AR016957A1 - Derivado de amida y composicion farmaceutica util para la inhibicion del canal de ca2+ activado por liberacion de ca2+ - Google Patents
Derivado de amida y composicion farmaceutica util para la inhibicion del canal de ca2+ activado por liberacion de ca2+Info
- Publication number
- AR016957A1 AR016957A1 ARP980105064A ARP980105064A AR016957A1 AR 016957 A1 AR016957 A1 AR 016957A1 AR P980105064 A ARP980105064 A AR P980105064A AR P980105064 A ARP980105064 A AR P980105064A AR 016957 A1 AR016957 A1 AR 016957A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- substituted
- formula
- lower alkyl
- alkyl groups
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivado de amida, caracterizado porque está representado por la formula general (I), [los símbolos en la formula tienen los siguientes significados:D representa un grupo pirazolilo que puede tener 1 a 3 grupos alquilo inferior sustituidos o no sustituidos con halogeno como sustituyente(s); B representaun grupo fenileno o tiofenediilo; X representa un grupo de formula -NH-CO- -CO-NH-; y A representa un grupo fenilo que puede ser sustituido por uno o másátomos de halogeno, o un grupo heteroarilomonocíclico de 5 o 6 miembros que puede estar sustituido por uno o más grupos alquilo inferior, con lacondicion de que se excluyan 4-metil-4[((3,5-bis)trifluorometil)-1H-pirazol-1-il]-1,2,3-tiadiazol-5-carboxianilida y 4-cloro-5-(1-metil-5-trifluorometil-1H-pirazol-3-il)tiofeno-2-carboxianilida o una sal farmacéuticamente aceptable del mismo. Una composicion farmacéutica que incluye un derivado de amida deformula (I)[los símbolos en la formula tienen los siguientes significados: D representa ungrupo pirazolilo que puede tener 1 a 3 grupos alquilo inferiorsustituidos o no sustituidos con halogeno como sustituyente(s); B representa un grupo fenileno o tiofenediilo; X representa un grupo de formula -NH-CO- o-CO-NH-, y A representa un grupo fenilo que puede ser sustituido por uno o más átomos de halogeno, o un grupo heteroarilo monocíclico de 5 o 6 miembros quepuede estar sustituido por uno o más grupos alquilo inferior y un vehículo farmacéuticamente aceptable, particularmente para ser usada en la inhibiciondel canal Ca2+.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27909397 | 1997-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR016957A1 true AR016957A1 (es) | 2001-08-01 |
Family
ID=17606326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980105064A AR016957A1 (es) | 1997-10-13 | 1998-10-13 | Derivado de amida y composicion farmaceutica util para la inhibicion del canal de ca2+ activado por liberacion de ca2+ |
Country Status (18)
Country | Link |
---|---|
US (4) | US6348480B1 (es) |
EP (1) | EP1024138B1 (es) |
KR (1) | KR100589868B1 (es) |
CN (1) | CN1107671C (es) |
AR (1) | AR016957A1 (es) |
AT (1) | ATE360618T1 (es) |
AU (2) | AU751139B2 (es) |
BR (1) | BR9803883A (es) |
CA (1) | CA2304979A1 (es) |
DE (1) | DE69837675T2 (es) |
ES (1) | ES2285784T3 (es) |
HU (1) | HUP9802310A1 (es) |
NO (1) | NO317417B1 (es) |
PL (1) | PL192411B1 (es) |
PT (1) | PT1024138E (es) |
RU (1) | RU2185381C2 (es) |
TW (1) | TW495498B (es) |
WO (1) | WO1999019303A1 (es) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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CA2332957A1 (en) * | 1998-06-05 | 1999-12-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents |
JP2002521441A (ja) * | 1998-07-28 | 2002-07-16 | スミスクライン・ビーチャム・コーポレイション | Ccr5モジュレーターとしてのプロペンアミド |
WO2000006550A1 (fr) * | 1998-07-31 | 2000-02-10 | Nippon Soda Co., Ltd. | Composes phenylazole, procede de production desdits composes et medicaments pour le traitement de l'hyperlipidemie |
JP2001031509A (ja) * | 1999-07-15 | 2001-02-06 | Nippon Bayer Agrochem Co Ltd | チエニル−ピラゾール類の有害生物防除剤としての利用 |
US6794397B2 (en) * | 2000-01-27 | 2004-09-21 | Cytovia, Inc. | Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US6451820B1 (en) | 2000-03-23 | 2002-09-17 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents |
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WO2002051397A1 (fr) * | 2000-12-22 | 2002-07-04 | Ishihara Sangyo Kaisha, Ltd. | Derives d'aniline ou sels de ceux-ci, ainsi qu'inhibiteurs de production de cytokine contenant ces derives |
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JP2008546751A (ja) | 2005-06-22 | 2008-12-25 | アステックス・セラピューティクス・リミテッド | 医薬組成物 |
JP5345842B2 (ja) | 2005-06-23 | 2013-11-20 | アステックス・セラピューティクス・リミテッド | プロテインキナーゼモジュレーターとしてのピラゾール誘導体を含む医薬組み合わせ |
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BRPI0708353A8 (pt) | 2006-02-28 | 2017-09-19 | Dart Neuroscience Cayman Ltd | Compostos terapêuticos |
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JP2012524754A (ja) | 2009-04-24 | 2012-10-18 | グラクソ グループ リミテッド | Cracチャネル阻害剤としてのピラゾールおよびトリアゾ−ルカルボキサミド |
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CN105503832B (zh) * | 2015-12-18 | 2018-03-27 | 浙江大学 | 取代吡唑环类衍生物及其用途 |
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1998
- 1998-09-29 AU AU87139/98A patent/AU751139B2/en not_active Ceased
- 1998-10-06 BR BR9803883-4A patent/BR9803883A/pt not_active IP Right Cessation
- 1998-10-09 RU RU98118557/04A patent/RU2185381C2/ru not_active IP Right Cessation
- 1998-10-12 HU HU9802310A patent/HUP9802310A1/hu unknown
- 1998-10-12 EP EP98947818A patent/EP1024138B1/en not_active Expired - Lifetime
- 1998-10-12 AT AT98947818T patent/ATE360618T1/de not_active IP Right Cessation
- 1998-10-12 CA CA002304979A patent/CA2304979A1/en not_active Abandoned
- 1998-10-12 AU AU94593/98A patent/AU9459398A/en not_active Abandoned
- 1998-10-12 ES ES98947818T patent/ES2285784T3/es not_active Expired - Lifetime
- 1998-10-12 DE DE69837675T patent/DE69837675T2/de not_active Expired - Fee Related
- 1998-10-12 US US09/529,131 patent/US6348480B1/en not_active Expired - Fee Related
- 1998-10-12 WO PCT/JP1998/004583 patent/WO1999019303A1/ja active IP Right Grant
- 1998-10-12 PL PL329150A patent/PL192411B1/pl not_active IP Right Cessation
- 1998-10-12 TW TW087116918A patent/TW495498B/zh not_active IP Right Cessation
- 1998-10-12 KR KR1019980042475A patent/KR100589868B1/ko not_active IP Right Cessation
- 1998-10-12 PT PT98947818T patent/PT1024138E/pt unknown
- 1998-10-13 AR ARP980105064A patent/AR016957A1/es unknown
- 1998-10-13 CN CN98121354A patent/CN1107671C/zh not_active Expired - Fee Related
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2000
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2001
- 2001-02-02 US US09/773,736 patent/US6958339B2/en not_active Expired - Fee Related
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2005
- 2005-06-17 US US11/154,591 patent/US7247635B2/en not_active Expired - Fee Related
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2006
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AU8713998A (en) | 1999-04-29 |
TW495498B (en) | 2002-07-21 |
US7247635B2 (en) | 2007-07-24 |
US20010011090A1 (en) | 2001-08-02 |
CN1218046A (zh) | 1999-06-02 |
US6348480B1 (en) | 2002-02-19 |
AU9459398A (en) | 1999-05-03 |
US7285554B2 (en) | 2007-10-23 |
US20060264430A1 (en) | 2006-11-23 |
DE69837675D1 (en) | 2007-06-06 |
ATE360618T1 (de) | 2007-05-15 |
EP1024138B1 (en) | 2007-04-25 |
US6958339B2 (en) | 2005-10-25 |
CN1107671C (zh) | 2003-05-07 |
NO317417B1 (no) | 2004-10-25 |
EP1024138A4 (en) | 2002-02-06 |
PT1024138E (pt) | 2007-08-01 |
ES2285784T3 (es) | 2007-11-16 |
WO1999019303A1 (fr) | 1999-04-22 |
BR9803883A (pt) | 2000-05-16 |
EP1024138A1 (en) | 2000-08-02 |
CA2304979A1 (en) | 1999-04-22 |
US20050234055A1 (en) | 2005-10-20 |
RU2185381C2 (ru) | 2002-07-20 |
PL192411B1 (pl) | 2006-10-31 |
HUP9802310A1 (hu) | 2000-03-28 |
KR100589868B1 (ko) | 2006-10-24 |
NO20001907L (no) | 2000-06-09 |
DE69837675T2 (de) | 2008-01-10 |
PL329150A1 (en) | 1999-04-26 |
AU751139B2 (en) | 2002-08-08 |
NO20001907D0 (no) | 2000-04-12 |
HU9802310D0 (en) | 1998-12-28 |
KR19990037018A (ko) | 1999-05-25 |
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