NO306676B1 - Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler - Google Patents
Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler Download PDFInfo
- Publication number
- NO306676B1 NO306676B1 NO940497A NO940497A NO306676B1 NO 306676 B1 NO306676 B1 NO 306676B1 NO 940497 A NO940497 A NO 940497A NO 940497 A NO940497 A NO 940497A NO 306676 B1 NO306676 B1 NO 306676B1
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- Norway
- Prior art keywords
- arrhythmias
- new
- oxocyclic
- antiarrhythmic
- lubricants
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74486791A | 1991-08-14 | 1991-08-14 | |
| PCT/US1992/006684 WO1993004061A1 (fr) | 1991-08-14 | 1992-08-10 | Nouvelles urees cycliques utilisees comme agents antiarythmiques et antifibrillants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO940497L NO940497L (no) | 1994-02-14 |
| NO940497D0 NO940497D0 (no) | 1994-02-14 |
| NO306676B1 true NO306676B1 (no) | 1999-12-06 |
Family
ID=24994275
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO940497A NO306676B1 (no) | 1991-08-14 | 1994-02-14 | Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler |
| NO19992898A NO310145B1 (no) | 1991-08-14 | 1999-06-14 | Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler |
| NO19992897A NO310148B1 (no) | 1991-08-14 | 1999-06-14 | Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler |
| NO19992900A NO310147B1 (no) | 1991-08-14 | 1999-06-14 | Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler |
| NO19992899A NO310146B1 (no) | 1991-08-14 | 1999-06-14 | Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19992898A NO310145B1 (no) | 1991-08-14 | 1999-06-14 | Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler |
| NO19992897A NO310148B1 (no) | 1991-08-14 | 1999-06-14 | Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler |
| NO19992900A NO310147B1 (no) | 1991-08-14 | 1999-06-14 | Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler |
| NO19992899A NO310146B1 (no) | 1991-08-14 | 1999-06-14 | Nye 4-oksocykliske urinstoffer som er nyttige som antiarytmiske og antifibrillatoriske midler |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5462940A (fr) |
| EP (2) | EP0598061B1 (fr) |
| JP (1) | JP3040473B2 (fr) |
| KR (2) | KR100273605B1 (fr) |
| AT (1) | ATE220675T1 (fr) |
| AU (1) | AU668360B2 (fr) |
| BR (1) | BR9206369A (fr) |
| CA (1) | CA2115427C (fr) |
| CZ (1) | CZ282368B6 (fr) |
| DE (1) | DE69232681T2 (fr) |
| DK (1) | DK0598061T3 (fr) |
| ES (1) | ES2180537T3 (fr) |
| FI (1) | FI109696B (fr) |
| HK (1) | HK1048806A1 (fr) |
| HU (1) | HU221317B1 (fr) |
| IL (1) | IL102793A (fr) |
| MX (1) | MX9204730A (fr) |
| MY (1) | MY109205A (fr) |
| NO (5) | NO306676B1 (fr) |
| NZ (1) | NZ243938A (fr) |
| PH (1) | PH31451A (fr) |
| PL (2) | PL170984B1 (fr) |
| PT (1) | PT100777B (fr) |
| RU (2) | RU2130935C1 (fr) |
| SK (1) | SK282656B6 (fr) |
| TW (1) | TW232691B (fr) |
| WO (1) | WO1993004061A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083945A (en) * | 1995-06-07 | 2000-07-04 | The Procter & Gamble Company | Cyclic ureas useful as antiarrhythmic and antifibrillatory agents |
| WO1998037068A1 (fr) | 1997-02-21 | 1998-08-27 | Bristol-Myers Squibb Company | Derives d'acide benzoïque et composes apparentes utilises comme agents antiarythmiques |
| US6048877A (en) * | 1997-02-21 | 2000-04-11 | Bristol-Myers Squibb Company | Tetralone derivatives as antiarrhythmic agents |
| US6262068B1 (en) | 1997-02-21 | 2001-07-17 | Bristol-Myers Squibb Company | Lactam derivatives as antiarrhythmic agents |
| US6664250B2 (en) | 1998-01-20 | 2003-12-16 | Bristol-Myers Squibb Co. | Lactam derivatives as antiarrhythmic agents |
| EP1056726A1 (fr) | 1998-02-20 | 2000-12-06 | The Procter & Gamble Company | Synthese en phase solide de-1-aminohydantoines |
| BR9910074A (pt) * | 1998-04-29 | 2000-12-26 | Procter & Gamble | Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas |
| PL198951B1 (pl) | 1998-04-29 | 2008-08-29 | Procter & Gamble | Sposób wytwarzania 1,3-dipodstawionych-4-oksocyklicznych moczników |
| CN100443473C (zh) * | 2005-04-30 | 2008-12-17 | 中国药科大学 | 1-氨基-3-(氮杂环基烷基)-2,4-咪唑二酮的合成方法 |
| ATE466873T1 (de) * | 2005-10-18 | 2010-05-15 | Seoul Nat Univ Ind Foundation | Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzung |
| US20120178762A1 (en) | 2006-12-15 | 2012-07-12 | Warner Chilcott Company, Llc | Compositions of azimilide dihydrochloride |
| TW200840578A (en) * | 2006-12-15 | 2008-10-16 | Procter & Gamble | Compositions of azimilide dihydrochloride |
| CN101735203B (zh) * | 2009-12-17 | 2012-05-23 | 天津药物研究院 | 盐酸阿齐利特的晶型ⅱ及其制备方法和用途 |
| CN101735202B (zh) * | 2009-12-17 | 2012-05-30 | 天津药物研究院 | 盐酸阿齐利特的晶型ⅰ及其制备方法和用途 |
| CN101735205B (zh) * | 2009-12-17 | 2013-05-15 | 天津药物研究院 | 盐酸阿齐利特的晶型ⅴ及其制备方法和用途 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB939941A (en) * | 1959-04-14 | 1963-10-16 | Norwich Pharma Co | Improvements in or relating to the manufacture of derivatives of 5-nitrofuran |
| US3182058A (en) * | 1960-10-31 | 1965-05-04 | Pfizer & Co C | Nitrofuran derivatives |
| DE1202281B (de) * | 1960-11-21 | 1965-10-07 | Josef Klosa Dipl Chem Dr | Verfahren zur Herstellung von N-(5-Nitro-2-furfuryliden)-1-aminohydantoinen |
| FR1310188A (fr) * | 1960-12-27 | 1963-03-06 | ||
| NL272957A (fr) * | 1960-12-27 | 1900-01-01 | ||
| NL272958A (fr) * | 1960-12-27 | |||
| FR1310190A (fr) * | 1960-12-27 | 1963-03-06 | ||
| DE1201845B (de) * | 1962-07-14 | 1965-09-30 | Zambon Spa | Verfahren zur Herstellung von N-(5-Nitro-2-furfuryliden)-1-aminohydantoin |
| NL300307A (fr) * | 1963-06-10 | |||
| US3415821A (en) * | 1965-09-07 | 1968-12-10 | Norwich Pharma Co | 1-(5-substituted)furfurylideneamino hydantoins and imidazolidinones |
| NL6900631A (fr) * | 1968-01-26 | 1969-07-29 | ||
| JPS5032271B2 (fr) * | 1973-06-06 | 1975-10-18 | ||
| US4001222A (en) * | 1975-10-14 | 1977-01-04 | Morton-Norwich Products, Inc. | 3-(Aminoacyl)-1-{[5-(substituted phenyl)furfurylidene]amino}hydantoins and process for their preparation thereof |
| US4775670A (en) * | 1980-09-29 | 1988-10-04 | E. R. Squibb & Sons, Inc. | 2-oxo-1-azetidinesulfonic acid salts |
| US4393204A (en) * | 1982-05-21 | 1983-07-12 | Norwich Eaton Pharmaceuticals, Inc. | 3-[[5-(4-Chlorophenyl)furfurylidene]amino]-5-(substituted)-2-oxazolidinones |
| JPS5913780A (ja) * | 1982-07-13 | 1984-01-24 | Takeda Chem Ind Ltd | フルオロウラシル誘導体および抗腫瘍剤 |
| US4543359A (en) * | 1982-10-01 | 1985-09-24 | Eaton Laboratories, Inc. | Treating cardiac arrhythmias with dantrolene sodium |
| FR2539412B1 (fr) * | 1983-01-13 | 1986-02-21 | Shoichiro Ozaki | Derives du 5-fluoruracile et leurs utilisations therapeutiques en tant qu'agents carcinostatiques |
| US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| US4581370A (en) * | 1983-07-12 | 1986-04-08 | Schering A.G. | Antiarrhythmic imidazoliums |
| US4720580A (en) * | 1984-09-21 | 1988-01-19 | American Home Products Corporation | N-(aminoalkylene)benzenesulfonamides |
| US4713382A (en) * | 1985-05-30 | 1987-12-15 | Syntex (U.S.A.) Inc. | N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents |
| US4707499A (en) * | 1985-12-02 | 1987-11-17 | G. D. Searle & Co. | 3-alkyl-5-(substituted amino)methyl)dihydro-3-phenyl-2(3H)-furanones and imino analogs thereof used for treatment of arrhythmia |
| GB8603120D0 (en) * | 1986-02-07 | 1986-03-12 | Pfizer Ltd | Anti-dysrhythmia agents |
| PH23283A (en) * | 1986-02-26 | 1989-06-30 | Eisai Co Ltd | Piperidine derivative, pharmaceutical composition containing the same and method of use thereof |
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| RU2125568C1 (ru) * | 1991-08-14 | 1999-01-27 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Соединения циклического уретана или их фармацевтически приемлемые соли, способ лечения людей и других млекопитающих, страдающих сердечной аритмией и/или сердечной фибрилляцией, фармацевтическая композиция для лечения аритмии и фибрилляции |
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1992
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- 1992-08-10 RU RU94015844A patent/RU2130935C1/ru not_active IP Right Cessation
- 1992-08-10 SK SK171-94A patent/SK282656B6/sk not_active IP Right Cessation
- 1992-08-10 PL PL92314009A patent/PL170984B1/pl unknown
- 1992-08-10 AT AT92918467T patent/ATE220675T1/de active
- 1992-08-10 DK DK92918467T patent/DK0598061T3/da active
- 1992-08-10 PL PL92302377A patent/PL170961B1/pl unknown
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- 1992-08-10 CZ CZ94306A patent/CZ282368B6/cs not_active IP Right Cessation
- 1992-08-10 WO PCT/US1992/006684 patent/WO1993004061A1/fr active IP Right Grant
- 1992-08-10 BR BR9206369A patent/BR9206369A/pt not_active Application Discontinuation
- 1992-08-10 HU HU9400396A patent/HU221317B1/hu unknown
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- 1992-08-10 CA CA002115427A patent/CA2115427C/fr not_active Expired - Lifetime
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1994
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- 1994-02-14 NO NO940497A patent/NO306676B1/no not_active IP Right Cessation
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1999
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2003
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