NO319787B1 - Anvendelse av allogenisk eller xenogenisk celle som vekselvirker med en gp39-antagonist ved fremstilling av et preparat til induksjon av T-celle-toleranse hos et vevs- eller organ-transplantat. - Google Patents

Anvendelse av allogenisk eller xenogenisk celle som vekselvirker med en gp39-antagonist ved fremstilling av et preparat til induksjon av T-celle-toleranse hos et vevs- eller organ-transplantat. Download PDF

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Publication number
NO319787B1
NO319787B1 NO19964440A NO964440A NO319787B1 NO 319787 B1 NO319787 B1 NO 319787B1 NO 19964440 A NO19964440 A NO 19964440A NO 964440 A NO964440 A NO 964440A NO 319787 B1 NO319787 B1 NO 319787B1
Authority
NO
Norway
Prior art keywords
cells
cell
allogeneic
use according
tissue
Prior art date
Application number
NO19964440A
Other languages
English (en)
Norwegian (no)
Other versions
NO964440D0 (no
NO964440L (no
Inventor
Randolph J Noelle
Fiona H Durie
David C Parker
Michael C Appel
Nancy E Philips
John P Mordes
Dale L Grenier
Aldo A Rossini
Original Assignee
Dartmouth College
Univ Massachusetts Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dartmouth College, Univ Massachusetts Medical filed Critical Dartmouth College
Publication of NO964440D0 publication Critical patent/NO964440D0/no
Publication of NO964440L publication Critical patent/NO964440L/no
Publication of NO319787B1 publication Critical patent/NO319787B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/001Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/39Pancreas; Islets of Langerhans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/46433Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/46434Antigens related to induction of tolerance to non-self
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
NO19964440A 1994-04-25 1996-10-18 Anvendelse av allogenisk eller xenogenisk celle som vekselvirker med en gp39-antagonist ved fremstilling av et preparat til induksjon av T-celle-toleranse hos et vevs- eller organ-transplantat. NO319787B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/234,987 US5683693A (en) 1994-04-25 1994-04-25 Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
PCT/US1995/004832 WO1995028957A2 (fr) 1994-04-25 1995-04-25 Procedes servant a provoquer la tolerance des lymphocytes t a une greffe de tissu ou d'organe

Publications (3)

Publication Number Publication Date
NO964440D0 NO964440D0 (no) 1996-10-18
NO964440L NO964440L (no) 1996-12-23
NO319787B1 true NO319787B1 (no) 2005-09-12

Family

ID=22883593

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19964440A NO319787B1 (no) 1994-04-25 1996-10-18 Anvendelse av allogenisk eller xenogenisk celle som vekselvirker med en gp39-antagonist ved fremstilling av et preparat til induksjon av T-celle-toleranse hos et vevs- eller organ-transplantat.
NO20051182A NO20051182L (no) 1994-04-25 2005-03-04 Fremgangmater for a indusere T-celle-toleranse hos et vevs- eller organtransplantat

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20051182A NO20051182L (no) 1994-04-25 2005-03-04 Fremgangmater for a indusere T-celle-toleranse hos et vevs- eller organtransplantat

Country Status (34)

Country Link
US (4) US5683693A (fr)
EP (2) EP1530973A3 (fr)
JP (1) JP2974415B2 (fr)
KR (1) KR100468330B1 (fr)
CN (1) CN1134266C (fr)
AP (1) AP764A (fr)
AT (1) ATE288281T1 (fr)
AU (1) AU710925B2 (fr)
BG (1) BG62121B1 (fr)
BR (1) BR9507509A (fr)
CA (1) CA2188672A1 (fr)
CZ (1) CZ291266B6 (fr)
DE (1) DE69533984T2 (fr)
DK (1) DK0757557T3 (fr)
EE (1) EE03516B1 (fr)
ES (1) ES2237757T3 (fr)
FI (1) FI118792B (fr)
GE (1) GEP20022648B (fr)
HU (1) HU221752B1 (fr)
IS (1) IS2118B (fr)
LT (1) LT4309B (fr)
LV (1) LV11785B (fr)
MD (1) MD1444B2 (fr)
NO (2) NO319787B1 (fr)
NZ (1) NZ284905A (fr)
OA (1) OA10591A (fr)
PL (1) PL180031B1 (fr)
PT (1) PT757557E (fr)
RO (1) RO114743B1 (fr)
RU (1) RU2169009C2 (fr)
SI (1) SI9520057A (fr)
SK (1) SK136996A3 (fr)
UA (1) UA44892C2 (fr)
WO (1) WO1995028957A2 (fr)

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KR102656470B1 (ko) 2014-12-10 2024-04-09 리전츠 오브 더 유니버스티 오브 미네소타 질환을 치료하기 위한 유전적으로 변형된 세포, 조직 및 장기
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Also Published As

Publication number Publication date
BG62121B1 (bg) 1999-03-31
SI9520057A (sl) 1998-06-30
RO114743B1 (ro) 1999-07-30
KR100468330B1 (ko) 2005-12-30
ES2237757T3 (es) 2005-08-01
US5683693A (en) 1997-11-04
AU710925B2 (en) 1999-09-30
FI964272A (fi) 1996-12-19
BR9507509A (pt) 1997-02-02
DK0757557T3 (da) 2005-05-23
WO1995028957A2 (fr) 1995-11-02
IS2118B (is) 2006-06-15
JP2974415B2 (ja) 1999-11-10
MD970009A (en) 1999-01-31
US6375950B1 (en) 2002-04-23
EP0757557A1 (fr) 1997-02-12
CZ312596A3 (en) 1997-03-12
RU2169009C2 (ru) 2001-06-20
SK136996A3 (en) 1999-01-11
EP1530973A2 (fr) 2005-05-18
DE69533984T2 (de) 2006-04-27
PL180031B1 (pl) 2000-12-29
IS4378A (is) 1996-10-22
EP1530973A3 (fr) 2006-12-27
CZ291266B6 (cs) 2003-01-15
NZ284905A (en) 2004-10-29
EE03516B1 (et) 2001-10-15
UA44892C2 (uk) 2002-03-15
AU2358595A (en) 1995-11-16
NO20051182L (no) 1996-12-23
FI118792B (fi) 2008-03-31
AP9600906A0 (en) 1997-01-31
US7501124B2 (en) 2009-03-10
CA2188672A1 (fr) 1995-11-02
DE69533984D1 (de) 2005-03-10
AP764A (en) 1999-09-16
WO1995028957A3 (fr) 1995-11-23
LV11785A (lv) 1997-06-20
LT4309B (lt) 1998-03-25
LV11785B (en) 1998-02-20
LT96165A (en) 1997-11-25
EE9600162A (et) 1997-06-16
CN1150760A (zh) 1997-05-28
EP0757557B1 (fr) 2005-02-02
HU221752B1 (hu) 2002-12-28
FI964272A0 (fi) 1996-10-23
JPH09512271A (ja) 1997-12-09
US20050152897A1 (en) 2005-07-14
MD1444B2 (ro) 2000-04-30
ATE288281T1 (de) 2005-02-15
CN1134266C (zh) 2004-01-14
PL317022A1 (en) 1997-03-03
US5902585A (en) 1999-05-11
BG100991A (en) 1998-01-30
NO964440D0 (no) 1996-10-18
OA10591A (en) 2002-07-15
GEP20022648B (en) 2002-03-25
NO964440L (no) 1996-12-23
PT757557E (pt) 2005-05-31
HU9602924D0 (en) 1996-12-30
HUT76091A (en) 1997-06-30

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