NO317417B1 - Pyrazolderivater - Google Patents

Pyrazolderivater Download PDF

Info

Publication number
NO317417B1
NO317417B1 NO20001907A NO20001907A NO317417B1 NO 317417 B1 NO317417 B1 NO 317417B1 NO 20001907 A NO20001907 A NO 20001907A NO 20001907 A NO20001907 A NO 20001907A NO 317417 B1 NO317417 B1 NO 317417B1
Authority
NO
Norway
Prior art keywords
substituted
group
pyrazol
trifluoromethyl
alkyl
Prior art date
Application number
NO20001907A
Other languages
English (en)
Norwegian (no)
Other versions
NO20001907D0 (no
NO20001907L (no
Inventor
Yoshinori Okamoto
Hirokazu Kubota
Yasuhiro Yonetoku
Keizo Sugasawa
Masashi Funatsu
Souichirou Kawazoe
Jun Ishikawa
Makoto Takeuchi
Akira Toyoshima
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of NO20001907D0 publication Critical patent/NO20001907D0/no
Publication of NO20001907L publication Critical patent/NO20001907L/no
Publication of NO317417B1 publication Critical patent/NO317417B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20001907A 1997-10-13 2000-04-12 Pyrazolderivater NO317417B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27909397 1997-10-13
PCT/JP1998/004583 WO1999019303A1 (fr) 1997-10-13 1998-10-12 Derives de pyrazole

Publications (3)

Publication Number Publication Date
NO20001907D0 NO20001907D0 (no) 2000-04-12
NO20001907L NO20001907L (no) 2000-06-09
NO317417B1 true NO317417B1 (no) 2004-10-25

Family

ID=17606326

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001907A NO317417B1 (no) 1997-10-13 2000-04-12 Pyrazolderivater

Country Status (18)

