NO315254B1 - Ern¶ringsformuleringer inneholdende Lacto-N-neotetraose - Google Patents
Ern¶ringsformuleringer inneholdende Lacto-N-neotetraose Download PDFInfo
- Publication number
- NO315254B1 NO315254B1 NO19994722A NO994722A NO315254B1 NO 315254 B1 NO315254 B1 NO 315254B1 NO 19994722 A NO19994722 A NO 19994722A NO 994722 A NO994722 A NO 994722A NO 315254 B1 NO315254 B1 NO 315254B1
- Authority
- NO
- Norway
- Prior art keywords
- composition according
- neotetraose
- lacto
- approx
- amount
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- IEQCXFNWPAHHQR-UHFFFAOYSA-N lacto-N-neotetraose Natural products OCC1OC(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)C(NC(=O)C)C(O)C1OC1OC(CO)C(O)C(O)C1O IEQCXFNWPAHHQR-UHFFFAOYSA-N 0.000 title claims abstract description 38
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 26
- 229940062780 lacto-n-neotetraose Drugs 0.000 title claims abstract description 18
- RBMYDHMFFAVMMM-PLQWBNBWSA-N neolactotetraose Chemical compound O([C@H]1[C@H](O)[C@H]([C@@H](O[C@@H]1CO)O[C@@H]1[C@H]([C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@H](CO)[C@@H]1O)O)NC(=O)C)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O RBMYDHMFFAVMMM-PLQWBNBWSA-N 0.000 title claims abstract description 18
- 238000009472 formulation Methods 0.000 title abstract description 19
- 230000002503 metabolic effect Effects 0.000 claims abstract description 12
- 241000588724 Escherichia coli Species 0.000 claims abstract description 9
- 241000193403 Clostridium Species 0.000 claims abstract description 7
- 241000606125 Bacteroides Species 0.000 claims abstract 2
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims description 13
- 229940004120 bifidobacterium infantis Drugs 0.000 claims description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
- 239000005862 Whey Substances 0.000 claims description 8
- 108010046377 Whey Proteins Proteins 0.000 claims description 8
- 102000007544 Whey Proteins Human genes 0.000 claims description 8
- 235000021073 macronutrients Nutrition 0.000 claims description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 6
- 239000011707 mineral Substances 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 230000004936 stimulating effect Effects 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 239000003240 coconut oil Substances 0.000 claims description 4
- 235000019864 coconut oil Nutrition 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 4
- 239000011574 phosphorus Substances 0.000 claims description 4
- 229910052698 phosphorus Inorganic materials 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- 229910052700 potassium Inorganic materials 0.000 claims description 4
- 239000011669 selenium Substances 0.000 claims description 4
- 229910052711 selenium Inorganic materials 0.000 claims description 4
- 235000011649 selenium Nutrition 0.000 claims description 4
- 235000020183 skimmed milk Nutrition 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 235000012424 soybean oil Nutrition 0.000 claims description 4
- 235000019155 vitamin A Nutrition 0.000 claims description 4
- 239000011719 vitamin A Substances 0.000 claims description 4
- 235000019154 vitamin C Nutrition 0.000 claims description 4
- 239000011718 vitamin C Substances 0.000 claims description 4
- 235000019166 vitamin D Nutrition 0.000 claims description 4
- 239000011710 vitamin D Substances 0.000 claims description 4
- 235000019165 vitamin E Nutrition 0.000 claims description 4
- 239000011709 vitamin E Substances 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- 235000016804 zinc Nutrition 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000003549 soybean oil Substances 0.000 claims description 3
- 235000019156 vitamin B Nutrition 0.000 claims description 3
- 239000011720 vitamin B Substances 0.000 claims description 3
- 108010073771 Soybean Proteins Proteins 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 229940001941 soy protein Drugs 0.000 claims description 2
- 108010009736 Protein Hydrolysates Proteins 0.000 claims 1
- 239000003531 protein hydrolysate Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 241000186000 Bifidobacterium Species 0.000 abstract description 17
- 208000035143 Bacterial infection Diseases 0.000 abstract description 6
- 208000022362 bacterial infectious disease Diseases 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 2
- IEQCXFNWPAHHQR-YKLSGRGUSA-N beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc Chemical compound O([C@H]1[C@H](O)[C@H]([C@@H](O[C@@H]1CO)O[C@@H]1[C@H]([C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)O[C@H](CO)[C@@H]1O)O)NC(=O)C)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O IEQCXFNWPAHHQR-YKLSGRGUSA-N 0.000 description 20
- 235000013350 formula milk Nutrition 0.000 description 20
- 241000894006 Bacteria Species 0.000 description 15
- 235000020256 human milk Nutrition 0.000 description 13
- 230000001580 bacterial effect Effects 0.000 description 10
- 150000001720 carbohydrates Chemical class 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- 229920001542 oligosaccharide Polymers 0.000 description 7
- 150000002482 oligosaccharides Chemical class 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000000758 substrate Substances 0.000 description 7
- 235000014633 carbohydrates Nutrition 0.000 description 6
- 210000004251 human milk Anatomy 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000000638 stimulation Effects 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- 235000013343 vitamin Nutrition 0.000 description 5
- 239000011782 vitamin Substances 0.000 description 5
- 229940088594 vitamin Drugs 0.000 description 5
- 229930003231 vitamin Natural products 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 4
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000051366 Glycosyltransferases Human genes 0.000 description 3
- 108700023372 Glycosyltransferases Proteins 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 241001148536 Bacteroides sp. Species 0.000 description 2
- 241000186016 Bifidobacterium bifidum Species 0.000 description 2
- 241000186012 Bifidobacterium breve Species 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 description 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 2
- 239000000370 acceptor Substances 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000021255 galacto-oligosaccharides Nutrition 0.000 description 2
- 150000003271 galactooligosaccharides Chemical class 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 235000021129 infant diet Nutrition 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 244000005706 microflora Species 0.000 description 2
- 229950006780 n-acetylglucosamine Drugs 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- MBIJFIUDKPXMAV-UHFFFAOYSA-N 1,8-dinitroanthracene-9,10-dione Chemical compound O=C1C2=CC=CC([N+]([O-])=O)=C2C(=O)C2=C1C=CC=C2[N+](=O)[O-] MBIJFIUDKPXMAV-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- OPIFSICVWOWJMJ-YGEXGZRRSA-N 5-bromo-4-chloro-3-indolyl alpha-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 OPIFSICVWOWJMJ-YGEXGZRRSA-N 0.000 description 1
- OPIFSICVWOWJMJ-AEOCFKNESA-N 5-bromo-4-chloro-3-indolyl beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 OPIFSICVWOWJMJ-AEOCFKNESA-N 0.000 description 1
- 231100000699 Bacterial toxin Toxicity 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- 241001112695 Clostridiales Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000000688 bacterial toxin Substances 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 244000005709 gut microbiome Species 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- ODXINVOINFDDDD-UHFFFAOYSA-N laricitrin 3-O-glucoside Natural products OC1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)OC2C(C(O)C(O)C(CO)O2)O)=C1 ODXINVOINFDDDD-UHFFFAOYSA-N 0.000 description 1
- 230000003050 macronutrient Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000037125 natural defense Effects 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 244000005714 skin microbiome Species 0.000 description 1
