NO306457B1 - 2,4-disulfonylfenylbutylnitron, salter derav, farmasöytisk sammensetning, samt anvendelse av denne forbindelse til fremstilling av et medikament - Google Patents

2,4-disulfonylfenylbutylnitron, salter derav, farmasöytisk sammensetning, samt anvendelse av denne forbindelse til fremstilling av et medikament

Info

Publication number
NO306457B1
NO306457B1 NO962637A NO962637A NO306457B1 NO 306457 B1 NO306457 B1 NO 306457B1 NO 962637 A NO962637 A NO 962637A NO 962637 A NO962637 A NO 962637A NO 306457 B1 NO306457 B1 NO 306457B1
Authority
NO
Norway
Prior art keywords
nervous system
central nervous
salts
disulfonylphenylbutylnitron
medicament
Prior art date
Application number
NO962637A
Other languages
English (en)
Norwegian (no)
Other versions
NO962637L (no
NO962637D0 (no
Inventor
John M Carney
Original Assignee
Oklahoma Med Res Found
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Univ Kentucky Res Found filed Critical Oklahoma Med Res Found
Publication of NO962637D0 publication Critical patent/NO962637D0/no
Publication of NO962637L publication Critical patent/NO962637L/no
Publication of NO306457B1 publication Critical patent/NO306457B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO962637A 1993-12-23 1996-06-20 2,4-disulfonylfenylbutylnitron, salter derav, farmasöytisk sammensetning, samt anvendelse av denne forbindelse til fremstilling av et medikament NO306457B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
PCT/US1994/014545 WO1995017876A2 (en) 1993-12-23 1994-12-22 2,4-disulphophenyl butylnitrone, its salts, and their use as pharmaceutical spintraps

Publications (3)

Publication Number Publication Date
NO962637D0 NO962637D0 (no) 1996-06-20
NO962637L NO962637L (no) 1996-08-13
NO306457B1 true NO306457B1 (no) 1999-11-08

Family

ID=22632663

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962637A NO306457B1 (no) 1993-12-23 1996-06-20 2,4-disulfonylfenylbutylnitron, salter derav, farmasöytisk sammensetning, samt anvendelse av denne forbindelse til fremstilling av et medikament

Country Status (28)

Country Link
US (4) US5488145A (cs)
EP (1) EP0736004B1 (cs)
JP (3) JP3412821B2 (cs)
KR (1) KR100370522B1 (cs)
CN (1) CN1070176C (cs)
AT (1) ATE192736T1 (cs)
AU (1) AU679835B2 (cs)
BR (2) BR9408378A (cs)
CA (1) CA2179521C (cs)
CZ (1) CZ289629B6 (cs)
DE (1) DE69424441T2 (cs)
DK (1) DK0736004T3 (cs)
ES (1) ES2145264T3 (cs)
FI (1) FI111718B (cs)
GR (1) GR3034134T3 (cs)
HR (1) HRP950358B1 (cs)
HU (1) HU221167B1 (cs)
MY (1) MY114178A (cs)
NO (1) NO306457B1 (cs)
NZ (1) NZ279025A (cs)
PL (1) PL185189B1 (cs)
PT (1) PT736004E (cs)
RU (1) RU2159231C2 (cs)
SG (1) SG64903A1 (cs)
SK (1) SK282403B6 (cs)
TW (1) TW299315B (cs)
UA (1) UA45964C2 (cs)
WO (1) WO1995017876A2 (cs)

