DE69813876D1 - Susstituierte alkanhydroxamisaeure und verfahren zur verminderung des tnf-alphaspiegels - Google Patents
Susstituierte alkanhydroxamisaeure und verfahren zur verminderung des tnf-alphaspiegelsInfo
- Publication number
- DE69813876D1 DE69813876D1 DE69813876T DE69813876T DE69813876D1 DE 69813876 D1 DE69813876 D1 DE 69813876D1 DE 69813876 T DE69813876 T DE 69813876T DE 69813876 T DE69813876 T DE 69813876T DE 69813876 D1 DE69813876 D1 DE 69813876D1
- Authority
- DE
- Germany
- Prior art keywords
- sussititated
- alphasic
- alkanhydroxamizers
- mirror
- reducing tnf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90397597A | 1997-07-31 | 1997-07-31 | |
PCT/US1998/015868 WO1999006041A1 (en) | 1997-07-31 | 1998-07-30 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNFα LEVELS |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69813876D1 true DE69813876D1 (de) | 2003-05-28 |
DE69813876T2 DE69813876T2 (de) | 2004-01-29 |
Family
ID=25418328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69813876T Expired - Fee Related DE69813876T2 (de) | 1997-07-31 | 1998-07-30 | Susstituierte alkanhydroxamisaeure und verfahren zur verminderung des tnf-alphaspiegels |
Country Status (20)
Country | Link |
---|---|
US (3) | US6214857B1 (de) |
EP (1) | EP1035848B1 (de) |
JP (1) | JP2001511448A (de) |
KR (1) | KR100716475B1 (de) |
CN (1) | CN1265590A (de) |
AT (1) | ATE238052T1 (de) |
AU (1) | AU737008B2 (de) |
BR (1) | BR9815895A (de) |
CA (1) | CA2295295A1 (de) |
CZ (1) | CZ299873B6 (de) |
DE (1) | DE69813876T2 (de) |
ES (1) | ES2196592T3 (de) |
FI (1) | FI119841B (de) |
HU (1) | HUP0003761A3 (de) |
NO (1) | NO315043B1 (de) |
NZ (1) | NZ502379A (de) |
PT (1) | PT1035848E (de) |
RU (1) | RU2199530C2 (de) |
TR (1) | TR200000221T2 (de) |
WO (1) | WO1999006041A1 (de) |
Families Citing this family (80)
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US6429221B1 (en) | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
US6518281B2 (en) * | 1995-08-29 | 2003-02-11 | Celgene Corporation | Immunotherapeutic agents |
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EP1035848B1 (de) | 1997-07-31 | 2003-04-23 | Celgene Corporation | Susstituierte alkanhydroxamisaeure und verfahren zur verminderung des tnf-alphaspiegels |
US6455522B1 (en) | 1998-02-11 | 2002-09-24 | Bristol-Myers Squibb Pharma Company | Cyclic sulfonamide derivatives as metalloproteinase inhibitors |
US7629360B2 (en) * | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
US6667316B1 (en) * | 1999-11-12 | 2003-12-23 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
US7182953B2 (en) | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
US6699899B1 (en) * | 1999-12-21 | 2004-03-02 | Celgene Corporation | Substituted acylhydroxamic acids and method of reducing TNFα levels |
US8030343B2 (en) * | 2000-06-08 | 2011-10-04 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
EP3492100B1 (de) | 2001-06-26 | 2021-12-08 | Amgen Inc. | Antikörper gegen opgl |
US7276529B2 (en) | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
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KR20050056247A (ko) * | 2002-10-15 | 2005-06-14 | 셀진 코포레이션 | 골수형성이상증후군의 치료 및 관리를 위한 선택적인사이토킨 저해 약물의 사용 방법 및 이를 포함하는 조성물 |
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-
1998
- 1998-07-30 EP EP98938151A patent/EP1035848B1/de not_active Expired - Lifetime
- 1998-07-30 JP JP2000504855A patent/JP2001511448A/ja active Pending
- 1998-07-30 CN CN98807775A patent/CN1265590A/zh active Pending
- 1998-07-30 RU RU2000102639/04A patent/RU2199530C2/ru not_active IP Right Cessation
- 1998-07-30 NZ NZ502379A patent/NZ502379A/xx unknown
- 1998-07-30 AT AT98938151T patent/ATE238052T1/de not_active IP Right Cessation
- 1998-07-30 AU AU86741/98A patent/AU737008B2/en not_active Ceased
- 1998-07-30 BR BR9815895-3A patent/BR9815895A/pt not_active Application Discontinuation
- 1998-07-30 CZ CZ20000256A patent/CZ299873B6/cs not_active IP Right Cessation
- 1998-07-30 HU HU0003761A patent/HUP0003761A3/hu unknown
- 1998-07-30 KR KR1020007001011A patent/KR100716475B1/ko not_active IP Right Cessation
- 1998-07-30 US US09/126,157 patent/US6214857B1/en not_active Expired - Fee Related
- 1998-07-30 PT PT98938151T patent/PT1035848E/pt unknown
- 1998-07-30 TR TR2000/00221T patent/TR200000221T2/xx unknown
- 1998-07-30 DE DE69813876T patent/DE69813876T2/de not_active Expired - Fee Related
- 1998-07-30 WO PCT/US1998/015868 patent/WO1999006041A1/en active IP Right Grant
- 1998-07-30 ES ES98938151T patent/ES2196592T3/es not_active Expired - Lifetime
- 1998-07-30 CA CA002295295A patent/CA2295295A1/en not_active Abandoned
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1999
- 1999-12-28 NO NO19996529A patent/NO315043B1/no not_active IP Right Cessation
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2000
- 2000-01-12 FI FI20000061A patent/FI119841B/fi active IP Right Grant
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2001
- 2001-02-09 US US09/780,725 patent/US6656964B2/en not_active Expired - Fee Related
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2003
- 2003-06-16 US US10/462,319 patent/US7091356B2/en not_active Expired - Fee Related
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CZ2000256A3 (cs) | 2000-06-14 |
US20010049371A1 (en) | 2001-12-06 |
ATE238052T1 (de) | 2003-05-15 |
HUP0003761A3 (en) | 2001-04-28 |
CA2295295A1 (en) | 1999-02-11 |
FI20000061A (fi) | 2000-03-02 |
AU737008B2 (en) | 2001-08-09 |
NO996529D0 (no) | 1999-12-28 |
EP1035848A1 (de) | 2000-09-20 |
FI119841B (fi) | 2009-04-15 |
HUP0003761A2 (en) | 2001-03-28 |
BR9815895A (pt) | 2001-01-16 |
TR200000221T2 (tr) | 2000-09-21 |
US6656964B2 (en) | 2003-12-02 |
WO1999006041A1 (en) | 1999-02-11 |
KR20010022429A (ko) | 2001-03-15 |
RU2199530C2 (ru) | 2003-02-27 |
NO315043B1 (no) | 2003-06-30 |
AU8674198A (en) | 1999-02-22 |
EP1035848B1 (de) | 2003-04-23 |
JP2001511448A (ja) | 2001-08-14 |
US20040006096A1 (en) | 2004-01-08 |
PT1035848E (pt) | 2003-09-30 |
CN1265590A (zh) | 2000-09-06 |
EP1035848A4 (de) | 2001-05-23 |
ES2196592T3 (es) | 2003-12-16 |
NO996529L (no) | 2000-03-28 |
NZ502379A (en) | 2002-10-25 |
US6214857B1 (en) | 2001-04-10 |
DE69813876T2 (de) | 2004-01-29 |
CZ299873B6 (cs) | 2008-12-17 |
US7091356B2 (en) | 2006-08-15 |
KR100716475B1 (ko) | 2007-05-10 |
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