NO321382B1 - Nye rensete og isolerte neurotrofiske proteiner, nukleinsyresekvensen som koder for disse proteiner, ny vektor og vertscelle som inneholder nevnte vektor, en fremgangsmate for fremstilling av nevnte proteiner, en innretning for a behandle nerveskade, en farmasoytisk sammensetning samt anvendelse av nevnte proteiner. - Google Patents

Nye rensete og isolerte neurotrofiske proteiner, nukleinsyresekvensen som koder for disse proteiner, ny vektor og vertscelle som inneholder nevnte vektor, en fremgangsmate for fremstilling av nevnte proteiner, en innretning for a behandle nerveskade, en farmasoytisk sammensetning samt anvendelse av nevnte proteiner. Download PDF

Info

Publication number
NO321382B1
NO321382B1 NO19940922A NO940922A NO321382B1 NO 321382 B1 NO321382 B1 NO 321382B1 NO 19940922 A NO19940922 A NO 19940922A NO 940922 A NO940922 A NO 940922A NO 321382 B1 NO321382 B1 NO 321382B1
Authority
NO
Norway
Prior art keywords
gdnf
acid sequence
cells
cell
amino acid
Prior art date
Application number
NO19940922A
Other languages
English (en)
Norwegian (no)
Other versions
NO940922L (no
NO940922D0 (no
Inventor
Daniel H Doherty
Franklin D Collins
Jack Lile
Leu-Fen Lin
Susan Bektesh
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of NO940922D0 publication Critical patent/NO940922D0/no
Publication of NO940922L publication Critical patent/NO940922L/no
Publication of NO321382B1 publication Critical patent/NO321382B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0085Brain, e.g. brain implants; Spinal cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809Fused cells, e.g. hybridoma
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/839Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
NO19940922A 1991-09-20 1994-03-15 Nye rensete og isolerte neurotrofiske proteiner, nukleinsyresekvensen som koder for disse proteiner, ny vektor og vertscelle som inneholder nevnte vektor, en fremgangsmate for fremstilling av nevnte proteiner, en innretning for a behandle nerveskade, en farmasoytisk sammensetning samt anvendelse av nevnte proteiner. NO321382B1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US76468591A 1991-09-20 1991-09-20
US77410991A 1991-10-08 1991-10-08
US78842391A 1991-11-06 1991-11-06
US85541392A 1992-03-19 1992-03-19
PCT/US1992/007888 WO1993006116A1 (en) 1991-09-20 1992-09-17 Glial derived neurotrophic factor

Publications (3)

Publication Number Publication Date
NO940922D0 NO940922D0 (no) 1994-03-15
NO940922L NO940922L (no) 1994-05-19
NO321382B1 true NO321382B1 (no) 2006-05-02

Family

ID=27505700

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19940922A NO321382B1 (no) 1991-09-20 1994-03-15 Nye rensete og isolerte neurotrofiske proteiner, nukleinsyresekvensen som koder for disse proteiner, ny vektor og vertscelle som inneholder nevnte vektor, en fremgangsmate for fremstilling av nevnte proteiner, en innretning for a behandle nerveskade, en farmasoytisk sammensetning samt anvendelse av nevnte proteiner.

Country Status (21)

Country Link
US (7) US7226758B1 (es)
EP (2) EP1243652A3 (es)
KR (1) KR100242093B1 (es)
AT (1) ATE275197T1 (es)
AU (2) AU679167B2 (es)
CA (1) CA2119463C (es)
DE (1) DE69233407T2 (es)
DK (1) DK0610254T3 (es)
ES (1) ES2225819T3 (es)
FI (1) FI117556B (es)
GE (1) GEP20002243B (es)
HK (2) HK1017816A1 (es)
HU (2) HU220795B1 (es)
IL (5) IL103223A (es)
MX (1) MX9205293A (es)
NO (1) NO321382B1 (es)
NZ (1) NZ244392A (es)
PT (1) PT100879B (es)
SG (1) SG48145A1 (es)
TW (1) TW401422B (es)
WO (1) WO1993006116A1 (es)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981165A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
WO1995006662A1 (en) * 1993-09-01 1995-03-09 Start Technology Partnership Neuron regulatory factor for promoting neuron survival
AU1443095A (en) * 1993-12-22 1995-07-10 University Of Medicine And Dentistry Of New Jersey Novel nucleic acid sequences isolated from glial cells
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US7258983B2 (en) 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor
JP3906314B2 (ja) * 1994-04-25 2007-04-18 ジェネンテク・インコーポレイテッド カルジオトロフィンおよびその使用
US5853385A (en) * 1994-08-26 1998-12-29 Cytotherapeutics, Inc. Encapsulated PC12 cell transplants for treatment of Parkinson's disease
US5733875A (en) * 1994-11-15 1998-03-31 Amgen Inc. Methods of using GDNF as a neuroprotective agent
JP3093974B2 (ja) * 1995-06-27 2000-10-03 住友ベークライト株式会社 神経細胞用培養液、その製造方法及びこれを用いる神経細胞の培養方法
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US6743628B1 (en) 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
US5731284A (en) * 1995-09-28 1998-03-24 Amgen Inc. Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
US6184200B1 (en) 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
WO1997019693A1 (en) * 1995-11-29 1997-06-05 Amgen Inc. Method for treating sensory neuropathy using glial cell line-derived neurotrophic factor (gdnf) protein product
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US5905027A (en) * 1995-12-27 1999-05-18 Uab Research Foundation Method of diagnosing and treating gliomas
US5929041A (en) * 1996-02-23 1999-07-27 Amgen Inc. Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
US5837681A (en) * 1996-02-23 1998-11-17 Amgen Inc. Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product
US6222022B1 (en) * 1996-03-14 2001-04-24 Washington University Persephin and related growth factors
IL125839A0 (en) 1996-03-14 1999-04-11 Genentech Inc Uses of gdnf and gdnf receptor
EP0886651B1 (en) * 1996-03-14 2005-01-26 Washington University Persephin and related growth factors
US6716600B1 (en) 1996-03-14 2004-04-06 Washington University Persephin and related growth factors
US5741778A (en) * 1996-03-19 1998-04-21 Amgen Inc. Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US6455277B1 (en) 1996-04-22 2002-09-24 Amgen Inc. Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides
US7138251B1 (en) 1996-04-22 2006-11-21 Amgen Inc. Polynucleotides encoding a neurotrophic factor receptor
AU2677797A (en) * 1996-04-25 1997-11-12 Genetic Therapy, Inc. Viral vectors including polynucleotides encoding neurotrophic factors and uses therefor
ES2213221T3 (es) * 1996-07-29 2004-08-16 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum Vertrieb Von Pharmaka Mbh Factor de tipo egf de granulos de cromafina y factor neurotrofico derivado de celulas de glia con actividad promotora de la supervivencia sobre neuronas daergicas.
ES2308800T3 (es) * 1997-01-08 2008-12-01 Invitrogen Corporation Metodos para la produccion de proteinas.
US6025157A (en) 1997-02-18 2000-02-15 Genentech, Inc. Neurturin receptor
US6777196B2 (en) 1997-02-18 2004-08-17 Genentech, Inc. Neurturin receptor
US6372453B1 (en) 1997-02-18 2002-04-16 Genetech, Inc. Neurturin receptor
US6042579A (en) * 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
SI1005358T1 (en) * 1997-07-30 2003-06-30 Amgen Inc. Use of a neurturin protein product for preventing and treating hearing loss
CA2299586C (en) * 1997-08-05 2007-09-18 F. Hoffmann-La Roche Ag Human glial cell line-derived neurotrophic factor promoters, vectors containing same, and methods of screening compounds therewith
IL138593A0 (en) 1998-03-23 2001-10-31 Genentech Inc GFRα3 AND ITS USES
US7026138B1 (en) 1998-03-23 2006-04-11 Genentech, Inc. Polynucleotides encoding GFRα3
DE19816186A1 (de) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-kodierende DNA, Teile davon und GDNF-Varianten
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
US20020002269A1 (en) * 1998-09-29 2002-01-03 Jeffrey D. Milbrandt Artemin, a neurotrophic factor
US7060676B2 (en) 1999-12-20 2006-06-13 Trustees Of Tufts College T. cruzi-derived neurotrophic agents and methods of use therefor
US20040014082A1 (en) * 2000-08-11 2004-01-22 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
US6426065B1 (en) * 2000-11-07 2002-07-30 Clairol Incorporated Use of tris(hydroxymethyl)aminomethane in cold permanent waving processes
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
EP1395279B1 (en) 2001-03-28 2011-10-05 Biogen Idec MA Inc. Use of neublastin polypeptides for treating neuropathic pain
US20030050273A1 (en) * 2001-08-29 2003-03-13 Keiya Ozawa Compositions and methods for treating neurodegenerative diseases
US7828728B2 (en) * 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7613491B2 (en) * 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
CA2484223A1 (en) * 2002-04-25 2003-11-06 Wisconsin Alumni Research Foundation Use of human neural stem cells secreting gdnf for treatment of parkinson's and other neurodegenerative diseases
US20060088899A1 (en) * 2002-05-31 2006-04-27 Alvarez Vernon L Combination chemotherapy with chlorotoxin
US7528112B2 (en) 2002-11-15 2009-05-05 Drexel University Small survival-promoting/immunomodulatory peptide for treatment of brain damage, neurodegenerative disorders, and inflammatory disorders
US7388079B2 (en) * 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
US20050048041A1 (en) * 2003-01-13 2005-03-03 Rao Mahendra S. Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products
EP1587545A2 (en) * 2003-01-13 2005-10-26 Mahendra S. Rao Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products
US20040209810A1 (en) * 2003-02-24 2004-10-21 Gill Steven S. Method of treating Parkinson's disease in humans by intraputaminal infusion of glial cell-line derived neurotrophic factor
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
NZ574121A (en) 2003-04-18 2011-06-30 Biogen Idec Inc Polyethylene glycol-conjugated gylcosylated neublastin and uses thereof for treatment of pain
US7875293B2 (en) * 2003-05-21 2011-01-25 Dexcom, Inc. Biointerface membranes incorporating bioactive agents
BRPI0411243A (pt) 2003-06-10 2006-07-11 Nsgene As método de produzir um polipeptìdio de neublastina biologicamente ativo, ácido nucléico, vetor de expressão, composição farmacêutica, célula, linha de células de compactação, mamìfero não-humano transgênico, dispositivo de cultura de células implantável, uso do vetor, método de tratar uma doença do sistema nervoso, e, polipetìdio de neublastina
JP4708342B2 (ja) 2003-07-25 2011-06-22 デックスコム・インコーポレーテッド 埋設可能な装置に用いる酸素増大膜システム
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
WO2005021065A2 (en) * 2003-08-29 2005-03-10 New York University Indirect delivery of growth factors into the central nervous system
US20060258576A1 (en) * 2003-09-05 2006-11-16 Licentia, Ltd Gdnf-related neuropeptides
US7598059B2 (en) 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs
US20060239966A1 (en) * 2003-10-20 2006-10-26 Tornoee Jens In vivo gene therapy of parkinson's disease
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8093205B2 (en) * 2003-12-01 2012-01-10 Medtronic, Inc. Method for treating a stroke by implanting a first therapy delivery element in the CNS and a second therapy delivery element in a damaged tissue of the CNS to promote neurogenesis
US20050123526A1 (en) * 2003-12-01 2005-06-09 Medtronic Inc. Administration of growth factors for neurogenesis and gliagenesis
US7364592B2 (en) * 2004-02-12 2008-04-29 Dexcom, Inc. Biointerface membrane with macro-and micro-architecture
WO2009048462A1 (en) 2007-10-09 2009-04-16 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
US20050208090A1 (en) * 2004-03-18 2005-09-22 Medtronic, Inc. Methods and systems for treatment of neurological diseases of the central nervous system
GB2414934A (en) * 2004-06-11 2005-12-14 Gill Steven Streatfield Treatment of Parkinson's disease with GDNF
EP1773401B1 (en) * 2004-06-21 2013-01-02 Medtronic, Inc. Medical systems and methods for delivering compositions to cells
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
NZ553431A (en) 2004-08-19 2010-04-30 Biogen Idec Inc Neublastin variants with decreased heparin binding
CA2577690C (en) 2004-08-19 2013-08-06 Biogen Idec Ma Inc. Refolding transforming growth factor beta family proteins
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
CA2619017A1 (en) 2005-08-16 2007-02-22 Copenhagen University Gdnf derived peptides
US8741260B2 (en) * 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
US8142781B2 (en) * 2005-10-07 2012-03-27 Armagen Technologies, Inc. Fusion proteins for blood-brain barrier delivery
US8124095B2 (en) * 2005-10-07 2012-02-28 Armagen Technologies, Inc. Fusion proteins for delivery of erythropoietin to the CNS
AU2006308312A1 (en) * 2005-10-28 2007-05-03 Nsgene A/S Implantable Biocompatible Immunoisolatory Vehicle for Delivery of GDNF
DE602005023550D1 (de) 2005-12-14 2010-10-21 Licentia Ltd Verwendungen eines neurotrophischen Faktors
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
WO2007127803A2 (en) 2006-04-25 2007-11-08 The Regents Of The University Of California Administration of growth factors for the treatment of cns disorders
US20070259031A1 (en) * 2006-04-26 2007-11-08 The Regents Of The University Of California Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
EP1872790A1 (en) 2006-06-26 2008-01-02 DeveloGen Aktiengesellschaft New formulation for increasing bioavailability of neurturin
US8759297B2 (en) 2006-08-18 2014-06-24 Armagen Technologies, Inc. Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns
KR100770440B1 (ko) * 2006-08-29 2007-10-26 삼성전기주식회사 질화물 반도체 발광소자
US8637459B2 (en) * 2006-11-08 2014-01-28 Emory University Enhancing a population of insulin releasing cells using GFR-A1 agonists
EP2142205B1 (en) 2007-05-01 2014-04-02 Biogen Idec MA Inc. Neublastin peptides for use in increasing vascularisation in tissue with impaired blood flow
US20090011040A1 (en) * 2007-05-02 2009-01-08 Naash Muna I Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases
US20200037875A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US20110021469A1 (en) * 2007-06-13 2011-01-27 Meythaler Jay M baclofen solution for low-volume therapeutic delivery
US20100210604A1 (en) * 2007-06-13 2010-08-19 Meythaler Jay M Zwitterion solution for low-volume therapeutic delivery
WO2009018122A2 (en) 2007-07-27 2009-02-05 Armagen Technologies, Inc. Methods and compositions for increasing alpha-iduronidase activity in the cns
FI20070808A0 (fi) 2007-10-25 2007-10-25 Mart Saarma GDNF:n silmukointivariantit ja niiden käytöt
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
GB0803352D0 (en) 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
CN102047101A (zh) 2008-03-28 2011-05-04 德克斯康公司 用于连续的分析物传感器的聚合物膜
FI20080326A0 (fi) 2008-04-30 2008-04-30 Licentia Oy Neurotroofinen tekijä MANF ja sen käytöt
US8227439B2 (en) 2008-05-15 2012-07-24 Morphotek, Inc. Treatment of metastatic tumors
EP2396408B1 (en) 2009-02-12 2017-09-20 CuRNA, Inc. Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf
WO2010108048A2 (en) 2009-03-18 2010-09-23 Armagen Technologies, Inc. Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
ES2725200T3 (es) * 2009-10-09 2019-09-20 Armagen Inc Métodos y composiciones para aumentar la actividad de iduronato 2-sulfatasa en el SNC
WO2011064437A2 (es) 2009-11-26 2011-06-03 Proyecto De Biomedicina Cima, S.L. Vectores virales y procedimientos útiles en la preparación de gdnf
LT2531206T (lt) 2010-02-04 2017-09-25 Morphotek, Inc. Chlorotoksino polipeptidai ir konjugatai ir jų naudojimas
ES2601182T3 (es) 2010-05-11 2017-02-14 Fred Hutchinson Cancer Research Center Variantes de clorotoxina, conjugados y métodos para su utilización
JP2014506119A (ja) 2010-12-02 2014-03-13 ニューロテック ユーエスエー, インコーポレイテッド 抗血管新生抗体足場および可溶性受容体を分泌する細胞株およびその使用
UA112981C2 (uk) 2011-04-11 2016-11-25 Елі Ліллі Енд Компані Варіант людського gdnf
US9549692B2 (en) 2011-08-26 2017-01-24 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8486399B2 (en) 2011-12-02 2013-07-16 Armagen Technologies, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
US9788765B2 (en) 2012-09-28 2017-10-17 Dexcom, Inc. Zwitterion surface modifications for continuous sensors
CA2913029A1 (en) 2012-12-10 2014-06-19 Fred Hutchinson Cancer Research Center Lipocalin fusion partners
WO2014152511A1 (en) 2013-03-15 2014-09-25 The Jackson Laboratory Methods for promoting wound healing and hair growth
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
US10369329B2 (en) 2014-01-30 2019-08-06 Renishaw Plc Neurosurgical apparatus and method
EP3140429B1 (en) 2014-05-05 2020-02-19 Medtronic Inc. Methods for scd, crt, crt-d, or sca therapy identification and/or selection
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
GB201506052D0 (en) 2015-04-09 2015-05-27 Renishaw Plc Movement disorder
ES2833457T3 (es) 2015-05-27 2021-06-15 Neurotech Usa Inc Uso de terapia con células encapsuladas para el tratamiento del glaucoma
EP4253536A3 (en) 2015-12-30 2023-12-20 DexCom, Inc. Diffusion resistance layer for analyte sensors
CN110461880A (zh) 2016-11-10 2019-11-15 科乐斯疗法公司 Gdnf融合多肽及其使用方法
CA3210177A1 (en) 2021-03-19 2022-09-22 Dexcom, Inc. Drug releasing membrane for analyte sensor
CA3230350A1 (en) 2021-09-15 2023-03-23 Shanger Wang Bioactive releasing membrane for analyte sensor
US20230240589A1 (en) 2022-02-02 2023-08-03 Dexcom, Inc. Sensing systems and methods for diagnosing, staging, treating, and assessing risks of liver disease using monitored analyte data
US20230263434A1 (en) 2022-02-23 2023-08-24 Dexcom, Inc. Sensing systems and methods for providing decision support around kidney health and/or diabetes
US20230390466A1 (en) 2022-06-01 2023-12-07 Dexcom, Inc. Systems and methods for optimizing treatment using physiological profiles
WO2024050126A2 (en) 2022-09-02 2024-03-07 Dexcom, Inc. Continuous analyte sensor devices and methods

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
EP0154434B1 (en) 1984-02-17 1993-01-27 Genentech, Inc. Human transforming growth factor and precursor or fragment thereof, cells, dna, vectors and methods for their production, compositions and products containing them, and related antibodies and diagnostic methods
US4886747A (en) 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US5284763A (en) 1985-03-22 1994-02-08 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
US5089396A (en) 1985-10-03 1992-02-18 Genentech, Inc. Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5427780A (en) 1985-10-30 1995-06-27 Biogen, Inc. Composition comprising Mullerian inhibiting substance-like polypeptides
EP0233838A3 (en) 1986-02-04 1990-01-31 Incyte Pharmaceuticals, Inc. Neurite-promoting factor and process for the manufacture thereof
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5158881A (en) 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5106627A (en) 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5324819A (en) 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
WO1990005191A1 (en) 1988-11-04 1990-05-17 Erziehungsdirektion Of The Canton Zurich Neurite growth regulatory factors
US5250414A (en) 1988-11-04 1993-10-05 Erziehungsdirektion Of The Canton Zurich Diagnostic methods using neurite growth regulatory factors
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5017735A (en) 1989-07-24 1991-05-21 Catalytica, Inc. Selective sorption of 2,6-diisopropylnaphthalene
WO1991002003A1 (en) 1989-08-04 1991-02-21 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor
US5215969A (en) 1989-08-11 1993-06-01 Hahnemann University Dopaminergic neurotrophic factor for treatment of Parkinson's disease
EP0486584A4 (en) * 1989-08-11 1993-02-03 Hahnemann University Dopaminergic neurotrophic factor for treatment of parkinson's disease
WO1991010470A1 (en) 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US5270181A (en) 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules

Also Published As

Publication number Publication date
IL140654A0 (en) 2002-02-10
AU2681192A (en) 1993-04-27
DK0610254T3 (da) 2005-01-10
US6093802A (en) 2000-07-25
EP1243652A3 (en) 2003-03-26
HU211984A9 (en) 1996-01-29
CA2119463A1 (en) 1993-04-01
EP0610254A1 (en) 1994-08-17
FI941285A0 (fi) 1994-03-18
NZ244392A (en) 1995-03-28
TW401422B (en) 2000-08-11
ES2225819T3 (es) 2005-03-16
FI941285A (fi) 1994-03-18
FI117556B (fi) 2006-11-30
AU1900197A (en) 1997-09-18
EP0610254B1 (en) 2004-09-01
PT100879B (pt) 1999-08-31
IL121913A0 (en) 1998-03-10
US6015572A (en) 2000-01-18
IL103223A0 (en) 1993-02-21
DE69233407T2 (de) 2005-09-08
KR940702505A (ko) 1994-08-20
ATE275197T1 (de) 2004-09-15
EP0610254A4 (en) 1995-05-03
DE69233407D1 (de) 2004-10-07
EP1243652A2 (en) 2002-09-25
NO940922L (no) 1994-05-19
WO1993006116A1 (en) 1993-04-01
GEP20002243B (en) 2000-09-25
US20020197675A1 (en) 2002-12-26
US5935795A (en) 1999-08-10
PT100879A (pt) 1994-02-28
CA2119463C (en) 2003-09-16
AU679167B2 (en) 1997-06-26
NO940922D0 (no) 1994-03-15
HK1047438A1 (zh) 2003-02-21
IL140653A0 (en) 2002-02-10
HU220795B1 (hu) 2002-05-28
HU9400717D0 (en) 1994-06-28
IL103223A (en) 2005-06-19
AU694387B2 (en) 1998-07-16
SG48145A1 (en) 1998-04-17
MX9205293A (es) 1993-05-01
US6362319B1 (en) 2002-03-26
US6221376B1 (en) 2001-04-24
KR100242093B1 (ko) 2000-02-01
US7226758B1 (en) 2007-06-05
IL147488A0 (en) 2002-08-14
HK1017816A1 (en) 1999-11-26
HUT66137A (en) 1994-09-28

Similar Documents

Publication Publication Date Title
NO321382B1 (no) Nye rensete og isolerte neurotrofiske proteiner, nukleinsyresekvensen som koder for disse proteiner, ny vektor og vertscelle som inneholder nevnte vektor, en fremgangsmate for fremstilling av nevnte proteiner, en innretning for a behandle nerveskade, en farmasoytisk sammensetning samt anvendelse av nevnte proteiner.
CN101123978B (zh) 神经胚素变体
AU707838B2 (en) Neurotrophic peptides of activity dependent neurotrophic factor
CN100582121C (zh) 胸腺素β4衍生物及其应用
EP0542892A4 (en) Chimeric neurotrophic factors
NO322521B1 (no) Avkortet gliacellelinjeavledet neurotrof faktor (GDNF)-proteinprodukt, plynukleotid som koder for dette, vektor omfattende polynukleotidet, anvendelse av GDNF-proteinproduktet for fremstilling av medikament, anvendelse av nebnte polynukleotid for fremstilling av medikament, anvendelse av celle som er transformert med polynukleotidet for fremstilling av medikament, prokaryot eller eukaryot vertscelle som er transfektert med polynukleotidet, fremgangsmate for fremstilling av avkortet GDNF-protein, farmasoytisk preparat som omfatter dette og fremgangsmate for fremstilling av preparatet.
JP2003159083A (ja) 新規な神経栄養因子
WO2000012553A1 (en) Cyclic prosaposin-derived peptides and uses thereof
CN104710535B (zh) 重组人g-csf二聚体及其在治疗神经系统疾病中的用途
CN102924585A (zh) 神经胚素变体
US6511823B1 (en) Heparin binding neurotrophic factor gene sequence
KR20170042366A (ko) 디스인테그린 변이체 및 이의 약학적 용도
JP2968840B2 (ja) グリア由来神経栄養因子
US20040175795A1 (en) Glial derived neurotrophic factor
CA2202496C (en) Neurotrophic peptides of activity dependent neurotrophic factor
AU666327B2 (en) Purification of recombinant ciliary neurotrophic factor and C-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage
CA2337964A1 (en) Treatment of central nervous system ischemia or trauma with epidermal growth factor-like polypeptides
WO2015042580A1 (en) Compositions and methods for treatment of neuropathic pain

Legal Events

Date Code Title Description
MK1K Patent expired