Country Link
US (4) US6348480B1 (de)
EP (1) EP1024138B1 (de)
KR (1) KR100589868B1 (de)
CN (1) CN1107671C (de)
AR (1) AR016957A1 (de)
AT (1) ATE360618T1 (de)
AU (2) AU751139B2 (de)
BR (1) BR9803883A (de)
CA (1) CA2304979A1 (de)
DE (1) DE69837675T2 (de)
ES (1) ES2285784T3 (de)
HU (1) HUP9802310A1 (de)
NO (1) NO317417B1 (de)
PL (1) PL192411B1 (de)
PT (1) PT1024138E (de)
RU (1) RU2185381C2 (de)
TW (1) TW495498B (de)
WO (1) WO1999019303A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
EP1068187A1 (de) * 1998-04-08 2001-01-17 Abbott Laboratories Pyrazole als inhibitoren der cytokinproduktion
US6506747B1 (en) * 1998-06-05 2003-01-14 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
CA2338804A1 (en) * 1998-07-28 2000-02-10 Smithkline Beecham Corporation Propenamides as ccr5 modulators
EP1101759A4 (de) * 1998-07-31 2001-12-12 Nippon Soda Co Phenylazol-derivate, verfahren zu ihrer herstellung und medikamente für hyperlipemie
JP2001031509A (ja) * 1999-07-15 2001-02-06 Nippon Bayer Agrochem Co Ltd チエニル−ピラゾール類の有害生物防除剤としての利用
WO2001055115A1 (en) * 2000-01-27 2001-08-02 Cytovia, Inc. Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof
US6451820B1 (en) * 2000-03-23 2002-09-17 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents
US6353007B1 (en) * 2000-07-13 2002-03-05 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents
EP1186661A1 (de) * 2000-09-05 2002-03-13 Warner-Lambert Company Identifizierung eines kapazitativen Calcium Kanals in Antigen-präsentierenden Zellen und dessen Verwendung
EP1184457A1 (de) * 2000-09-05 2002-03-06 Warner-Lambert Company Identifizierung eines kapazitiven Calcium Kanals in Antigen-präsentierenden Zellen und dessen Verwendung
US7132546B2 (en) 2000-12-22 2006-11-07 Ishihara Sangyo Kaisha, Ltd. Aniline derivatives or salts thereof and cytokine production inhibitors containing the same
MXPA03011002A (es) * 2001-06-06 2004-10-28 Agouron Pharma Agentes gnrh no peptidicos, composiciones farmaceuticas y procedimientos para su uso y procesos para prepararlos a ellos y a sus intermedios.
US6831082B2 (en) 2001-06-29 2004-12-14 Boehringer Ingelheim Pharmaceuticals, Inc. Method of using soluble epoxide hydrolase inhibitors
GB0209715D0 (en) * 2002-04-27 2002-06-05 Astrazeneca Ab Chemical compounds
CA2495437A1 (en) * 2002-08-27 2004-03-11 Yamanouchi Pharmaceutical Co., Ltd. Novel crystal
AU2003267728A1 (en) * 2002-10-18 2004-05-04 Pfizer Products Inc. Cannabinoid receptor ligands and uses thereof
US7790724B2 (en) * 2003-04-25 2010-09-07 Janssen Pharmaceutica N.V. c-fms kinase inhibitors
US20050107436A1 (en) * 2003-07-23 2005-05-19 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
JP4928949B2 (ja) 2003-12-23 2012-05-09 アステックス、セラピューティックス、リミテッド タンパク質キナーゼモジュレーターとしてのピラゾール誘導体
EP1725544B1 (de) * 2004-03-09 2009-05-27 Boehringer Ingelheim Pharmaceuticals Inc. 3-[4-heterocyclyl-1,2,3-triazol-1-yl]-n-arylbenzamide als inhibitoren der cytokinenproduktion für die behandlung von chronischen entzündlichen erkrankungen
AU2005226741A1 (en) * 2004-03-25 2005-10-06 Synta Pharmaceuticals Corp. Acrylonitrile derivatives for inflammation and immune-related uses
TW200633990A (en) 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
JPWO2006115140A1 (ja) * 2005-04-22 2008-12-18 アステラス製薬株式会社 腸疾患の予防若しくは治療剤
GB2427406A (en) * 2005-06-21 2006-12-27 Astex Technology Ltd Silicon-containing PKB/PKA kinase inhibitors
WO2006136821A1 (en) 2005-06-22 2006-12-28 Astex Therapeutics Limited Pharmaceutical compounds
WO2006136837A2 (en) 2005-06-23 2006-12-28 Astex Therapeutics Limited Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators
CA2640091A1 (en) * 2006-01-25 2007-08-02 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses
AU2007221020B9 (en) * 2006-02-28 2013-04-04 Dart Neuroscience (Cayman) Ltd. Therapeutic compounds
ES2462240T3 (es) 2006-02-28 2014-05-22 Dart Neuroscience (Cayman) Ltd Piperazinas terapéuticas como inhibidores de PDE4
AU2013200480B2 (en) * 2006-02-28 2016-06-09 Dart Neuroscience (Cayman) Ltd. Therapeutic compounds
US7803799B2 (en) * 2006-07-07 2010-09-28 National Health Research Institutes Selenophene compounds
WO2008016131A1 (fr) * 2006-08-04 2008-02-07 Takeda Pharmaceutical Company Limited Composé hétérocyclique à cycles fusionnés
CN101506203B (zh) * 2006-08-24 2013-10-16 诺瓦提斯公司 治疗代谢病、心血管病和其他病症的作为硬脂酰辅酶a脱饱和酶(scd)抑制剂的2-(吡嗪-2-基)-噻唑和2-(1h-吡唑-3-基)-噻唑衍生物及相关化合物
CN103641829A (zh) 2006-08-30 2014-03-19 塞尔佐姆有限公司 作为激酶抑制剂的三唑衍生物
TWI339205B (en) * 2006-10-02 2011-03-21 Nat Health Research Institutes Pyrazole compounds and pharmaceutical composition