- 235000013597 soy food Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000004044 tetrasaccharides Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
- A23C9/203—Dietetic milk products not covered by groups A23C9/12 - A23C9/18 containing bifidus-active substances, e.g. lactulose; containing oligosaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S426/00—Food or edible material: processes, compositions, and products
- Y10S426/801—Pediatric
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Pediatric Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Dairy Products (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/829,220 US5906982A (en) | 1997-03-31 | 1997-03-31 | Nutritional formulations containing Lacto-N-neoTetraose |
| PCT/US1998/006217 WO1998043495A1 (fr) | 1997-03-31 | 1998-03-30 | Formulations nutritionnelles contenant de la lacto-n-neotetraose |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO994722L NO994722L (no) | 1999-09-28 |
| NO994722D0 NO994722D0 (no) | 1999-09-28 |
| NO315254B1 true NO315254B1 (no) | 2003-08-11 |
Family
ID=25253891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19994722A NO315254B1 (no) | 1997-03-31 | 1999-09-28 | Ern¶ringsformuleringer inneholdende Lacto-N-neotetraose |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5906982A (fr) |
| EP (1) | EP0973413B2 (fr) |
| JP (1) | JP4148535B2 (fr) |
| AT (1) | ATE271788T1 (fr) |
| CA (1) | CA2285066C (fr) |
| DE (1) | DE69825260T3 (fr) |
| DK (1) | DK0973413T4 (fr) |
| ES (1) | ES2229486T5 (fr) |
| NO (1) | NO315254B1 (fr) |
| PT (1) | PT973413E (fr) |
| WO (1) | WO1998043495A1 (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5906982A (en) * | 1997-03-31 | 1999-05-25 | Abbott Laboratories | Nutritional formulations containing Lacto-N-neoTetraose |
| US6375994B1 (en) * | 1999-08-20 | 2002-04-23 | Sun Ten Laboratories, Inc. | Preparation of fiber, L-glutamine and a soy derivative for the purpose of enhancement of isoflavone bioavailability |
| EP1062873A1 (fr) * | 1999-12-13 | 2000-12-27 | N.V. Nutricia | Aliment amélioré pour bébés, hydrolysat de protéines utilisables dans un tel aliment pour bébés, et procédé de préparation de cet hydrolysat |
| ATE305309T1 (de) | 2002-02-04 | 2005-10-15 | Kyowa Hakko Kogyo Kk | Pharmazeutische und lebenmittelzusammensetzungen mit einem di- oder oligosaccharid, das die insulinfreisetzung steigert |
| US20040047866A1 (en) * | 2002-09-09 | 2004-03-11 | President And Fellows Of Harvard College | Immunomodulatory methods using carbohydrate antigens |
| GB0321996D0 (en) * | 2003-09-19 | 2003-10-22 | Novartis Nutrition Ag | Organic compounds |
| US20080126195A1 (en) | 2004-07-22 | 2008-05-29 | Ritter Andrew J | Methods and Compositions for Treating Lactose Intolerance |
| DE102004040452A1 (de) * | 2004-08-20 | 2006-02-23 | N.V. Nutricia | Peptidgemisch |
| PT1629850E (pt) | 2004-08-24 | 2007-08-14 | Nutricia Nv | Composição nutricional que compreende a administração de oligossacarídeos indigeríveis |
| EP1869985B1 (fr) * | 2005-04-08 | 2018-05-23 | Megmilk Snow Brand Co., Ltd. | Utilisation d'une protéine de lait dans une composition comprenant du fer et de la vitamine c afin d'éviter un goût astringent de fer ou la formation de précipités, la protéine de lait étant du lait écrémé ou un isolat de protéine de lactosérum |
| US8197872B2 (en) * | 2007-05-17 | 2012-06-12 | The Regents Of The University Of California | Human milk oligosaccharides to promote growth of beneficial gut bacteria |
| RU2486904C2 (ru) * | 2007-11-08 | 2013-07-10 | Нестек С.А. | Применение олигосахаридов, содержащих n-ацетиллактозамин, для развития иммунных ответов у новорожденных |
| US20110223248A1 (en) * | 2007-12-12 | 2011-09-15 | Ritter Pharmaceuticals, Inc. | Methods and compositions for treating lactose intolerance |
| CA2984935C (fr) * | 2009-02-24 | 2021-01-12 | Ritter Pharmaceuticals, Inc. | Formulations prebiotiques et methodes d'utilisation |
| EP3202406A1 (fr) | 2010-04-28 | 2017-08-09 | Ritter Pharmaceuticals, Inc. | Formulations prébiotiques et méthodes d'utilisation |
