NO320745B1 - Farmasoytisk medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer eller substrat av P450 isoenzym 3A4 samt anvendelse derav - Google Patents

Farmasoytisk medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer eller substrat av P450 isoenzym 3A4 samt anvendelse derav Download PDF

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Publication number
NO320745B1
NO320745B1 NO20013811A NO20013811A NO320745B1 NO 320745 B1 NO320745 B1 NO 320745B1 NO 20013811 A NO20013811 A NO 20013811A NO 20013811 A NO20013811 A NO 20013811A NO 320745 B1 NO320745 B1 NO 320745B1
Authority
NO
Norway
Prior art keywords
drug
isoenzyme
inhibitor
combination according
inducer
Prior art date
Application number
NO20013811A
Other languages
English (en)
Norwegian (no)
Other versions
NO20013811L (no
NO20013811D0 (no
Inventor
Ali Raza
John Stuart Pears
Howard Gerard Hutchinson
Takahiko Baba
Dennis Schneck
Akira Touchi
Yoshitaka Yamaguchi
Original Assignee
Shionogi & Co
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27269637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO320745(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9902593.4A external-priority patent/GB9902593D0/en
Priority claimed from GBGB9921064.3A external-priority patent/GB9921064D0/en
Priority claimed from GBGB9921063.5A external-priority patent/GB9921063D0/en
Application filed by Shionogi & Co, Astrazeneca Ab filed Critical Shionogi & Co
Publication of NO20013811D0 publication Critical patent/NO20013811D0/no
Publication of NO20013811L publication Critical patent/NO20013811L/no
Publication of NO320745B1 publication Critical patent/NO320745B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
NO20013811A 1999-02-06 2001-08-03 Farmasoytisk medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer eller substrat av P450 isoenzym 3A4 samt anvendelse derav NO320745B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9902593.4A GB9902593D0 (en) 1999-02-06 1999-02-06 Drug combinations
GBGB9921064.3A GB9921064D0 (en) 1999-09-08 1999-09-08 Drug combination
GBGB9921063.5A GB9921063D0 (en) 1999-09-08 1999-09-08 Therapy
PCT/GB2000/000278 WO2000045817A1 (en) 1999-02-06 2000-02-01 Drug combinations comprising (e) -7 - [4 -(4 -fluorophenyl) -6 - isopropyl -2 - [methyl (methylsulfonyl) amino] pyrimidin -5 -yl] (3r,5s) -3,5 - dihydroxyhept -6 - enoic acid and an inhibitor, inducer or substrate of p450 isoenzyme 3a4

Publications (3)

Publication Number Publication Date
NO20013811D0 NO20013811D0 (no) 2001-08-03
NO20013811L NO20013811L (no) 2001-10-02
NO320745B1 true NO320745B1 (no) 2006-01-23

Family

ID=27269637

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013811A NO320745B1 (no) 1999-02-06 2001-08-03 Farmasoytisk medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer eller substrat av P450 isoenzym 3A4 samt anvendelse derav

Country Status (29)