TWI408136B (zh) * 2006-10-02 2013-09-11 Nat Health Research Institutes 噻吩化合物及其醫藥組成物
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
EP2136820A4 (de) * 2007-03-05 2010-09-15 Univ Queensland Target für die brustkrebstherapie und/oder diagnose
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
MX2010002258A (es) 2007-08-27 2010-04-22 Helicon Therapeutics Inc Compuestos terapeuticos de isoxazol.
GB0801888D0 (en) * 2008-02-01 2008-03-12 Isis Innovation Treatment of mast cell related disorders
DE102008014523A1 (de) * 2008-03-15 2009-09-17 Robert Bosch Gmbh Heizgerät
KR101612971B1 (ko) * 2008-05-14 2016-04-15 아스테라스 세이야쿠 가부시키가이샤 아미드 화합물
JP2010030970A (ja) * 2008-07-31 2010-02-12 Bayer Cropscience Ag 殺虫性ベンゼンジカルボキサミド誘導体
TWI434686B (zh) * 2008-11-03 2014-04-21 Nat Health Research Institutes 咪唑－４－酮及咪唑－４－硫酮化合物
JP2012516344A (ja) * 2009-01-30 2012-07-19 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 結晶質ｎ−｛（１ｓ）−２−アミノ−１−［（３−フルオロフェニル）メチル］エチル｝−５−クロロ−４−（４−クロロ−１−メチル−１ｈ−ピラゾール−５−イル）−２−チオフェンカルボキサミド塩酸塩
WO2010122089A1 (en) 2009-04-24 2010-10-28 Glaxo Group Limited N-pyrazolyl carboxamides as crac channel inhibitors
US20120035237A1 (en) 2009-04-24 2012-02-09 Diane Mary Coe Pyrazole and triazole carboxamides as crac chann el inhibitors
WO2010126002A1 (ja) * 2009-04-28 2010-11-04 塩野義製薬株式会社 ヘテロ環スルホンアミド化合物を含有する医薬
EP2440553B1 (de) * 2009-06-12 2017-08-23 Merck Sharp & Dohme Corp. Thiophene als glucagonrezeptorantagonisten, zusammensetzungen und verfahren zu ihrer verwendung
US8377970B2 (en) 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
US8993612B2 (en) * 2009-10-08 2015-03-31 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
CA2797533A1 (en) 2010-04-27 2011-11-10 Calcimedica, Inc. Compounds that modulate intracellular calcium
DK2563776T3 (en) 2010-04-27 2016-09-19 Calcimedica Inc Relations that modulate intracellular calcium
AU2011293201B2 (en) * 2010-08-27 2015-11-05 Calcimedica Inc. Compounds that modulate intracellular calcium
WO2012052459A1 (en) 2010-10-21 2012-04-26 Glaxo Group Limited Pyrazole compounds acting against allergic, inflammatory and immune disorders
WO2012052458A1 (en) 2010-10-21 2012-04-26 Glaxo Group Limited Pyrazole compounds acting against allergic, immune and inflammatory conditions
JP5985611B2 (ja) 2011-05-03 2016-09-06 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連用途のための化合物
WO2012170931A2 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
AU2012325901A1 (en) * 2011-10-19 2014-05-15 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9856240B2 (en) 2011-10-19 2018-01-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9409898B2 (en) 2012-05-02 2016-08-09 Lupin Limited Substituted pyrazole compounds as CRAC modulators
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
BR112015016394A2 (pt) 2013-01-10 2017-07-11 Gruenenthal Gmbh carboxamidas ii baseadas em pirazolil como inibidoras do canal crac
CA2897562A1 (en) 2013-01-10 2014-07-17 Grunenthal Gmbh Pyrazolyl-based carboxamides i as crac channel inhibitors
EP3027221A1 (de) 2013-07-30 2016-06-08 PhaseRx, Inc. Blockcopolymere und deren konjugate oder komplexe mit oligonukleotiden
MX2016007951A (es) * 2013-12-19 2016-09-09 Gruenenthal Gmbh Pirrol carboxamidas iv fluorometil-sustituidas.
MX2016007955A (es) * 2013-12-19 2016-09-09 Gruenenthal Gmbh Pirrol carboxamidas iii fluorometil-sustituidas.
CN104926801B (zh) * 2014-03-22 2019-06-04 浙江大学 取代氮杂环类衍生物、含其的药物组合物及其在抗肿瘤中的应用
WO2015197187A1 (en) 2014-06-24 2015-12-30 Grünenthal GmbH Pyrazolyl-based carboxamides v
WO2016118697A1 (en) 2015-01-21 2016-07-28 Phaserx, Inc. Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells
EP4275705A3 (de) 2015-02-27 2024-01-17 Calcimedica, Inc. Pankreatitisbehandlung
WO2017027400A1 (en) 2015-08-07 2017-02-16 Calcimedica, Inc. Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury
CN105503832B (zh) * 2015-12-18 2018-03-27 浙江大学 取代吡唑环类衍生物及其用途
US11684584B2 (en) 2016-12-30 2023-06-27 Genevant Sciences Gmbh Branched peg molecules and related compositions and methods
EP3849552A1 (de) 2018-09-14 2021-07-21 Rhizen Pharmaceuticals AG Zusammensetzungen mit einem crac-inhibitor und einem kortikosteroid und verfahren zu deren verwendung
CN111187204B (zh) * 2020-01-13 2022-11-08 海利尔药业集团股份有限公司 一种啶虫脒共晶及其制备方法、用途
CA3169697A1 (en) * 2020-02-28 2021-09-02 Dominic Reynolds Thiophenyl derivatives useful for modulating nucleic acid splicing
WO2024126777A1 (en) * 2022-12-16 2024-06-20 Astrazeneca Ab Heteroaromatic compounds