| EP2465508A1 (fr) * | 2010-11-23 | 2012-06-20 | Nestec S.A. | Composition comportant des protéines hydrolysées et oligosaccharides pour le traitement des maladies de la peau |
| WO2012092082A1 (fr) * | 2010-12-30 | 2012-07-05 | Abbott Laboratories | Préparation hypocalorique pour nourrissons à capacité de tampon réduite |
| MY171620A (en) | 2010-12-31 | 2019-10-21 | Abbott Lab | Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers or children using human milk oligosaccharides |
| MY166945A (en) | 2010-12-31 | 2018-07-25 | Abbott Lab | Nutritional formulations including human milk oligosaccharides and long chain polyunsaturated polyunsaturated fatty acids and uses thereof |
| CA2822495C (fr) | 2010-12-31 | 2020-12-22 | Abbott Laboratories | Methodes d'utilisation d'oligosaccharides du lait humain afin d'ameliorer la sante respiratoire des voies aeriennes |
| CN103501638A (zh) | 2010-12-31 | 2014-01-08 | 雅培制药有限公司 | 包含人乳低聚糖和核苷酸的营养型组合物以及其治疗和/或预防肠病毒感染的用途 |
| US9283240B2 (en) | 2010-12-31 | 2016-03-15 | Abbott Laboratories | Human milk oligosaccharides for modulating inflammation |
| CN103763940B (zh) * | 2010-12-31 | 2015-10-14 | 雅培制药有限公司 | 促进有益微生物群生长的益生菌和人乳寡糖的合益素组合 |
| MX338174B (es) | 2010-12-31 | 2016-04-06 | Abbott Lab | Metodos para reducir la incidencia de la tension oxidativa al usar los oligosacaridos de leche humana, la vitamina c y los agentes antiinflamatorios. |
| SG10201707519PA (en) | 2010-12-31 | 2017-10-30 | Abbott Lab | Neutral human milk oligosaccharides to promote growth of beneficial bacteria |
| WO2013016111A1 (fr) | 2011-07-22 | 2013-01-31 | Abbott Laboratories | Galacto-oligosaccharides pour prévenir une lésion et/ou favoriser la cicatrisation du tractus gastro-intestinal |
| MX368124B (es) | 2011-08-29 | 2019-09-19 | Abbott Lab | Oligosacaridos de leche humana para prevenir lesion y/o promover cicatrizacion del tracto gastrointestinal. |
| PT2768313E (pt) * | 2011-10-18 | 2015-10-14 | Nestec Sa | Complexos de derivados de hidratos de carbono-ferro hidrossolúveis, a sua produção e os medicamentos que os contêm |
| EP2842560A4 (fr) * | 2012-04-23 | 2015-12-02 | Univ Kyoto | Composition favorisant la croissance de bifidobacterium |
| CN104853621A (zh) * | 2012-12-20 | 2015-08-19 | 雅培制药有限公司 | 使用人乳寡糖用于调节炎症的营养制剂 |
| US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
| US10987368B2 (en) * | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
| WO2016091265A1 (fr) | 2014-12-08 | 2016-06-16 | Glycom A/S | Composition synthétique pour le traitement de troubles métaboliques |
| US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| ES2947458T3 (es) | 2015-03-05 | 2023-08-09 | Nestle Sa | Composiciones para su uso en la prevención o el tratamiento de infecciones gastrointestinales en lactantes o niños pequeños |
| US20180220690A1 (en) | 2015-08-04 | 2018-08-09 | Nestec S.A. | Nutritional compositions with 2fl and lnnt for use in inducing a gut microbiota close to the one of breast fed infants |
| WO2017215721A1 (fr) * | 2016-06-15 | 2017-12-21 | Glycom A/S | Compositions synthétiques comprenant des oligosaccharides du lait humain pour l'utilisation dans la prévention et le traitement de troubles |
| CN109562117A (zh) | 2016-08-04 | 2019-04-02 | 雀巢产品技术援助有限公司 | 具有2FL和LNnT的营养组合物，用于通过作用于肠道微生物群生态失调来预防和/或治疗非轮状病毒腹泻 |
| WO2024024906A1 (fr) * | 2022-07-29 | 2024-02-01 | 森永乳業株式会社 | Composition favorisant l'utilisation d'oligosaccharide dans bifidobacterium breve |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE518409A (fr) * | ||||
| AU561067B2 (en) * | 1982-03-22 | 1987-04-30 | Biocarb Ab | Anti-bacterial composition containing an oligosaccharide |
| SE462134B (sv) * | 1987-10-22 | 1990-05-14 | Biocarb Ab | Livsmedel innehaallande lacto-n-tetraos och foerfarande foer dess framstaellning |
| US4895838A (en) * | 1988-03-09 | 1990-01-23 | Trustees Of Boston University | Method for provoking angiogenesis by administration of angiogenically active oligosaccharides |
| EP0481038B1 (fr) * | 1990-04-16 | 2002-10-02 | The Trustees Of The University Of Pennsylvania | Compositions saccharides et procedes et appareil servant a les synthetiser |
| WO1995024488A1 (fr) * | 1994-03-09 | 1995-09-14 | Abbott Laboratories | Animaux transgeniques produisant des oligosaccharides et des glycoconjugues |
| US5750176A (en) * | 1994-03-09 | 1998-05-12 | Abbott Laboratories | Transgenic non-human mammal milk comprising 2'-fucosyl-lactose |
| US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
| US5906982A (en) * | 1997-03-31 | 1999-05-25 | Abbott Laboratories | Nutritional formulations containing Lacto-N-neoTetraose |
-
1997
- 1997-03-31 US US08/829,220 patent/US5906982A/en not_active Expired - Lifetime
-
1998
- 1998-03-30 WO PCT/US1998/006217 patent/WO1998043495A1/fr active IP Right Grant
- 1998-03-30 JP JP54189398A patent/JP4148535B2/ja not_active Expired - Lifetime
- 1998-03-30 AT AT98913279T patent/ATE271788T1/de active
- 1998-03-30 ES ES98913279T patent/ES2229486T5/es not_active Expired - Lifetime
- 1998-03-30 EP EP98913279A patent/EP0973413B2/fr not_active Expired - Lifetime
- 1998-03-30 DE DE69825260T patent/DE69825260T3/de not_active Expired - Lifetime
- 1998-03-30 CA CA2285066A patent/CA2285066C/fr not_active Expired - Lifetime
- 1998-03-30 PT PT98913279T patent/PT973413E/pt unknown
- 1998-03-30 DK DK98913279.0T patent/DK0973413T4/da active
-
1999
- 1999-03-19 US US09/273,137 patent/US6083934A/en not_active Expired - Lifetime
- 1999-09-28 NO NO19994722A patent/NO315254B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0973413T3 (da) | 2004-11-29 |
| JP2001517950A (ja) | 2001-10-09 |
| WO1998043495A1 (fr) | 1998-10-08 |
| NO994722L (no) | 1999-09-28 |
| JP4148535B2 (ja) | 2008-09-10 |
| DE69825260D1 (de) | 2004-09-02 |
| US5906982A (en) | 1999-05-25 |
| ES2229486T5 (es) | 2012-01-10 |
| DE69825260T3 (de) | 2012-04-26 |
| DK0973413T4 (da) | 2012-02-27 |
| EP0973413B2 (fr) | 2011-11-09 |
| EP0973413B1 (fr) | 2004-07-28 |
| ATE271788T1 (de) | 2004-08-15 |
| CA2285066A1 (fr) | 1998-10-08 |
| PT973413E (pt) | 2004-11-30 |
| US6083934A (en) | 2000-07-04 |
| DE69825260T2 (de) | 2005-08-04 |
| NO994722D0 (no) | 1999-09-28 |
| EP0973413A1 (fr) | 2000-01-26 |
| ES2229486T3 (es) | 2005-04-16 |
| CA2285066C (fr) | 2010-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO315254B1 (no) | Ern¶ringsformuleringer inneholdende Lacto-N-neotetraose | |
| ES2284028T5 (es) | Nueva composición de galactooligosacárido y la preparación de la misma | |
| CN105146614B (zh) | 一种功能性钙果酵素、酵素饮料及其生产方法 | |
| CN108004189A (zh) | 一种复合益生乳酸菌粉剂及其制备方法与应用 | |
| EP4129302A1 (fr) | Oligosaccharides du lait maternel pour l'amélioration de la résistance d'un organisme contre une infection au staphylococcus aureus | |
| CN104642870B (zh) | 一种益生元组合物 | |
| CN105722515A (zh) | 用于预防或治疗有风险婴儿或幼儿的urt感染的组合物 | |
| PT1255449E (pt) | Formulação nutricional contendo substâncias pré-bióticas | |
| CN114504109B (zh) | 一种含乳双歧杆菌与母乳低聚糖的组合物及其应用 | |
| CN105982009A (zh) | 用于调节人体肠道微生态的组合物 | |
| PL107561B1 (pl) | Sposob wytwarzania fermentowanego produktu z mleka | |
| CN100482104C (zh) | 一种乳酸菌口服液的制备方法 | |
| JP2549638B2 (ja) | ビフイズス菌増殖促進組成物 | |
| CN102018217A (zh) | 一种含双歧杆菌的组合物及其应用 | |
| CN107751880A (zh) | 一种含有益生元的改善肠道微生物的粉剂组合物及制备方法 | |
| WO2023098541A1 (fr) | Composition de prébiotique et de probiotique apte à renforcer la défense d'un organisme contre une infection par staphylococcus aureus | |
| CN104825380A (zh) | 一种快速恢复口腔正常菌群的护理液及其制备方法 | |
| CN110169452A (zh) | 一种含变性淀粉的助消化酸奶及其制备方法 | |
| CN104799147B (zh) | 一种复合低聚糖组方 | |
| CN114504107B (zh) | 一种含鼠李糖乳杆菌与母乳低聚糖的组合物及其应用 | |
| CN114504108B (zh) | 一种含副干酪乳杆菌与母乳低聚糖的组合物及其应用 | |
| MXPA99008954A (en) | Nutritional formulations containing lacto-n-neotetraose | |
| CN108719752A (zh) | 一种富含营养成分的功能性面粉 | |
| Elgazouly et al. | Survival of Bifidobacterium Longum BB536 in Fermented Peanut Milk Supplemented with Gum Arabic during the Storage Hala Mahmoud Mohamed Elgazouly1, Yousif Mohamed Ahmed Idris1 and Baraka Mohamed Kabeir Baraka1 | |
| CN114431484A (zh) | 人乳寡糖在提高肠道对沙门氏菌感染抵御能力中的应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |