NO318193B1 - Anvendelse av en proteinkinase C-inhibitor til behandling av kongestiv hjertesvikt - Google Patents
Anvendelse av en proteinkinase C-inhibitor til behandling av kongestiv hjertesvikt Download PDFInfo
- Publication number
- NO318193B1 NO318193B1 NO19985808A NO985808A NO318193B1 NO 318193 B1 NO318193 B1 NO 318193B1 NO 19985808 A NO19985808 A NO 19985808A NO 985808 A NO985808 A NO 985808A NO 318193 B1 NO318193 B1 NO 318193B1
- Authority
- NO
- Norway
- Prior art keywords
- protein kinase
- inhibitor
- endothelial cell
- heart failure
- congestive heart
- Prior art date
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Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61P13/00—Drugs for disorders of the urinary system
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
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- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/662,623 US5723456A (en) | 1993-12-07 | 1996-06-13 | Therapeutic treatment for cardiovascular diseases |
| PCT/US1997/009661 WO1997047298A1 (en) | 1996-06-13 | 1997-06-12 | Therapeutic treatment for cardiovascular diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO985808D0 NO985808D0 (no) | 1998-12-11 |
| NO985808L NO985808L (no) | 1999-02-12 |
| NO318193B1 true NO318193B1 (no) | 2005-02-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19985808A NO318193B1 (no) | 1996-06-13 | 1998-12-11 | Anvendelse av en proteinkinase C-inhibitor til behandling av kongestiv hjertesvikt |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5723456A (ru) |
| EP (1) | EP0954308B1 (ru) |
| JP (1) | JP2000512293A (ru) |
| KR (1) | KR20000016625A (ru) |
| AT (1) | ATE315933T1 (ru) |
| AU (1) | AU725582B2 (ru) |
| BR (1) | BR9709727A (ru) |
| CA (1) | CA2257693A1 (ru) |
| CZ (1) | CZ406798A3 (ru) |
| DE (1) | DE69735134T2 (ru) |
| EA (1) | EA005035B1 (ru) |
| ES (1) | ES2255106T3 (ru) |
| HU (1) | HUP0003679A3 (ru) |
| IL (1) | IL127524A0 (ru) |
| NO (1) | NO318193B1 (ru) |
| NZ (1) | NZ333341A (ru) |
| PL (1) | PL189253B1 (ru) |
| UA (1) | UA49025C2 (ru) |
| WO (1) | WO1997047298A1 (ru) |
| YU (1) | YU57398A (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6147109A (en) * | 1997-10-14 | 2000-11-14 | The General Hospital Corporation | Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA reductase inhibitors |
| US6180597B1 (en) * | 1998-03-19 | 2001-01-30 | Brigham And Women's Hospital, Inc. | Upregulation of Type III endothelial cell nitric oxide synthase by rho GTPase function inhibitors |
| US6127401A (en) | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
| US6423751B1 (en) | 1998-07-14 | 2002-07-23 | The Brigham And Women's Hospital, Inc. | Upregulation of type III endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization |
| US6303646B1 (en) | 1999-08-09 | 2001-10-16 | Zhimin Lu | Cancer treatment with Gö 6976 |
| CA2538999A1 (en) * | 2003-09-19 | 2005-03-31 | Children's Hospital Medical Center | Regulation of cardiac contractility and heart failure propensity |
| US20080182801A1 (en) | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
| GB0513881D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
| GB0329667D0 (en) | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
| DE102004019413A1 (de) * | 2004-04-19 | 2005-11-24 | Phenos Gmbh | Hemmung der Proteinkinase C epsilon zur Behandlung von Krankheiten |
| CN1274303C (zh) * | 2004-07-09 | 2006-09-13 | 吕志民 | 一种化合物及其衍生物在制备防治癌症药物中的应用 |
| GB0513888D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| US7741290B2 (en) * | 2006-06-01 | 2010-06-22 | The Board of Trustee of The Leland Stanford Juinior University | Method of preventing progression of hypertension-induced heart failure with PKC peptides |
Family Cites Families (29)
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| JPH0699311B2 (ja) * | 1986-11-06 | 1994-12-07 | 旭化成工業株式会社 | 抗血管レン縮剤および血管弛緩剤 |
| US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
| US4808613A (en) * | 1986-11-21 | 1989-02-28 | Bristol-Myers Company | Rebeccamycin derivative containing pharmaceutical composition |
| DE3752123T2 (de) * | 1987-03-09 | 1998-05-14 | Kyowa Hakko Kogyo Kk | Derivate des physiologisch aktiven mittels k-252 |
| JPH07113027B2 (ja) * | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | Ｋ−２５２誘導体 |
| DE3803620A1 (de) * | 1988-02-06 | 1989-08-17 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| US5438050A (en) * | 1988-02-06 | 1995-08-01 | Godecke Aktiengesellschaft | Indolocarbazole derivatives, processes for their preparation and compositions containing them |
| IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
| MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
| CA2015996C (en) * | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| DE3914764A1 (de) * | 1989-05-05 | 1990-11-08 | Goedecke Ag | Maleinimid-derivate und deren verwendung als arzneimittel |
| DE3924538A1 (de) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
| DE3942296A1 (de) * | 1989-12-21 | 1991-06-27 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung |
| DE4005970A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
| CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
| JPH04187687A (ja) * | 1990-11-21 | 1992-07-06 | Fuji Photo Film Co Ltd | フルオラン化合物の製造方法 |
| JPH06503837A (ja) * | 1991-04-11 | 1994-04-28 | シェリング・コーポレーション | 抗腫瘍および抗乾癬薬 |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| US5589472A (en) * | 1992-09-25 | 1996-12-31 | Vice; Susan F. | Diindolo compounds and pharmaceutical compositions containing them |
| DE4243321A1 (de) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
| AU678435B2 (en) * | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
| ES2162843T3 (es) * | 1993-12-07 | 2002-01-16 | Lilly Co Eli | Inhibidores de la proteina quinasa c. |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| UA54427C2 (ru) * | 1996-05-01 | 2003-03-17 | Елі Ліллі Енд Компані | Способ лечения заболеваний глаз, связанных с фактором роста эндотелия сосудов |
-
1996
- 1996-06-13 US US08/662,623 patent/US5723456A/en not_active Expired - Fee Related
-
1997
- 1997-06-12 DE DE69735134T patent/DE69735134T2/de not_active Expired - Fee Related
- 1997-06-12 ES ES97931034T patent/ES2255106T3/es not_active Expired - Lifetime
- 1997-06-12 AU AU34763/97A patent/AU725582B2/en not_active Ceased
- 1997-06-12 YU YU57398A patent/YU57398A/sh unknown
- 1997-06-12 UA UA99010154A patent/UA49025C2/ru unknown
- 1997-06-12 KR KR1019980710221A patent/KR20000016625A/ko not_active Application Discontinuation
- 1997-06-12 JP JP10501674A patent/JP2000512293A/ja not_active Withdrawn
- 1997-06-12 WO PCT/US1997/009661 patent/WO1997047298A1/en not_active Application Discontinuation
- 1997-06-12 AT AT97931034T patent/ATE315933T1/de not_active IP Right Cessation
- 1997-06-12 HU HU0003679A patent/HUP0003679A3/hu unknown
- 1997-06-12 BR BR9709727A patent/BR9709727A/pt not_active Application Discontinuation
- 1997-06-12 IL IL12752497A patent/IL127524A0/xx unknown
- 1997-06-12 CA CA002257693A patent/CA2257693A1/en not_active Abandoned
- 1997-06-12 EP EP97931034A patent/EP0954308B1/en not_active Expired - Lifetime
- 1997-06-12 NZ NZ333341A patent/NZ333341A/xx unknown
- 1997-06-12 EA EA199900025A patent/EA005035B1/ru not_active IP Right Cessation
- 1997-06-12 PL PL97330604A patent/PL189253B1/pl not_active IP Right Cessation
- 1997-06-12 CZ CZ984067A patent/CZ406798A3/cs unknown
-
1998
- 1998-12-11 NO NO19985808A patent/NO318193B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL330604A1 (en) | 1999-05-24 |
| AU3476397A (en) | 1998-01-07 |
| HUP0003679A2 (hu) | 2001-04-28 |
| EA199900025A1 (ru) | 1999-06-24 |
| NO985808D0 (no) | 1998-12-11 |
| EP0954308A4 (en) | 2001-06-06 |
| PL189253B1 (pl) | 2005-07-29 |
| EP0954308B1 (en) | 2006-01-18 |
| YU57398A (sh) | 2000-10-30 |
| JP2000512293A (ja) | 2000-09-19 |
| CZ406798A3 (cs) | 1999-08-11 |
| ES2255106T3 (es) | 2006-06-16 |
| DE69735134T2 (de) | 2006-08-17 |
| HUP0003679A3 (en) | 2002-09-30 |
| WO1997047298A1 (en) | 1997-12-18 |
| IL127524A0 (en) | 1999-10-28 |
| NZ333341A (en) | 2000-05-26 |
| DE69735134D1 (de) | 2006-04-06 |
| KR20000016625A (ko) | 2000-03-25 |
| US5723456A (en) | 1998-03-03 |
| NO985808L (no) | 1999-02-12 |
| UA49025C2 (ru) | 2002-09-16 |
| EP0954308A1 (en) | 1999-11-10 |
| AU725582B2 (en) | 2000-10-12 |
| CA2257693A1 (en) | 1997-12-18 |
| ATE315933T1 (de) | 2006-02-15 |
| EA005035B1 (ru) | 2004-10-28 |
| BR9709727A (pt) | 1999-08-10 |
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