NO313735B1 - Matriks-pelleter med langsom frigiving, samt fremstilling av disse - Google Patents
Matriks-pelleter med langsom frigiving, samt fremstilling av disse Download PDFInfo
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- NO313735B1 NO313735B1 NO19964410A NO964410A NO313735B1 NO 313735 B1 NO313735 B1 NO 313735B1 NO 19964410 A NO19964410 A NO 19964410A NO 964410 A NO964410 A NO 964410A NO 313735 B1 NO313735 B1 NO 313735B1
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- matrix pellets
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- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 229960000654 sulfafurazole Drugs 0.000 description 1
- 229960005158 sulfamethizole Drugs 0.000 description 1
- VACCAVUAMIDAGB-UHFFFAOYSA-N sulfamethizole Chemical compound S1C(C)=NN=C1NS(=O)(=O)C1=CC=C(N)C=C1 VACCAVUAMIDAGB-UHFFFAOYSA-N 0.000 description 1
- 229960005404 sulfamethoxazole Drugs 0.000 description 1
- GPTONYMQFTZPKC-UHFFFAOYSA-N sulfamethoxydiazine Chemical compound N1=CC(OC)=CN=C1NS(=O)(=O)C1=CC=C(N)C=C1 GPTONYMQFTZPKC-UHFFFAOYSA-N 0.000 description 1
- 229960002229 sulfametoxydiazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- 229960001544 sulfathiazole Drugs 0.000 description 1
- JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 description 1
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
- 229960004940 sulpiride Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- IQWYAQCHYZHJOS-UHFFFAOYSA-N tetrazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CCCCC1 IQWYAQCHYZHJOS-UHFFFAOYSA-N 0.000 description 1
- 229960005214 tetrazepam Drugs 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 229960001312 tiaprofenic acid Drugs 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 229960002277 tolazamide Drugs 0.000 description 1
- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
- 229960005371 tolbutamide Drugs 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229960004380 tramadol Drugs 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
- 229960003386 triazolam Drugs 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229960002726 vincamine Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Glanulating (AREA)
- Powder Metallurgy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4413350A DE4413350A1 (de) | 1994-04-18 | 1994-04-18 | Retard-Matrixpellets und Verfahren zu ihrer Herstellung |
| PCT/EP1995/001236 WO1995028147A1 (de) | 1994-04-18 | 1995-04-05 | Retard-matrixpellets und verfahren zu ihrer herstellung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO964410D0 NO964410D0 (no) | 1996-10-17 |
| NO964410L NO964410L (no) | 1996-12-17 |
| NO313735B1 true NO313735B1 (no) | 2002-11-25 |
Family
ID=6515707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19964410A NO313735B1 (no) | 1994-04-18 | 1996-10-17 | Matriks-pelleter med langsom frigiving, samt fremstilling av disse |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6290990B1 (ko) |
| EP (1) | EP0756480B1 (ko) |
| JP (1) | JP4099225B2 (ko) |
| KR (1) | KR100371885B1 (ko) |
| CN (1) | CN1131024C (ko) |
| AT (1) | ATE204747T1 (ko) |
| AU (1) | AU2256495A (ko) |
| BR (1) | BR9507328A (ko) |
| CA (1) | CA2188185C (ko) |
| CZ (1) | CZ301396A3 (ko) |
| DE (2) | DE4413350A1 (ko) |
| DK (1) | DK0756480T3 (ko) |
| ES (1) | ES2162635T3 (ko) |
| FI (1) | FI964175A (ko) |
| HU (1) | HU221981B1 (ko) |
| IL (1) | IL113316A (ko) |
| MX (1) | MXPA96004911A (ko) |
| NO (1) | NO313735B1 (ko) |
| NZ (1) | NZ284064A (ko) |
| PL (1) | PL317936A1 (ko) |
| PT (1) | PT756480E (ko) |
| RU (1) | RU2155031C2 (ko) |
| WO (1) | WO1995028147A1 (ko) |
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| DE19531277A1 (de) * | 1995-08-25 | 1997-02-27 | Basf Ag | Verwendung von Lipiden als Hilfsmittel bei der Herstellung von festen Arzneiformen nach dem Schmelzextrusionsverfahren |
| DE19539362A1 (de) * | 1995-10-23 | 1997-04-24 | Basf Ag | Verfahren zur Herstellung von festen Arzneiformen |
| DE19539360A1 (de) * | 1995-10-23 | 1997-04-24 | Basf Ag | Verfahren zur Herstellung von festen Arzneiformen |
| FR2748209B1 (fr) * | 1996-05-06 | 1998-06-05 | Adir | Composition pharmaceutique a base de matrices lipophiles stabilisees pour la liberation controlee de principes actifs |
| DE19637082A1 (de) * | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Schnellzerfallende Pellets |
| US8828432B2 (en) * | 1996-10-28 | 2014-09-09 | General Mills, Inc. | Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles |
| FR2761605B1 (fr) * | 1997-04-07 | 2001-02-23 | Prographarm Lab | Forme pharmaceutique multiparticulaire, ses particules constitutives, procede et installation pour leur fabrication |