Country Link
US (3) US6982157B1 (ko)
EP (1) EP1185274B1 (ko)
JP (2) JP2002536331A (ko)
KR (2) KR20060117381A (ko)
CN (1) CN1165310C (ko)
AR (1) AR029333A1 (ko)
AT (1) ATE282415T1 (ko)
AU (1) AU767304B2 (ko)
BR (1) BR0007999A (ko)
CA (1) CA2358632C (ko)
CZ (1) CZ301296B6 (ko)
DE (1) DE60015965T2 (ko)
EE (1) EE04929B1 (ko)
EG (1) EG23858A (ko)
ES (1) ES2232418T3 (ko)
GB (1) GB0000710D0 (ko)
HK (1) HK1041817A1 (ko)
ID (1) ID30485A (ko)
IL (1) IL144715A0 (ko)
IS (1) IS2337B (ko)
MX (1) MXPA01007905A (ko)
MY (1) MY130606A (ko)
NO (1) NO320745B1 (ko)
NZ (1) NZ512982A (ko)
PL (1) PL198034B1 (ko)
PT (1) PT1185274E (ko)
TR (1) TR200102228T2 (ko)
TW (1) TWI282738B (ko)
WO (1) WO2000045817A1 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
DE19944803A1 (de) * 1999-09-20 2001-03-29 Bayer Ag Kombination von Dihydropyridinverbindungen und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
US9173847B2 (en) 2003-10-10 2015-11-03 Veloxis Pharmaceuticals A/S Tablet comprising a fibrate
CA2540984C (en) 2003-10-10 2011-02-08 Lifecycle Pharma A/S A solid dosage form comprising a fibrate
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
KR20070038553A (ko) 2004-08-06 2007-04-10 트렌스폼 파마수티컬스 인코퍼레이티드 신규한 스타틴 약제학적 조성물 및 관련된 치료방법
US20090162316A1 (en) 2005-07-05 2009-06-25 Harvard University Liver targeted conjugates
AU2006329006B2 (en) * 2005-12-20 2013-02-28 Lek Pharmaceuticals D.D. Pharmaceutical composition comprising (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid
US20080109252A1 (en) * 2006-11-08 2008-05-08 Lafountain Andrea Predicting patient compliance with medical treatment
US20120130202A1 (en) * 2010-11-24 2012-05-24 Fujitsu Limited Diagnosis and Monitoring of Musculoskeletal Pathologies
US11417416B2 (en) * 2018-06-14 2022-08-16 Astrazeneca Uk Limited Methods for lowering blood pressure with a dihydropyridine-type calcium channel blocker pharmaceutical composition
US20220273652A1 (en) 2019-07-31 2022-09-01 Intas Pharmaceuticals Ltd. Pharmaceutical composition comprising hmg-coa reductase inhibitors and fenofibrate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
EP0521417B1 (de) * 1991-07-02 1994-11-23 Joh. A. Benckiser GmbH Zusammenfaltbare Vorratsflasche
JP3852621B2 (ja) * 1992-01-21 2006-12-06 あすか製薬株式会社 血管内皮細胞機能改善剤
FR2730231B1 (fr) * 1995-02-02 1997-04-04 Fournier Sca Lab Association de fenofibrate et de vitamine e, utilisation en therapeutique
JP4738592B2 (ja) * 1997-10-31 2011-08-03 アーチ・デヴェロップメント・コーポレイション 5α−還元酵素活性を調節するための方法及び組成物

Also Published As

Publication number Publication date
TWI282738B (en) 2007-06-21
AU2121800A (en) 2000-08-25
KR20060117381A (ko) 2006-11-16
ID30485A (id) 2001-12-13
PL198034B1 (pl) 2008-05-30
CZ20012844A3 (cs) 2001-11-14
JP2002536331A (ja) 2002-10-29
KR20010101790A (ko) 2001-11-14
NO20013811L (no) 2001-10-02
CA2358632A1 (en) 2000-08-10
DE60015965D1 (de) 2004-12-23
PT1185274E (pt) 2005-03-31
MXPA01007905A (es) 2003-06-04
AR029333A1 (es) 2003-06-25
BR0007999A (pt) 2001-11-06
IL144715A0 (en) 2002-06-30
GB0000710D0 (en) 2000-03-08
CA2358632C (en) 2008-10-28
IS6009A (is) 2001-07-17
US6982157B1 (en) 2006-01-03
EP1185274B1 (en) 2004-11-17
CZ301296B6 (cs) 2010-01-06
US20060040969A1 (en) 2006-02-23
NO20013811D0 (no) 2001-08-03
EE200100406A (et) 2002-10-15
AU767304B2 (en) 2003-11-06
EP1185274A1 (en) 2002-03-13
HK1041817A1 (en) 2002-07-26
DE60015965T2 (de) 2006-01-05
PL364780A1 (en) 2004-12-13
US20090042911A1 (en) 2009-02-12
ATE282415T1 (de) 2004-12-15
EG23858A (en) 2007-11-18
IS2337B (is) 2008-02-15
ES2232418T3 (es) 2005-06-01
NZ512982A (en) 2003-08-29
MY130606A (en) 2007-07-31
EE04929B1 (et) 2007-12-17
TR200102228T2 (tr) 2002-03-21
JP2007277267A (ja) 2007-10-25
CN1165310C (zh) 2004-09-08
WO2000045817A1 (en) 2000-08-10
CN1338936A (zh) 2002-03-06

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