NO306408B1 - L-nukleosidforbindelse, anvendelse derav og farmasöytisk sammensetning - Google Patents
L-nukleosidforbindelse, anvendelse derav og farmasöytisk sammensetningInfo
- Publication number
- NO306408B1 NO306408B1 NO963138A NO963138A NO306408B1 NO 306408 B1 NO306408 B1 NO 306408B1 NO 963138 A NO963138 A NO 963138A NO 963138 A NO963138 A NO 963138A NO 306408 B1 NO306408 B1 NO 306408B1
- Authority
- NO
- Norway
- Prior art keywords
- fluoro
- beta
- arabinofuranosyl
- ebv
- deoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/189,070 US5587362A (en) | 1994-01-28 | 1994-01-28 | L-nucleosides |
PCT/US1995/001253 WO1995020595A1 (en) | 1994-01-28 | 1995-01-30 | L-nucleosides for the treatment of hepatitis b-virus and epstein-bar virus |
Publications (3)
Publication Number | Publication Date |
---|---|
NO963138D0 NO963138D0 (no) | 1996-07-26 |
NO963138L NO963138L (no) | 1996-09-26 |
NO306408B1 true NO306408B1 (no) | 1999-11-01 |
Family
ID=22695792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO963138A NO306408B1 (no) | 1994-01-28 | 1996-07-26 | L-nukleosidforbindelse, anvendelse derav og farmasöytisk sammensetning |
Country Status (23)
Country | Link |
---|---|
US (3) | US5587362A (de) |
EP (2) | EP1283211B1 (de) |
JP (1) | JP3899440B2 (de) |
KR (1) | KR100321209B1 (de) |
CN (1) | CN1043769C (de) |
AT (2) | ATE236186T1 (de) |
AU (1) | AU710262B2 (de) |
BG (1) | BG62571B1 (de) |
BR (1) | BRPI9506596B8 (de) |
CA (1) | CA2182273C (de) |
CZ (1) | CZ292574B6 (de) |
DE (2) | DE69530192T2 (de) |
DK (2) | DK0748330T3 (de) |
ES (2) | ES2266402T3 (de) |
FI (4) | FI117475B (de) |
HK (1) | HK1014716A1 (de) |
HU (1) | HU228135B1 (de) |
NO (1) | NO306408B1 (de) |
NZ (2) | NZ281058A (de) |
PT (2) | PT748330E (de) |
RO (1) | RO116623B1 (de) |
SK (1) | SK285191B6 (de) |
WO (1) | WO1995020595A1 (de) |
Families Citing this family (68)
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US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
US20020120130A1 (en) * | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
AU722214B2 (en) | 1995-06-07 | 2000-07-27 | Centre National De La Recherche Scientifique (Cnrs) | Nucleosides with anti-hepatitis B virus activity |
US6025335A (en) * | 1995-09-21 | 2000-02-15 | Lipitek International, Inc. | L-Nucleoside Dimer Compounds and therapeutic uses |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
CZ126799A3 (cs) * | 1996-10-16 | 1999-07-14 | Icn Pharmaceuticals | Purinové L-nukleosidy a jejich analogy a farmaceutické prostředky, které je obsahují |
SK284054B6 (sk) * | 1996-10-16 | 2004-08-03 | Icn Pharmaceuticals, Inc. | Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie |
EP1254911A1 (de) * | 1996-10-16 | 2002-11-06 | ICN Pharmaceuticals, Inc. | Monozyklische L-Nukleoside, analoga und ihre Anwendungen |
US6509320B1 (en) * | 1996-10-16 | 2003-01-21 | Icn Pharmaceuticals, Inc. | Purine L-nucleosides, analogs and uses thereof |
EP1072607A3 (de) * | 1996-10-16 | 2001-09-12 | ICN Pharmaceuticals, Inc. | Purin-L-Nukleoside, deren Analoga und Verwendungen |
TW434252B (en) * | 1997-07-23 | 2001-05-16 | Univ Georgia Res Found | Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine |
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US6090602A (en) | 1998-02-18 | 2000-07-18 | Promelas Research Corporation | Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent |
ES2276515T3 (es) | 1998-02-25 | 2007-06-16 | Emory University | 2'-fluoronucleosidos. |
KR100449618B1 (ko) * | 1998-03-27 | 2004-11-16 | 부광약품 주식회사 | 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법 |
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US6444652B1 (en) | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
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ATE287268T1 (de) | 1998-11-02 | 2005-02-15 | Gilead Sciences Inc | Kombinationstherapie zur behandlung von hepatitis b infektionen |
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NZ241625A (en) * | 1991-02-22 | 1996-03-26 | Univ Emory | 1,3-oxathiolane derivatives, anti-viral compositions containing such and method of resolving racemic mixture of enantiomers |
DE69233693T2 (de) * | 1991-03-06 | 2008-01-24 | Emory University | Salze und Amide von (-) cis 5-Fluoro-2'-deoxy-3'-thiacytidine geeignet für die Behandlung von Hepatitis B |
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GB9111902D0 (en) * | 1991-06-03 | 1991-07-24 | Glaxo Group Ltd | Chemical compounds |
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