| DK1065936T3 (da) * | 1998-03-23 | 2009-11-02 | Gen Mills Inc | Indkapsling af bestanddele i spiselige produkter |
| DE19842753A1 (de) | 1998-09-18 | 2000-03-23 | Bayer Ag | Agitationsunabhängige pharmazeutische Retardzubereitungen und Verfahren zu ihrer Herstellung |
| CA2391707C (en) | 1999-07-30 | 2010-05-11 | Smithkline Beecham Plc | Multi-component pharmaceutical dosage form |
| DE10045904B4 (de) * | 1999-10-01 | 2007-07-12 | Degussa Gmbh | alpha-Liponsäure(-Derivate) enthaltende Retardform |
| KR20130010512A (ko) | 1999-10-29 | 2013-01-28 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| CA2359945C (en) * | 1999-11-12 | 2011-04-26 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
| US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
| US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
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| DE3612212A1 (de) | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
| US5326572A (en) * | 1989-03-23 | 1994-07-05 | Fmc Corporation | Freeze-dried polymer dispersions and the use thereof in preparing sustained-release pharmaceutical compositions |
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| WO1993007859A1 (en) * | 1991-10-23 | 1993-04-29 | Warner-Lambert Company | Novel pharmaceutical pellets and process for their production |
| DE4138513A1 (de) * | 1991-11-23 | 1993-05-27 | Basf Ag | Feste pharmazeutische retardform |
-
1994
- 1994-04-18 DE DE4413350A patent/DE4413350A1/de not_active Withdrawn
-
1995
- 1995-04-05 DE DE59509563T patent/DE59509563D1/de not_active Expired - Lifetime
- 1995-04-05 PT PT95915844T patent/PT756480E/pt unknown
- 1995-04-05 CZ CZ963013A patent/CZ301396A3/cs unknown
- 1995-04-05 AT AT95915844T patent/ATE204747T1/de active
- 1995-04-05 CA CA002188185A patent/CA2188185C/en not_active Expired - Lifetime
- 1995-04-05 BR BR9507328A patent/BR9507328A/pt not_active Application Discontinuation
- 1995-04-05 WO PCT/EP1995/001236 patent/WO1995028147A1/de active IP Right Grant
- 1995-04-05 PL PL95317936A patent/PL317936A1/xx unknown
- 1995-04-05 MX MXPA96004911A patent/MXPA96004911A/es active IP Right Grant
- 1995-04-05 HU HU9602878A patent/HU221981B1/hu active IP Right Grant
- 1995-04-05 RU RU96122469/14A patent/RU2155031C2/ru active
- 1995-04-05 AU AU22564/95A patent/AU2256495A/en not_active Abandoned
- 1995-04-05 EP EP95915844A patent/EP0756480B1/de not_active Expired - Lifetime
- 1995-04-05 DK DK95915844T patent/DK0756480T3/da active
- 1995-04-05 JP JP52666695A patent/JP4099225B2/ja not_active Expired - Fee Related
- 1995-04-05 KR KR1019960705854A patent/KR100371885B1/ko not_active IP Right Cessation
- 1995-04-05 CN CN95192933A patent/CN1131024C/zh not_active Expired - Lifetime
- 1995-04-05 ES ES95915844T patent/ES2162635T3/es not_active Expired - Lifetime
- 1995-04-05 NZ NZ284064A patent/NZ284064A/en unknown
- 1995-04-11 IL IL11331695A patent/IL113316A/xx not_active IP Right Cessation
- 1995-04-15 US US08/727,666 patent/US6290990B1/en not_active Expired - Lifetime
-
1996
- 1996-10-17 NO NO19964410A patent/NO313735B1/no not_active IP Right Cessation
- 1996-10-17 FI FI964175A patent/FI964175A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ284064A (en) | 1998-03-25 |
| HUT75161A (en) | 1997-04-28 |
| US6290990B1 (en) | 2001-09-18 |
| EP0756480A1 (de) | 1997-02-05 |
| CN1131024C (zh) | 2003-12-17 |
| CA2188185C (en) | 2005-06-07 |
| ATE204747T1 (de) | 2001-09-15 |
| NO964410L (no) | 1996-12-17 |
| PT756480E (pt) | 2002-02-28 |
| CN1147764A (zh) | 1997-04-16 |
| RU2155031C2 (ru) | 2000-08-27 |
| NO964410D0 (no) | 1996-10-17 |
| WO1995028147A1 (de) | 1995-10-26 |
| PL317936A1 (en) | 1997-04-28 |
| IL113316A (en) | 1999-12-31 |
| HU9602878D0 (en) | 1996-12-30 |
| KR100371885B1 (ko) | 2003-04-10 |
| EP0756480B1 (de) | 2001-08-29 |
| IL113316A0 (en) | 1995-07-31 |
| KR970702028A (ko) | 1997-05-13 |
| FI964175A (fi) | 1996-12-16 |
| CA2188185A1 (en) | 1995-10-26 |
| CZ301396A3 (en) | 1997-03-12 |
| JPH09511992A (ja) | 1997-12-02 |
| DK0756480T3 (da) | 2001-10-08 |
| DE59509563D1 (de) | 2001-10-04 |
| DE4413350A1 (de) | 1995-10-19 |
| JP4099225B2 (ja) | 2008-06-11 |
| BR9507328A (pt) | 1997-09-30 |
| AU2256495A (en) | 1995-11-10 |
| HU221981B1 (hu) | 2003-03-28 |
| ES2162635T3 (es) | 2002-01-01 |
| FI964175A0 (fi) | 1996-10-17 |
| MXPA96004911A (es) | 2004-08-19 |
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| Date | Code | Title | Description |
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| MK1K | Patent expired |