-N 0.000 description 1
- MHIITNFQDPFSES-UHFFFAOYSA-N 25,26,27,28-tetrazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1(25),2,4,6,8(27),9,11,13,15,17,19,21,23-tridecaene Chemical class N1C(C=C2C3=CC=CC=C3C(C=C3NC(=C4)C=C3)=N2)=CC=C1C=C1C=CC4=N1 MHIITNFQDPFSES-UHFFFAOYSA-N 0.000 description 1
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- KFKRXESVMDBTNQ-UHFFFAOYSA-N 3-[18-(2-carboxylatoethyl)-8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-21,24-diium-2-yl]propanoate Chemical class N1C2=C(C)C(C(C)O)=C1C=C(N1)C(C)=C(C(O)C)C1=CC(C(C)=C1CCC(O)=O)=NC1=CC(C(CCC(O)=O)=C1C)=NC1=C2 KFKRXESVMDBTNQ-UHFFFAOYSA-N 0.000 description 1
- BUNGCZLFHHXKBX-UHFFFAOYSA-N 8-methoxypsoralen Natural products C1=CC(=O)OC2=C1C=C1CCOC1=C2OC BUNGCZLFHHXKBX-UHFFFAOYSA-N 0.000 description 1
- 208000029483 Acquired immunodeficiency Diseases 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 101710081722 Antitrypsin Proteins 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 1
- 108010075016 Ceruloplasmin Proteins 0.000 description 1
- 102100023321 Ceruloplasmin Human genes 0.000 description 1
- 102100022641 Coagulation factor IX Human genes 0.000 description 1
- 102100030556 Coagulation factor XII Human genes 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 231100001074 DNA strand break Toxicity 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010076282 Factor IX Proteins 0.000 description 1
- 108010014173 Factor X Proteins 0.000 description 1
- 108010074864 Factor XI Proteins 0.000 description 1
- 108010080865 Factor XII Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical group C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 1
- 102100025255 Haptoglobin Human genes 0.000 description 1
- 108050005077 Haptoglobin Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 description 1
- 229940123973 Oxygen scavenger Drugs 0.000 description 1
- 206010034668 Peritoneal infections Diseases 0.000 description 1
- 206010034972 Photosensitivity reaction Diseases 0.000 description 1
- 108090000113 Plasma Kallikrein Proteins 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 108010023197 Streptokinase Proteins 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 108010058907 Tiopronin Proteins 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- GLEVLJDDWXEYCO-UHFFFAOYSA-N Trolox Chemical compound O1C(C)(C(O)=O)CCC2=C1C(C)=C(C)C(O)=C2C GLEVLJDDWXEYCO-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000000999 acridine dye Substances 0.000 description 1
- QEUYATCJHJUQML-UHFFFAOYSA-N acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride;hydrochloride Chemical compound Cl.[Cl-].C1=CC(N)=CC2=NC3=CC(N)=CC=C3C=C21.C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 QEUYATCJHJUQML-UHFFFAOYSA-N 0.000 description 1
- 229940002707 acriflavine hydrochloride Drugs 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 239000010868 animal carcass Substances 0.000 description 1
- 230000001475 anti-trypsic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
- 229960001076 chlorpromazine Drugs 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 150000004775 coumarins Chemical class 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000005274 electronic transitions Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 229960004222 factor ix Drugs 0.000 description 1
- 229940012426 factor x Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229940093632 flavin-adenine dinucleotide Drugs 0.000 description 1
- 150000002211 flavins Chemical class 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000004023 fresh frozen plasma Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000010409 ironing Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- DZVCFNFOPIZQKX-LTHRDKTGSA-M merocyanine Chemical compound [Na+].O=C1N(CCCC)C(=O)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 DZVCFNFOPIZQKX-LTHRDKTGSA-M 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229960004469 methoxsalen Drugs 0.000 description 1
- SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002991 molded plastic Substances 0.000 description 1
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000002990 phenothiazines Chemical class 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 238000007539 photo-oxidation reaction Methods 0.000 description 1
- 239000000906 photoactive agent Substances 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 231100000434 photosensitization Toxicity 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 229950003776 protoporphyrin Drugs 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000006950 reactive oxygen species formation Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004071 soot Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000012414 sterilization procedure Methods 0.000 description 1
- 239000012536 storage buffer Substances 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 229960004402 tiopronin Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 150000004992 toluidines Chemical class 0.000 description 1
- 238000006276 transfer reaction Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 108010047303 von Willebrand Factor Proteins 0.000 description 1
- 102100036537 von Willebrand factor Human genes 0.000 description 1
- 229960001134 von willebrand factor Drugs 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0047—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0052—Visible light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3616—Batch-type treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36222—Details related to the interface between cassette and machine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36224—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with sensing means or components thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362263—Details of incorporated filters
- A61M1/362264—Details of incorporated filters the filter being a blood filter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362266—Means for adding solutions or substances to the blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
- A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- External Artificial Organs (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/119,666 US6258577B1 (en) | 1998-07-21 | 1998-07-21 | Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers |
| US09/357,188 US6277337B1 (en) | 1998-07-21 | 1999-07-20 | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| PCT/US1999/016404 WO2000004930A2 (en) | 1998-07-21 | 1999-07-21 | Method for inactivation of microorganisms using photosensitizers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20001440D0 NO20001440D0 (no) | 2000-03-20 |
| NO20001440L NO20001440L (no) | 2000-05-19 |
| NO322633B1 true NO322633B1 (no) | 2006-11-06 |
Family
ID=26817564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20001440A NO322633B1 (no) | 1998-07-21 | 2000-03-20 | Fremgangsmate og system til inaktivering av mikroorganismer ved a bruke foto-sensitiviserende stoffer, samt anordning for separering av fullblod i blodkomponenter. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6277337B1 (de) |
| EP (2) | EP1972351B1 (de) |
| JP (3) | JP3854068B2 (de) |
| KR (2) | KR100746792B1 (de) |
| CN (2) | CN100369633C (de) |
| AP (1) | AP2000001770A0 (de) |
| AT (2) | ATE511861T1 (de) |
| AU (1) | AU744978B2 (de) |
| BG (1) | BG104362A (de) |
| CA (1) | CA2304696C (de) |
| EA (1) | EA002655B1 (de) |
| EE (1) | EE200000172A (de) |
| HU (1) | HUP0004907A3 (de) |
| IL (3) | IL160481A0 (de) |
| NO (1) | NO322633B1 (de) |
| NZ (2) | NZ503474A (de) |
| OA (1) | OA11633A (de) |
| PL (1) | PL340630A1 (de) |
| SK (1) | SK5832000A3 (de) |
| TR (1) | TR200001216T1 (de) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030194433A1 (en) * | 2002-03-12 | 2003-10-16 | Ecolab | Antimicrobial compositions, methods and articles employing singlet oxygen- generating agent |
| US20040055965A1 (en) * | 1997-06-13 | 2004-03-25 | Hubig Stephan M. | Recreational water treatment employing singlet oxygen |
| US20030073650A1 (en) * | 1998-07-21 | 2003-04-17 | Heather Reddy | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US7094378B1 (en) * | 2000-06-15 | 2006-08-22 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US7648699B2 (en) | 2000-06-02 | 2010-01-19 | Caridianbct Biotechnologies, Llc | Preventing transfusion related complications in a recipient of a blood transfusion |
| US7985588B2 (en) | 2000-06-02 | 2011-07-26 | Caridianbct Biotechnologies, Llc | Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light |
| TW590780B (en) | 2000-06-02 | 2004-06-11 | Gambro Inc | Additive solutions containing riboflavin |
| US9044523B2 (en) | 2000-06-15 | 2015-06-02 | Terumo Bct, Inc. | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
| US20020176796A1 (en) * | 2000-06-20 | 2002-11-28 | Purepulse Technologies, Inc. | Inactivation of microbes in biological fluids |
| US20030141260A1 (en) * | 2001-12-28 | 2003-07-31 | Frank Corbin | Oxygen-enhanced pathogen inactivation |
| US20030228564A1 (en) * | 2001-05-30 | 2003-12-11 | Edrich Richard Alan | Nitric oxide in a pathogen inactivation process |
| US7252799B2 (en) * | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
| US7264608B2 (en) * | 2001-12-05 | 2007-09-04 | Fenwal, Inc. | Manual processing systems and methods for providing blood components conditioned for pathogen inactivation |
| US7235392B2 (en) * | 2001-12-07 | 2007-06-26 | The Ohio State University Research Foundation | Apoptotic EBV-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder |
| US20040038373A1 (en) * | 2001-12-07 | 2004-02-26 | Platz Matthew S. | Apoptotic EBV-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder |
| DE10162712A1 (de) * | 2001-12-19 | 2003-07-17 | Blutspendienst Der Landesverba | Verfahren zur Inaktivierung von Bakterien und Leukozyten in Blut oder Blutprodukten |
| US20070020300A1 (en) * | 2002-03-12 | 2007-01-25 | Ecolab Inc. | Recreational water treatment employing singlet oxygen |
| JP2005519744A (ja) | 2002-03-14 | 2005-07-07 | バクスター・インターナショナル・インコーポレイテッド | 化合物除去器 |
| US7183045B2 (en) * | 2002-04-24 | 2007-02-27 | Gambro Inc. | Removal of adenine during a pathogen reduction process in whole blood or red blood cell by dilution |
| CA2484116C (en) * | 2002-04-26 | 2010-08-03 | Gambro, Inc. | Apparatus and method for irradiating and mixing fluids in containers |
| WO2003090794A1 (en) * | 2002-04-26 | 2003-11-06 | Gambro, Inc. | Solution containing platelet activation inhibitors for pathogen reducing and storing blood platelets |
| SI1592441T1 (sl) * | 2003-02-06 | 2012-09-28 | Aduro Biotech | Atenuirana listeria za vstop v nefagocitiäśne celice, cepiva vsebujoäśa listerijo in postopki za njihovo uporabo |
| DE10324668A1 (de) * | 2003-05-30 | 2004-12-23 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung zur extrakorporalen Bestrahlung einer Bilirubin enthaltenden Flüssigkeit und Verfahren hierfür |
| WO2005000365A1 (en) * | 2003-06-06 | 2005-01-06 | Inventive Holdings Llc | Lighting apparatus and system for decontamination |
| US7534348B2 (en) * | 2003-09-12 | 2009-05-19 | Fenwal, Inc. | Flow-through removal device and system using such device |
| US20050064583A1 (en) * | 2003-09-24 | 2005-03-24 | Frank Caruso | Temperature controlled illuminator for treating biological samples |
| US20050137517A1 (en) * | 2003-12-19 | 2005-06-23 | Baxter International Inc. | Processing systems and methods for providing leukocyte-reduced blood components conditioned for pathogen inactivation |
| US8296071B2 (en) * | 2004-03-15 | 2012-10-23 | Terumo Bct Biotechnologies, Llc | Methods for uniformly treating biological samples with electromagnetic radiation |
| US7384558B2 (en) | 2004-07-26 | 2008-06-10 | Baxter International Inc. | Compositions capable of inhibiting reactive oxygen and carbonyl species |
| US7993580B2 (en) | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
| AU2005302256B2 (en) * | 2004-10-29 | 2011-01-20 | Cerus Corporation | Improved quenching methods for red blood cell inactivation process |
| US20070009377A1 (en) * | 2005-07-06 | 2007-01-11 | Navigant Biotechnologies, Inc. | Methods for Reducing Pathogens in Biological Samples |
| CN1323952C (zh) * | 2005-07-20 | 2007-07-04 | 上海自来水市北科技有限公司 | 维生素k3在防治供水系统中红虫污染的应用 |
| US20070025918A1 (en) * | 2005-07-28 | 2007-02-01 | General Electric Company | Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization |
| US20070102858A1 (en) * | 2005-11-07 | 2007-05-10 | Navigant Biotechnologies, Inc. | Clamps and methods for displacing fluid from portions of fluid containers |
| US20070128693A1 (en) * | 2005-12-06 | 2007-06-07 | Advantek Serum Laboratories Limited3/F | Method for the inactivation and removal of dengue virus from biological samples |
| CA2849648A1 (en) * | 2006-01-27 | 2007-08-09 | Terumo Bct Biotechnologies, Llc | Method for inactivating pathogens in a biological fluid |
| US8580192B2 (en) | 2006-10-31 | 2013-11-12 | Ethicon, Inc. | Sterilization of polymeric materials |
| US20080234622A1 (en) | 2007-03-20 | 2008-09-25 | Gambro Bct Inc. | Methods and Systems for Preparing Blood Products |
| EP2175889A1 (de) * | 2007-07-02 | 2010-04-21 | CaridianBCT Biotechnologies, LLC | Gerät zur photoreduktion von verunreinigungen in blut und blutprodukten mit kalibrationsmitteln |
| JP2010535235A (ja) | 2007-08-01 | 2010-11-18 | カリディアンビーシーティ バイオテクノロジーズ，エルエルシー | 全血の病原性不活性化 |
| US20100190676A1 (en) * | 2008-07-22 | 2010-07-29 | Ecolab Inc. | Composition for enhanced removal of blood soils |
| US8123713B2 (en) * | 2008-08-12 | 2012-02-28 | Caridian Bct, Inc. | System and method for collecting plasma protein fractions from separated blood components |
| WO2010132167A1 (en) * | 2009-05-11 | 2010-11-18 | Caridianbct Biotechnologies, Llc | Stable calibration means for apparatus for photo reduction of contaminants in blood |
| US8753807B2 (en) * | 2009-06-02 | 2014-06-17 | Biolitec Pharma Marketing Ltd | Method for microbes depletion in human blood or full serum using antimicrobial photodynamic laser therapy |
| WO2011063252A2 (en) * | 2009-11-19 | 2011-05-26 | Uv Technologies, Llc | Ultraviolet light applicator system and method |
| MX2012008386A (es) * | 2010-01-19 | 2013-01-29 | Biolitec Pharma Marketing Ltd | Pdt antimicrobiana mejorada. |
| GB201113880D0 (en) * | 2011-08-12 | 2011-09-28 | Archimed Llp | Novel compositions |
| WO2013106605A1 (en) | 2012-01-11 | 2013-07-18 | Terumo Bct Biotechnologies, Llc | Slidable clamp for port isolation |
| US20140127077A1 (en) | 2012-11-05 | 2014-05-08 | Gail Rock | Device and method for sterilization of instruments and surfaces |
| US10172995B2 (en) | 2013-02-06 | 2019-01-08 | Fenwal, Inc. | System and method for determining irradiation exposure time with irradiation sensors during extracorporeal photopheresis |
| WO2014123521A1 (en) | 2013-02-06 | 2014-08-14 | Fenwal, Inc. | Method for delivering desired light dose to cells in a light attenuating medium |
| US20160088853A1 (en) * | 2013-04-17 | 2016-03-31 | The Regents Of The University Of California | Ultraviolet Disinfection of Produce, Liquids and Surfaces |
| US10117428B2 (en) | 2013-07-17 | 2018-11-06 | Rythrx Therapeutics, Llc | Compositions and methods for preserving donated blood |
| CN106461327B (zh) | 2014-06-09 | 2019-12-13 | 泰尔茂比司特公司 | 冻干法 |
| US10858643B2 (en) | 2015-10-30 | 2020-12-08 | Sensor Electronic Technology, Inc. | Vaccine preparation using ultraviolet radiation |
| CN105879133A (zh) * | 2016-03-31 | 2016-08-24 | 四川南格尔生物科技有限公司 | 一种血浆病毒灭活装置及方法 |
| EP3462859B1 (de) | 2016-05-27 | 2024-04-17 | Bloodworks | Verfahren zur vorbeugung von thrombozytenalloimmunisierung und alloimmunthrombozytenresistenz sowie toleranzinduktion bei transfusionsempfängern |
| JP2020515359A (ja) * | 2017-04-04 | 2020-05-28 | ユニバーシティー ヘルス ネットワーク | 臓器潅流液を照射処理するための装置および方法 |
| KR101909831B1 (ko) * | 2017-08-28 | 2018-10-18 | 한국외국어대학교 연구산학협력단 | 반응성 산소종을 포함하는 박테리오파아지의 생산량 증가 조성물 및 방법 |
| WO2019133929A1 (en) | 2017-12-29 | 2019-07-04 | Cerus Corporation | Systems and methods for treating biological fluids |
| CA3089175A1 (en) * | 2018-02-28 | 2019-09-06 | Plas-free Ltd. | Extracorporeal device and matrix for removing fibrinolytic proteins from biological fluids, methods and uses thereof |
| EP3616750A1 (de) * | 2018-08-27 | 2020-03-04 | S1 Sähkö Oy | System und verfahren zur verringerung von mikroorganismen |
| RU2702646C1 (ru) * | 2018-12-20 | 2019-10-09 | Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт туберкулеза" Министерства здравоохранения Российской Федерации (ФГБУ "ННИИТ" Минздрава России) | Способ инактивации лекарственно чувствительных и лекарственно устойчивых штаммов Mycobacterium tuberculosis в экспериментальных условиях in vitro |
| CN109717352B (zh) * | 2019-01-30 | 2022-07-05 | 广东温氏佳味食品有限公司 | 汤品的减菌方法、光敏水冷系统及其应用 |
| US12011510B2 (en) | 2019-06-22 | 2024-06-18 | Cerus Corporation | Biological fluid treatment systems |
| JP2022539154A (ja) | 2019-06-28 | 2022-09-07 | シーラス コーポレイション | 生物学的流体処理デバイスを実装するためのシステム及び方法 |
| CN111067007A (zh) * | 2019-12-26 | 2020-04-28 | 上海海洋大学 | 一种光动力杀灭沙门氏菌的方法 |
| US20230174889A1 (en) * | 2020-05-22 | 2023-06-08 | Yushiro Chemical Industry Co., Ltd. | Water-miscible functional fluid, undiluted stock of water-miscible functional fluid, sterilizer for water-miscible functional fluid, and method of sterilizing water-miscible function fluid |
| CN111840596B (zh) * | 2020-06-11 | 2022-03-11 | 南岳生物制药有限公司 | 核黄素光化学血浆灭活装置及其控制系统、控制方法 |
| CN113332460A (zh) * | 2021-03-30 | 2021-09-03 | 张耀绵 | 一种含有维生素c溶液的紫外线c波处理方法 |
| WO2023058144A1 (ja) * | 2021-10-06 | 2023-04-13 | 日本電信電話株式会社 | 紫外光照射システム及び紫外光照射方法 |
| CN114403209A (zh) * | 2021-12-27 | 2022-04-29 | 中国农业大学 | 植物源食品原料的处理方法 |
Family Cites Families (147)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1961700A (en) | 1932-07-29 | 1934-06-05 | Gen Electric Vapor Lamp Co | Apparatus for sterilizing articles by ultraviolet radiation |
| US2056614A (en) | 1933-06-13 | 1936-10-06 | Gen Electric Vapor Lamp Co | Ultraviolet sterilizer |
| US2212330A (en) | 1938-05-03 | 1940-08-20 | Albert G Thomas | Sterilizing device |
| US2212230A (en) | 1938-05-28 | 1940-08-20 | Internat Telephone Dev Co Inc | Airplane guiding beacon |
| US3456053A (en) | 1966-05-06 | 1969-07-15 | Pfizer & Co C | Inactivated hog cholera virus vaccine |
| US3852032A (en) | 1971-06-07 | 1974-12-03 | Uroptics Int Inc | Process for sterilizing hydrophilic gelatin lenses having ultraviolet stabilizers |
| US3776694A (en) | 1972-04-04 | 1973-12-04 | L Leittl | Germicidal toiletry cabinet for different personal hygiene items |
| US3926556A (en) | 1973-05-30 | 1975-12-16 | Raymond Marcel Gut Boucher | Biocidal electromagnetic synergistic process |
| US4139348A (en) | 1975-11-28 | 1979-02-13 | Massachusetts Institute Of Technology | Electrochemical process and apparatus to control the chemical state of a material |
| US4196281A (en) | 1976-10-20 | 1980-04-01 | Regents Of The University Of California | Psoralens |
| US4169204A (en) | 1976-10-20 | 1979-09-25 | Regents Of The University Of California | Psoralens |
| US4124598A (en) | 1976-10-20 | 1978-11-07 | Hoffmann-La Roche Inc. | Psoralens |
| US4424201A (en) | 1978-11-28 | 1984-01-03 | Rockefeller University | Employment of a mereyanine dye for the detection of malignant leukocytic cells |
| JPS55115484A (en) * | 1979-02-28 | 1980-09-05 | Asahi Chem Ind Co Ltd | Heterogeneous sensitizer for photosensitized oxidation |
| IT1166343B (it) | 1979-08-20 | 1987-04-29 | Francarosa Baccichetti | Furocumarina per la fotochemioterapia della fsoriasi e di altre malattie cutanee ad essa sensibili |
| DE8007265U1 (de) | 1980-03-17 | 1981-08-27 | ESPE Fabrik pharmazeutischer Präparate GmbH, 8031 Seefeld | Geraet zum behandeln von zahnersatzteilen |
| US4481167A (en) | 1980-04-11 | 1984-11-06 | The Dow Chemical Company | Sanitizing complexes of polyoxazolines or polyoxazines and polyhalide anions |
| US4398031A (en) | 1980-06-11 | 1983-08-09 | The Regents Of The University Of California | Coumarin derivatives and method for synthesizing 5'-methyl psoralens therefrom |
| JPS616899Y2 (de) | 1981-04-27 | 1986-03-03 | ||
| US4612007A (en) | 1981-06-16 | 1986-09-16 | Edelson Richard Leslie | Method and system for externally treating the blood |
| EP0087441A1 (de) | 1981-09-08 | 1983-09-07 | Quentron Optics Pty. Ltd. | Photostrahlungsverfahren und anordnung |
| JPS5862333A (ja) | 1981-10-09 | 1983-04-13 | Mazda Motor Corp | エンジンのアイドル回転制御装置 |
| US4456512A (en) | 1982-03-10 | 1984-06-26 | The Dow Chemical Company | Photochemical reactor and method |
| US4649151A (en) | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
| CA1216518A (en) | 1982-11-01 | 1987-01-13 | Gail A. Rock | Plasma-free medium for platelet storage |
| US4683889A (en) | 1983-03-29 | 1987-08-04 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
| US4727027A (en) | 1983-05-02 | 1988-02-23 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
| US4861704A (en) | 1983-09-01 | 1989-08-29 | The Trustees Of Columbia University In The City Of New York | Processes for development of acceptance of transplanted organs and tissues |
| US4946438A (en) | 1983-09-01 | 1990-08-07 | The Trustees Of Columbia University In The City Of New York | Process for development of acceptance of transplanted organs and tissues |
| US4992363A (en) | 1983-11-09 | 1991-02-12 | Thomas Jefferson University | Method for preparing glucose free media for storing blood platelets |
| US4693981A (en) | 1983-12-20 | 1987-09-15 | Advanced Genetics Research Institute | Preparation of inactivated viral vaccines |
| US4604356A (en) | 1983-12-21 | 1986-08-05 | Miles Laboratories, Inc. | Purification of flavin adenine dinucleotide synthetase |
| CH657864A5 (de) | 1984-02-17 | 1986-09-30 | Ciba Geigy Ag | Wasserloesliche phthalocyaninverbindungen und deren verwendung als photoaktivatoren. |
| US4493981A (en) | 1984-03-05 | 1985-01-15 | General Electric Company | Boil dry protection system for cooking appliance |
| JPH0622222B2 (ja) | 1984-09-18 | 1994-03-23 | 株式会社東芝 | 光処理装置 |
| JPS6176160A (ja) | 1984-09-21 | 1986-04-18 | 松永 是 | 殺細胞方法 |
| US4623328A (en) | 1984-10-29 | 1986-11-18 | Mcneilab, Inc. | Pump monitor for photoactivation patient treatment system |
| US4737140A (en) | 1984-10-29 | 1988-04-12 | Mcneilab, Inc. | Irradiation chamber for photoactivation patient treatment system |
| US4568328A (en) | 1984-10-29 | 1986-02-04 | Extracorporeal Medical Specialties, Inc. | Automated photophoresis blood portion control methods and apparatus |
| US4578056A (en) | 1984-10-29 | 1986-03-25 | Extracorporeal Medical Specialties, Inc. | Patient photopheresis treatment apparatus and method |
| US4596547A (en) | 1984-10-29 | 1986-06-24 | Mcneilab, Inc. | Valve apparatus for photoactivation patient treatment system |
| US4708715A (en) | 1984-10-29 | 1987-11-24 | Mcneilab, Inc. | Light array assembly for photoactivation patient treatment system |
| GB8501955D0 (en) * | 1985-01-25 | 1985-02-27 | Contact Lens Mfg Ltd | Disinfection of contact lenses |
| JPS61275228A (ja) * | 1985-03-14 | 1986-12-05 | バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド | 治療用タンパク組成物中のビ−ルスの光動的不活性化 |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4998931A (en) | 1985-07-05 | 1991-03-12 | Puget Sound Blood Center | Method of reducing immunogenicity and inducing immunologic tolerance |
| US5248506A (en) | 1986-03-19 | 1993-09-28 | American National Red Cross | Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets |
| US4695460A (en) | 1986-03-19 | 1987-09-22 | American Red Cross | Synthetic, plasma-free, transfusible platelet storage medium |
| US4961928A (en) | 1986-03-19 | 1990-10-09 | American Red Cross | Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets |
| US5017338A (en) | 1986-04-11 | 1991-05-21 | The Center For Blood Research, Inc. | Platelet concentrates |
| US4866282A (en) | 1986-08-26 | 1989-09-12 | Baxter International Inc. | Irradiation of blood products |
| WO1988003369A1 (en) * | 1986-11-13 | 1988-05-19 | Maxwell Laboratories, Inc. | Methods and apparatus for preservation of foodstuffs |
| US4915683A (en) | 1986-11-21 | 1990-04-10 | The Medical College Of Wisconsin, Inc. | Antiviral method, agents and apparatus |
| US5304113A (en) | 1986-11-21 | 1994-04-19 | The Mcw Research Foundation, Inc. | Method of eradicating infectious biological contaminants |
| US5039483A (en) | 1987-03-10 | 1991-08-13 | The Medical College Of Wisconsin, Inc. | Antiprotozoan method |
| US4878891A (en) * | 1987-06-25 | 1989-11-07 | Baylor Research Foundation | Method for eradicating infectious biological contaminants in body tissues |
| US4880788A (en) | 1987-10-30 | 1989-11-14 | Baylor College Of Medicine | Method for preventing and treating thrombosis |
| US5229081A (en) | 1988-02-12 | 1993-07-20 | Regal Joint Co., Ltd. | Apparatus for semiconductor process including photo-excitation process |
| US5288647A (en) | 1988-05-02 | 1994-02-22 | Stratagene | Method of irradiating biological specimens |
| IT1217938B (it) * | 1988-06-28 | 1990-03-30 | Girolamo Sirchia | Procedimento per la preparazione e la conservazione di concentrati eritrocitari e piastrinici |
| AU4181089A (en) | 1988-08-01 | 1990-03-05 | George D. Cimino | Identification of allele specific nucleic acid sequences by hybridization with crosslinkable oligonucleotide probes |
| US4994367A (en) | 1988-10-07 | 1991-02-19 | East Carolina University | Extended shelf life platelet preparations and process for preparing the same |
| US5571666A (en) | 1988-10-28 | 1996-11-05 | Oklahoma Medical Research Foundation | Thiazine dyes used to inactivate HIV in biological fluids |
| US5089384A (en) | 1988-11-04 | 1992-02-18 | Amoco Corporation | Method and apparatus for selective cell destruction using amplified immunofluorescence |
| US5020995A (en) | 1989-01-18 | 1991-06-04 | Guy Levy | Surgical treatment method and instrument |
| US5092773A (en) | 1989-01-18 | 1992-03-03 | Endo Technic Corporation | Method and apparatus for filling a tooth canal |
| US5273713A (en) | 1989-01-18 | 1993-12-28 | Laser Medical Technology, Inc. | Water purification and sterilization process |
| US4921473A (en) | 1989-02-02 | 1990-05-01 | Therakos, Inc. | Multicomponent fluid separation and irradiation system |
| US5041078A (en) | 1989-03-06 | 1991-08-20 | Baylor Research Foundation, A Nonprofit Corporation Of The State Of Texas | Photodynamic viral deactivation with sapphyrins |
| US5150705A (en) | 1989-07-12 | 1992-09-29 | Stinson Randy L | Apparatus and method for irradiating cells |
| US5503721A (en) | 1991-07-18 | 1996-04-02 | Hri Research, Inc. | Method for photoactivation |
| US5556958A (en) * | 1989-10-26 | 1996-09-17 | Steritech, Inc. | Inactivation of pathogens in clinical samples |
| US5184020A (en) | 1989-10-26 | 1993-02-02 | Hearst David P | Device and method for photoactivation |
| US5089146A (en) | 1990-02-12 | 1992-02-18 | Miles Inc. | Pre-storage filtration of platelets |
| US5236716A (en) | 1990-02-12 | 1993-08-17 | Miles Inc. | Platelets concentrate with low white blood cells content |
| US5147776A (en) | 1990-02-26 | 1992-09-15 | University Of Iowa Research Foundation | Use of 2,5-anhydromannitol for control of pH during blood storage |
| US5798238A (en) | 1990-04-16 | 1998-08-25 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants with quinolines as photosensitizer |
| US5516629A (en) | 1990-04-16 | 1996-05-14 | Cryopharm Corporation | Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins |
| US5587490A (en) | 1990-04-16 | 1996-12-24 | Credit Managers Association Of California | Method of inactivation of viral and bacterial blood contaminants |
| ZA912842B (en) | 1990-04-16 | 1992-03-25 | Cryopharm Corp | Method of inactivation of viral and bacterial blood contaminants |
| US5418130A (en) | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
| US5545516A (en) | 1990-05-01 | 1996-08-13 | The American National Red Cross | Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light |
| US5114957A (en) | 1990-05-08 | 1992-05-19 | Biodor U.S. Holding | Tocopherol-based antiviral agents and method of using same |
| US5658722A (en) | 1990-05-15 | 1997-08-19 | New York Blood Center, Inc. | Process for the sterilization of biological compositions using UVA1 irradiation |
| US5712086A (en) | 1990-05-15 | 1998-01-27 | New York Blood Center, Inc. | Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions |
| US5120649A (en) | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
| US5232844A (en) | 1990-05-15 | 1993-08-03 | New York Blood Center | Photodynamic inactivation of viruses in cell-containing compositions |
| US6077659A (en) * | 1990-05-15 | 2000-06-20 | New York Blood Center, Inc. | Vitamin E and derivatives thereof prevent potassium ion leakage and other types of damage in red cells that are virus sterilized by phthalocyanines and light |
| US5114670A (en) | 1990-08-30 | 1992-05-19 | Liqui-Box/B-Bar-B Corporation | Process for sterilizing surfaces |
| CA2074806A1 (en) | 1990-12-20 | 1992-06-21 | Ludwig Wolf Jr. | Systems for eradicating contaminants in fluids |
| US5935092A (en) | 1990-12-20 | 1999-08-10 | Baxter International Inc. | Systems and methods for removing free and entrained contaminants in plasma |
| WO1992011059A1 (en) | 1990-12-20 | 1992-07-09 | Baxter International Inc. | Systems and methods for simultaneously removing free and entrained contaminants in fluids like blood using photoactive therapy and cellular separation techniques |
| US5376524A (en) | 1991-04-01 | 1994-12-27 | Thomas Jefferson University | Platelet storage medium containing acetate and phosphate |
| US5569579A (en) | 1991-04-01 | 1996-10-29 | Thomas Jefferson University | Synthetic-based platelet storage media |
| FR2674753B1 (fr) | 1991-04-02 | 1995-03-10 | Jean Berque | Nouvelles indications therapeutiques, en particulier pour le traitement du sida, d'un medicament deja existant et fabrique a partir d'une molecule denuee de contre-indications et d'effets indesirables. |
| FR2715303A1 (fr) | 1991-04-02 | 1995-07-28 | Berque Jean | Utilisation du FAD et/ou du NAD comme médicaments. |
| US5185532A (en) | 1991-05-21 | 1993-02-09 | Oral Card Products | Dental instrument sterilizer |
| US5269946A (en) | 1991-05-22 | 1993-12-14 | Baxter Healthcare Corporation | Systems and methods for removing undesired matter from blood cells |
| CA2089005C (en) | 1991-06-21 | 1999-01-19 | John Chapman | Method for inactivating pathogens in a body fluid |
| US5166528A (en) | 1991-10-04 | 1992-11-24 | Le Vay Thurston C | Microwave-actuated ultraviolet sterilizer |
| US5216251A (en) | 1991-10-18 | 1993-06-01 | Matschke Arthur L | Apparatus and method for a bio-conditioning germicidal dryer |
| US5474891A (en) | 1991-10-30 | 1995-12-12 | Thomas Jefferson University | Plasma-based platelet concentrate preparations with additive |
| US5234808A (en) | 1991-10-30 | 1993-08-10 | Thomas Jefferson University | Acetate addition to platelets stored in plasma |
| US5344752A (en) | 1991-10-30 | 1994-09-06 | Thomas Jefferson University | Plasma-based platelet concentrate preparations |
| US5258124A (en) | 1991-12-06 | 1993-11-02 | Solarchem Enterprises, Inc. | Treatment of contaminated waste waters and groundwaters with photolytically generated hydrated electrons |
| FR2684999A1 (fr) | 1991-12-16 | 1993-06-18 | Aquitaine Dev Transf Sanguine | Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag. |
| US5639382A (en) | 1991-12-23 | 1997-06-17 | Baxter International Inc. | Systems and methods for deriving recommended storage parameters for collected blood components |
| US5607924A (en) | 1992-01-21 | 1997-03-04 | Pharmacyclics, Inc. | DNA photocleavage using texaphyrins |
| AU4107396A (en) | 1992-03-02 | 1996-06-06 | Cerus Corporation | Synthetic media for blood components |
| US5709991A (en) | 1992-03-02 | 1998-01-20 | Cerus Corporation | Proralen inactivation of microorganisms and psoralen removal |
| US5459030A (en) | 1992-03-02 | 1995-10-17 | Steritech, Inc. | Synthetic media compositions for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen |
| US5378601A (en) | 1992-07-24 | 1995-01-03 | Montefiore Medical Center | Method of preserving platelets with apyrase and an antioxidant |
| DK0653911T3 (da) | 1992-08-07 | 2000-10-02 | Cerus Corp | Fremgangsmåder til inaktivering af bakterier i blodpræparater med 8-methoxypsoralen |
| US5405957A (en) * | 1992-10-30 | 1995-04-11 | The University Of British Columbia | Wavelength-specific photosensitive compounds and expanded porphyrin-like compounds and methods of use |
| US5597722A (en) | 1993-01-28 | 1997-01-28 | Baxter International Inc. | Method for inactivating pathogens in compositions containing cells and plasma using photoactive compounds and plasma protein reduction |
| US5358844A (en) | 1993-02-18 | 1994-10-25 | Brigham And Women's Hospital, Inc. | Preservation of blood platelets |
| US5686436A (en) | 1993-05-13 | 1997-11-11 | Hiv Diagnostics, Inc. | Multi-faceted method to repress reproduction of latent viruses in humans and animals |
| US5556993A (en) | 1993-06-28 | 1996-09-17 | Steritech, Inc. | Compounds for the photodecontamination of pathogens in blood |
| US5593823A (en) | 1993-06-28 | 1997-01-14 | Cerus Corporation | Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens |
| US5399719A (en) | 1993-06-28 | 1995-03-21 | Steritech, Inc. | Compounds for the photodecontamination of pathogens in blood |
| US5871900A (en) | 1993-06-28 | 1999-02-16 | Cerus Corporation | Method of inactivating pathogens in biological fluids using photoactivated 5-primaryamino psoralens |
| EG20321A (en) | 1993-07-21 | 1998-10-31 | Otsuka Pharma Co Ltd | Medical material and process for producing the same |
| US5427695A (en) | 1993-07-26 | 1995-06-27 | Baxter International Inc. | Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate |
| CA2176258C (en) | 1993-11-10 | 2001-12-25 | George D. Cimino | Device and method for photoactivation |
| US5639376A (en) | 1994-01-10 | 1997-06-17 | Hemasure, Inc. | Process for simultaneously removing leukocytes and methylene blue from plasma |
| FR2718353B3 (fr) | 1994-04-11 | 1996-06-28 | Jean Berque | Compositions pharmaceutiques à base de produits biologiques atoxiques destinées à la protection locale des muqueuses génitales et rectales. |
| CN1069162C (zh) | 1994-05-02 | 2001-08-08 | 诺尔科化学公司 | 用作改进的抗微生物剂的荧光杀生物剂组合物 |
| DE4416166C2 (de) | 1994-05-06 | 1997-11-20 | Immuno Ag | Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen |
| WO1996009776A1 (en) | 1994-09-27 | 1996-04-04 | Purepulse Technologies, Inc. | Photocatalyst and pulsed light synergism in deactivation of contaminants |
| US5622867A (en) | 1994-10-19 | 1997-04-22 | Lifecell Corporation | Prolonged preservation of blood platelets |
| US5691132A (en) | 1994-11-14 | 1997-11-25 | Cerus Corporation | Method for inactivating pathogens in red cell compositions using quinacrine mustard |
| US5527704A (en) | 1994-12-06 | 1996-06-18 | Baxter International Inc. | Apparatus and method for inactivating viral contaminants in body fluids |
| US5557098A (en) | 1994-12-20 | 1996-09-17 | Baxter International Inc. | System to identify bags disinfected by irradiation which punches holes in a polarized portion of the bag to indicate processing thereof |
| US5683768A (en) | 1994-12-21 | 1997-11-04 | Baxter International Inc. | Plastic formulations for platelet storage containers and the like |
| US5653887A (en) | 1995-06-07 | 1997-08-05 | Cobe Laboratories, Inc. | Apheresis blood processing method using pictorial displays |
| US5714328A (en) | 1995-06-07 | 1998-02-03 | Board Of Regents, The University Of Texas System | RNA photocleavage using texaphyrins |
| US5679661A (en) * | 1995-07-25 | 1997-10-21 | The Procter & Gamble Company | Low hue photodisinfectants |
| ES2163574T3 (es) | 1995-12-04 | 2002-02-01 | Jms Co Ltd | Recipiente para uso medico. |
| US5817519A (en) | 1995-12-28 | 1998-10-06 | Bayer Corporation | Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
| US5843459A (en) | 1996-01-19 | 1998-12-01 | Human Gene Therapy Research Institute | Differential inactivation of nucleic acids by chemical modification |
| US5834198A (en) | 1996-03-21 | 1998-11-10 | Boehringer Mamnnheim Gmbh | Selective photoinducted flavin-dependent cleavage of RNA at G-U base pairs and kits therefor |
| CN1058764C (zh) * | 1996-04-22 | 2000-11-22 | 北京工商大学 | 含光敏化合物的光敏漂白剂及其制备方法 |
| US5798523A (en) | 1996-07-19 | 1998-08-25 | Theratechnologies Inc. | Irradiating apparatus using a scanning light source for photodynamic treatment |
| US5922278A (en) | 1996-11-19 | 1999-07-13 | Baxter International Inc. | Method and apparatus for inactivating contaminants in biological fluid |
| US5866074A (en) | 1996-12-20 | 1999-02-02 | Baxter International Inc. | Systems for quantifying the illumination characteristics of vessels such as blood processing containers with respect to light energy |
| US6200287B1 (en) | 1997-09-05 | 2001-03-13 | Gambro, Inc. | Extracorporeal blood processing methods and apparatus |
-
1999
- 1999-07-20 US US09/357,188 patent/US6277337B1/en not_active Expired - Lifetime
- 1999-07-21 HU HU0004907A patent/HUP0004907A3/hu unknown
- 1999-07-21 PL PL99340630A patent/PL340630A1/xx not_active Application Discontinuation
- 1999-07-21 AT AT99937340T patent/ATE511861T1/de not_active IP Right Cessation
- 1999-07-21 CA CA002304696A patent/CA2304696C/en not_active Expired - Fee Related
- 1999-07-21 TR TR2000/01216T patent/TR200001216T1/xx unknown
- 1999-07-21 IL IL16048199A patent/IL160481A0/xx active IP Right Grant
- 1999-07-21 SK SK583-2000A patent/SK5832000A3/sk unknown
- 1999-07-21 OA OA1200000080A patent/OA11633A/en unknown
- 1999-07-21 EP EP08006177A patent/EP1972351B1/de not_active Expired - Lifetime
- 1999-07-21 CN CNB998015881A patent/CN100369633C/zh not_active Expired - Fee Related
- 1999-07-21 JP JP2000560923A patent/JP3854068B2/ja not_active Expired - Fee Related
- 1999-07-21 NZ NZ503474A patent/NZ503474A/xx not_active IP Right Cessation
- 1999-07-21 AU AU52198/99A patent/AU744978B2/en not_active Ceased
- 1999-07-21 EA EA200000344A patent/EA002655B1/ru not_active IP Right Cessation
- 1999-07-21 EE EEP200000172A patent/EE200000172A/xx unknown
- 1999-07-21 CN CN2007101964536A patent/CN101239075B/zh not_active Expired - Fee Related
- 1999-07-21 EP EP10000970.3A patent/EP2174669B1/de not_active Expired - Lifetime
- 1999-07-21 AT AT08006177T patent/ATE508755T1/de not_active IP Right Cessation
- 1999-07-21 KR KR1020067013222A patent/KR100746792B1/ko not_active IP Right Cessation
- 1999-07-21 NZ NZ521054A patent/NZ521054A/xx not_active IP Right Cessation
- 1999-07-21 IL IL13510099A patent/IL135100A0/xx not_active IP Right Cessation
- 1999-07-21 KR KR1020007002971A patent/KR100753321B1/ko not_active IP Right Cessation
-
2000
- 2000-03-15 AP APAP/P/2000/001770A patent/AP2000001770A0/en unknown
- 2000-03-20 NO NO20001440A patent/NO322633B1/no not_active IP Right Cessation
- 2000-04-21 BG BG104362A patent/BG104362A/bg unknown
-
2004
- 2004-02-19 IL IL160481A patent/IL160481A/en not_active IP Right Cessation
-
2006
- 2006-02-10 JP JP2006033243A patent/JP4549983B2/ja not_active Expired - Fee Related
- 2006-07-03 JP JP2006182909A patent/JP4464939B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO322633B1 (no) | Fremgangsmate og system til inaktivering av mikroorganismer ved a bruke foto-sensitiviserende stoffer, samt anordning for separering av fullblod i blodkomponenter. | |
| EP1047458B1 (de) | Verfahren zur inaktivierung von mikroorganismen unter verwendung von photosensibilisatoren | |
| CA2397862C (en) | Storage solution containing photosensitizer for inactivation of biological contaminants | |
| EP1289991B1 (de) | Verfahren zur inaktivierung von mikroorganismen unter verwendung von photosensibilisatoren | |
| JP2004500316A5 (de) | ||
| TW590780B (en) | Additive solutions containing riboflavin | |
| US20030215784A1 (en) | Method and apparatus for inactivation of biological contaminants using photosensitizers | |
| CA2585179C (en) | Method and apparatus for inactivation of biological contaminants using photosensitizers | |
| AU770614B2 (en) | Method and apparatus for inactivation of biological contaminants using photosensitizers | |
| MXPA00002800A (en) | Method and apparatus for inactivation of biological contaminants using photosensitizers | |
| CZ20001406A3 (cs) | Řešení se týká léčiva k léčení získaného hyperkoagulovatelného stavu nebo získané nedostatečnosti proteinu C. Týká se lidských pacientů se získaným hyperkoagulovatelným stavem nebo získanou nedostatečností proteinu C souvisejícím se sepsí, purpura fulminans, meningokokální sepsí, transplantací kostní dřeně nebo dalšími transplantacemi, těžkými popáleninami, těhotenstvím, těžkými chirurgickými zákroky, těžkým traumatem nebo ARDS, které zahrnuje podávání aktivovaného proteinu C, který představuje vysoce selektivní terapeutické činidlo s nízkým potenciálem způsobení komplikací představujících krvácením. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |