NO313289B1 - Bisykliske aminosyrer, fremgangsmåte for fremstilling derav, farmasöytisk preparat, fremgangsmåte for fremstilling derav, samtanvendelse av forbindelsene til fremstilling av et legemiddel foranvendelse som <alfa>v-integrininhibitor - Google Patents
Bisykliske aminosyrer, fremgangsmåte for fremstilling derav, farmasöytisk preparat, fremgangsmåte for fremstilling derav, samtanvendelse av forbindelsene til fremstilling av et legemiddel foranvendelse som <alfa>v-integrininhibitor Download PDFInfo
- Publication number
- NO313289B1 NO313289B1 NO19993901A NO993901A NO313289B1 NO 313289 B1 NO313289 B1 NO 313289B1 NO 19993901 A NO19993901 A NO 19993901A NO 993901 A NO993901 A NO 993901A NO 313289 B1 NO313289 B1 NO 313289B1
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- Norway
- Prior art keywords
- formula
- compounds
- propionic acid
- dihydro
- alkyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 96
- 238000000034 method Methods 0.000 title claims description 15
- 238000002360 preparation method Methods 0.000 title claims description 11
- 239000003814 drug Substances 0.000 title claims description 8
- 229940079593 drug Drugs 0.000 title claims description 4
- 229940125798 integrin inhibitor Drugs 0.000 title claims 2
- 150000001413 amino acids Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract description 29
- 201000010099 disease Diseases 0.000 claims abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 11
- 238000011282 treatment Methods 0.000 claims abstract description 10
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- 208000007536 Thrombosis Diseases 0.000 claims abstract description 7
- 208000010125 myocardial infarction Diseases 0.000 claims abstract description 7
- 230000001575 pathological effect Effects 0.000 claims abstract description 7
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- 208000011775 arteriosclerosis disease Diseases 0.000 claims abstract description 6
- 208000029078 coronary artery disease Diseases 0.000 claims abstract description 6
- 239000003112 inhibitor Substances 0.000 claims abstract description 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 78
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- -1 2-imino-4- oxoimidazolidin-5-yl Chemical group 0.000 claims description 35
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- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
- 230000004054 inflammatory process Effects 0.000 claims description 8
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims description 7
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19705450A DE19705450A1 (de) | 1997-02-13 | 1997-02-13 | Bicyclische aromatische Aminosäuren |
| PCT/EP1998/000636 WO1998035949A1 (de) | 1997-02-13 | 1998-02-06 | Bicyclische aromatische aminosäuren |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO993901D0 NO993901D0 (no) | 1999-08-12 |
| NO993901L NO993901L (no) | 1999-10-12 |
| NO313289B1 true NO313289B1 (no) | 2002-09-09 |
Family
ID=7820093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19993901A NO313289B1 (no) | 1997-02-13 | 1999-08-12 | Bisykliske aminosyrer, fremgangsmåte for fremstilling derav, farmasöytisk preparat, fremgangsmåte for fremstilling derav, samtanvendelse av forbindelsene til fremstilling av et legemiddel foranvendelse som <alfa>v-integrininhibitor |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0964856B1 (zh) |
| JP (1) | JP4327257B2 (zh) |
| KR (1) | KR20000071030A (zh) |
| CN (1) | CN1085205C (zh) |
| AR (1) | AR010894A1 (zh) |
| AT (1) | ATE225776T1 (zh) |
| AU (1) | AU735313B2 (zh) |
| BR (1) | BR9807345A (zh) |
| CA (1) | CA2280727C (zh) |
| CY (1) | CY2341B1 (zh) |
| CZ (1) | CZ297366B6 (zh) |
| DE (2) | DE19705450A1 (zh) |
| DK (1) | DK0964856T3 (zh) |
| ES (1) | ES2183332T3 (zh) |
| HU (1) | HUP0001138A3 (zh) |
| ID (1) | ID22533A (zh) |
| NO (1) | NO313289B1 (zh) |
| PL (1) | PL335101A1 (zh) |
| PT (1) | PT964856E (zh) |
| RU (1) | RU2187506C2 (zh) |
| SI (1) | SI0964856T1 (zh) |
| SK (1) | SK284646B6 (zh) |
| TR (1) | TR199901962T2 (zh) |
| WO (1) | WO1998035949A1 (zh) |
| ZA (1) | ZA981178B (zh) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040063790A1 (en) * | 1996-05-31 | 2004-04-01 | The Scripps Research Institute | Methods for inhibition of angiogenesis |
| CN1140511C (zh) | 1998-04-09 | 2004-03-03 | 明治制果株式会社 | 作为整合素αvβ3拮抗剂的氨基哌啶衍生物 |
| BR0009739A (pt) | 1999-04-13 | 2002-04-09 | Basf Ag | Composto, medicamento, preparação farmacêutica, e, usos de um elemento estrutural, de um composto e de uma preparação farmacêutica |
| WO2001010844A1 (en) | 1999-08-05 | 2001-02-15 | Meiji Seika Kaisha, Ltd. | φ-AMINO-α-HYDROXYCARBOXYLIC ACID DERIVATIVES HAVING INTEGRIN αvβ3 ANTAGONISM |
| JP2003519119A (ja) * | 1999-12-24 | 2003-06-17 | スミスクライン ビーチャム パブリック リミテッド カンパニー | （ヘテロ）ビシクリルメタンスルホニルアミノ置換ヒドロキサム酸誘導体 |
| WO2001055104A1 (fr) * | 2000-01-25 | 2001-08-02 | Kaneka Corporation | Procede de preparation d'acides azetidine-2-carboxyliques a substitution n optiquement actifs |
| KR20030061390A (ko) * | 2000-11-01 | 2003-07-18 | 메르크 파텐트 게엠베하 | 안구 질환 치료용 조성물 및 방법 |
| US7514098B2 (en) | 2001-05-30 | 2009-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Use of targeted cross-linked nanoparticles for in vivo gene delivery |
| MXPA04000839A (es) | 2001-08-01 | 2004-05-14 | Merck Patent Gesellscahft Mit | Metodos y composiciones para el tratamiento de enfermedades oftalmicas. |
| CN1658894A (zh) * | 2002-02-14 | 2005-08-24 | 默克专利股份有限公司 | 用于治疗眼病的方法和组合物 |
| DE10305784A1 (de) * | 2003-02-12 | 2004-08-26 | Merck Patent Gmbh | Verfahren zur Herstellug bicyclischer aromatischer Aminosäuren sowie deren Zwischenprodukte |
| DE10337863A1 (de) | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Verwendung von Chromen-4-on-Derivaten |
| EP1765362B1 (en) * | 2004-06-04 | 2012-03-28 | The Scripps Research Institute | Compositions and methods for treatment of neovascular diseases |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| RU2518073C2 (ru) * | 2008-12-26 | 2014-06-10 | ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. | Новое бициклическое гетероциклическое соединение |
| WO2011024987A1 (ja) * | 2009-08-31 | 2011-03-03 | 塩野義製薬株式会社 | 芳香族縮合へテロ環誘導体およびそれらを含有する医薬組成物 |
| TW201350475A (zh) | 2012-03-06 | 2013-12-16 | Boehringer Ingelheim Int | 用於組合療法之白三烯素生成之苯并二噁烷抑制劑 |
| JP6256467B2 (ja) | 2012-07-17 | 2018-01-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成を阻害するピラゾール誘導体 |
| JP2016523982A (ja) | 2013-07-15 | 2016-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
| EP3022193B1 (en) | 2013-07-15 | 2017-04-26 | Boehringer Ingelheim International GmbH | Inhibitors of leukotriene production |
| US10328082B2 (en) | 2014-05-30 | 2019-06-25 | Pfizer Inc. | Methods of use and combinations |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
| CA3221177A1 (en) | 2021-11-01 | 2023-05-04 | Meghan Kerrisk Campbell | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU675689B2 (en) * | 1992-12-01 | 1997-02-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| EP0760658B1 (en) * | 1994-05-27 | 2002-11-13 | Merck & Co. Inc. | Compounds for inhibiting osteoclast-mediated bone resorption |
| DE19548709A1 (de) * | 1995-12-23 | 1997-07-03 | Merck Patent Gmbh | Tyrosinderivate |
| DE19654483A1 (de) * | 1996-06-28 | 1998-01-02 | Merck Patent Gmbh | Phenylalanin-Derivate |
| KR20000022190A (ko) * | 1996-06-28 | 2000-04-25 | 플레믹 크리스티안 | 인테그린 저해제로서의 페닐알라닌 유도체 |
-
1997
- 1997-02-13 DE DE19705450A patent/DE19705450A1/de not_active Withdrawn
-
1998
- 1998-02-06 DK DK98908063T patent/DK0964856T3/da active
- 1998-02-06 BR BR9807345A patent/BR9807345A/pt not_active Application Discontinuation
- 1998-02-06 SI SI9830304T patent/SI0964856T1/xx unknown
- 1998-02-06 CA CA002280727A patent/CA2280727C/en not_active Expired - Fee Related
- 1998-02-06 PL PL98335101A patent/PL335101A1/xx unknown
- 1998-02-06 HU HU0001138A patent/HUP0001138A3/hu unknown
- 1998-02-06 PT PT98908063T patent/PT964856E/pt unknown
- 1998-02-06 DE DE59805895T patent/DE59805895D1/de not_active Expired - Lifetime
- 1998-02-06 ES ES98908063T patent/ES2183332T3/es not_active Expired - Lifetime
- 1998-02-06 AU AU66206/98A patent/AU735313B2/en not_active Ceased
- 1998-02-06 KR KR1019997007297A patent/KR20000071030A/ko not_active Application Discontinuation
- 1998-02-06 ID IDW990812A patent/ID22533A/id unknown
- 1998-02-06 SK SK1071-99A patent/SK284646B6/sk unknown
- 1998-02-06 RU RU99119223/04A patent/RU2187506C2/ru not_active IP Right Cessation
- 1998-02-06 AT AT98908063T patent/ATE225776T1/de not_active IP Right Cessation
- 1998-02-06 EP EP98908063A patent/EP0964856B1/de not_active Expired - Lifetime
- 1998-02-06 CZ CZ0287599A patent/CZ297366B6/cs not_active IP Right Cessation
- 1998-02-06 CN CN98803959A patent/CN1085205C/zh not_active Expired - Fee Related
- 1998-02-06 JP JP53530398A patent/JP4327257B2/ja not_active Expired - Fee Related
- 1998-02-06 TR TR1999/01962T patent/TR199901962T2/xx unknown
- 1998-02-06 WO PCT/EP1998/000636 patent/WO1998035949A1/de active IP Right Grant
- 1998-02-12 ZA ZA981178A patent/ZA981178B/xx unknown
- 1998-02-13 AR ARP980100654A patent/AR010894A1/es not_active Application Discontinuation
-
1999
- 1999-08-12 NO NO19993901A patent/NO313289B1/no not_active IP Right Cessation
-
2003
- 2003-03-17 CY CY0300028A patent/CY2341B1/xx unknown
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Legal Events
| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |