NO319999B1 - Tabletterte, brusende multippelenhet-doseringsformer omfattende en protonpumpeinhibitor, fremgangsmate for fremstilling av slike doseringsformer, og anvendelse derav. - Google Patents
Tabletterte, brusende multippelenhet-doseringsformer omfattende en protonpumpeinhibitor, fremgangsmate for fremstilling av slike doseringsformer, og anvendelse derav. Download PDFInfo
- Publication number
- NO319999B1 NO319999B1 NO19974051A NO974051A NO319999B1 NO 319999 B1 NO319999 B1 NO 319999B1 NO 19974051 A NO19974051 A NO 19974051A NO 974051 A NO974051 A NO 974051A NO 319999 B1 NO319999 B1 NO 319999B1
- Authority
- NO
- Norway
- Prior art keywords
- effervescent
- tableted
- dosage form
- enteric coating
- coating layer
- Prior art date
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- 239000002552 dosage form Substances 0.000 title claims abstract description 54
- 229940126409 proton pump inhibitor Drugs 0.000 title claims abstract description 40
- 239000000612 proton pump inhibitor Substances 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 title claims abstract description 18
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- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims abstract description 18
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 14
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600073A SE512835C2 (sv) | 1996-01-08 | 1996-01-08 | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| PCT/SE1996/001738 WO1997025030A1 (en) | 1996-01-08 | 1996-12-20 | Multiple unit effervescent dosage forms comprising protonpump inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO974051D0 NO974051D0 (no) | 1997-09-03 |
| NO974051L NO974051L (no) | 1997-10-15 |
| NO319999B1 true NO319999B1 (no) | 2005-10-10 |
Family
ID=20400971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19974051A NO319999B1 (no) | 1996-01-08 | 1997-09-03 | Tabletterte, brusende multippelenhet-doseringsformer omfattende en protonpumpeinhibitor, fremgangsmate for fremstilling av slike doseringsformer, og anvendelse derav. |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6132770A (ko) |
| EP (1) | EP0814783B1 (ko) |
| JP (1) | JP4638561B2 (ko) |
| KR (1) | KR100459363B1 (ko) |
| CN (1) | CN100335043C (ko) |
| AR (1) | AR005280A1 (ko) |
| AT (1) | ATE251451T1 (ko) |
| AU (1) | AU712325B2 (ko) |
| BR (1) | BR9607367A (ko) |
| CA (1) | CA2214027C (ko) |
| CZ (1) | CZ280797A3 (ko) |
| DE (1) | DE69630286T2 (ko) |
| DK (1) | DK0814783T3 (ko) |
| EE (1) | EE9700189A (ko) |
| ES (1) | ES2208775T3 (ko) |
| HR (1) | HRP970005A2 (ko) |
| HU (1) | HUP0000976A3 (ko) |
| ID (1) | ID15819A (ko) |
| IL (1) | IL121653A (ko) |
| IS (1) | IS4551A (ko) |
| MX (1) | MX9706768A (ko) |
| NO (1) | NO319999B1 (ko) |
| NZ (1) | NZ325978A (ko) |
| PL (1) | PL322161A1 (ko) |
| PT (1) | PT814783E (ko) |
| SE (1) | SE512835C2 (ko) |
| SI (1) | SI0814783T1 (ko) |
| SK (1) | SK117197A3 (ko) |
| TN (1) | TNSN97002A1 (ko) |
| TR (1) | TR199700918T1 (ko) |
| WO (1) | WO1997025030A1 (ko) |
| YU (1) | YU70196A (ko) |
| ZA (1) | ZA9610939B (ko) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6558952B1 (en) * | 1992-12-14 | 2003-05-06 | Waratah Pharmaceuticals, Inc. | Treatment for diabetes |
| US20050054682A1 (en) * | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| SE512835C2 (sv) * | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| SE9702533D0 (sv) | 1997-07-01 | 1997-07-01 | Astra Ab | New oral formulation |
| HUP0100065A2 (hu) * | 1997-12-08 | 2001-08-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Savérzékeny vegyületet tartalmazó új kúp gyógyszerforma |
| AU742620B2 (en) * | 1998-01-30 | 2002-01-10 | Sepracor, Inc. | R-lansoprazole compositions and methods |
| DK2263660T3 (en) * | 1998-05-18 | 2018-01-02 | Takeda Pharmaceuticals Co | Orally disintegrating tablets. |
| EP1100469B1 (en) * | 1998-07-28 | 2005-03-23 | Takeda Pharmaceutical Company Limited | Rapidly disintegrable solid preparation |
| MXPA01009934A (es) * | 1999-03-29 | 2002-06-21 | American Home Prod | Sistema de recubrimiento. |
| US6174902B1 (en) | 1999-04-28 | 2001-01-16 | Sepracor Inc. | R-rabeprazole compositions and methods |
| WO2000074654A1 (en) | 1999-06-07 | 2000-12-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel preparation and administration form comprising an acid-labile active compound |
| US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
| WO2002026210A2 (en) * | 2000-09-29 | 2002-04-04 | Geneva Pharmaceuticals Inc. | Proton pump inhibitor formulation |
| BR0115986A (pt) | 2000-12-07 | 2003-12-23 | Altana Pharma Ag | Comprimido de desintegração rápida contendo um ingrediente ativo instável aos ácidos |
| UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| US20020192299A1 (en) * | 2000-12-28 | 2002-12-19 | Rajneesh Taneja | Pharmaceutical compositions of a non-enteric coated proton pump inhibitor with a carbonate salt and bicarbonate salt combination |
| CA2472103A1 (en) * | 2002-01-25 | 2003-08-07 | Santarus, Inc. | Transmucosal delivery of proton pump inhibitors |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| DE60318826T2 (de) * | 2002-03-27 | 2009-01-22 | Nycomed Gmbh | Alkoxypyridinderivate |
| FR2838647B1 (fr) * | 2002-04-23 | 2006-02-17 | Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant | |
| US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
| US20040082618A1 (en) * | 2002-07-03 | 2004-04-29 | Rajneesh Taneja | Liquid dosage forms of acid labile drugs |
| US20040005362A1 (en) * | 2002-07-03 | 2004-01-08 | Rajneesh Taneja | Liquid dosage forms of acid labile drugs |
| US20070243251A1 (en) * | 2002-12-20 | 2007-10-18 | Rajneesh Taneja | Dosage Forms Containing A PPI, NSAID, and Buffer |
| US20040121004A1 (en) * | 2002-12-20 | 2004-06-24 | Rajneesh Taneja | Dosage forms containing a PPI, NSAID, and buffer |
| WO2004066924A2 (en) * | 2003-01-24 | 2004-08-12 | Andrx Labs Llc | Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid |
| DE602004023921D1 (de) | 2003-03-10 | 2009-12-17 | Nycomed Gmbh | Neues verfahren zur herstellung vonroflumilast |
| WO2004082679A1 (ja) * | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | 放出制御組成物 |
| ES2234393B2 (es) * | 2003-04-29 | 2006-09-01 | Laboratorios Belmac, S.A. | "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido". |
| PE20050150A1 (es) * | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
| CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| JP2006528181A (ja) * | 2003-07-18 | 2006-12-14 | サンタラス インコーポレイティッド | 酸分泌を阻害するために有用な薬学的製剤ならびにそれらを作製および使用する方法 |
| DE602004014523D1 (de) | 2003-10-01 | 2008-07-31 | Nycomed Gmbh | Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase |
| WO2005030770A1 (en) | 2003-10-01 | 2005-04-07 | Altana Pharma Ag | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
| CN100415746C (zh) * | 2003-10-01 | 2008-09-03 | 奥坦纳医药公司 | 氨基吡啶衍生物作为可诱导的no-合酶抑制剂 |
| US7468377B2 (en) | 2003-10-01 | 2008-12-23 | Altana Pharma Ag | Imidazopyridine-derivatives as inductible no-synthase inhibitors |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| JP5383183B2 (ja) | 2005-03-16 | 2014-01-08 | タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロフルミラストを含有する矯味された剤形 |
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
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-
1996
- 1996-01-08 SE SE9600073A patent/SE512835C2/sv not_active IP Right Cessation
- 1996-12-20 CN CNB961937637A patent/CN100335043C/zh not_active Expired - Lifetime
- 1996-12-20 DE DE69630286T patent/DE69630286T2/de not_active Expired - Lifetime
- 1996-12-20 HU HU0000976A patent/HUP0000976A3/hu unknown
- 1996-12-20 KR KR1019970706237A patent/KR100459363B1/ko not_active IP Right Cessation
- 1996-12-20 DK DK96944727T patent/DK0814783T3/da active
- 1996-12-20 JP JP52513297A patent/JP4638561B2/ja not_active Expired - Lifetime
- 1996-12-20 NZ NZ325978A patent/NZ325978A/xx unknown
- 1996-12-20 WO PCT/SE1996/001738 patent/WO1997025030A1/en active IP Right Grant
- 1996-12-20 CZ CZ972807A patent/CZ280797A3/cs unknown
- 1996-12-20 US US08/793,077 patent/US6132770A/en not_active Expired - Lifetime
- 1996-12-20 PT PT96944727T patent/PT814783E/pt unknown
- 1996-12-20 AU AU13242/97A patent/AU712325B2/en not_active Ceased
- 1996-12-20 IL IL12165396A patent/IL121653A/en not_active IP Right Cessation
- 1996-12-20 SI SI9630657T patent/SI0814783T1/xx unknown
- 1996-12-20 SK SK1171-97A patent/SK117197A3/sk unknown
- 1996-12-20 EP EP96944727A patent/EP0814783B1/en not_active Expired - Lifetime
- 1996-12-20 AT AT96944727T patent/ATE251451T1/de not_active IP Right Cessation
- 1996-12-20 TR TR97/00918T patent/TR199700918T1/xx unknown
- 1996-12-20 CA CA002214027A patent/CA2214027C/en not_active Expired - Lifetime
- 1996-12-20 PL PL96322161A patent/PL322161A1/xx unknown
- 1996-12-20 MX MX9706768A patent/MX9706768A/es not_active IP Right Cessation
- 1996-12-20 ES ES96944727T patent/ES2208775T3/es not_active Expired - Lifetime
- 1996-12-20 BR BR9607367A patent/BR9607367A/pt not_active IP Right Cessation
- 1996-12-20 EE EE9700189A patent/EE9700189A/xx unknown
- 1996-12-26 AR ARP960105897A patent/AR005280A1/es unknown
- 1996-12-26 YU YU70196A patent/YU70196A/sh unknown
- 1996-12-30 ZA ZA9610939A patent/ZA9610939B/xx unknown
-
1997
- 1997-01-03 HR HR9600073-2A patent/HRP970005A2/hr not_active Application Discontinuation
- 1997-01-06 TN TNTNSN97002A patent/TNSN97002A1/fr unknown
- 1997-01-08 ID IDP970023A patent/ID15819A/id unknown
- 1997-08-25 IS IS4551A patent/IS4551A/is unknown
- 1997-09-03 NO NO19974051A patent/NO319999B1/no unknown
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