NO321925B1 - 2-Alkyl-19-nor-vitamin D-forbindelser samt anvendelse derav ved fremstilling av farmasoytiske blandinger og slike blandinger - Google Patents
2-Alkyl-19-nor-vitamin D-forbindelser samt anvendelse derav ved fremstilling av farmasoytiske blandinger og slike blandinger Download PDFInfo
- Publication number
- NO321925B1 NO321925B1 NO19994489A NO994489A NO321925B1 NO 321925 B1 NO321925 B1 NO 321925B1 NO 19994489 A NO19994489 A NO 19994489A NO 994489 A NO994489 A NO 994489A NO 321925 B1 NO321925 B1 NO 321925B1
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- Norway
- Prior art keywords
- vitamin
- methyl
- compounds
- dihydroxyvitamin
- group
- Prior art date
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- 235000010265 sodium sulphite Nutrition 0.000 description 1
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- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/819,694 US5945410A (en) | 1997-03-17 | 1997-03-17 | 2-alkyl-19-nor-vitamin D compounds |
| PCT/US1998/002975 WO1998041500A1 (en) | 1997-03-17 | 1998-02-11 | 2-alkyl-19-nor-vitamin d compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO994489L NO994489L (no) | 1999-09-16 |
| NO994489D0 NO994489D0 (no) | 1999-09-16 |
| NO321925B1 true NO321925B1 (no) | 2006-07-24 |
Family
ID=25228795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19994489A NO321925B1 (no) | 1997-03-17 | 1999-09-16 | 2-Alkyl-19-nor-vitamin D-forbindelser samt anvendelse derav ved fremstilling av farmasoytiske blandinger og slike blandinger |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5945410A (ja) |
| EP (1) | EP0971888B1 (ja) |
| JP (2) | JP3786712B2 (ja) |
| KR (1) | KR100345820B1 (ja) |
| AT (1) | ATE253046T1 (ja) |
| AU (1) | AU714390B2 (ja) |
| BR (1) | BR9808010B1 (ja) |
| CA (1) | CA2272745C (ja) |
| DE (1) | DE69819312T2 (ja) |
| DK (1) | DK0971888T3 (ja) |
| ES (1) | ES2206893T3 (ja) |
| NO (1) | NO321925B1 (ja) |
| NZ (1) | NZ337262A (ja) |
| PT (1) | PT971888E (ja) |
| WO (1) | WO1998041500A1 (ja) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19619036A1 (de) * | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US6306844B1 (en) | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| MA26481A1 (fr) * | 1997-04-21 | 2004-12-20 | Hoffmann La Roche | Derives d'arylsecocholadiene |
| US6538145B2 (en) * | 1998-02-24 | 2003-03-25 | Chugai Seiyaku Kabushiki Kaisha | 24-hydroxy vitamin D derivatives |
| US6114317A (en) | 1998-05-21 | 2000-09-05 | Wisconsin Alumni Research Foundation | Method of locking 1α-OH of vitamin D compounds in axial orientation |
| DE19935771A1 (de) * | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
| EP1284259A4 (en) * | 2000-05-23 | 2009-11-11 | Hiroaki Takayama | 5,6-TRANS-2-alkyl-vitamin D derivatives |
| IL152942A (en) * | 2000-05-31 | 2007-09-20 | Wisconsin Alumni Res Found | Compounds 2 - Ethyl and 2 - Ethylaidine - 19 - Nur - Vitamin D and pharmaceutical preparations containing them |
| EP1524264A3 (en) * | 2000-05-31 | 2010-01-20 | Wisconsin Alumni Research Foundation | 2-ethylidene-19-nor-vitamin D compounds |
| JP4022144B2 (ja) | 2000-09-08 | 2007-12-12 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | １アルファ−ヒドロキシ−２−メチレン−１９−ノル−ホモプレグナカルシフェロール及びその療法的適用 |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| US20030195175A1 (en) * | 2002-03-25 | 2003-10-16 | Deluca Hector F. | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
| EP1490332B1 (en) | 2002-03-29 | 2006-11-29 | Wisconsin Alumni Research Foundation | Method of synthesizing 1-alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| US6723755B2 (en) | 2002-06-12 | 2004-04-20 | Piotr Chomczynski | Method of treating rosacea |
| JP2006506445A (ja) | 2002-08-28 | 2006-02-23 | ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド | 治療処置の方法 |
| US7402688B2 (en) * | 2002-10-10 | 2008-07-22 | Wisconsin Alumni Research Foundation | 2,2-Di-substituted 1alpha,25-dihydroxy-19-norvitamin D derivative |
| BRPI0407104A (pt) * | 2003-01-30 | 2006-01-24 | Teijin Pharma Ltd | Composto, agente terapêutico, composição farmacêutica, e, processo para sintetizar um composto |
| WO2004067504A1 (ja) * | 2003-01-31 | 2004-08-12 | Chugai Seiyaku Kabushiki Kaisha | ２位置換ビタミンｄ誘導体 |
| JP4469794B2 (ja) | 2003-02-25 | 2010-05-26 | 神戸天然物化学株式会社 | ビタミンｄ誘導体を合成するための新規な中間体 |
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| AU650751B2 (en) * | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
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- 1998-02-11 AT AT98905101T patent/ATE253046T1/de active
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| NO994489L (no) | 1999-09-16 |
| CA2272745C (en) | 2005-12-06 |
| US6277837B1 (en) | 2001-08-21 |
| DE69819312T2 (de) | 2004-07-29 |
| NZ337262A (en) | 2000-09-29 |
| EP0971888A1 (en) | 2000-01-19 |
| JP2000513010A (ja) | 2000-10-03 |
| NO994489D0 (no) | 1999-09-16 |
| AU6280098A (en) | 1998-10-12 |
| US6127559A (en) | 2000-10-03 |
| ATE253046T1 (de) | 2003-11-15 |
| EP0971888B1 (en) | 2003-10-29 |
| JP4035143B2 (ja) | 2008-01-16 |
| BR9808010A (pt) | 2000-03-08 |
| DK0971888T3 (da) | 2004-03-08 |
| JP2006096759A (ja) | 2006-04-13 |
| CA2272745A1 (en) | 1998-09-24 |
| KR20000076303A (ko) | 2000-12-26 |
| AU714390B2 (en) | 1999-12-23 |
| DE69819312D1 (de) | 2003-12-04 |
| WO1998041500A1 (en) | 1998-09-24 |
| BR9808010B1 (pt) | 2013-11-26 |
| JP3786712B2 (ja) | 2006-06-14 |
| KR100345820B1 (ko) | 2002-07-24 |
| US5945410A (en) | 1999-08-31 |
| PT971888E (pt) | 2004-03-31 |
| ES2206893T3 (es) | 2004-05-16 |
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