NO315043B1 - Substituerte alkanohydroxaminsyrer og fremgangsmåte for å redusere TNF-<alfa>-nivåer - Google Patents
Substituerte alkanohydroxaminsyrer og fremgangsmåte for å redusere TNF-<alfa>-nivåer Download PDFInfo
- Publication number
- NO315043B1 NO315043B1 NO19996529A NO996529A NO315043B1 NO 315043 B1 NO315043 B1 NO 315043B1 NO 19996529 A NO19996529 A NO 19996529A NO 996529 A NO996529 A NO 996529A NO 315043 B1 NO315043 B1 NO 315043B1
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- NO
- Norway
- Prior art keywords
- methoxyphenyl
- ethoxy
- hydroxy
- propionamide
- hydroxamic acid
- Prior art date
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US90397597A | 1997-07-31 | 1997-07-31 | |
PCT/US1998/015868 WO1999006041A1 (fr) | 1997-07-31 | 1998-07-30 | ACIDES ALCANOHYDROXAMIQUES SUBSTITUES ET PROCEDE PERMETTANT DE REDUIRE LE NIVEAU DE TNF-$g(a) |
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NO996529D0 NO996529D0 (no) | 1999-12-28 |
NO996529L NO996529L (no) | 2000-03-28 |
NO315043B1 true NO315043B1 (no) | 2003-06-30 |
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NO19996529A NO315043B1 (no) | 1997-07-31 | 1999-12-28 | Substituerte alkanohydroxaminsyrer og fremgangsmåte for å redusere TNF-<alfa>-nivåer |
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US (3) | US6214857B1 (fr) |
EP (1) | EP1035848B1 (fr) |
JP (1) | JP2001511448A (fr) |
KR (1) | KR100716475B1 (fr) |
CN (1) | CN1265590A (fr) |
AT (1) | ATE238052T1 (fr) |
AU (1) | AU737008B2 (fr) |
BR (1) | BR9815895A (fr) |
CA (1) | CA2295295A1 (fr) |
CZ (1) | CZ299873B6 (fr) |
DE (1) | DE69813876T2 (fr) |
ES (1) | ES2196592T3 (fr) |
FI (1) | FI119841B (fr) |
HU (1) | HUP0003761A3 (fr) |
NO (1) | NO315043B1 (fr) |
NZ (1) | NZ502379A (fr) |
PT (1) | PT1035848E (fr) |
RU (1) | RU2199530C2 (fr) |
TR (1) | TR200000221T2 (fr) |
WO (1) | WO1999006041A1 (fr) |
Families Citing this family (80)
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US6429221B1 (en) * | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
US6518281B2 (en) * | 1995-08-29 | 2003-02-11 | Celgene Corporation | Immunotherapeutic agents |
ES2315435T3 (es) * | 1996-08-12 | 2009-04-01 | Celgene Corporation | Nuevos agentes inmunoterapeuticos y su uso para la reduccion de los niveles de citoquinas. |
CZ299873B6 (cs) * | 1997-07-31 | 2008-12-17 | Celgene Corporation | Derivát hydroxamové kyseliny a farmaceutický prostredek s jeho obsahem |
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- 1998-07-30 CA CA002295295A patent/CA2295295A1/fr not_active Abandoned
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PT1035848E (pt) | 2003-09-30 |
US20040006096A1 (en) | 2004-01-08 |
US20010049371A1 (en) | 2001-12-06 |
TR200000221T2 (tr) | 2000-09-21 |
AU737008B2 (en) | 2001-08-09 |
KR100716475B1 (ko) | 2007-05-10 |
HUP0003761A3 (en) | 2001-04-28 |
NO996529L (no) | 2000-03-28 |
CZ2000256A3 (cs) | 2000-06-14 |
FI119841B (fi) | 2009-04-15 |
US6656964B2 (en) | 2003-12-02 |
AU8674198A (en) | 1999-02-22 |
ATE238052T1 (de) | 2003-05-15 |
CA2295295A1 (fr) | 1999-02-11 |
BR9815895A (pt) | 2001-01-16 |
JP2001511448A (ja) | 2001-08-14 |
EP1035848A1 (fr) | 2000-09-20 |
EP1035848B1 (fr) | 2003-04-23 |
EP1035848A4 (fr) | 2001-05-23 |
RU2199530C2 (ru) | 2003-02-27 |
KR20010022429A (ko) | 2001-03-15 |
DE69813876T2 (de) | 2004-01-29 |
US6214857B1 (en) | 2001-04-10 |
CZ299873B6 (cs) | 2008-12-17 |
HUP0003761A2 (en) | 2001-03-28 |
FI20000061A (fi) | 2000-03-02 |
NO996529D0 (no) | 1999-12-28 |
ES2196592T3 (es) | 2003-12-16 |
DE69813876D1 (de) | 2003-05-28 |
US7091356B2 (en) | 2006-08-15 |
WO1999006041A1 (fr) | 1999-02-11 |
NZ502379A (en) | 2002-10-25 |
CN1265590A (zh) | 2000-09-06 |
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