NO312399B1 - Terapeutisk aktiv forbindelse, preparat inneholdende forbindelsen samt dens anvendelse - Google Patents
Terapeutisk aktiv forbindelse, preparat inneholdende forbindelsen samt dens anvendelse Download PDFInfo
- Publication number
- NO312399B1 NO312399B1 NO19932980A NO932980A NO312399B1 NO 312399 B1 NO312399 B1 NO 312399B1 NO 19932980 A NO19932980 A NO 19932980A NO 932980 A NO932980 A NO 932980A NO 312399 B1 NO312399 B1 NO 312399B1
- Authority
- NO
- Norway
- Prior art keywords
- ftc
- cells
- oxathiolane
- compound
- hiv
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/659,760 US5210085A (en) | 1990-02-01 | 1991-02-22 | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
| US73608991A | 1991-07-26 | 1991-07-26 | |
| US83115392A | 1992-02-12 | 1992-02-12 | |
| PCT/US1992/001339 WO1992014743A2 (en) | 1991-02-22 | 1992-02-20 | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO932980L NO932980L (no) | 1993-08-20 |
| NO932980D0 NO932980D0 (no) | 1993-08-20 |
| NO312399B1 true NO312399B1 (no) | 2002-05-06 |
Family
ID=35276919
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19932980A NO312399B1 (no) | 1991-02-22 | 1993-08-20 | Terapeutisk aktiv forbindelse, preparat inneholdende forbindelsen samt dens anvendelse |
| NO2005015C NO2005015I2 (no) | 1991-02-22 | 2005-07-01 | Terapeutisk aktiv forbindelse preparat inneholdende forbindelsen samt den anvendelse |
| NO2008010C NO2008010I1 (no) | 1991-02-22 | 2008-06-13 | Kombinasjon av efavirenz, emtricitabin og tenofovirdisoproks: 1 eller salter derav |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2005015C NO2005015I2 (no) | 1991-02-22 | 2005-07-01 | Terapeutisk aktiv forbindelse preparat inneholdende forbindelsen samt den anvendelse |
| NO2008010C NO2008010I1 (no) | 1991-02-22 | 2008-06-13 | Kombinasjon av efavirenz, emtricitabin og tenofovirdisoproks: 1 eller salter derav |
Country Status (25)
| Country | Link |
|---|---|
| EP (3) | EP1439177B1 (ko) |
| JP (2) | JP2901160B2 (ko) |
| KR (1) | KR0172590B1 (ko) |
| CN (4) | CN1037682C (ko) |
| AT (2) | ATE469147T1 (ko) |
| AU (2) | AU679649B2 (ko) |
| BG (1) | BG62053B1 (ko) |
| BR (1) | BR9205661A (ko) |
| CA (2) | CA2513440C (ko) |
| CZ (1) | CZ295074B6 (ko) |
| DE (2) | DE69233379T2 (ko) |
| DK (2) | DK0984013T3 (ko) |
| ES (2) | ES2345102T3 (ko) |
| FI (2) | FI114915B (ko) |
| HK (1) | HK1026419A1 (ko) |
| HU (2) | HU227823B1 (ko) |
| IE (1) | IE920545A1 (ko) |
| IL (1) | IL100965A (ko) |
| MX (1) | MX9200747A (ko) |
| MY (1) | MY114350A (ko) |
| NO (3) | NO312399B1 (ko) |
| NZ (2) | NZ241625A (ko) |
| PT (1) | PT100151B (ko) |
| RO (2) | RO119365B1 (ko) |
| WO (1) | WO1992014743A2 (ko) |
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| US6175008B1 (en) | 1988-04-11 | 2001-01-16 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
| US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
| ATE237613T1 (de) * | 1989-02-08 | 2003-05-15 | Iaf Biochem Int | Verfahren für die herstellung von antiviralen substituierten 1, 3-oxathiolanen |
| US6703396B1 (en) | 1990-02-01 | 2004-03-09 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers |
| US5728575A (en) | 1990-02-01 | 1998-03-17 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
| US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| US5914331A (en) * | 1990-02-01 | 1999-06-22 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
| US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
| IL100502A (en) * | 1991-01-03 | 1995-12-08 | Iaf Biochem Int | PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (- |
| US6812233B1 (en) | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
| IL101144A (en) * | 1991-03-06 | 1996-09-12 | Wellcome Found | Pharmaceutical preparations containing 1 -) 2 -) hydroxymethyl (- 1, 3 - oxathiolan-5 - il (5) fluorescitosin and its derivatives for the treatment of their hepatitis B virus infections |
| US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
| GB9110874D0 (en) * | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
| ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| GB9116601D0 (en) * | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
| US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
| AU4079593A (en) * | 1992-05-13 | 1993-12-13 | Wellcome Foundation Limited, The | Therapeutic combinations |
| GB9226927D0 (en) * | 1992-12-24 | 1993-02-17 | Iaf Biochem Int | Dideoxy nucleoside analogues |
| TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
| US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
| US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
| JPH09504785A (ja) * | 1993-09-10 | 1997-05-13 | エモリー、ユニバーシティー | 抗ｂ型肝炎ウイルス活性を有するヌクレオシド |
| GB9320316D0 (en) * | 1993-10-01 | 1993-11-17 | Smithkline Beecham Plc | Pharmaceuticals |
| US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| FR2720397B1 (fr) * | 1994-05-24 | 1996-08-23 | Laphal Laboratoires Sa | Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment. |
| IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
| US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
| US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
| US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
| US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
| WO1996040164A1 (en) | 1995-06-07 | 1996-12-19 | Emory University | Nucleosides with anti-hepatitis b virus activity |
| PL330747A1 (en) * | 1996-06-25 | 1999-05-24 | Glaxo Group Ltd | Vx478, zidovudin, ftc and/or 3tc containing combinations for use in treating hiv infections |
| US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
| EA001920B1 (ru) | 1997-03-19 | 2001-10-22 | Эмори Юниверсити | Синтез 1,3-оксаселеноланнуклеозидов, их активность против вируса иммунодефицита человека и против вируса гепатита-b |
| IT1290447B1 (it) | 1997-03-28 | 1998-12-03 | Zambon Spa | Derivati 1,3-ossatiolanici ad attivita' antivirale |
| JP2001518899A (ja) | 1997-04-07 | 2001-10-16 | トライアングル ファーマシューティカルズ，インコーポレイティド | 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用 |
| AU2241799A (en) * | 1998-01-26 | 1999-08-09 | Pharm-Eco Laboratories, Inc. | Enzyme activated supports for enantiomeric separations |
| EP2390257A1 (en) | 1998-02-25 | 2011-11-30 | Emory University | 2'-fluoronucleosides |
| AU771779B2 (en) | 1998-08-12 | 2004-04-01 | Emory University | Method of manufacture of 1,3-oxathiolane nucleosides |
| US6979561B1 (en) | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
| DK1140937T3 (da) | 1998-12-23 | 2004-03-22 | Shire Biochem Inc | Antivirale nucleosid-analoger |
| KR100339786B1 (ko) * | 1999-04-02 | 2002-06-07 | 안용현 | 라세미 혼합물 상태로 존재하는 뉴클레오시드로부터 거울상 이성질체의 분리 방법 |
| EP1600452A3 (en) | 1999-11-12 | 2008-09-10 | Pharmasset, Inc. | Synthesis of 2'-deoxy-L-nucleosides |
| US6436948B1 (en) | 2000-03-03 | 2002-08-20 | University Of Georgia Research Foundation Inc. | Method for the treatment of psoriasis and genital warts |
| CA2308559C (en) | 2000-05-16 | 2005-07-26 | Brantford Chemicals Inc. | 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues |
| PT1411954E (pt) | 2000-10-18 | 2011-03-16 | Pharmasset Inc | Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal |
| US6828119B2 (en) * | 2001-01-04 | 2004-12-07 | Bristol Myers Squibb Company | Enzymatic deprotection of amines and hydroxides |
| DE10104231A1 (de) | 2001-01-31 | 2002-08-08 | Consortium Elektrochem Ind | Verfahren zur enzymatischen Herstellung von enantiomerenreinen 1,3-Dioxolan-4-on-Derivaten |
| AU2008202336B2 (en) * | 2001-03-01 | 2011-11-10 | Abbvie Inc. | Polymorphic and other crystalline forms of cis-FTC |
| KR101150250B1 (ko) * | 2001-03-01 | 2012-06-12 | 아보트 래버러토리즈 | 시스-ｆｔｃ의 다형 및 기타 결정형 |
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| AU2003285230B2 (en) * | 2002-11-18 | 2010-04-22 | Takeda Pharmaceutical Company Limited | Stereoselective process for the production of dioxolane nucleoside analogues |
| SI1583542T1 (sl) * | 2003-01-14 | 2008-12-31 | Gilead Sciences Inc | Sestavki in postopki za kombinacijsko antivirusnoterapijo |
| ITMI20030578A1 (it) * | 2003-03-24 | 2004-09-25 | Clariant Lsm Italia Spa | Processo ed intermedi per la preparazione di emtricitabina |
| ES2446102T3 (es) * | 2005-03-14 | 2014-03-06 | Shire Canada Inc. | Proceso y procedimientos para la preparación de cis-2-hidroximetil-4-(citosin-1-il)-1,3-oxatiolano ópticamente activo o sales farmacéuticamente aceptables del mismo |
| TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| DK2144604T3 (da) | 2007-02-28 | 2011-10-17 | Conatus Pharmaceuticals Inc | Fremgangsmåder til behandling af kronisk viral hepatitis C under anvendelse af RO 113-0830 |
| KR101173892B1 (ko) | 2007-06-18 | 2012-08-16 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 브로모-페닐 치환된 티아졸릴 디하이드로피리미딘 |
| WO2009084033A2 (en) | 2007-12-07 | 2009-07-09 | Matrix Laboratories Limited | Process for producing 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yi]cytosine |
| EP2258709A1 (en) * | 2008-02-29 | 2010-12-08 | Kaneka Corporation | 2'-hydroxyl-protected ribonucleoside derivative and manufacturing method of same |
| EP2376515A1 (en) | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Synthesis of purine nucleosides |
| SG172361A1 (en) | 2008-12-23 | 2011-07-28 | Pharmasset Inc | Nucleoside analogs |
| AR074897A1 (es) | 2008-12-23 | 2011-02-23 | Pharmasset Inc | Fosforamidatos de nucleosidos |
| EP2377862A1 (en) | 2010-03-29 | 2011-10-19 | Esteve Química, S.A. | Process for obtaining emtricitabine |
| PT3290428T (pt) | 2010-03-31 | 2021-12-27 | Gilead Pharmasset Llc | Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino |
| SG190333A1 (en) | 2010-11-19 | 2013-06-28 | Gilead Sciences Inc | Therapeutic compositions comprising rilpivirine hcl and tenofovir disoproxil fumarate |
| JP2015520144A (ja) | 2012-05-11 | 2015-07-16 | アクロン・モレキュールズ・アクチェンゲゼルシャフトＡｋｒｏｎ Ｍｏｌｅｃｕｌｅｓ Ａｇ | 疼痛の治療のための化合物の使用 |
| AU2013340559B2 (en) | 2012-10-29 | 2018-03-15 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
| CN102911167B (zh) * | 2012-11-09 | 2014-06-25 | 合肥工业大学 | 一种高光学纯度的核苷类中间体的制备方法 |
| CN104059057A (zh) * | 2014-01-03 | 2014-09-24 | 石家庄龙泽制药有限公司 | 拉米夫定杂质3-tu的制备方法 |
| CN108285895B (zh) * | 2018-01-26 | 2020-06-23 | 中国科学院南海海洋研究所 | 一种酯酶EstC11及其编码基因和应用 |
| KR102069443B1 (ko) | 2018-08-31 | 2020-01-22 | (주)대한뷰티산업진흥원 | 울금, 비트 및 무 추출물을 포함하는 바이오셀룰로오스 및 이의 제조방법 |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| WO2022011554A1 (zh) * | 2020-07-14 | 2022-01-20 | 四川大学 | 3-去氧-2-酮糖酸含氮衍生物及其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4914028A (en) * | 1988-02-10 | 1990-04-03 | Eli Lilly And Company | Method of preparing beta-2',2'-difluoronucleosides |
| US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
| US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| CA2095613C (en) * | 1990-11-13 | 2001-01-02 | Bernard Belleau | Substituted 1, 3-oxathiolanes and substituted 1, 3-dithiolanes with antiviral properties |
| IL101144A (en) | 1991-03-06 | 1996-09-12 | Wellcome Found | Pharmaceutical preparations containing 1 -) 2 -) hydroxymethyl (- 1, 3 - oxathiolan-5 - il (5) fluorescitosin and its derivatives for the treatment of their hepatitis B virus infections |
-
1992
- 1992-02-17 NZ NZ241625A patent/NZ241625A/en not_active IP Right Cessation
- 1992-02-17 IL IL10096592A patent/IL100965A/en not_active IP Right Cessation
- 1992-02-17 NZ NZ250842A patent/NZ250842A/en not_active IP Right Cessation
- 1992-02-20 DK DK99203367T patent/DK0984013T3/da active
- 1992-02-20 DE DE69233379T patent/DE69233379T2/de not_active Expired - Lifetime
- 1992-02-20 EP EP04076245A patent/EP1439177B1/en not_active Expired - Lifetime
- 1992-02-20 DE DE69233786T patent/DE69233786D1/de not_active Expired - Lifetime
- 1992-02-20 CA CA2513440A patent/CA2513440C/en not_active Expired - Lifetime
- 1992-02-20 WO PCT/US1992/001339 patent/WO1992014743A2/en active IP Right Grant
- 1992-02-20 HU HU9302377A patent/HU227823B1/hu active Protection Beyond IP Right Term
- 1992-02-20 BR BR9205661A patent/BR9205661A/pt not_active Application Discontinuation
- 1992-02-20 AT AT04076245T patent/ATE469147T1/de active
- 1992-02-20 EP EP99203367A patent/EP0984013B1/en not_active Expired - Lifetime
- 1992-02-20 CZ CS1992497A patent/CZ295074B6/cs not_active IP Right Cessation
- 1992-02-20 AT AT99203367T patent/ATE270291T1/de active
- 1992-02-20 RO RO93-01137A patent/RO119365B1/ro unknown
- 1992-02-20 DK DK04076245.2T patent/DK1439177T3/da active
- 1992-02-20 KR KR1019930702516A patent/KR0172590B1/ko not_active IP Right Cessation
- 1992-02-20 ES ES04076245T patent/ES2345102T3/es not_active Expired - Lifetime
- 1992-02-20 JP JP4507549A patent/JP2901160B2/ja not_active Expired - Lifetime
- 1992-02-20 RO ROA200400584A patent/RO122814B1/ro unknown
- 1992-02-20 ES ES99203367T patent/ES2224547T3/es not_active Expired - Lifetime
- 1992-02-20 CA CA002104399A patent/CA2104399C/en not_active Expired - Lifetime
- 1992-02-20 EP EP19920908027 patent/EP0575482A1/en not_active Ceased
- 1992-02-21 MX MX9200747A patent/MX9200747A/es active IP Right Grant
- 1992-02-21 MY MYPI92000287A patent/MY114350A/en unknown
- 1992-02-21 IE IE054592A patent/IE920545A1/en not_active Application Discontinuation
- 1992-02-21 PT PT100151A patent/PT100151B/pt not_active IP Right Cessation
- 1992-02-22 CN CN92101981A patent/CN1037682C/zh not_active Expired - Lifetime
-
1993
- 1993-08-20 NO NO19932980A patent/NO312399B1/no active IP Right Maintenance
- 1993-08-20 BG BG98062A patent/BG62053B1/bg unknown
- 1993-08-20 FI FI933684A patent/FI114915B/fi not_active IP Right Cessation
-
1995
- 1995-06-28 HU HU95P/P00510P patent/HU211344A9/hu unknown
- 1995-08-18 CN CN95109814A patent/CN1109108C/zh not_active Expired - Lifetime
- 1995-11-20 AU AU37943/95A patent/AU679649B2/en not_active Withdrawn - After Issue
-
1997
- 1997-11-06 JP JP34046997A patent/JP3292830B2/ja not_active Expired - Lifetime
-
1998
- 1998-05-15 CN CN98108905A patent/CN1084745C/zh not_active Expired - Lifetime
- 1998-08-17 AU AU80773/98A patent/AU8077398A/en not_active Abandoned
- 1998-12-28 HK HK00105566A patent/HK1026419A1/xx not_active IP Right Cessation
-
2002
- 2002-09-30 CN CNB021440336A patent/CN100396785C/zh not_active Expired - Lifetime
-
2003
- 2003-06-24 FI FI20030932A patent/FI20030932A/fi unknown
-
2005
- 2005-07-01 NO NO2005015C patent/NO2005015I2/no not_active Application Discontinuation
-
2008
- 2008-06-13 NO NO2008010C patent/NO2008010I1/no unknown
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