NO305055B1 - Farmas°ytisk t°rr blanding, farmas°ytisk doseringsenhet, fremgangsmÕte ved fremstilling derav og fremgangsmÕte ved fremstilling av tabletter - Google Patents
Farmas°ytisk t°rr blanding, farmas°ytisk doseringsenhet, fremgangsmÕte ved fremstilling derav og fremgangsmÕte ved fremstilling av tabletter Download PDFInfo
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- NO305055B1 NO305055B1 NO920958A NO920958A NO305055B1 NO 305055 B1 NO305055 B1 NO 305055B1 NO 920958 A NO920958 A NO 920958A NO 920958 A NO920958 A NO 920958A NO 305055 B1 NO305055 B1 NO 305055B1
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- medical
- tablets
- steroid compound
- mixture
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 229940084921 micronized glyburide Drugs 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91200524 | 1991-03-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO920958D0 NO920958D0 (no) | 1992-03-11 |
| NO920958L NO920958L (no) | 1992-09-14 |
| NO305055B1 true NO305055B1 (no) | 1999-03-29 |
Family
ID=8207548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO920958A NO305055B1 (no) | 1991-03-12 | 1992-03-11 | Farmas°ytisk t°rr blanding, farmas°ytisk doseringsenhet, fremgangsmÕte ved fremstilling derav og fremgangsmÕte ved fremstilling av tabletter |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5382434A (fi) |
| EP (1) | EP0503521B2 (fi) |
| JP (1) | JP3474210B2 (fi) |
| KR (1) | KR100198017B1 (fi) |
| CN (1) | CN1039086C (fi) |
| AT (1) | ATE125155T1 (fi) |
| AU (1) | AU651869B2 (fi) |
| CA (1) | CA2062428C (fi) |
| DE (1) | DE69203488T3 (fi) |
| DK (1) | DK0503521T4 (fi) |
| ES (1) | ES2077897T5 (fi) |
| FI (1) | FI100770B (fi) |
| GR (1) | GR3017737T3 (fi) |
| HK (1) | HK1002018A1 (fi) |
| IE (1) | IE67345B1 (fi) |
| NO (1) | NO305055B1 (fi) |
| NZ (1) | NZ241915A (fi) |
| ZA (1) | ZA921659B (fi) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA924617B (en) | 1991-03-25 | 1994-05-27 | Boart International S A Pty Lt | A percussion drill bit |
| US5928668A (en) * | 1993-12-21 | 1999-07-27 | Applied Analytical Industries, Inc. | Method for dry blend compression of medicaments |
| ZA939566B (en) * | 1993-12-21 | 1994-08-11 | Applied Analytical Ind Inc | Method for dry blend compression od medicaments. |
| ZA939565B (en) * | 1993-12-21 | 1994-08-11 | Applied Analytical Ind Inc | Method for preparing low dose pharmaceutical products. |
| US5976570A (en) * | 1993-12-21 | 1999-11-02 | Applied Analytical Industries, Inc. | Method for preparing low dose pharmaceutical products |
| ZA949929B (en) * | 1993-12-23 | 1995-08-23 | Akzo Nobel Nv | Sugar-coated pharmaceutical dosage unit. |
| US6077533A (en) * | 1994-05-25 | 2000-06-20 | Purdue Pharma L.P. | Powder-layered oral dosage forms |
| PT782449E (pt) * | 1994-09-22 | 2003-07-31 | Akzo Nobel Nv | Processo de fabrico de unidades de dosagem por granulacao humida |
| IL115445A (en) * | 1994-10-17 | 1999-08-17 | Akzo Nobel Nv | Solid pharmaceutical compositions comprising low dosage active ingredient oil and excipient capable of binding water and their preparation |
| WO1997026798A1 (en) * | 1995-01-25 | 1997-07-31 | Wm. Wrigley Jr. Company | Improved rolling compound and methods of manufacturing chewing gum using same |
| US6063403A (en) * | 1995-06-22 | 2000-05-16 | Akzo Nobel N.V. | Compressed dry-granulation desogestrel tablets |
| DE19652196A1 (de) | 1996-12-16 | 1998-06-18 | Jenapharm Gmbh | Homogene steroidhaltige Präformulierungen zur Herstellung niedrigdosierter fester und halbfester pharmazeutischer Zubereitungen |
| WO2000050041A1 (en) * | 1999-02-24 | 2000-08-31 | Akzo Nobel N.V. | Pharmaceutical compositions containing a crystalline form of the progestagen-(17alpha)-17-hydroxy-11-methylene-19-nor-pregna-4,15-dien-20-yn-3-one (org 30659) and lactose |
| KR20010006835A (ko) * | 1999-03-25 | 2001-01-26 | 김선진 | 경구용 속붕해정 |
| DE19917347A1 (de) * | 1999-04-16 | 2000-11-09 | Gsf Forschungszentrum Umwelt | Verfahren und Vorrichtung zum trockenen Anbringen von Substanzen an inhalierbare pulverförmige Trägerstoffe |
| ITMI991582A1 (it) * | 1999-07-16 | 2001-01-16 | Chiesi Farma Spa | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
| FR2796840B1 (fr) * | 1999-07-26 | 2003-06-20 | Ethypharm Lab Prod Ethiques | Comprimes faiblement doses et procede de preparation |
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| FR2801218B1 (fr) * | 1999-11-23 | 2001-12-28 | Hoechst Marion Roussel Inc | Compositions pharmaceutiques comprenant de la trimegestone, leurs procedes de preparation ainsi que le conditionnement primaire les renfermant |
| JP2003518038A (ja) * | 1999-12-20 | 2003-06-03 | ニコラス， ジェイ カークホフ， | 流動床噴霧乾燥によるナノ粒子製造方法 |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| ATE374261T1 (de) | 2000-07-20 | 2007-10-15 | Campina Nederland Holding Bv | Methode zur herstellung eines kristallinen tablettierungshilfstoffes, der so erhaltene hilfsstoff und seine verwendung |
| ES2253451T3 (es) * | 2000-12-14 | 2006-06-01 | Ortho-Mcneil Pharmaceutical, Inc. | Productos a base de hormona esteroide y sus procedimientos de fabricacion. |
| US20040121006A1 (en) * | 2001-03-06 | 2004-06-24 | Shoichi Narita | Utilization of spray-dried powder containing sugar alcohol |
| KR20030081472A (ko) * | 2001-03-06 | 2003-10-17 | 교와 핫꼬 고교 가부시끼가이샤 | 구강내 속붕괴성 제제 |
| OA12596A (en) * | 2001-05-01 | 2006-06-08 | Pfizer Prod Inc | Method for manufacturing a low dose pharmaceuticalcomposition. |
| US7118765B2 (en) | 2001-12-17 | 2006-10-10 | Spi Pharma, Inc. | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
| US6962908B2 (en) | 2001-12-21 | 2005-11-08 | Warner Chilcott Company Inc. | Oral pharmaceutical products containing 17 β-estradiol-3-lower alkanoate, method of administering the same and process of preparation |
| EP1620060B1 (en) | 2003-04-29 | 2010-03-24 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
| US7799273B2 (en) | 2004-05-06 | 2010-09-21 | Smp Logic Systems Llc | Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes |
| US7444197B2 (en) | 2004-05-06 | 2008-10-28 | Smp Logic Systems Llc | Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes |
| TWI428271B (zh) * | 2004-06-09 | 2014-03-01 | Smithkline Beecham Corp | 生產藥物之裝置及方法 |
| US8617597B2 (en) | 2006-07-06 | 2013-12-31 | Bayer Intellectual Property Gmbh | Pharmaceutical composition containing a tetrahydrofolic acid |
| EP2178540A4 (en) * | 2007-08-01 | 2012-01-04 | Stellan Hjerten | PHARMACEUTICAL COMPOSITION FOR ADSORBED ON THE CELL SURFACE OF PATHOGENIC MICROBES |
| BRPI0914024A2 (pt) * | 2008-10-10 | 2015-11-03 | Teva Womens Health Inc | formas de dosagem farmacêutica, embalagens e uso de acetato de ciproterona |
| WO2010104563A2 (en) | 2009-03-09 | 2010-09-16 | Spi Pharma, Inc. | Highly compactable and durable direct compression excipients and excipient systems |
| HUP0900698A2 (en) | 2009-11-06 | 2011-06-28 | Richter Gedeon Nyrt | Pharmaceutical compositions of enhanced stability containing drospirenone and ethynyl estradiol and process for their preparation |
| EP2354150A1 (en) * | 2010-02-09 | 2011-08-10 | Laboratoire Theramex | Process for the preparation of gestodene |
| WO2012120365A1 (en) | 2011-03-07 | 2012-09-13 | Aurobindo Pharma Limited | Stable pharmaceutical composition comprising ethinyl estradiol |
| CN102416003A (zh) * | 2011-12-08 | 2012-04-18 | 南京优科生物医药有限公司 | 一种制备恩替卡韦片剂的方法 |
| ES2804702T3 (es) * | 2013-03-04 | 2021-02-09 | Besins Healthcare Lu Sarl | Composiciones farmacéuticas secas que comprenden nanopartículas de agente activo unidas a partículas de portador |
| CZ309820B6 (cs) * | 2021-04-23 | 2023-11-08 | Pro.Med.Cs Praha A.S. | Způsob přípravy pevné lékové formy obsahující kompozici s nízkým obsahem účinné látky |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3626063A (en) * | 1959-08-11 | 1971-12-07 | Upjohn Co | Therapeutic compositions comprising 6-fluoro-16-methyl prednisolone, the 21 acylates and salts thereof |
| US3344030A (en) * | 1964-06-15 | 1967-09-26 | American Home Prod | Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables |
| US3423507A (en) * | 1966-02-25 | 1969-01-21 | Schering Corp | Method of treating benign prostratic hypertrophy |
| US3568828A (en) * | 1967-03-01 | 1971-03-09 | Squibb & Sons Inc | Modified sequential oral contraceptive |
| US3671633A (en) * | 1971-05-10 | 1972-06-20 | American Cyanamid Co | Process for tabletting acetazolamide |
| US3802914A (en) * | 1972-04-10 | 1974-04-09 | Kraftco Corp | Method of treating lactose |
| SE378109B (fi) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| DE2365103C3 (de) * | 1973-12-21 | 1980-08-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | V erwendung von Hormonen zur Kontrazeption |
| DE2524902C2 (de) * | 1975-06-02 | 1984-10-25 | Schering AG, 1000 Berlin und 4709 Bergkamen | Vorrichtung zur Inhalation von Arzneimitteln |
| US4143136A (en) * | 1976-11-20 | 1979-03-06 | Akzona Incorporated | Method of contraception |
| DE2716323C2 (de) * | 1977-04-07 | 1986-03-13 | Schering AG, 1000 Berlin und 4709 Bergkamen | Vorrichtung zur Inhalation von Arzneimitteln |
| NL8001593A (nl) * | 1980-03-18 | 1981-10-16 | Akzo Nv | Meerfasisch combinatiepreparaat voor orale anticonceptie. |
| US4628051A (en) * | 1983-09-26 | 1986-12-09 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| DE3505433A1 (de) * | 1985-02-16 | 1986-08-21 | Basf Ag, 6700 Ludwigshafen | Direkttablettierhilfsmittel |
| DE3506276C1 (de) * | 1985-02-22 | 1986-04-24 | Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring | Direkttablettiermittel |
| US4916163A (en) * | 1985-06-04 | 1990-04-10 | The Upjohn Company | Spray-dried lactose formulation of micronized glyburide |
-
1992
- 1992-02-27 IE IE920634A patent/IE67345B1/en not_active IP Right Cessation
- 1992-03-05 CA CA002062428A patent/CA2062428C/en not_active Expired - Lifetime
- 1992-03-05 ZA ZA921659A patent/ZA921659B/xx unknown
- 1992-03-06 AU AU12119/92A patent/AU651869B2/en not_active Expired
- 1992-03-09 DE DE69203488T patent/DE69203488T3/de not_active Expired - Lifetime
- 1992-03-09 ES ES92103963T patent/ES2077897T5/es not_active Expired - Lifetime
- 1992-03-09 FI FI921023A patent/FI100770B/fi not_active IP Right Cessation
- 1992-03-09 AT AT92103963T patent/ATE125155T1/de active
- 1992-03-09 DK DK92103963T patent/DK0503521T4/da active
- 1992-03-09 EP EP92103963A patent/EP0503521B2/en not_active Expired - Lifetime
- 1992-03-10 NZ NZ241915A patent/NZ241915A/en not_active IP Right Cessation
- 1992-03-11 KR KR1019920003956A patent/KR100198017B1/ko not_active IP Right Cessation
- 1992-03-11 NO NO920958A patent/NO305055B1/no not_active IP Right Cessation
- 1992-03-11 CN CN92101566A patent/CN1039086C/zh not_active Expired - Lifetime
- 1992-03-12 JP JP05393692A patent/JP3474210B2/ja not_active Expired - Lifetime
-
1994
- 1994-03-22 US US08/216,236 patent/US5382434A/en not_active Expired - Lifetime
-
1995
- 1995-10-16 GR GR950402836T patent/GR3017737T3/el unknown
-
1998
- 1998-02-11 HK HK98101029A patent/HK1002018A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO920958D0 (no) | 1992-03-11 |
| EP0503521B2 (en) | 2005-11-09 |
| ES2077897T3 (es) | 1995-12-01 |
| FI921023A0 (fi) | 1992-03-09 |
| CN1064810A (zh) | 1992-09-30 |
| DE69203488D1 (de) | 1995-08-24 |
| FI100770B (fi) | 1998-02-27 |
| KR100198017B1 (ko) | 1999-06-15 |
| EP0503521A1 (en) | 1992-09-16 |
| NO920958L (no) | 1992-09-14 |
| CA2062428A1 (en) | 1992-09-13 |
| ES2077897T5 (es) | 2006-06-16 |
| CA2062428C (en) | 2002-07-30 |
| JP3474210B2 (ja) | 2003-12-08 |
| IE67345B1 (en) | 1996-03-20 |
| DE69203488T2 (de) | 1996-01-11 |
| NZ241915A (en) | 1994-04-27 |
| HK1002018A1 (en) | 1998-07-24 |
| IE920634A1 (en) | 1992-09-23 |
| DK0503521T3 (da) | 1995-11-27 |
| AU651869B2 (en) | 1994-08-04 |
| KR920017656A (ko) | 1992-10-21 |
| DK0503521T4 (da) | 2005-12-05 |
| DE69203488T3 (de) | 2006-07-06 |
| JPH0578251A (ja) | 1993-03-30 |
| FI921023A (fi) | 1992-09-13 |
| AU1211992A (en) | 1992-09-17 |
| GR3017737T3 (en) | 1996-01-31 |
| US5382434A (en) | 1995-01-17 |
| CN1039086C (zh) | 1998-07-15 |
| ZA921659B (en) | 1992-11-25 |
| ATE125155T1 (de) | 1995-08-15 |
| EP0503521B1 (en) | 1995-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |