NO316354B1 - Liposompreparat samt fremgangsmåte for fremstilling av liposompreparater inneholdende selegilin og/eller et salt derav - Google Patents
Liposompreparat samt fremgangsmåte for fremstilling av liposompreparater inneholdende selegilin og/eller et salt derav Download PDFInfo
- Publication number
- NO316354B1 NO316354B1 NO19971870A NO971870A NO316354B1 NO 316354 B1 NO316354 B1 NO 316354B1 NO 19971870 A NO19971870 A NO 19971870A NO 971870 A NO971870 A NO 971870A NO 316354 B1 NO316354 B1 NO 316354B1
- Authority
- NO
- Norway
- Prior art keywords
- weight
- selegiline
- liposome
- salt
- preparation
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 62
- 238000000034 method Methods 0.000 title claims abstract description 16
- 150000003839 salts Chemical class 0.000 title claims abstract description 13
- 239000002502 liposome Substances 0.000 title claims description 56
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 title claims description 39
- 229960003946 selegiline Drugs 0.000 title claims description 29
- 239000004480 active ingredient Substances 0.000 claims abstract description 23
- 150000002632 lipids Chemical class 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 13
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 10
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 10
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 10
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 8
- 208000018737 Parkinson disease Diseases 0.000 claims abstract description 5
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 5
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 5
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 5
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 5
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000003755 preservative agent Substances 0.000 claims abstract description 5
- 208000003926 Myelitis Diseases 0.000 claims abstract description 4
- 208000006011 Stroke Diseases 0.000 claims abstract description 4
- 201000003152 motion sickness Diseases 0.000 claims abstract description 4
- 239000003085 diluting agent Substances 0.000 claims abstract 2
- 239000000945 filler Substances 0.000 claims abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 208000024827 Alzheimer disease Diseases 0.000 claims description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims description 2
- RYCNUMLMNKHWPZ-SNVBAGLBSA-N 1-acetyl-sn-glycero-3-phosphocholine Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C RYCNUMLMNKHWPZ-SNVBAGLBSA-N 0.000 claims description 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 230000008020 evaporation Effects 0.000 claims description 2
- 239000003791 organic solvent mixture Substances 0.000 claims description 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 229960001295 tocopherol Drugs 0.000 claims description 2
- 229930003799 tocopherol Natural products 0.000 claims description 2
- 235000010384 tocopherol Nutrition 0.000 claims description 2
- 239000011732 tocopherol Substances 0.000 claims description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 238000011049 filling Methods 0.000 abstract description 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000010909 Monoamine Oxidase Human genes 0.000 description 17
- 108010062431 Monoamine oxidase Proteins 0.000 description 17
- 230000005764 inhibitory process Effects 0.000 description 12
- 239000002207 metabolite Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 210000004556 brain Anatomy 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 210000000056 organ Anatomy 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 241000282887 Suidae Species 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 230000036765 blood level Effects 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 241000700198 Cavia Species 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000011324 bead Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 229960001252 methamphetamine Drugs 0.000 description 4
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 4
- 239000003599 detergent Substances 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 230000001430 anti-depressive effect Effects 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- IYETZZCWLLUHIJ-UHFFFAOYSA-N methyl-(1-phenylpropan-2-yl)-prop-2-ynylazanium;chloride Chemical compound Cl.C#CCN(C)C(C)CC1=CC=CC=C1 IYETZZCWLLUHIJ-UHFFFAOYSA-N 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 229960003678 selegiline hydrochloride Drugs 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- UUFAJPMQSFXDFR-LLVKDONJSA-N Norselegiline Chemical compound C#CCN[C@H](C)CC1=CC=CC=C1 UUFAJPMQSFXDFR-LLVKDONJSA-N 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000012675 alcoholic extract Substances 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 239000001913 cellulose Chemical class 0.000 description 1
- 229920002678 cellulose Chemical class 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229940084238 eldepryl Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000005567 liquid scintillation counting Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- -1 methamphetamine Chemical class 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 239000003368 psychostimulant agent Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000941 radioactive substance Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 239000002691 unilamellar liposome Substances 0.000 description 1
- 239000006200 vaporizer Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Detergent Compositions (AREA)
- Dental Preparations (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9403073A HU223475B1 (hu) | 1994-10-24 | 1994-10-24 | Selegilint tartalmazó liposzoma-készítmény és eljárás ennek előállítására |
| PCT/HU1995/000052 WO1996012472A1 (en) | 1994-10-24 | 1995-10-20 | Liposome composition containing selegilin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO971870D0 NO971870D0 (no) | 1997-04-23 |
| NO971870L NO971870L (no) | 1997-06-24 |
| NO316354B1 true NO316354B1 (no) | 2004-01-19 |
Family
ID=10985697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19971870A NO316354B1 (no) | 1994-10-24 | 1997-04-23 | Liposompreparat samt fremgangsmåte for fremstilling av liposompreparater inneholdende selegilin og/eller et salt derav |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5888536A (de) |
| EP (1) | EP0788349B1 (de) |
| JP (1) | JPH10507749A (de) |
| KR (1) | KR100313149B1 (de) |
| CN (1) | CN1084186C (de) |
| AT (1) | ATE205387T1 (de) |
| AU (1) | AU691348B2 (de) |
| BG (1) | BG63327B1 (de) |
| BR (1) | BR9509517A (de) |
| CA (1) | CA2203513C (de) |
| CZ (1) | CZ287349B6 (de) |
| DE (1) | DE69522701T2 (de) |
| DK (1) | DK0788349T3 (de) |
| EE (1) | EE03418B1 (de) |
| ES (1) | ES2160718T3 (de) |
| FI (1) | FI971743A (de) |
| HU (1) | HU223475B1 (de) |
| IL (1) | IL115754A (de) |
| NO (1) | NO316354B1 (de) |
| NZ (1) | NZ294660A (de) |
| PL (1) | PL183104B1 (de) |
| PT (1) | PT788349E (de) |
| RO (1) | RO116768B1 (de) |
| RU (1) | RU2159106C2 (de) |
| SK (1) | SK281599B6 (de) |
| TW (1) | TW412420B (de) |
| UA (1) | UA44289C2 (de) |
| WO (1) | WO1996012472A1 (de) |
| YU (1) | YU49313B (de) |
| ZA (1) | ZA958999B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2472499A (en) * | 1998-01-27 | 1999-08-09 | Thomas N. Thomas | Methods of treatment using mao-a and mao-b inhibitors such as l-deprenyl |
| DE19814257A1 (de) | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Brauseformulierungen |
| GB9815785D0 (en) * | 1998-07-20 | 1998-09-16 | Cerebrus Ltd | Chemical compounds |
| CA2536393A1 (en) * | 2003-09-09 | 2005-06-16 | Gilead Sciences, Inc. | Use of liposomes which are small unilamellar vesicles for the removal of an entity from a biological sample |
| EP1848541A4 (de) * | 2005-02-07 | 2013-01-16 | Pharmalight Inc | Verfahren und vorrichtung zur ophthalmischen verabreichung von pharmazeutischen wirksstoffen |
| CN1813679A (zh) * | 2005-11-30 | 2006-08-09 | 上海医药(集团)有限公司 | 一种紫杉烷脂质体冻干组合物及其制备方法 |
| US9445975B2 (en) * | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
| JP5623102B2 (ja) * | 2010-03-12 | 2014-11-12 | 株式会社フジモト・コーポレーション | セレギリン含有貼付製剤 |
| JP5693026B2 (ja) * | 2010-03-12 | 2015-04-01 | 株式会社フジモト・コーポレーション | セレギリン含有貼付製剤 |
| RU2678433C2 (ru) | 2012-05-10 | 2019-01-29 | Пейнреформ Лтд. | Депо-составы гидрофобного активного ингредиента и способы их получения |
| AU2015326378B2 (en) * | 2014-09-29 | 2021-01-21 | Council Of Scientific & Industrial Research | A formulation useful for delivery of neuro protecting agent |
| EP3600435B1 (de) * | 2017-03-23 | 2024-03-20 | Lipid Systems sp. z.o.o. | Hochwirksame verkapselung hydrophiler verbindungen in unilamellaren liposomen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH588887A5 (de) * | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
| US4485054A (en) * | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4761288A (en) * | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
| GB8807504D0 (en) * | 1988-03-29 | 1988-05-05 | Sandoz Ltd | Improvements in/relating to organic compounds |
| US4937078A (en) * | 1988-08-26 | 1990-06-26 | Mezei Associates Limited | Liposomal local anesthetic and analgesic products |
| FR2713087B1 (fr) * | 1993-11-30 | 1996-02-23 | Saurat Jean Hilaire | Utilisation de la sélégiline et ses dérivés pour la préparation d'un médicament destiné au traitement du psoriasis. |
-
1994
- 1994-10-24 HU HU9403073A patent/HU223475B1/hu not_active IP Right Cessation
-
1995
- 1995-10-20 NZ NZ294660A patent/NZ294660A/en not_active IP Right Cessation
- 1995-10-20 UA UA97052395A patent/UA44289C2/uk unknown
- 1995-10-20 ES ES95935530T patent/ES2160718T3/es not_active Expired - Lifetime
- 1995-10-20 CN CN95195853A patent/CN1084186C/zh not_active Expired - Fee Related
- 1995-10-20 SK SK517-97A patent/SK281599B6/sk unknown
- 1995-10-20 RO RO97-00792A patent/RO116768B1/ro unknown
- 1995-10-20 JP JP8513742A patent/JPH10507749A/ja active Pending
- 1995-10-20 US US08/817,433 patent/US5888536A/en not_active Expired - Fee Related
- 1995-10-20 EE EE9700102A patent/EE03418B1/xx not_active IP Right Cessation
- 1995-10-20 CZ CZ19971147A patent/CZ287349B6/cs not_active IP Right Cessation
- 1995-10-20 PL PL95319875A patent/PL183104B1/pl not_active IP Right Cessation
- 1995-10-20 DK DK95935530T patent/DK0788349T3/da active
- 1995-10-20 RU RU97108051/14A patent/RU2159106C2/ru not_active IP Right Cessation
- 1995-10-20 CA CA002203513A patent/CA2203513C/en not_active Expired - Fee Related
- 1995-10-20 WO PCT/HU1995/000052 patent/WO1996012472A1/en active IP Right Grant
- 1995-10-20 AT AT95935530T patent/ATE205387T1/de not_active IP Right Cessation
- 1995-10-20 EP EP95935530A patent/EP0788349B1/de not_active Expired - Lifetime
- 1995-10-20 DE DE69522701T patent/DE69522701T2/de not_active Expired - Fee Related
- 1995-10-20 PT PT95935530T patent/PT788349E/pt unknown
- 1995-10-20 BR BR9509517A patent/BR9509517A/pt not_active IP Right Cessation
- 1995-10-20 KR KR1019970702682A patent/KR100313149B1/ko not_active IP Right Cessation
- 1995-10-20 AU AU37518/95A patent/AU691348B2/en not_active Ceased
- 1995-10-24 IL IL11575495A patent/IL115754A/xx not_active IP Right Cessation
- 1995-10-24 TW TW084111224A patent/TW412420B/zh not_active IP Right Cessation
- 1995-10-24 ZA ZA958999A patent/ZA958999B/xx unknown
- 1995-10-25 YU YU67195A patent/YU49313B/sh unknown
-
1997
- 1997-04-22 BG BG101432A patent/BG63327B1/bg unknown
- 1997-04-23 FI FI971743A patent/FI971743A/fi not_active IP Right Cessation
- 1997-04-23 NO NO19971870A patent/NO316354B1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210093566A1 (en) | Composition of matter comprising liposomes embedded in a polymeric matrix and methods of using same | |
| NO316354B1 (no) | Liposompreparat samt fremgangsmåte for fremstilling av liposompreparater inneholdende selegilin og/eller et salt derav | |
| US6562371B1 (en) | Liposomes | |
| WO1989003689A1 (en) | Tocopherol-based pharmaceutical systems | |
| US9078812B2 (en) | Particulate drug carriers as desensitizing agents | |
| JP2002503209A (ja) | 著しく改善された抗腫瘍活性によるリポソーム抗腫瘍療法 | |
| MXPA97003019A (en) | Liposoma composition containing selegil | |
| JPH11171772A (ja) | 抗腫瘍薬のリポソーム化製剤 | |
| US20230285293A1 (en) | Pharmaceutical composition of intra-articular corticosteroid for pain control | |
| CA2066698A1 (en) | Liposomal compositions | |
| JP2001181207A (ja) | 難水溶性薬理活性物質のろ過滅菌可能化方法 |