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JP3887020B2 (ja) * 1995-11-17 2007-02-28 フロリダ インターナショナル ユニバーシティー アズレニルニトロンスピントラッピング剤、ならびにその製造方法および使用方法
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NZ505757A (en) * 1998-01-16 2002-09-27 Centaur Pharmaceuticals Inc Thioether furan nitrone compounds and pharmaceuticals thereof; useful for the treatment or prophylaxis of neurodegenerative, autoimmune and inflammatory conditions
DE69904018D1 (en) * 1998-01-16 2003-01-02 Centaur Pharmaceuticals Inc Thiophennitronderivate
EP1061916A2 (en) * 1998-03-13 2000-12-27 Centaur Pharmaceuticals, Inc. Use os nitrone compounds for the inhibition of angiogenesis
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UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
CN1156478C (zh) 1999-01-25 2004-07-07 国家犹太医疗及研究中心 取代的卟啉
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US20020022743A1 (en) * 2000-01-10 2002-02-21 Sergei Pouhov Method for the purification of aryl sulfonic acids and salts
SE0000055D0 (sv) * 2000-01-10 2000-01-10 Centaur Pharmaceuticals Inc Novel process
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US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
US6835754B2 (en) 2001-01-08 2004-12-28 Renovis, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
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US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US20060183800A1 (en) * 2004-11-12 2006-08-17 Xianqi Kong Methods and fluorinated compositions for treating amyloid-related diseases
JP2008520647A (ja) * 2004-11-16 2008-06-19 ニューロケム （インターナショナル） リミテッド Ｃｎｓおよびアミロイド関連疾患治療のための化合物
CN101128421A (zh) 2004-12-22 2008-02-20 神经化学（国际）有限公司 治疗淀粉样相关疾病用的方法与组合物
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WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
WO2007013842A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain
WO2007013841A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimine)methyl) benzene-1,3-disulfonate n-oxide against cerebral oedema
WO2007125385A2 (en) * 2005-12-22 2007-11-08 Neurochem (International) Limited Treatment of renal disorders, diabetic nephopathy and dyslipidemias
JP5236641B2 (ja) * 2006-07-25 2013-07-17 ハフ イヤ インスティテュート 急性音響外傷の治療方法
KR101443573B1 (ko) 2006-10-12 2014-11-03 비에이치아이 리미티드 파트너쉽 3-아미노-1-프로판설폰산을 전달하기 위한 방법, 화합물, 조성물 및 비히클
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US9289404B2 (en) * 2011-02-04 2016-03-22 Hough Ear Institute Methods for treating brain injury
WO2018081614A1 (en) 2016-10-31 2018-05-03 Hough Ear Institute Methods for enhancing synaptogenesis and neuritogenesis
CN110392568A (zh) 2017-01-19 2019-10-29 耳科制药公司 N-乙酰半胱氨酸的制剂及其用途
CA3074102A1 (en) 2017-09-20 2019-03-28 Oklahoma Medical Research Foundation Treatment of drug resistant gliomas
US10829441B2 (en) 2017-11-14 2020-11-10 The University Of Toledo Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke
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EP3849530A4 (en) 2018-09-12 2022-06-22 Hough Ear Institute Methods for treating hearing loss incident to cochlear implant surgery
JP2023514742A (ja) * 2020-02-24 2023-04-07 オブラート，インコーポレーテッド がん及び腫瘍を処置する組成物及び方法

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CA2069961C (en) * 1989-10-17 2000-05-02 John M. Carney Method and compositions for inhibition of disorders associated with oxidative damage
DE3937342A1 (de) * 1989-11-09 1991-05-16 Bayer Ag Verfahren zur herstellung von 2-aminobenzol-disulfonsaeuren-(1,4) und die neue verbindung 6-chlor-2-aminobenzol-disulfonsaeure-(1,4)
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US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
JPH09507232A (ja) 1997-07-22
GR3034134T3 (en) 2000-11-30
TW299315B (cs) 1997-03-01
CZ177596A3 (en) 1996-12-11
JP2004075696A (ja) 2004-03-11
HU221167B1 (en) 2002-08-28
WO1995017876A2 (en) 1995-07-06
ES2145264T3 (es) 2000-07-01
HK1001768A1 (en) 1998-07-10
NZ279025A (en) 1998-02-26
CZ289629B6 (cs) 2002-03-13
BR1100626A (pt) 1999-11-23
DK0736004T3 (da) 2000-10-09
NO962637L (no) 1996-08-13
WO1995017876A3 (en) 1995-08-10
HRP950358B1 (en) 2001-04-30
FI111718B (fi) 2003-09-15
FI962589A0 (fi) 1996-06-20
NO962637D0 (no) 1996-06-20
US5488145A (en) 1996-01-30
CN1070176C (zh) 2001-08-29
EP0736004A1 (en) 1996-10-09
HK1008294A1 (en) 1999-05-07
DE69424441D1 (de) 2000-06-15
JP2001010953A (ja) 2001-01-16
US5475032A (en) 1995-12-12
ATE192736T1 (de) 2000-05-15
AU1552795A (en) 1995-07-17
PT736004E (pt) 2000-09-29
AU679835B2 (en) 1997-07-10
KR100370522B1 (ko) 2003-05-16
PL185189B1 (pl) 2003-03-31
FI962589L (fi) 1996-08-20
CN1156447A (zh) 1997-08-06
US5780510A (en) 1998-07-14
EP0736004B1 (en) 2000-05-10
SK78896A3 (en) 1997-09-10
CA2179521A1 (en) 1995-07-06
HU9601739D0 (en) 1996-08-28
PL315154A1 (en) 1996-10-14
UA45964C2 (uk) 2002-05-15
MY114178A (en) 2002-08-30
HRP950358A2 (en) 1997-08-31
JP3412821B2 (ja) 2003-06-03
RU2159231C2 (ru) 2000-11-20
DE69424441T2 (de) 2000-10-12
US5508305A (en) 1996-04-16
HUT76788A (en) 1997-11-28
BR9408378A (pt) 1997-08-19
CA2179521C (en) 2002-03-19
SK282403B6 (sk) 2002-01-07
SG64903A1 (en) 1999-05-25

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