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3401911A1 (de) * 1984-01-20 1985-08-01 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 4,5-dihydro-6-vinyl-3(2h)-pyridazinone und 6-vinyl-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
GB8409986D0 (en) * 1984-04-17 1984-05-31 Beecham Group Plc Beta-lactam antibacterial agents
NZ212209A (en) * 1984-05-29 1988-08-30 Pfizer Quinolone derivatives and pharmaceutical compositions
JPS6455557A (en) * 1987-08-26 1989-03-02 Fuji Photo Film Co Ltd Silver halide color photographic sensitive material
US5571821A (en) * 1993-05-20 1996-11-05 Texas Biotechnology Corporation Sulfonamides and derivatives thereof that modulate the activity of endothelin
JPH0419721Y2 (de) 1987-09-29 1992-05-06
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
JP2867450B2 (ja) 1989-08-17 1999-03-08 吉富製薬株式会社 アルキレンビスアミド化合物
PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
FR2659655B1 (fr) * 1990-03-19 1992-07-24 Union Pharma Scient Appl Nouveaux derives d'oxypyrazole antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE4126994A1 (de) * 1991-08-16 1993-02-18 Basf Ag (alpha)-arylacrylsaeurederivate, ihre herstellung und verwendung zur bekaempfung von schaedlingen und pilzen
JP3141261B2 (ja) 1992-10-22 2001-03-05 松下電工株式会社 警報表示器
US5739135A (en) 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
JPH07225401A (ja) * 1994-02-14 1995-08-22 Fuji Photo Film Co Ltd 非線形光学材料
JPH10510512A (ja) * 1994-10-04 1998-10-13 藤沢薬品工業株式会社 尿素誘導体とａｃａｔ阻害剤としての用途
WO1996023783A1 (en) * 1995-02-02 1996-08-08 Smithkline Beecham Plc Indole derivatives as 5-ht receptor antagonist
WO1996031517A1 (en) * 1995-04-04 1996-10-10 E.I. Du Pont De Nemours And Company Herbicidal heteroaryl-substituted anilides
MX9702380A (es) 1995-08-02 1998-02-28 Uriach & Cia Sa J Nuevas carboxamidas con actividad antifungica.
JPH1072434A (ja) * 1996-04-08 1998-03-17 Nissan Chem Ind Ltd ２，４−置換アニリン誘導体
AU6229298A (en) 1997-02-20 1998-09-09 Shionogi & Co., Ltd. Indole dicarboxylic acid derivatives
WO1998037068A1 (en) 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents
DE19708928A1 (de) * 1997-03-05 1998-09-10 Bayer Ag Substituierte aromatische Aminoverbindungen
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
EP1068187A1 (de) * 1998-04-08 2001-01-17 Abbott Laboratories Pyrazole als inhibitoren der cytokinproduktion
US6506747B1 (en) * 1998-06-05 2003-01-14 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
US6140509A (en) * 1998-06-26 2000-10-31 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof
US20010044445A1 (en) 1999-04-08 2001-11-22 Bamaung Nwe Y. Azole inhibitors of cytokine production

Also Published As

Publication number Publication date
NO20001907D0 (no) 2000-04-12
DE69837675T2 (de) 2008-01-10
US20060264430A1 (en) 2006-11-23
DE69837675D1 (en) 2007-06-06
PT1024138E (pt) 2007-08-01
ATE360618T1 (de) 2007-05-15
HUP9802310A1 (hu) 2000-03-28
PL329150A1 (en) 1999-04-26
RU2185381C2 (ru) 2002-07-20
AU9459398A (en) 1999-05-03
US6348480B1 (en) 2002-02-19
US6958339B2 (en) 2005-10-25
KR19990037018A (ko) 1999-05-25
CA2304979A1 (en) 1999-04-22
US7247635B2 (en) 2007-07-24
TW495498B (en) 2002-07-21
US20050234055A1 (en) 2005-10-20
AR016957A1 (es) 2001-08-01
CN1107671C (zh) 2003-05-07
EP1024138A1 (de) 2000-08-02
EP1024138A4 (de) 2002-02-06
HU9802310D0 (en) 1998-12-28
KR100589868B1 (ko) 2006-10-24
US20010011090A1 (en) 2001-08-02
US7285554B2 (en) 2007-10-23
AU751139B2 (en) 2002-08-08
ES2285784T3 (es) 2007-11-16
PL192411B1 (pl) 2006-10-31
CN1218046A (zh) 1999-06-02
EP1024138B1 (de) 2007-04-25
BR9803883A (pt) 2000-05-16
NO20001907L (no) 2000-06-09
AU8713998A (en) 1999-04-29
WO1999019303A1 (fr) 1999-04-22

Similar Documents

Publication Publication Date Title
NO317417B1 (no) Pyrazolderivater
JP4208925B2 (ja) 治療薬
JP4740115B2 (ja) 置換ピラゾール
WO2006126695A1 (ja) ピラゾール化合物及びそれらピラゾール化合物を含んでなる糖尿病治療薬
CZ200036A3 (cs) Triazolové sloučeniny a jejich použití
BG65193B1 (bg) Производно на пиразолкарбоксилна киселина, неговото използване и фармацевтични състави, които го съдържат
WO2004020393A1 (ja) ジベンジルアミン化合物及びその医薬用途
JP2000256358A (ja) ピラゾール誘導体
CA2332957A1 (en) Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
JP2011153144A (ja) 置換ピラゾール化合物
AU714701B2 (en) Novel thiophene derivative and pharmaceutical composition thereof
CA2666975C (en) Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same
JP4385414B2 (ja) アミド若しくはアミン誘導体
CA2521199A1 (en) Pyrazole compounds
US7705029B2 (en) Acrylonitrile derivatives for inflammation and immune-related uses
MXPA98008433A (en) Derivatives of amida and pharmaceutical composition that contains them, useful as caliber channel inhibitor activated by the release of cal
JP2023134657A (ja) 新規抗腫瘍剤

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees